Table 174GRADE evidence profile: Open nephrostomy, percutaneous nephrostomy, retrograde stents for malignant obstructions

Quality assessmentNo of patientsEffectQuality
No of studiesDesignRisk of biasInconsistencyIndirectnessImprecisionOther considerationsOpen nephrostomyPCNRetrograde stentsRelative
(95% CI)
Absolute
Improvement of renal function (assessed with: proportion with normal renal function 2 weeks after procedure)
11observational study2nonenoneserious3serious4none60/88 (68%)
not reported separately by procedure
--⊕○○○
VERY LOW
Improvement of renal function (assessed with: proportion with improved renal function 2 weeks after procedure)
11observational study2nonenoneserious3serious4none21/88 (24%)
not reported separately by procedure
--⊕○○○
VERY LOW
Symptom relief
0No evidence available
Treatment-related morbidity
11observational study2nonenoneserious3serious4none8/14
(57%)
13/53
(24%)
5/27
(19%)
--⊕○○○
VERY LOW
Overall survival
11observational study2nonenoneserious3serious4none3.8 months6.5 months--⊕○○○
VERY LOW
Subsequent chemotherapy
0No evidence available
Subsequent cystectomy
0No evidence available
Health-related quality of life
0No evidence available
1
2

case series

3

Included patients with primary tumour sites other than the bladder

4

Small sample size limits precision of the outcome

From: 5, Managing locally advanced or metastatic bladder cancer

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Bladder Cancer: Diagnosis and Management.
NICE Guideline, No. 2.
National Collaborating Centre for Cancer (UK).
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