| Quality assessment | Number of patients | Effect | Quality | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Number of studies | Design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Amlodipine | Aspirin | Relative (95% CI) | Absolute | ||
| Stillbirth | ||||||||||||
| 1 (Vigil de Gracia 2014) | randomised trials | serious1 | no serious inconsistency | no serious indirectness | very serious2 | none |
0/20 (0%) |
1/19 (5.3%) | RR 0.32 (0.01 to 7.35) | 36 fewer per 1000 (from 52 fewer to 334 more) | VERY LOW | CRITICAL |
| Neonatal death | ||||||||||||
| 1 (Vigil de Gracia 2014) | randomised trials | serious1 | no serious inconsistency | no serious indirectness | no serious imprecision | none |
0/20 (0%) |
0/19 (0%) | not calculable | not calculable | MODERATE | CRITICAL |
| Small-for-gestational age | ||||||||||||
| 1 (Vigil de Gracia 2014) | randomised trials | serious1 | no serious inconsistency | no serious indirectness | very serious2 | none |
2/20 (10%) |
2/19 (10.5%) | RR 0.95 (0.15 to 6.08) | 5 fewer per 1000 (from 89 fewer to 535 more) | VERY LOW | CRITICAL |
| Birth weight (grams) (Better indicated by higher values) | ||||||||||||
| 1 (Vigil de Gracia 2014) | randomised trials | serious1 | no serious inconsistency | no serious indirectness | serious3 | none | 20 | 19 | - | MD 63 lower (467.79 lower to 341.79 higher) | LOW | IMPORTANT |
| Preterm birth (weeks not specified) | ||||||||||||
| 1 (Vigil de Gracia 2014) | randomised trials | serious1 | no serious inconsistency | no serious indirectness | very serious2 | none |
3/20 (15%) |
1/19 (5.3%) | RR 2.85 (0.32 to 25.07) | 97 more per 1000 (from 36 fewer to 1000 more) | VERY LOW | IMPORTANT |
| Severe hypertension | ||||||||||||
| 1 (Vigil de Gracia 2014) | randomised trials | serious1 | no serious inconsistency | no serious indirectness | very serious2 | none |
7/20 (35%) |
6/19 (31.6%) | RR 1.11 (0.45 to 2.70) | 35 more per 1000 (from 174 fewer to 537 more) | VERY LOW | CRITICAL |
| Placental abruption | ||||||||||||
| 1 (Vigil de Gracia 2014) | randomised trials | serious1 | no serious inconsistency | no serious indirectness | very serious2 | none |
1/20 (5%) |
0/19 (0%) | RR 2.86 (0.12 to 66.11)4 | - | VERY LOW | IMPORTANT |
| Mode of birth (caesarean section) | ||||||||||||
| 1 (Vigil de Gracia 2014) | randomised trials | serious1 | no serious inconsistency | no serious indirectness | very serious2 | none |
12/20 (60%) |
10/19 (52.6%) | RR 1.14 (0.65 to 1.99) | 74 more per 1000 (from 184 fewer to 521 more) | VERY LOW | IMPORTANT |
The quality of the evidence was downgraded by 1 level due to a high risk of performance and selection bias and an unclear risk of selective reporting
The quality of the evidence was downgraded by 2 levels as the 95% CI crossed 2 default MID thresholds (0.8 and 1.25)
The quality of the evidence was downgraded by 1 level as the 95% CI crossed 1 default MID threshold (740 × +/− 0.5= +/− 370)
The corresponding absolute risk was not calculated as there were no events reported in the control arm.
From: Evidence review for interventions for chronic hypertension
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