8GCC: T. cruzi topoisomerase II alpha bound to dsDNA and the covalent inhibitor CT1

PDB ID: 8GCCDownload
MMDB ID: 232841
PDB Deposition Date: 2023/3/1
Updated in MMDB: 2023/07
Experimental Method:
electron microscopy
Resolution: 2.94  Å
Source Organism:
Trypanosoma cruzi strain CL Brener▼
Similar Structures:
Biological Unit for 8GCC: tetrameric; determined by author
Molecular Components in 8GCC
Label Count Molecule
Proteins (2 molecules)
2
DNA Topoisomerase 2
Molecule annotation
Nucleotides(2 molecules)
2
DNA (28-mer)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
2
2-{3-[(Z)-iminomethyl]-1H-1,2,4-triazol-1-yl}-1-{(3M)-3-[2-(trifluoromethyl)phenyl]-6H-pyrrolo[3,4-b]pyridin-6-yl}ethan-1-one2-{3-[(Z)-iminomethyl]-1H-1,2,4-triazol-1-yl}-1-{(3M)-3-[2-(trifluoromethyl)phenyl]-6H-pyrrolo[3,4-b]pyridin-6-yl}ethan-1-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303