Table 19Research recommendation modified PICO table

CriterionExplanation
PopulationWomen who require treatment for chronic hypertension, including in the first trimester. Setting – hospital-based care.
InterventionAntihypertensive agents, to include labetalol, calcium channel blocker, and to consider use of methyldopa, with specific choice of these and other agents to be justified.
Comparator
  • Comparator antihypertensive agents in head-to-head trial.
Outcome
  • Women: severe hypertension, adverse maternal outcomes to be defined, side-effects.
  • Baby: pregnancy loss; congenital anomalies; birthweight centile; neonatal care admission; neonatal hypoglycaemia.
Study designRandomised controlled trial with an internal pilot phase with clear progression criteria to the main trial.
TimeframeMinimum duration of follow-up: To primary discharge of woman and baby.

From: Evidence review for interventions for chronic hypertension

Cover of Evidence review for interventions for chronic hypertension
Evidence review for interventions for chronic hypertension: Hypertension in pregnancy: diagnosis and management: Evidence review A.
NICE Guideline, No. 133.
National Guideline Alliance (UK).
Copyright © NICE 2019.

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