• Essential (primary) hypertension
• Secondary hypertension e.g. secondary to chronic kidney disease, diabetes.

• Centrally acting alpha2-adrenoceptor agonists
• Beta-blockers/mixed alpha/beta-blockers
• Calcium channel blockers
• Diuretics
• Angiotensin converting enzyme (ACE) inhibitors
• Acetylsalicylic acid/aspirin
• Elective (planned) delivery versus expectant management
• Tight management (for example, diastolic target = 85mmHg)
• Less-tight management (for example, diastolic target = 100 mmHg)
• Automated monitoring of blood pressure
• Ambulatory/self-monitoring of blood pressure
• Exercise
• Dietary interventions
• Dietary salt reduction

• No intervention
• Placebo
• Each other of the interventions outlined above
• Combinations of the interventions outlined above

Outcomes for babies

Critical outcomes:

• Perinatal mortality

  • Stillbirth (include if reported as part of perinatal mortality)
  • Neonatal death up to 7 days (include if reported as part of perinatal mortality)
• Small-for-gestational age (birthweight <10th centile)

• Birth weight
• Gestational age at birth
• Preterm birth (<28 weeks, <34 weeks, <37 weeks)
• Admission to neonatal unit
• Neurodevelopmental outcomes:

  • Cerebral palsy (CP) (dichotomous outcome, reported as present/absent, not severity of condition)
  • Neurodevelopmental delay (dichotomous outcome, not continuous outcomes such as mean change in score):

    -

    Severe (score of >2SD below normal on validated assessment scales, or Bayley assessment scale of mental development index [MDI] or psychomotor developmental index [PDI] <70, or complete inability to assign score due to CP or severe cognitive delay)

    -

    Moderate (score of 1-2 SD below normal on validated assessment scales, or Bayley assessment scale MDI or PDI 70-84)

  • Neurosensory impairment (dichotomous outcome, present or absent, not severity of condition)

    -

    Severe hearing impairment (for example, deaf)

    -

    Severe visual impairment (for example, blind)

Critical outcomes:

• Blood pressure control

  • Severe hypertension

• Superimposed pre-eclampsia

  • including eclampsia and HELLP syndrome
• Placental abruption
• Onset of labour
• Mode of birth
• Maternal death