| Quality assessment | Number of patients | Effect | Quality | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Number of studies | Design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Less-tight control | Tight control | Relative (95% CI) | Absolute | ||
| Stillbirth | ||||||||||||
| 1 (Magee 2015) | randomised trials | serious1 | no serious inconsistency | serious2 | very serious3 | none |
12/493 (2.4%) |
7/488 (1.4%) | RR 1.70 (0.67 to 4.27) | 10 more per 1000 (from 5 fewer to 47 more) | VERY LOW | CRITICAL |
| Neonatal death | ||||||||||||
| 1 (Magee 2015) | randomised trials | serious1 | no serious inconsistency | serious2 | very serious3 | none |
2/493 (0.41%) |
4/488 (0.82%) | RR 0.49 (0.09 to 2.69) | 4 fewer per 1000 (from 7 fewer to 14 more) | VERY LOW | CRITICAL |
| Small for gestational age (birthweight <10th percentile) | ||||||||||||
| 1 (Magee 2015) | randomised trials | serious1 | no serious inconsistency | no serious indirectness | serious4 | none |
51/366 (13.9%) |
71/361 (19.7%) | RR 0.71 (0.51 to 0.98) | 57 fewer per 1000 (from 4 fewer to 96 fewer) | LOW | CRITICAL |
| Birth weight (grams) (Better indicated by higher values) | ||||||||||||
| 1 (Magee 2015) | randomised trials | serious1 | no serious inconsistency | serious2 | no serious imprecision | none | 493 | 488 | - | MD 31.07 lower (66.68 lower to 4.54 higher) | LOW | IMPORTANT |
| Gestational age at delivery (weeks) (Better indicated by higher values) | ||||||||||||
| 1 (Magee 2015) | randomised trials | serious1 | no serious inconsistency | serious2 | no serious imprecision | none | 493 | 488 | - | MD 0.40 lower (0.81 lower to 0.01 higher) | LOW | IMPORTANT |
| Admission to neonatal unit | ||||||||||||
| 1 (Magee 2015) | randomised trials | serious1 | no serious inconsistency | serious2 | no serious imprecision | none |
141/480 (29.4%) |
139/479 (29%) | RR 1.01 (0.83 to 1.23) | 3 more per 1000 (from 49 fewer to 67 more) | LOW | IMPORTANT |
| Severe hypertension | ||||||||||||
| 1 (Magee 2015) | randomised trials | serious1 | no serious inconsistency | no serious indirectness | no serious imprecision | none |
159/369 (43.1%) |
96/363 (26.4%) | RR 1.63 (1.32 to 2.01) | 167 more per 1000 (from 85 more to 267 more) | MODERATE | CRITICAL |
| HELLP | ||||||||||||
| 1 (Magee 2015) | randomised trials | serious2 | no serious inconsistency | serious2 | very serious3 | none |
9/493 (1.8%) |
2/488 (0.41%) | RR 4.45 (0.97 to 20.51) | 14139 more per 1,000,000 (from 123 fewer to 79959 more) | VERY LOW | IMPORTANT |
| Placental abruption | ||||||||||||
| 1 (Magee 2015) | randomised trials | serious1 | no serious inconsistency | serious2 | very serious3 | none |
11/493 (2.2%) |
11/488 (2.3%) | RR 0.99 (0.43 to 2.26) | 0 fewer per 1000 (from 13 fewer to 28 more) | VERY LOW | IMPORTANT |
| Pre-eclampsia | ||||||||||||
| 1 (Magee 2015) | randomised trials | serious1 | no serious inconsistency | no serious indirectness | serious5 | none |
176/368 (47.8%) |
155/363 (42.7%) | RR 1.12 (0.95 to 1.31) | 51 more per 1000 (from 21 fewer to 132 more) | LOW | IMPORTANT |
| Onset of labour (spontaneous onset) | ||||||||||||
| 1 (Magee 2015) | randomised trials | serious1 | no serious inconsistency | serious2 | serious5 | none |
109/493 (22.1%) |
104/488 (21.3%) | RR 1.04 (0.82 to 1.32) | 9 more per 1000 (from 38 fewer to 68 more) | VERY LOW | IMPORTANT |
| Onset of labour (induced) | ||||||||||||
| 1 (Magee 2015) | randomised trials | serious1 | no serious inconsistency | serious2 | no serious imprecision | none |
224/493 (45.4%) |
218/488 (44.7%) | RR 1.02 (0.89 to 1.17) | 9 more per 1000 (from 49 fewer to 76 more) | LOW | IMPORTANT |
| Onset of labour (elective caesarean section) | ||||||||||||
| 1 (Magee 2015) | randomised trials | serious1 | no serious inconsistency | serious2 | no serious imprecision | none |
159/493 (32.3%) |
164/488 (33.6%) | RR 0.96 (0.80 to 1.15) | 13 fewer per 1000 (from 67 fewer to 50 more) | LOW | IMPORTANT |
| Mode of birth (C-section) | ||||||||||||
| 1 (Magee 2015) | randomised trials | serious1 | no serious inconsistency | serious2 | no serious imprecision | none |
231/493 (46.9%) |
250/488 (51.2%) | RR 0.91 (0.80 to 1.04) | 46 fewer per 1000 (from 102 fewer to 20 more) | LOW | IMPORTANT |
The quality of the evidence was downgraded by 1 level due to a high risk of performance and detection bias
The quality of the evidence was downgraded by 1 level as 25.5% of women did not present with chronic hypertension
The quality of the evidence was downgraded by 2 levels as the 95% CI crossed 2 default MID thresholds (0.8 and 1.25)
The quality of the evidence was downgraded by 1 level as the 95% CI crossed 1 default MID threshold (0.8)
The quality of the evidence was downgraded by 1 level as the 95% CI crossed 1 default MID threshold (1.25)
From: Evidence review for interventions for chronic hypertension
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