Table 6Clinical evidence profile. Comparison 2. Exercise versus no intervention

Quality assessmentNumber of patientsEffectQualityImportance
Number of studiesDesignRisk of biasInconsistencyIndirectnessImprecisionOther considerationsExerciseNo interventionRelative (95% CI)Absolute
Birth weight <2500 grams
1 (Kasawara 2013)randomised trialsvery serious1no serious inconsistencyserious2very serious3none

9/56

(16.1%)

11/53

(20.8%)

RR 0.77 (0.35 to 1.72)48 fewer per 1000 (from 135 fewer to 149 more)VERY LOWIMPORTANT
Birth weight 2500-3999 grams
1 (Kasawara 2013)randomised trialsvery serious1no serious inconsistencyserious2serious4none

41/56

(73.2%)

35/53

(66%)

RR 1.11 (0.86 to 1.42)73 more per 1000 (from 92 fewer to 277 more)VERY LOWIMPORTANT
Birth weight ≥4000 grams
1 (Kasawara 2013)randomised trialsvery serious1no serious inconsistencyserious2serious5none

5/56

(8.9%)

11/53

(20.8%)

RR 0.43 (0.16 to 1.16)118 fewer per 1000 (from 174 fewer to 33 more)VERY LOWIMPORTANT
Admission to neonatal unit
1 (Kasawara 2013)randomised trialsvery serious1no serious inconsistencyserious2very serious3none

12/56

(21.4%)

13/53

(24.5%)

RR 0.87 (0.44 to 1.74)32 fewer per 1000 (from 137 fewer to 182 more)VERY LOWIMPORTANT
Mode of birth (caesarean section)
1 (Kasawara 2013)randomised trialsvery serious1no serious inconsistencyno serious indirectnessserious5none

36/56

(64.3%)

41/53

(77.4%)

RR 0.83 (0.65 to 1.06)132 fewer per 1000 (from 271 fewer to 46 more)VERY LOWIMPORTANT
1

The quality of the evidence was downgraded by 2 levels as participants and personnel were not blinded to treatment allocation; it was unclear whether outcome assessors were blinded to treatment allocation and there was an unclear risk of selective reporting

2

The quality of the evidence was downgraded by 1 level as 9.49% of women did not present with chronic hypertension

3

The quality of the evidence was downgraded by 2 levels as the 95% CI crossed 2 default MID thresholds (0.8 and 1.25)

4

The quality of the evidence was downgraded by 1 level as the 95% CI crossed 1 default MID threshold (1.25)

5

The quality of the evidence was downgraded by 1 level as the 95% CI crossed 1 default MID threshold (0.8)

From: Evidence review for interventions for chronic hypertension

Cover of Evidence review for interventions for chronic hypertension
Evidence review for interventions for chronic hypertension: Hypertension in pregnancy: diagnosis and management: Evidence review A.
NICE Guideline, No. 133.
National Guideline Alliance (UK).
Copyright © NICE 2019.

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