| Quality assessment | Number of patients | Effect | Quality | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Number of studies | Design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Labetalol | No intervention | Relative (95% CI) | Absolute | ||
| Perinatal death | ||||||||||||
| 1 (Sibai 1990) | randomised trials | very serious1 | no serious inconsistency | no serious indirectness | very serious2 | none |
1/86 (1.2%) |
1/90 (1.1%) | RR 1.05 (0.07 to 16.47) | 1 more per 1000 (from 10 fewer to 172 more) | VERY LOW | CRITICAL |
| Small-for-gestational age | ||||||||||||
| 1 (Sibai 1990) | randomised trials | very serious1 | no serious inconsistency | no serious indirectness | very serious2 | none |
7/86 (8.1%) |
8/90 (8.9%) | RR 0.92 (0.35 to 2.42) | 7 fewer per 1000 (from 58 fewer to 126 more) | VERY LOW | CRITICAL |
| Preterm birth (<37 weeks) | ||||||||||||
| 1 (Sibai 1990) | randomised trials | very serious1 | no serious inconsistency | no serious indirectness | very serious2 | none |
10/86 (11.6%) |
9/90 (10%) | RR 1.16 (0.50 to 2.72) | 16 more per 1000 (from 50 fewer to 172 more) | VERY LOW | IMPORTANT |
| Superimposed pre-eclampsia | ||||||||||||
| 1 (Sibai 1990) | randomised trials | very serious1 | no serious inconsistency | no serious indirectness | very serious2 | none |
14/86 (16.3%) |
14/90 (15.6%) | RR 1.05 (0.53 to 2.06) | 8 more per 1000 (from 73 fewer to 165 more) | VERY LOW | IMPORTANT |
| Placental abruption | ||||||||||||
| 1 (Sibai 1990) | randomised trials | very serious1 | no serious inconsistency | no serious indirectness | very serious2 | none |
2/86 (2.3%) |
2/90 (2.2%) | RR 1.05 (0.15 to 7.26) | 1 more per 1000 (from 19 fewer to 139 more) | VERY LOW | IMPORTANT |
| Mode of birth (caesarean section) | ||||||||||||
| 1 (Sibai 1990) | randomised trials | very serious1 | no serious inconsistency | no serious indirectness | very serious2 | none |
30/86 (34.9%) |
29/90 (32.2%) | RR 1.08 (0.71 to 1.64) | 26 more per 1000 (from 93 fewer to 206 more) | VERY LOW | IMPORTANT |
The quality of the evidence was downgraded by 2 levels due to an unclear risk of allocation concealment, performance and selection bias, and selective reporting
The quality of the evidence was downgraded by 2 levels as the 95% CI crossed 2 default MID thresholds (0.8 and 1.25)
From: Evidence review for interventions for chronic hypertension
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