| Quality assessment | Number of patients | Effect | Quality | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Number of studies | Design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Methyldopa | Placebo | Relative (95% CI) | Absolute | ||
| Stillbirth | ||||||||||||
| 1 (Weitz 1987) | randomised trials | serious1 | no serious inconsistency | no serious indirectness | no serious imprecision | none |
0/13 (0%) |
0/12 (0%) | not calculable | not calculable | MODERATE | CRITICAL |
| Neonatal death | ||||||||||||
| 1 (Weitz 1987) | randomised trials | serious1 | no serious inconsistency | no serious indirectness | no serious imprecision | none |
0/13 (0%) |
0/12 (0%) | not calculable | not calculable | MODERATE | CRITICAL |
| Gestational age at birth, weeks (Better indicated by higher values) | ||||||||||||
| 1 (Weitz 1987) | randomised trials | serious1 | no serious inconsistency | no serious indirectness | no serious imprecision | none | 13 | 12 | - | MD 1.43 higher (1.07 to 1.79 higher) | MODERATE | IMPORTANT |
| Superimposed pre-eclampsia | ||||||||||||
| 1 (Weitz 1987) | randomised trials | serious1 | no serious inconsistency | no serious indirectness | very serious2 | none |
5/13 (38.5%) |
4/12 (33.3%) | RR 1.15 (0.40 to 3.31) | 50 more per 1000 (from 200 fewer to 770 more) | VERY LOW | IMPORTANT |
The quality of the evidence was downgraded by 1 level due to an unclear risk of random sequence generation, allocation concealment and selective reporting
The quality of the evidence was downgraded by 2 levels as the 95% CI crossed 2 default MID thresholds (0.8 and 1.25)
From: Evidence review for interventions for chronic hypertension
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