Table 182Summary of results of comparative studies on retrograde stent placement versus PCN for malignant obstruction

Abbreviations: ON, open nephrostomy. PCN, percutaneous nephrostomy, Scr, serum creatinine, GI, gastrointestinal, Gynae, gynaecological, Uro, urological, NA, not available, hydrop, hydronephrosis

Study
(Study period)
N patients/uretersPrimary malignancyType of stentSuccessful stent insertionFailure of stent functionAverage survival time (range)Renal functionComplications
Ku 2004
(2000-2002)
68 stentNA7F/8F Percuflex87.2%11%NADecrease in Scr 1.4 ± 0.4 g/LStent/catheter 8/68 (12%)Febrile episodes 10%Acute pylonephritis 5.9%
80 PCNNA1.3%2.5 ± 0.2 g/L p=0.0587/80 (9%)15%3.8%
Kanou 2007
(1990-2003)
51 stentCervix 31%
Rectal 23%
Prostate 15%
6F C-Flex, Percuflex72.5%21.6%5.6 moScr (mg/dL)
Pre-op = 4.9
Post-op = 1.1
100% recovered renal insufficiency
Early catheter replacement 5/29 (17%)Lower abdominal discomfort 2/29 (7%)
24 PCN14-Fr Malecot or balloonNANA5.9 moAccidental catheter withdrawal 9/46 (20%)Pain + dermatitis 3/46 (7%) Minor haemorrhaging 2/46 (4%)
Chitale 2002
(1998-2000)
65
24 stent
Prostate 43%
Bladder 46%
NA21%14NANANA1 patient had cystectomy and urinary diversion for MIBC
60 PCN95%1.7%
Wong 2007
(1991-2003)
102
25 stent
Gynae 31%
Uro 29%
GI 21%
NA16%156.8 mo
9.2 mo
NAOverall
14/25 (56%)
Infection
5/25 (20%)
Blockage
8/25 (32%)
Haemorrhage
2/25 (8%)
77 PCN1%6.5 mo40/76 (53%)27/77 (35%)19/77 (25%)2/77 (3%)
Chang 2012
(2003-2009)
66 stent56/110 (51%) benign,
54/110 (49%) malignant mostly cervical16
7-Fr Inlay9/86 (10%) converted to PCN due to failureResidual hydrop
43/66 (65%)
Change in Scr
0.78 (-1.8 – 1.2) mg/dL
Stent group had more frequent UTI, including urosepsis and pyelonphritis, than the PCN group, although this difference was non-significant (numbers not reported).
44 PCN12/44 (27%)
p=0.01
0.21 (-2.4 – 1.9) mg/dL
p=0.003
Hübner 1993
(1986-1989)
24 stentColon 29%
Bladder 25%
Cervical 17%
NANANA6.1 mo (all patients)NAFlank pain
8/34 (24%)
Dysuria
7/34 (21%)
Stent dislocation
1/34 (3%)
28 PCNAccidental tube dislodgement 5/16 (31%)
14

Low success of retrograde stenting due to inability to cannulate the ureteric orifices due to trigonal distortion or failure to negotiate the lower segment ureter in 17/19 (89%) patients

15

All failures with primary retrograde stents occurred in prostate or bladder cancer

16

Malignant and benign obstructions not reported separately

From: 5, Managing locally advanced or metastatic bladder cancer

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