The_Phlebotomus_papatasi_transcriptomic_response_to_trypanosomatid_contaminated_blood_is_robust_but_non_specific
Identifiers: SRA: ERP112035
BioProject: PRJEB29708
SC: The_Phlebotomus_papatasi_transcriptomic_response_to_trypanosomatid_contaminated_blood_is_robust_but_non_specific-sc-5559
Wellcome Sanger Institute: The_Phlebotomus_papatasi_transcriptomic_response_to_trypanosomatid_contaminated_blood_is_robust_but_non_specific-sc-5559
BioProject: PRJEB29708
SC: The_Phlebotomus_papatasi_transcriptomic_response_to_trypanosomatid_contaminated_blood_is_robust_but_non_specific-sc-5559
Wellcome Sanger Institute: The_Phlebotomus_papatasi_transcriptomic_response_to_trypanosomatid_contaminated_blood_is_robust_but_non_specific-sc-5559
Study Type:
Transcriptome Analysis
Abstract: The Phlebotomus papatasi transcriptomic response to trypanosomatid-contaminated blood is robust but non-specific
Description: Leishmaniasis, caused by parasites of the genus Leishmania, is a disease that effects up to 8 million people worldwide. Parasites are transmitted to human and animal hosts through the bite of an infected sand fly. Novel strategies for disease control, require a better understanding of the key step for transmission namely, the establishment of infection inside the fly. In this work we wanted to identify fly transcriptomic signatures associated with infection success or failure. We used next generation sequencing to describe the transcriptome of the sand fly Phlebotomus papatasi when fed with blood alone or with blood containing one of three trypanosomatids: Leishmania major, Leishmania donovani and Herpetomonas muscarum: a parasite not transmitted to humans. Of these, only L. major was able to successfully establish an infection in P. papatasi. However, the transcriptional signatures observed were not specific to success or failure of infection but a generalised response to the blood meal. This implies that sand flies perceive Leishmania as just a feature of their microbiome landscape and that any strategy to tackle transmission should focus on the response towards the blood meal rather than parasite establishment. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/