2QL2: Crystal Structure of the basic-helix-loop-helix domains of the heterodimer E47/NeuroD1 bound to DNA

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PDB ID: 2QL2Download
MMDB ID: 67684
PDB Deposition Date: 2007/7/12
Updated in MMDB: 2008/12
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
synthetic construct
Similar Structures:
Molecular Graphic ?
2QL2: Crystal Structure of the basic-helix-loop-helix domains of the heterodimer E47/NeuroD1 bound to DNA
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Interactions?
AA: Transcription factor E2-alphaBB: Neurogenic differentiation factor 1CC: Transcription factor E2-alphaDD: Neurogenic differentiation factor 1EE: DNA (5'-D(*DTP*DAP*DGP*DGP*DCP*DCP*DAP*DTP*DCP*DTP*DGP*DGP*DTP*DCP*DCP*DT)-3')FF: DNA (5'-D(*DAP*DGP*DGP*DAP*DCP*DCP*DAP*DGP*DAP*DTP*DGP*DGP*DCP*DCP*DTP*DA)-3')GG: DNA (5'-D(*DTP*DAP*DGP*DGP*DCP*DCP*DAP*DTP*DCP*DTP*DGP*DGP*DTP*DCP*DCP*DT)-3')HH: DNA (5'-D(*DAP*DGP*DGP*DAP*DCP*DCP*DAP*DGP*DAP*DTP*DGP*DGP*DCP*DCP*DTP*DA)-3')
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Data Set:
Molecular Components in 2QL2
Label Count Molecule
Proteins (4 molecules)
2
Transcription Factor E2-alpha
2 Proteins
SS Diagram
Features
Domain Families
Specific Hits
Super Families
110203040506060 residues, click to see VAST similar structures.helix 2-30helix 39-58DNA binding siteDNA binding site(6)location: 9, residue: Elocation: 10, residue: Rlocation: 12, residue: Rlocation: 17, residue: Nlocation: 38, residue: Tlocation: 39, residue: Kdimer interfacedimer(15)location: 15, residue: Dlocation: 16, residue: Ilocation: 19, residue: Alocation: 20, residue: Flocation: 22, residue: Elocation: 23, residue: Llocation: 26, residue: Mlocation: 30, residue: Hlocation: 40, residue: Llocation: 43, residue: Llocation: 47, residue: Vlocation: 50, residue: Ilocation: 53, residue: Llocation: 54, residue: Elocation: 55, residue: QbHLH_E-proteincd11420 (9-55): basic helix-loop-helix (bHLH) domain found in E proteins familybHLH_SF superfamilycl00081(9-55): bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly...
2
Neurogenic Differentiation Factor 1
2 Proteins
SS Diagram
Features
Domain Families
Specific Hits
Super Families
110203040506060 residues, click to see VAST similar structures.helix 2-27helix 39-57DNA binding siteDNA binding site(8)location: 7, residue: Nlocation: 10, residue: Elocation: 11, residue: Rlocation: 13, residue: Rlocation: 15, residue: Hlocation: 18, residue: Nlocation: 38, residue: Slocation: 39, residue: Kdimer interfacedimer interface(17)location: 17, residue: Llocation: 20, residue: Alocation: 21, residue: Llocation: 23, residue: Nlocation: 24, residue: Llocation: 27, residue: Vlocation: 28, residue: Vlocation: 39, residue: Klocation: 40, residue: Ilocation: 43, residue: Llocation: 47, residue: Klocation: 49, residue: Ylocation: 50, residue: Ilocation: 53, residue: Llocation: 54, residue: Slocation: 56, residue: Ilocation: 57, residue: LbHLH_TS_NeuroDcd11427 (3-57): basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor (NeuroD) familybHLH_SF superfamilycl00081(3-57): bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly...
Nucleotides(4 molecules)
2
DNA (5'-d(*dtp*dap*dgp*dgp*dcp*dcp*dap*dtp*dcp*dtp*dgp*dgp*dtp*dcp*dcp*dt)-3')
2
DNA (5'-d(*dap*dgp*dgp*dap*dcp*dcp*dap*dgp*dap*dtp*dgp*dgp*dcp*dcp*dtp*da)-3')
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