NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
National Guideline Alliance (UK). Endometriosis: diagnosis and management. London: National Institute for Health and Care Excellence (NICE); 2017 Sep. (NICE Guideline, No. 73.)
H.1. Specialist services
| Reference | Reason for exclusion |
|---|---|
| Bruen, L., Shacaluga, A., Penketh, R., Nurse-led self-referral service for women with endometriosis and pelvic pain, Gynecological Surgery, 8, S124, 2011 | Insufficient information about services and comparison group. No publication identified. |
| Cambitzi, J., Nagaratnam, M., Endometriosis-associated pain syndrome: a nurse-led approach, British Journal of Pain, 7, 31–8, 2013 | Narrative review |
| Dakkak, R., Rosenow, G., Von Kleinsorgen, C., Thiel-Moder, U., Papadopolous, T., Kruger, K., Liehr, M. R., Adam, U., Ebert, A. D., Establishment of endometriosis centers of excellence: Facts, problems and fiction, Archives of Gynecology and Obstetrics, 282, S176, 2010 | Not enough information about data provided to analyse further |
| D’Hooghe, T., Hummelshoj, L., Multi-disciplinary centres/networks of excellence for endometriosis management and research: a proposal, Human Reproduction, 21, 2743–8, 2006 | Narrative review |
| Ebert, A. D., Rosenow, G., Kruger, K., Liehr, R. M., Adam, U., Braunig, P., Haselmann, J., Freitag, A., Papadopolous, T., Von Kleinsorgen, C., Development of centres of excellence for endometriosis - The Berlin experiences, Molecular Human Reproduction, 24, i54-i55, 2009 | Insufficient information regarding service, no comparator service |
| Ebert, A. D., Ulrich, U., Keckstein, J., Muller, M., Schindler, A. E., Sillem, M., Tinneberg, H. R., De Wilde, R. L., Schweppe, K. W., Endometriosis Research, Foundation, the European Endometriosis, League, Implementation of certified endometriosis centers: 5-year experience in German-speaking Europe, Gynecologic & Obstetric Investigation, 76, 4–9, 2013 | Narrative review |
| Greco, C. D., Management of adolescent chronic pelvic pain from endometriosis: a pain center perspective, Journal of Pediatric & Adolescent Gynecology, 16, S17–9, 2003 | Narrative review |
| Hogg, S., Vyas, S., Endometriosis, Obstetrics, Gynaecology and Reproductive Medicine, 25, 133–141, 2015 | Narrative review |
| Lasmar, R. B., Lasmar, B. P., Keller Celeste, R., Larbig, A., De Wilde, R. L., Validation of a score to guide endometriosis therapy for the non-specialized gynecologist, International Journal of Gynecology and Obstetrics, 131, 78–81, 2015 | The intervention is a tool, not a specialist service |
| Marqueta, L., Munoz, L., Tejerizo, A., Lopez, G., Lorenzo, E., Munoz, J. L., Jimenez, J. S., Multidisciplinary approach in the management of deep infiltrating endometriosis. 5 years follow up, Journal of Minimally Invasive Gynecology, 1), S126, 2012 | No comparator group; insufficient information regarding service. |
| Metzger, D.A., Treating endometriosis pain: A multidisciplinary approach, Seminars in Reproductive Endocrinology, 15, 245–250, 1997 | Narrative review |
| Moura, A. P. C., Nogueira, L. A. A., Demystifying the exam for the detection of deep endometriosis-5 step approach for non-specialists, Ultrasound in Medicine and Biology, 1), S36, 2013 | Intervention was ultrasonography, not specialist service. |
H.2. Timing of interventions: association between duration of symptoms before laparoscopy and treatment outcomes
| Reference | Reason for exclusion |
|---|---|
| Abbott, J., Hawe, J., Hunter, D., Holmes, M., Finn, P., Garry, R., Laparoscopic excision of endometriosis: a randomized, placebo-controlled trial, Fertility & Sterility, 82, 878–84, 2004 | There was no information regarding duration of symptoms of the women included in the study |
| Jia, S.Z., Leng, J.H., Shi, J.H., Sun, P.R., Lang, J.H., Health-related quality of life in women with endometriosis: A systematic review, Journal of Ovarian Research, 5, -, 2012 | The topic of the systematic review does not include duration of symptoms associated with laparoscopy |
H.3. Signs and symptoms of endometriosis (monitoring and referral)
| Study | Reason for Exclusion |
|---|---|
| Adamson, G. D., Diagnosis and clinical presentation of endometriosis, American Journal of Obstetrics & Gynecology, 162, 568–9, 1990 | A narrative paper; an opinion |
| Anonymous, Risk factors for pelvic endometriosis in women with pelvic pain or infertility. Gruppo Italiano per lo Studio dell’ endometriosi, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 83, 195–9, 1999 | Analysis does not look at any of the protocol’s listed factors; no comparison between pelvic pain and infertility, just trends in each group |
| Apostolopoulos, N. V., Alexandraki, K. I., Gorry, A., Coker, A., Association between chronic pelvic pain symptoms and the presence of endometriosis, Archives of gynecology and obstetrics, 293, 439–445, 2016 | No adjustment |
| Bai, S. W., Cho, H. J., Kim, J. Y., Jeong, K. A., Kim, S. K., Cho, D. J., Song, C. H., Park, K. H., Endometriosis in an adolescent population: the severance hospital in Korean experience, Yonsei Medical Journal, 43, 48–52, 2002 | No adjusted analysis, just descriptive |
| Ballard, K. D., Seaman, H. E., De Vries, C. S., Wright, J. T., Can symptomatology help in the diagnosis of endometriosis? Findings from a national case-control study - Part 1, BJOG: An International Journal of Obstetrics and Gynaecology, 115, 1382–1391, 2008 | Diagnosed not suspected endometriosis |
| Ballard, K., Lane, H., Hudelist, G., Banerjee, S., Wright, J., Can specific pain symptoms help in the diagnosis of endometriosis? A cohort study of women with chronic pelvic pain, Fertility & Sterility, 94, 20–7, 2010 | No adjusted analysis; pain intensity and not “cyclical/non-cyclical” pain as in protocol |
| Barcellos, M. B., Lasmar, B., Lasmar, R., Agreement between the preoperative findings and the operative diagnosis in patients with deep endometriosis, Archives of Gynecology & Obstetrics Arch Gynecol Obstet, 293, 845–50, 2016 | Not relevant to the PICO question |
| Becker, C., Diagnosis and management of endometriosis, Prescriber, 26, 17–21, 2015 | A narrative review |
| Bell, J. S., Endometriosis. Will identifying risk factors enable an early diagnosis?, Australian Family Physician, 30, 649–53, 2001 | Narrative review |
| Brown, Julie, Kives, Sari, Akhtar, Muhammad, Progestagens and anti-progestagens for pain associated with endometriosis, Cochrane Database of Systematic Reviews, 2012 | No investigation of signs and symptoms |
| Buck Louis, G. M., Backonja, U., Schliep, K. C., Sun, L., Peterson, C. M., Chen, Z., Women’s Reproductive History Before the Diagnosis of Incident Endometriosis, Journal of Women’s Health, 25, 1021–1029, 2016 | No investigation of signs/symptoms |
| Carneiro, M. M., Filogonio, I. D. D. S., Costa, L. M. P., De Avila, I., Ferreira, M. C., Accuracy of clinical signs and symptoms in the diagnosis of endometriosis, Journal of Endometriosis, 2, 63–70, 2010 | A narrative review/opinion |
| Chapron, C., Borghese, B., Streuli, I., de Ziegler, D., Markers of adult endometriosis detectable in adolescence, Journal of Pediatric & Adolescent Gynecology, 24, S7–12, 2011 | A clinical narrative paper about management of endometriosis |
| Cheewadhanaraks, S., Peeyananjarassri, K., Dhanaworavibul, K., Liabsuetrakul, T., Positive predictive value of clinical diagnosis of endometriosis, Journal of the Medical Association of Thailand, 87, 740–4, 2004 | The study was not a prognostic study design |
| Farland, L. V., Tamimi, R. M., Eliassen, A. H., Spiegelman, D., Collins, L. C., Schnitt, S. J., Missmer, S. A., A prospective study of endometriosis and risk of benign breast disease, Breast Cancer Research & Treatment, 159, 545–52, 2016 | Not relevant to the PICO question |
| Forman, R. G., Robinson, J. N., Mehta, Z., Barlow, D. H., Patient history as a simple predictor of pelvic pathology in subfertile women, Human Reproduction, 8, 53–5, 1993 | Not entirely clear if RR is adjusted |
| Fraser, I. A., Recognising, understanding and managing endometriosis, Medicine Today, 9, 31–41, 2008 | Narrative review |
| Fraser, I. S., Recognising, understanding and managing endometriosis, Journal of Human Reproductive Sciences, 1, 56–64, 2008 | A narrative review |
| French, L., Dysmenorrhea in adolescents: diagnosis and treatment, Paediatric Drugs, 10, 1–7, 2008 | Narrative review |
| Galle, P. C., Clinical presentation and diagnosis of endometriosis, Obstetrics & Gynecology Clinics of North America, 16, 29–42, 1989 | A narrative paper |
| Garad, R., Vancaillie, T. G., Farrell, E., Pelvic pain: a diagnosis in itself, Australian Nursing & Midwifery Journal, 21, 36–9, 2013 | A narrative review |
| Garry, R., Diagnosis of endometriosis and pelvic pain, Fertility and sterility, 86, 1307–1309, 2006 | A narrative paper, an opinion |
| Garry, R., The endometriosis syndromes: A clinical classification in the presence of aetiological confusion and therapeutic anarchy, Human Reproduction, 19, 760–768, 2004 | A clinical paper |
| Ghazi, N., Arjmand, M., Akbari, Z., Mellati, A. O., Saheb-Kashaf, H., Zamani, Z., (1)H NMR-based metabolomics approaches as non-invasive tools for diagnosis of endometriosis, International Journal of Reproductive Biomedicine Int, 14, 1–8, 2016 | No multivariate regression analysis |
| Griffiths, A. N., Koutsouridou, R. N., Penketh, R. J., Predicting the presence of rectovaginal endometriosis from the clinical history: a retrospective observational study, Journal of Obstetrics & Gynaecology, 27, 493–5, 2007 | No adjustment |
| Gruppo Italiano per lo Studio, dell’Endometriosi, Relationship between stage, site and morphological characteristics of pelvic endometriosis and pain, Human Reproduction, 16, 2668–71, 2001 | A cross-sectional study |
| Gungor, T., Kanat-Pektas, M., Ozat, M., Zayifoglu Karaca, M., A systematic review: endometriosis presenting with ascites, Archives of Gynecology & Obstetrics, 283, 513–8, 2011 | Diagnosed endometriosis |
| Gupta, Devashana, Hull, Louise M., Fraser, Ian, Miller, Laura, Bossuyt, M. M. Patrick, Johnson, Neil, Nisenblat, Vicki, Endometrial biomarkers for the non-invasive diagnosis of endometriosis, Cochrane Database of Systematic Reviews, 2016 | Not relevant to the PICO question |
| Halis, G., Mechsner, S., Ebert, A. D., The diagnosis and treatment of deep infiltrating endometriosis, Deutsches Arzteblatt International, 107, 446–55; quiz 456, 2010 | A narrative review |
| Harrison, B. T., Mittal, K., Morphologic features suggestive of endometriosis in nondiagnostic peritoneal biopsies, International Journal of Gynecological Pathology, 34, 507–516, 2015 | A study of morphologic and immunohistichemical features to improve diagnosis of endometriosis |
| Hassa, H., Tanir, H. M., Uray, M., Symptom distribution among infertile and fertile endometriosis cases with different stages and localisations, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 119, 82–6, 2005 | A cross-sectional study |
| Hickey, M., Ballard, K., Farquhar, C., Endometriosis, BMJ, 348, g1752, 2014 | Clinical (descriptive) review |
| Hickey, M., Balen, A., Menstrual disorders in adolescence: Investigation and management, Human Reproduction Update, 9, 493–504, 2003 | A descriptive clinical paper, an opinion |
| Hurd, W. W., Criteria that indicate endometriosis is the cause of chronic pelvic pain, Obstetrics and gynecology, 92, 1029–1032, 1998 | A clinical opinion |
| Hurd, W. W., Rothenberg, J. M., Schilder, J. M., Hurteau, J. A., Rogers, R. E., Chronic pelvic pain and endometriosis, Contemporary Reviews in Obstetrics and Gynaecology, 11, 289–295, 1999 | A clinical narrative paper, an opinion |
| Hwang, S. M., Lee, C. W., Lee, B. S., Park, J. H., Clinical features of thoracic endometriosis: A single center analysis, Obstetrics & Gynecology Science, 58, 223–31, 2015 | Thoracic endometriosis |
| Jansen, R. P., Endometriosis symptoms and the limitations of pathology-based classification of severity, International Journal of Gynaecology & Obstetrics, 40 Suppl, S3–7, 1993 | A descriptive study, an opinion |
| Jones, G. T., Psychosocial Vulnerability and Early Life Adversity as Risk Factors for Central Sensitivity Syndromes, Current Rheumatology Reviews, 12, 140–53, 2016 | Not relevant to the PICO question |
| Joseph, J., Sahn, S. A., Thoracic endometriosis syndrome: New observations from an analysis of 110 cases, American Journal of Medicine, 100, 164–170, 1996 | Thoracic endometriosis |
| Khetan, N., Torkington, J., Watkin, A., Jamison, M. H., Humphreys, W. V., Endometriosis: presentation to general surgeons, Annals of the Royal College of Surgeons of England, 81, 255–9, 1999 | Pathologically confirmed and not suspected endometriosis |
| Kirkegaard, K., Sundvall, L., Erlandsen, M., Hindkjaer, J. J., Knudsen, U. B., Ingerslev, H. J., Timing of human preimplantation embryonic development is confounded by embryo origin, Human Reproduction Hum Reprod, 31, 324–331, 2015 | No endometriosis |
| Klein, S., D’Hooghe, T., Meuleman, C., Dirksen, C., Dunselman, G., Simoens, S., What is the societal burden of endometriosis-associated symptoms? a prospective Belgian study, Reproductive Biomedicine Online, 28, 116–24, 2014 | A cost-off-illness study |
| Kumar, V., Khan, M., Vilos, G. A., Sharma, V., Revisiting the association between endometriosis and bipolar disorder, Journal of Obstetrics & Gynaecology Canada: JOGC, 33, 1141–5, 2011 | Not the review question; a cross-sectional study |
| Kuohung, W., Jones, G. L., Vitonis, A. F., Cramer, D. W., Kennedy, S. H., Thomas, D., Hornstein, M. D., Characteristics of patients with endometriosis in the United States and the United Kingdom, Fertility & Sterility, 78, 767–72, 2002 | Confirmed and not suspected endometriosis |
| Laufer, M. R., Sanfilippo, J., Rose, G., Adolescent endometriosis: diagnosis and treatment approaches, Journal of Pediatric & Adolescent Gynecology, 16, S3–11, 2003 | A narrative paper; an opinion about diagnosis and treatment of endometriosis |
| Lemaire, G. S., More than just menstrual cramps: symptoms and uncertainty among women with endometriosis, JOGNN - Journal of Obstetric, Gynecologic, & Neonatal Nursing, 33, 71–9, 2004 | A cross-sectional study |
| Liu, Emily, Nisenblat, Vicki, Farquhar, Cindy, Fraser, Ian, Bossuyt, M. M. Patrick, Johnson, Neil, Hull, Louise M., Urinary biomarkers for the non-invasive diagnosis of endometriosis, Cochrane Database of Systematic Reviews, 2015 | Not relevant to the PICO question |
| Liu, X., Guo, S. W., Dysmenorrhea: risk factors in women with endometriosis, Women’s health, 4, 399–411, 2008 | Not a systematic review management of disease |
| Lorencatto, C., Petta, C. A., Navarro, M. J., Bahamondes, L., Matos, A., Depression in women with endometriosis with and without chronic pelvic pain, Acta Obstetricia et Gynecologica Scandinavica, 85, 88–92, 2006 | Not suspected endometriosis; a cross-sectional study |
| Lu, DongHao, Song, Huan, Li, Yalun, Clarke, Jane, Shi, Gang, Pentoxifylline for endometriosis, Cochrane Database of Systematic Reviews, -, 2012 | Not relevant to the PICO question |
| Luciano, D.E., Luciano, A.A., Management of endometriosis-related pain: An update, Women’s health, 7, 585–590, 2011 | Narrative review |
| Luscombe, G. M., Markham, R., Judio, M., Grigoriu, A., Fraser, I. S., Abdominal bloating: an under-recognized endometriosis symptom, Journal of Obstetrics & Gynaecology Canada: JOGC, 31, 1159–71, 2009 | Women with diagnosed and not suspected endometriosis |
| Mahmood, T. A., Templeton, A., Pathophysiology of mild endometriosis: review of literature, Human Reproduction, 5, 765–84, 1990 | A narrative review |
| Majak, P., Langebrekke, A., Hagen, O. M., Qvigstad, E., Catamenial pneumothorax, clinical manifestations: A multidisciplinary challenge, Pneumonologia i Alergologia Polska, 79, 347–350, 2011 | Pleural endometriosis (not in the protocol); n=9 -> case reports? |
| Majmudar, T., Abdel-Rahman, H., Pelvic mass - diagnosis and management, Obstetrics, Gynaecology and Reproductive Medicine, 18, 193–198, 2008 | A clinical narrative paper |
| Manta, L., Suciu, N., Constantin, A., Toader, O., Popa, F., Focal adenomyosis (intramural endometriotic cyst) in a very young patient - differential diagnosis with uterine fibromatosis, Journal of Medicine & Life, 9, 180–2, 2016 | Not relevant to the PICO question |
| Maroun, P., Cooper, M. J., Reid, G. D., Keirse, M. J., Relevance of gastrointestinal symptoms in endometriosis, Australian & New Zealand Journal of Obstetrics & Gynaecology, 49, 411–4, 2009 | No adjusted analysis, just a descriptive analysis |
| Matorras, R., Rodriguez, F., Pijoan, J. I., Soto, E., Perez, C., Ramon, O., Rodriguez-Escudero, F., Are there any clinical signs and symptoms that are related to endometriosis in infertile women?, American Journal of Obstetrics & Gynecology, 174, 620–3, 1996 | Analysis adjusted for the total number of infertile patients; Not the confounder of interest |
| Menakaya, U., Lu, C., Infante, F., Lam, A., Condous, G., Relating historical variables at first presentation with operative findings at laparoscopy for endometriosis, Australian & New Zealand Journal of Obstetrics & Gynaecology, 54, 480–6, 2014 | Not adjusted |
| Mishra, V. V., Gaddagi, R. A., Aggarwal, R., Choudhary, S., Sharma, U., Patel, U., Prevalence; Characteristics and Management of Endometriosis Amongst Infertile Women: A One Year Retrospective Study, Journal of Clinical and Diagnostic Research JCDR, 9, QC01–3, 2015 | Not adjusted |
| Murphy, A. A., Clinical aspects of endometriosis, Annals of the New York Academy of Sciences, 955, 1–10, 2002 | Narrative review |
| Muse, K., Clinical manifestations and classification of endometriosis, Clinical Obstetrics & Gynecology, 31, 813–22, 1988 | A clinical narrative paper, an opinion |
| Nisenblat, Vicki, Bossuyt, M. M. Patrick, Farquhar, Cindy, Johnson, Neil, Hull, Louise M., Imaging modalities for the non-invasive diagnosis of endometriosis, Cochrane Database of Systematic Reviews, 2016 | Not relevant to the PICO question |
| Nisenblat, Vicki, Bossuyt, M. M. Patrick, Shaikh, Rabia, Farquhar, Cindy, Jordan, Vanessa, Scheffers, Carola S., Mol, Willem Ben, Johnson, Neil, Hull, Louise M., Blood biomarkers for the non-invasive diagnosis of endometriosis, Cochrane Database of Systematic Reviews, 2016 | Not relevant to the PICO question |
| Nisenblat, Vicki, Prentice, Lucy, Bossuyt, M. M. Patrick, Farquhar, Cindy, Hull, Louise M., Johnson, Neil, Combination of the noninvasive tests for the diagnosis of endometriosis, Cochrane Database of Systematic Reviews, 2016 | Not relevant to the PICO question |
| Osayande, A. S., Mehulic, S., Diagnosis and initial management of dysmenorrhea, American Family Physician, 89, 341–346, 2014 | A narrative review |
| Pagliardini, L., Vigano, P., Molgora, M., Persico, P., Salonia, A., Vailati, S. H., Paffoni, A., Somigliana, E., Papaleo, E., Candiani, M., High Prevalence of Vitamin D Deficiency in Infertile Women Referring for Assisted Reproduction, Nutrients, 7, 9972–84, 2015 | No study design |
| Petta, C. A., Matos, A. M., Bahamondes, L., Faundes, D., Current practice in the management of symptoms of endometriosis: a survey of Brazilian gynecologists, Revista Da Associacao Medica Brasileira, 53, 525–9, 2007 | A cross-sectional study |
| Pope, C. J., Sharma, V., Sharma, S., Mazmanian, D., A Systematic Review of the Association Between Psychiatric Disturbances and Endometriosis, Journal of Obstetrics & Gynaecology Canada: JOGC, 37, 1006–15, 2015 | Not relevant to the PICO question |
| Porpora, M.G., Koninckx, P.R., Piazze, J., Natili, M., Colagrande, S., Cosmi, E.V., Correlation between endometriosis and pelvic pain, Journal of the American Association of Gynecologic Laparoscopists, 6, 429–434, 1999 | Biopsy proven and not suspected endometriosis |
| Ripps, B. A., Martin, D. C., Focal pelvic tenderness, pelvic pain and dysmenorrhea in endometriosis, Journal of Reproductive Medicine, 36, 470–2, 1991 | No adjusted analysis, just a descriptive analysis |
| Signorile, P. G., Baldi, A., New evidence in endometriosis, International Journal of Biochemistry & Cell Biology, 60, 19–22, 2015 | Pathogenesis of endometriosis |
| Skoog, S. M., Foxx-Orenstein, A. E., Levy, M. J., Rajan, E., Session, D. R., Intestinal endometriosis: the great masquerader, Current Gastroenterology Reports, 6, 405–9, 2004 | A case study of 2 patients |
| Smorgick, N., Marsh, C. A., As-Sanie, S., Smith, Y. R., Quint, E. H., Prevalence of pain syndromes, mood conditions, and asthma in adolescents and young women with endometriosis, Journal of Pediatric & Adolescent Gynecology, 26, 171–5, 2013 | Women with diagnosed endometriosis; not suspected |
| Steed, H., Chapman, W., Laframboise, S., Endometriosis-associated ovarian cancer: a clinicopathologic review, Journal of obstetrics and gynaecology Canada: JOGC = Journal d’obstetrique et gynecologie du Canada: JOGC, 26, 709–715, 2004 | Not relevant to the PICO question |
| Steenberg, C. K., Tanbo, T. G., Qvigstad, E., Endometriosis in adolescence: predictive markers and management, Acta Obstetricia et Gynecologica Scandinavica, 92, 491–5, 2013 | A narrative paper; an opinion |
| Stovner, L. J., Aegidius, K., Linde, M., Endometriosis and headache, Current Pain & Headache Reports, 15, 415–9, 2011 | A narrative review |
| Tan-Kim, J., Menefee, S. A., Reinsch, C. S., O’Day, C. H., Bebchuk, J., Kennedy, J. S., Whitcomb, E. L., Laparoscopic Hysterectomy and Urinary Tract Injury: Experience in a Health Maintenance Organization, Journal of Minimally Invasive Gynecology, 22, 1278–86, 2015 | Not relevant to the PICO question |
| Tervila, L., Marttila, P., Headache as a symptom of endometriosis externa, Annales Chirurgiae et Gynaecologiae Fenniae, 64, 239–41, 1975 | Not suspected endometriosis |
| Tietjen, G. E., Conway, A., Utley, C., Gunning, W. T., Herial, N. A., Migraine is associated with menorrhagia and endometriosis, Headache, 46, 422–428, 2006 | Women with a migraine and not suspected endometriosis |
| Toor, K., Wessels, J. M., Agarwal, S. K., Leyland, N., Foster, W. G., Clinical markers of endometriosis: have we been too quick to judge?, Medical Hypotheses, 82, 493–501, 2014 | Systematic review reports on biomarkers for correlation of endometriosis, not prognostic factors |
| Vercellini, P., Bracco, B., Mosconi, P., Roberto, A., Alberico, D., Dhouha, D., Somigliana, E., Norethindrone acetate or dienogest for the treatment of symptomatic endometriosis: a before and after study, Fertility & Sterility Fertil Steril, 105, 734–43.e3, 2016 | Not relevant to the PICO question |
| Vercellini, P., De Giorgi, O., Aimi, G., Panazza, S., Uglietti, A., Crosignani, P. G., Menstrual characteristics in women with and without endometriosis, Obstetrics & Gynecology, 90, 264–8, 1997 | No adjusted analysis, just a descriptive analysis |
| Vercellini, P., Giudice, L. C., Evers, J. L., Abrao, M. S., Reducing low-value care in endometriosis between limited evidence and unresolved issues: a proposal, Human Reproduction, 30, 1996–2004, 2015 | Not relevant to the PICO question |
| Waller, K. G., Shaw, R. W., Risk factors for endometriosis: Menstrual and life-style characteristics, Medical Principles and Practice, 7, 127–133, 1998 | Confirmed and not suspected endometriosis |
| Wilson, A. L., Endometriosis. A common cause of infertility and pelvic pain, JAAPA, 16, 20–3, 2003 | A narrative paper; an opinion |
| Yeungr, P., Bazinet, C., Gavard, J. A., Development of a symptom-based, Screening tool for early-stage endometriosis in patients with chronic pelvic pain, Journal of Endometriosis and Pelvic Pain Disorders, 6, 174–189, 2014 | The authors report combining variables in the analysis to gain statistical significance |
| Zannoni, L., Forno, S. D., Paradisi, R., Seracchioli, R., Endometriosis in Adolescence: Practical Rules for an Earlier Diagnosis, Pediatric Annals, 45, e332–5, 2016 | No study design |
| Zannoni, L., Giorgi, M., Spagnolo, E., Montanari, G., Villa, G., Seracchioli, R., Dysmenorrhea, absenteeism from school, and symptoms suspicious for endometriosis in adolescents, Journal of Pediatric & Adolescent Gynecology, 27, 258–65, 2014 | Cross-sectional study design |
| Zondervan, K. T., Sivananthan, S., Nnoaham, K. E., Hummelshoj, L., Jenkinson, C., Webster, P., Kennedy, S. H., Susceptibility and risk factors for developing endometriosis: A diagnostic aid, International Journal of Gynecology and Obstetrics, 107, S92, 2009 | Unavailable |
| Zondervan, K. T., Yudkin, P. L., Vessey, M. P., Dawes, M. G., Barlow, D. H., Kennedy, S. H., Patterns of diagnosis and referral in women consulting for chronic pelvic pain in UK primary care, British Journal of Obstetrics & Gynaecology, 106, 1156–61, 1999 | Incidence of chronic pelvic pain |
H.4. Information and support
| Study | Reason for Exclusion |
|---|---|
| American Academy of Family, Physicians, Information from your family doctor. Endometriosis: what you should know, American Family Physician, 74, 601–2, 2006 | Leaflet on endometriosis |
| Anonymous, Patient information. Endometriosis: what it is and how it is treated.[Original report in Cleve Clin J Med. 2002 Aug;69(8):647–53; PMID: 12184473], Cleveland Clinic Journal of Medicine, 69, 654, 2002 | Leaflet on endometriosis |
| Anonymous, Endometriosis resources, Nursing, 45, 68, 2015 | Tools for health care professionals to give/explain information on endometriosis to women |
| Aragao, L. C., Liberman, D., Guerra, C. G., Sessa, F. V., Rodrigues, M. A., Costa, M. F., Crispi, C. P., Fonseca, M. F., Quality of life and deep infiltrating endometriosis: Worries about epidemiological quantitative studies using short form 36 and endometriosis health profile 30, Journal of Minimally Invasive Gynecology, 1), S98-S99, 2012 | Conference abstract, the abstract refers to the problems of studies using SF36 and EHP30 tools |
| Ballweg, M. L., Campbell, P. F., Psychosocial aspects of teen endo, Journal of Pediatric & Adolescent Gynecology, 16, S13–5, 2003 | Information already in included studies |
| Ballweg, ML, Endometriosis: the patient’s perspective, Infertility and Reproductive Medicine Clinics of North America, 3, 747–761, 1992 | Information already included from other studies |
| Barlow, D., Today’s treatments: how do you choose?, International Journal of Gynaecology & Obstetrics, 64 Suppl 1, S15–21, 1999 | Narrative |
| Barlow, J. H., Wright, C. C., Turner, A. P., Bancroft, G. V., A 12-month follow-up study of self-management training for people with chronic disease: are changes maintained over time?, British Journal of Health Psychology, 10, 589–99, 2005 | Study did not fit the protocol criteria |
| Bauer, E., Widschwendter, P., Stuck, D., Gundelach, T., Wulff, C., Janni, W., Hancke, K., Endometriosis Health Profile scores and their association with surgical diagnosis in premenopausal women, Journal of Endometriosis, 5, S31-S32, 2013 | Conference abstract |
| Brandes, I., Cluster analysis of endometriosis patients in an outpatient education programme, Archives of Gynecology and Obstetrics, 282, S174, 2010 | Conference abstract refers to the development and implementation of an outpatient intervention |
| Brown, Kristina Schelbert, Dyspareunia due to endometriosis: A qualitative study of its effect on the couple relationship, Dissertation Abstracts International: Section B: The Sciences and Engineering, 68, 3387, 2007 | Themes covered in the study already in other included studies |
| Campbell, P. F., Relieving endometriosis pain: why is it so tough?, Obstetrics & Gynecology Clinics of North America, 30, 209–20, 2003 | No information on participants, narrative |
| Charnock, D., Shepperd, S., Needham, G., Gann, R., DISCERN: an instrument for judging the quality of written consumer health information on treatment choices, Journal of Epidemiology & Community Health, 53, 105–11, 1999 | Validation tool not specific to endometriosis |
| Christian, A., The relationship between women’s symptoms of endometriosis and self-esteem, Journal of obstetric, gynecologic, and neonatal nursing: JOGNN / NAACOG, 22, 370–376, 1993 | Interventions not of interest |
| Culley, L., Law, C., Hudson, N., Denny, E., Mitchell, H., Baumgarten, M., Raine-Fenning, N., The social and psychological impact of endometriosis on women’s lives: a critical narrative review, Human Reproduction Update, 19, 625–39, 2013 | Systematic review, individual studies checked for inclusion according to protocol |
| Culley, L., Nudson, N., Law, C., Denny, E., Mitchell, H., Baumgarten, M., Raine-Fenning, N., Pain management decisions amongst couples living with endometriosis, Journal of Endometriosis, 5, S21-S22, 2013 | Conference abstract |
| Dancet, E. A. F., Apers, S., Kremer, J. A. M., Nelen, W. L. D. M., Sermeus, W., D’Hooghe, T. M., The patient-centeredness of endometriosis care and targets for improvement: A systematic review, Gynecologic and obstetric investigation, 78, 69–80, 2014 | Systematic review, individual studies checked for inclusion according to protocol |
| Deal, L. S., Williams, V. S., DiBenedetti, D. B., Fehnel, S. E., Development and psychometric evaluation of the Endometriosis Treatment Satisfaction Questionnaire, Quality of Life Research, 19, 899–905, 2010 | Account of the development of a questionnaire |
| Denny, E., ‘You are one of the unlucky ones’: Delay in the diagnosis of endometriosis, Diversity in Health and Social Care, 1, 39–44, 2004 | No available full text |
| Denny, E., Khan, K. S., Systematic reviews of qualitative evidence: what are the experiences of women with endometriosis?, Journal of Obstetrics & Gynaecology, 26, 501–6, 2006 | Systematic review, individual studies checked for inclusion according to protocol |
| Denny, E., Mann, C. H., Endometriosis and the primary care consultation, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 139, 111–5, 2008 | Themes in the study are covered by other included studies |
| Di Donato, N., Montanari, G., Benfenati, A., Leonardi, D., Bertoldo, V., Monti, G., Casadio, P., La Marca, A., Seracchioli, R., The impact of socioeconomic and anamnestic characteristics on quality of life and sexual function in women with endometriosis, Journal of Endometriosis and Pelvic Pain Disorders, 5, 159–165, 2013 | No study design |
| Duffy, O., Iversen, L., Hannaford, P.C., The menopause ‘It’s somewhere between a taboo and a joke’. A focus group study, Climacteric, 14, 497–505, 2011 | Topic out of scope |
| Dunselman, G., Vermeulen, N., Nap, A., The ESHRE’s endometriosis app, based on ESHRE’s 2013 guideline on the management of women with endometriosis, Human Reproduction, 29, i11-i12, 2014 | Not information and support, this is a conference abstract referring to an application developed by ESHRE |
| Facchin, F., Barbara, G., Saita, E., Mosconi, P., Roberto, A., Fedele, L., Vercellini, P., Impact of endometriosis on quality of life and mental health: pelvic pain makes the difference, Journal of Psychosomatic Obstetrics & Gynecology, 36, 135–41, 2015 | Study did not fit the protocol criteria |
| Fourquet, J., Gao, X., Zavala, D., Orengo, J. C., Abac, S., Ruiz, A., Laboy, J., Flores, I., Patients’ report on how endometriosis affects health, work, and daily life, Fertility & Sterility, 93, 2424–8, 2010 | Survey, not information and support |
| Fritzer, N., Haas, D., Oppelt, P., Renner, S., Hornung, D., Wolfler, M., Ulrich, U., Fischerlehner, G., Sillem, M., Hudelist, G., More than just bad sex: sexual dysfunction and distress in patients with endometriosis, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 169, 392–6, 2013 | Topic not of interest |
| Gherghe, M., Robert, H., David, Y., Christopher, H., The predictive value of endometriosis related information on the internet, Gynecological Surgery, 10, S37, 2013 | Conference abstract, looks at the diagnostic value of websites to provide key information about endometriosis |
| Gould, D., Endometriosis, Nursing Standard, 17, 47–53; quiz 54–5, 2003 | Leaflet that provides information on endometriosis for nurses |
| Haas, D., Wurm, P., Schimetta, W., Schabetsberger, K., Shamiyeh, A., Oppelt, P., Binder, H., Endometriosis patients in the postmenopausal period: pre- and post-menopausal factors influencing postmenopausal health, BioMed Research International, 2014, 746705, 2014 | Population was postmenopausal women |
| Halpern, Vera, Lopez, Laureen M., Grimes, David A., Stockton, Laurie L., Gallo, Maria F., Strategies to improve adherence and acceptability of hormonal methods of contraception, Cochrane Database of Systematic Reviews, -, 2013 | The systematic review investigates the role of client-provider interventions for women’s adherence to hormonal treatment |
| Hirsh, K. W., Ladipo, O. A., Bhal, P. S., Shaw, R. W., The management of endometriosis: a survey of patients’ aspirations, Journal of Obstetrics & Gynaecology, 21, 500–3, 2001 | Study focuses on the patients aspiration about a specialist endometriosis clinic |
| Hudson, N., Culley, L., Law, C., Denny, E., Mitchell, H., Baumgarten, M., Raine-Fenning, N., Improving the well being of couples living with endometriosis, Human Reproduction, 28, i281, 2013 | Conference abstract, theme covered by other included studies |
| Hudson, N., Culley, L., Mitchell, H., Law, C., Denny, E., Raine-Fenning, N., Men living with endometriosis: Perceptions and experiences of male partners of women with the condition, Human Reproduction, 30, i35, 2015 | Information from this study has been included from another conference abstract |
| Jacox, Cynthia Marlaine, Coping styles and psychological distress in women with endometriosis, Dissertation Abstracts International: Section B: The Sciences and Engineering, 56, 6394, 1996 | Research abstract, original paper not found |
| Jones, K. P., Emotional aspects of endometriosis: a physician’s perspective, Clinical Obstetrics & Gynecology, 31, 874–82, 1988 | Narrative |
| Karavadra, B., Simpson, P., Mullins, E., Prosser-Snelling, E., Morris, E., A mixed qualitative and quantitative analysis on the impact of endometriosis on women in the UK; a silent disease?, BJOG: An International Journal of Obstetrics and Gynaecology, 123, 56, 2016 | Conference abstract |
| Kennedy, S., What is important to the patient with endometriosis? British Journal of Clinical Practice. Supplement, 72, 8–10; discussion 11–3, 1991 | No available full text |
| Kilaru, A. S., Paciotti, B., Ha, Y., Ranard, B., Griffis, H., Merchant, R., What do patients say about emergency departments in online reviews?, Annals of Emergency Medicine, 1), S135, 2014 | Topic not of interest |
| Kundu, S., Wildgrube, J., Schippert, C., Hillemanns, P., Brandes, I., Supporting and inhibiting factors when coping with endometriosis from the patients’ perspective, Geburtshilfe und Frauenheilkunde, 75, 462–469, 2015 | No available full text |
| Manderson, L., Warren, N., Markovic, M., Circuit breaking: pathways of treatment seeking for women with endometriosis in Australia, Qualitative Health Research, 18, 522–34, 2008 | Themes in study covered by other included studies |
| Pope, C. J., Sharma, V., Sharma, S., Mazmanian, D., A Systematic Review of the Association Between Psychiatric Disturbances and Endometriosis, Journal of Obstetrics & Gynaecology Canada: JOGC, 37, 1006–15, 2015 | Study did not fit the protocol criteria |
| Quilliam, S., Endometriosis: the bloggers’ tales, Journal of Family Planning & Reproductive Health Care, 40, 142–4, 2014 | Narrative review |
| Roman, H., Loisel, C., Resch, B., Tuech, J. J., Hochain, P., Leroi, A. M., Marpeau, L., Delayed functional outcomes associated with surgical management of deep rectovaginal endometriosis with rectal involvement: giving patients an informed choice, Human Reproduction, 25, 890–9, 2010 | Outcomes not in protocol |
| Sahin, S., Beji, N. K., Assessment of quality of life of women with endometriosis, Human Reproduction, 27, 2012 | Validation of EHP30 questionnaire into Turkish to assess QOL of women with endometriosis |
| Schenken, R. S., Delayed diagnosis of endometriosis, Fertility and sterility, 86, 1305–1306, 2006 | Commentary on Ballard 2006 study |
| Sepulcri Rde, P., do Amaral, V. F., Depressive symptoms, anxiety, and quality of life in women with pelvic endometriosis, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 142, 53–6, 2009 | The study did not fit the protocol (no interventions) |
| Seyhan, A., Ata, B., Uncu, G., The Impact of Endometriosis and Its Treatment on Ovarian Reserve, Seminars in Reproductive Medicine, 33, 422–8, 2015 | Study did not fit the protocol criteria |
| Shadbolt, N. A., Parker, M. A., Orthia, L. A., Communicating endometriosis with young women to decrease diagnosis time, Health Promotion Journal of Australia, 24, 151–4, 2013 | Survey looked at women’s knowledge of endometriosis rather than what they would find useful in terms of information and support |
| Shah, D. K., Moravek, M. B., Vahratian, A., Dalton, V. K., Lebovic, D. I., Public perceptions of endometriosis: perspectives from both genders, Acta Obstetricia et Gynecologica Scandinavica, 89, 646–50, 2010 | Survey about endometriosis, not qualitative format |
| Soliman, A. M., Gooch, K. L., Winkel, C. A., Quality of life (QOL) in endometriosis patients and its correlation with symptomatic burden: A cross sectional survey among us women, Endocrine Reviews. Conference: 96th Annual Meeting and Expo of the Endocrine Society, ENDO, 35, 2014 | Conference abstract |
| Suchard, M. A., Hadfield, R., Elliott, T., Kennedy, S., Beyond providing information: the Internet as a research tool in reproductive medicine, Human Reproduction, 13, 6–7, 1998 | Response of women to a website developed at Oxford University |
| Toye, F., Seers, K., Barker, K., A meta-ethnography of patients’ experiences of chronic pelvic pain: struggling to construct chronic pelvic pain as ‘real’, Journal of Advanced Nursing, 70, 2713–27, 2014 | Systematic review, individual studies already checked for inclusion according to protocol |
| Tripoli, T. M., Sato, H., Sartori, M. G., de Araujo, F. F., Girao, M. J., Schor, E., Evaluation of quality of life and sexual satisfaction in women suffering from chronic pelvic pain with or without endometriosis, Journal of Sexual Medicine, 8, 497–503, 2011 | Study uses a questionnaire to look at quality of life and sexual satisfaction in women with endometriosis, not information and support |
| Turnbull, H., Mukhopadhyay, S., Morris, E., The effect of endometriosis on quality of life in patients with a diagnosis in their younger reproductive years, International Journal of Gynecology and Obstetrics, 107, S631, 2009 | This was a response of women to a website developed by Oxford University |
| van de Burgt, T. J., Kluivers, K. B., Hendriks, J. C., Responsiveness of the Dutch Endometriosis Health Profile-30 (EHP-30) questionnaire, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 168, 92–4, 2013 | Background information |
| Wang, C. Y., Coping with endometriosis, Lancet, 364, 1800, 2004 | Personal account of a woman with endometriosis |
| Weinstein, K., The emotional aspects of endometriosis: what the patient expects from her doctor, Clinical Obstetrics & Gynecology, 31, 866–73, 1988 | Narrative review |
| Whitney, M. L., Importance of lay organizations for coping with endometriosis, Journal of Reproductive Medicine, 43, 331–4, 1998 | Information already covered in included studies |
| Wingfield, M. B., Wood, C., Henderson, L. S., Wood, R. M., Treatment of endometriosis involving a self-help group positively affects patients’ perception of care, Journal of Psychosomatic Obstetrics & Gynecology, 18, 255–8, 1997 | Target population not endometriosis |
| Wright, C. C., Barlow, J. H., Turner, A. P., Bancroft, G. V., Self-management training for people with chronic disease: an exploratory study, British Journal of Health Psychology, 8, 465–76, 2003 | Only 10% of participants had endometriosis |
| Young-Lewis, L., Silverman, J., Endometriosis. Supportive care is essential, Advance for Nurse Practitioners, 9, 24–6, 29–30, 2001 | No available full text |
| Yuzpe, A. A., Oral contraception: Trends over time, Journal of Reproductive Medicine for the Obstetrician and Gynecologist, 47, 967–973, 2002 | Narrative review, not qualitative study |
H.5. Risk of cancer of reproductive organs
| Reference | Reason for exclusion |
|---|---|
| Aure, J. C., Hoeg, K., Kolstad, P., Carcinoma of the ovary and endometriosis, Acta Obstetricia et Gynecologica Scandinavica, 50, 63–7, 1971 | All have cancer |
| Borgfeldt, C., Andolf, E., Cancer risk after hospital discharge diagnosis of benign ovarian cysts and endometriosis, Acta Obstetricia et Gynecologica Scandinavica, 83, 395–400, 2004 | Case control study |
| Bounous, V. E., Ferrero, A., Fuso, L., Ravarino, N., Ceccaroni, M., Menato, G., Biglia, N., Endometriosis-associated Ovarian Cancer: A Distinct Clinical Entity?, Anticancer Research, 36, 3445–9, 2016 | Not adjusted or stratified for any of the confounders specified in the protocol |
| Devereux, W. P., Endometriosis: Long-Term Observation, with Particular Reference to Incidence of Pregnancy, Obstetrics & Gynecology, 22, 444–50, 1963 | Doesn’t look at reproductive cancer prevalence. |
| Dinkelspiel, H. E., Matrai, C., Pauk, S., Pierre-Louis, A., Chiu, Y. L., Gupta, D., Caputo, T., Ellenson, L. H., Holcomb, K., Does the Presence of Endometriosis Affect Prognosis of Ovarian Cancer?, Cancer Investigation, 34, 148–54, 2016 | Case-control study |
| Frick, H. C., 2nd, Munnell, E. W., Richart, R. M., Berger, A. P., Lawry, M. F., Carcinoma of the endometrium, American Journal of Obstetrics & Gynecology, 115, 663–76, 1973 | All have cancer |
| Gemmill, J. A., Stratton, P., Cleary, S. D., Ballweg, M. L., Sinaii, N., Cancers, infections, and endocrine diseases in women with endometriosis, Fertility & Sterility, 94, 1627–31, 2010 | Cross sectional study. All have endometriosis |
| Heidemann, L. N., Hartwell, D., Heidemann, C. H., Jochumsen, K. M., The relation between endometriosis and ovarian cancer - A review, Acta Obstetricia et Gynecologica Scandinavica, 93, 20–31, 2014 | Does not meet protocol. Includes case control and cross sectional studies. Used as a check list. |
| Hollander, D., History of endometriosis places women at high risk of ovarian cancer, but pill use remains protective, Perspectives on Sexual and Reproductive Health, 37, 52, 2005 | Summary of results from an excluded study (pooled case control) |
| Kim, H. S., Kim, T. H., Chung, H. H., Song, Y. S., Risk and prognosis of ovarian cancer in women with endometriosis: a meta-analysis, British Journal of Cancer, 110, 1878–90, 2014 | Does not meet protocol inclusion criteria. Includes case control. Used as a check list. |
| Kontoravdis, A., Augoulea, A., Lambrinoudaki, I., Christodoulakos, G., Tzortziotis, D., Grammatikakis, I., Kontoravdis, N., Creatsas, G., Ovarian endometriosis associated with ovarian cancer and endometrial-endocervical polyps, Journal of Obstetrics & Gynaecology Research, 33, 294–8, 2007 | Cross sectional study, no comparator |
| Kvaskoff, M., Mu, F., Terry, K. L., Harris, H. R., Poole, E. M., Farland, L., Missmer, S. A., Endometriosis: a high-risk population for major chronic diseases?, Human Reproduction Update, 21, 500–16, 2015 | Does not match protocol. Unclear inclusion/exclusion criteria. All study types are included. |
| Matalliotakis, I. M., Cakmak, H., Krasonikolakis, G. D., Dermitzaki, D., Fragouli, Y., Vlastos, G., Arici, A., Endometriosis related to family history of malignancies in the Yale series, Surgical Oncology, 19, 33–7, 2010 | Only looks at family history of cancer |
| Ness, R., Pearce, C., Stram, D., Berchuck, A., Pike, M., Pharoah, P., LIFETIME RISK OF OVARIAN CANCER BASED ON ENDOMETRIOSIS AND OTHER RISK FACTORS: IGCS-0014 06. Ovarian Cancer, International Journal of Gynecological Cancer, 25 Suppl 1, 50, 2015 | Case control meta-analysis |
| Nishida, M., Watanabe, K., Sato, N., Ichikawa, Y., Malignant transformation of ovarian endometriosis, Gynecologic & Obstetric Investigation, 50 Suppl 1, 18–25, 2000 | Cross sectional study, no comparator |
| Nomelini, R. S., Ferreira, F. A., Borges, R. C., Adad, S. J., Murta, E. F., Frequency of endometriosis and adenomyosis in patients with leiomyomas, gynecologic premalignant, and malignant neoplasias, Clinical & Experimental Obstetrics & Gynecology, 40, 40–4, 2013 | All have cancer |
| Olson, J. E., Cerhan, J. R., Janney, C. A., Anderson, K. E., Vachon, C. M., Sellers, T. A., Postmenopausal cancer risk after self-reported endometriosis diagnosis in the Iowa Women’s Health Study, Cancer, 94, 1612–1618, 2002 | Post-menopausal women population. Self-reported endo dx. |
| Szubert, M., Suzin, J., Obirek, K., Sochacka, A., Loszakiewicz, M., Clear cell ovarian cancer and endometriosis: Is there a relationship?, Przeglad Menopauzalny, 15, 85–89, 2016 | Descriptive data |
| Yoshikawa, H., Jimbo, H., Okada, S., Matsumoto, K., Onda, T., Yasugi, T., Taketani, Y., Prevalence of endometriosis in ovarian cancer, Gynecologic and Obstetric Investigation, 50, 11–17, 2000 | No methods listed. Not a Systematic Review. Looks at % of ovarian cancer have endometriosis. |
| Zafrakas, M., Grimbizis, G., Timologou, A., Tarlatzis, B. C., Endometriosis and ovarian cancer risk: a systematic review of epidemiological studies, Frontiers in Surgery, 1, 14, 2014 | Does not meet protocol. Includes case control and cross sectional studies. Used as a check list. |
| Zanetta, G. M., Webb, M. J., Li, H., Keeney, G. L., Hyperestrogenism: A relevant risk factor for the development of cancer from endometriosis, Gynecologic Oncology, 79, 18–22, 2000 | Wrong population comparison. Unable to calculate prevalence. |
H.6. Diagnosis – Ultrasound
| Study | Reason for Exclusion |
|---|---|
| Abrao, M. S., Goncalves, M. O., Dias, J. A., Jr., Podgaec, S., Chamie, L. P., Blasbalg, R., Comparison between clinical examination, transvaginal sonography and magnetic resonance imaging for the diagnosis of deep endometriosis, Human Reproduction, 22, 3092–7, 2007 | Included as one of the studies in the Nisenblat 2016 review |
| Abrao, M. S., Podgaec, S., Filho, B. M., Ramos, L. O., Pinotti, J. A., de Oliveira, R. M., The use of biochemical markers in the diagnosis of pelvic endometriosis, Human Reproduction, 12, 2523–7, 1997 | Case-control stud |
| Abrao, M. S., Podgaec, S., Pinotti, J. A., de Oliveira, R. M., Tumor markers in endometriosis, International Journal of Gynaecology & Obstetrics, 66, 19–22, 1999 | Case-control study |
| Acimovic, M., Vidakovic, S., Milic, N., Jeremic, K., Markovic, M., Milosevic-Djeric, A., Lazovic-Radonjic, G., Survivin and Vegf as Novel Biomarkers in Diagnosis of Endometriosis, Journal of Medical Biochemistry, 35, 63–68, 2016 | No laparoscopy/laparotomy and no histological confirmation |
| Alcazar, J. L., Laparte, C., Jurado, M., Lopez-Garcia, G., The role of transvaginal ultrasonography combined with color velocity imaging and pulsed Doppler in the diagnosis of endometrioma, Fertility & Sterility, 67, 487–91, 1997 | Postmenopausal women, analysis included number of lesions, not number of participants |
| Aleem, F., Pennisi, J., Zeitoun, K., Predanic, M., The role of color Doppler in diagnosis of endometriomas, Ultrasound in Obstetrics & Gynecology, 5, 51–4, 1995 | The aim of this study is to describe vascular appearance in endometriomas. No outcome of interest. |
| Anaf, V., El Nakadi, I., De Moor, V., Coppens, E., Zalcman, M., Noel, J. C., Anatomic significance of a positive barium enema in deep infiltrating endometriosis of the large bowel, World Journal of Surgery, 33, 822–7, 2009 | All patients had surgery and DCBE |
| Balasch, J., Creus, M., Fabregues, F., Carmona, F., Ordi, J., Martinez-Roman, S., Vanrell, J. A., Visible and non-visible endometriosis at laparoscopy in fertile and infertile women and in patients with chronic pelvic pain: a prospective study, Human Reproduction, 11, 387–91, 1996 | Not a diagnostic study |
| Balleyguier, C., Roupret, M., Nguyen, T., Kinkel, K., Helenon, O., Chapron, C., Ureteral endometriosis: the role of magnetic resonance imaging, Journal of the American Association of Gynecologic Laparoscopists, 11, 530–6, 2004 | No outcome of interest. Moreover, only 6 patients were included. |
| Barcellos, M. B., Lasmar, B., Lasmar, R., Agreement between the preoperative findings and the operative diagnosis in patients with deep endometriosis, Archives of Gynecology & Obstetrics Arch Gynecol Obstet, 293, 845–50, 2016 | Lesion-level analysis |
| Bazot, M., Detchev, R., Cortez, A., Amouyal, P., Uzan, S., Darai, E., Transvaginal sonography and rectal endoscopic sonography for the assessment of pelvic endometriosis: a preliminary comparison, Human Reproduction, 18, 1686–92, 2003 | Population overlap with Bazot 2009 |
| Bazot, M., Gasner, A., Ballester, M., Darai, E., Value of thin-section oblique axial T2-weighted magnetic resonance images to assess uterosacral ligament endometriosis, Human Reproduction, 26, 346–53, 2011 | Retrospective study; one MRI technique compared to conventional technique |
| Bazot, M., Gasner, A., Lafont, C., Ballester, M., Darai, E., Deep pelvic endometriosis: limited additional diagnostic value of postcontrast in comparison with conventional MR images, European Journal of Radiology, 80, e331–9, 2011 | Retrospective study; comparison of post-contrast MRI versus conventional MRI |
| Bazot, M., Lafont, C., Rouzier, R., Roseau, G., Thomassin-Naggara, I., Darai, E., Diagnostic accuracy of physical examination, transvaginal sonography, rectal endoscopic sonography, and magnetic resonance imaging to diagnose deep infiltrating endometriosis, Fertility & Sterility, 92, 1825–33, 2009 | Included as one of the studies in the Nisenblat 2016 review |
| Bazot, M., Malzy, P., Cortez, A., Roseau, G., Amouyal, P., Darai, E., Accuracy of transvaginal sonography and rectal endoscopic sonography in the diagnosis of deep infiltrating endometriosis, Ultrasound in Obstetrics & Gynecology, 30, 994–1001, 2007 | Population overlap with Bazot 2009 |
| Bazot, M., Stivalet, A., Darai, E., Coudray, C., Thomassin Naggara, I., Poncelet, E., Comparison of 3D and 2D FSE T2-weighted MRI in the diagnosis of deep pelvic endometriosis: preliminary results, Clinical Radiology, 68, 47–54, 2013 | Included in MRI review |
| Bazot, M., Thomassin, I., Hourani, R., Cortez, A., Darai, E., Diagnostic accuracy of transvaginal sonography for deep pelvic endometriosis, Ultrasound in Obstetrics & Gynecology, 24, 180–5, 2004 | Population overlap with Bazot 2009 |
| Bedaiwy, M. A., Falcone, T., Laboratory testing for endometriosis, Clinica Chimica Acta, 340, 41–56, 2004 | Narrative review |
| Bedaiwy, M. A., Falcone, T., Sharma, R. K., Goldberg, J. M., Attaran, M., Nelson, D. R., Agarwal, A., Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial, Human Reproduction, 17, 426–31, 2002 | Biomarkers not of interest |
| Belghiti, J., Thomassin-Naggara, I., Zacharopoulou, C., Zilberman, S., Jarboui, L., Bazot, M., Ballester, M., Darai, E., Contribution of Computed Tomography Enema and Magnetic Resonance Imaging to Diagnose Multifocal and Multicentric Bowel Lesions in Patients With Colorectal Endometriosis, Journal of Minimally Invasive Gynecology, 22, 776–84, 2015 | Lesion-level analysis |
| Belli, P., De Gaetano, A. M., Mirk, P., Speca, S., Valentini, A. L., Uterine adenomyosis and tubal endometriosis: diagnostic imaging, Rays, 23, 693–701, 1998 | Narrative review |
| Benacerraf, B. R., Finkler, N. J., Wojciechowski, C., Knapp, R. C., Sonographic accuracy in the diagnosis of ovarian masses, Journal of Reproductive Medicine for the Obstetrician and Gynecologist, 35, 491–495, 1990 | No outcome of interest |
| Benacerraf, B. R., Groszmann, Y., Sonography should be the first imaging examination done to evaluate patients with suspected endometriosis, Journal of Ultrasound in Medicine, 31, 651–3, 2012 | Narrative review |
| Bergamini, V., Ghezzi, F., Scarperi, S., Raffaelli, R., Cromi, A., Franchi, M., Preoperative assessment of intestinal endometriosis: A comparison of transvaginal sonography with water-contrast in the rectum, transrectal sonography, and barium enema, Abdominal Imaging, 35, 732–6, 2010 | Included as one of the studies in the Nisenblat 2016 review |
| Boog, G., Penot, P., Momber, A., Ultrasound as a diagnostic aid in endometriosis, Contributions to Gynecology & Obstetrics, 16, 119–24, 1987 | Retrospective study |
| Bordin, L., Fiore, C., Dona, G., Andrisani, A., Ambrosini, G., Faggian, D., Plebani, M., Clari, G., Armanini, D., Evaluation of erythrocyte band 3 phosphotyrosine level, glutathione content, CA-125, and human epididymal secretory protein E4 as combined parameters in endometriosis, Fertility & Sterility, 94, 1616–21, 2010 | All the patients have proven endometriosis |
| Carbognin, G., Girardi, V., Pinali, L., Raffaelli, R., Bergamini, V., Pozzi Mucelli, R., Assessment of pelvic endometriosis: correlation of US and MRI with laparoscopic findings, Radiologia Medica, 111, 687–701, 2006 | Analysis included number of lesions, not number of participants |
| Chapron, C., Vieira, M., Chopin, N., Balleyguier, C., Barakat, H., Dumontier, I., Roseau, G., Fauconnier, A., Foulot, H., Dousset, B., Accuracy of rectal endoscopic ultrasonography and magnetic resonance imaging in the diagnosis of rectal involvement for patients presenting with deeply infiltrating endometriosis, Ultrasound in Obstetrics & Gynecology, 24, 175–9, 2004 | Not initial diagnosis; retrospective study |
| Cheng, Y. M., Wang, S. T., Chou, C. Y., Serum CA-125 in preoperative patients at high risk for endometriosis, Obstetrics & Gynecology, 99, 375–80, 2002 | CA-125 has been used for identifying high risk woman not as a diagnostic tool. |
| Cho, S., Cho, H., Nam, A., Kim, H. Y., Choi, Y. S., Park, K. H., Cho, D. J., Lee, B. S., Neutrophil-to-lymphocyte ratio as an adjunct to CA-125 for the diagnosis of endometriosis, Fertility & Sterility, 90, 2073–9, 2008 | It is a case-control study |
| Chung, M. K., Chung, R. R., Gordon, D., Jennings, C., The evil twins of chronic pelvic pain syndrome: endometriosis and interstitial cystitis, JSLS: Journal of the Society of Laparoendoscopic Surgeons / Society of Laparoendoscopic Surgeons, 6, 311–314, 2002 | No outcome of interest |
| Cohen, L. S., Valle, R. F., Sabbagha, R. E., A comparison of preoperative ultrasound images of surgically proven endometriomas scanned by both transabdominal and transvaginal techniques, Journal of Gynecologic Surgery, 11, 27–32, 1995 | All the patients have surgically confirmed endometriosis. |
| Cohen, M. R., Laparoscopy in the diagnosis and management of endometriosis, Journal of Reproductive Medicine, 27, 240–2, 1982 | No outcome of interest |
| Colacurci, N., Fortunato, N., De Franciscis, P., Fratta, M., Cioffi, M., Zarcone, R., Cardone, A., Serum and peritoneal CA-125 levels as diagnostic test for endometriosis, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 66, 41–3, 1996 | Case-control study |
| Coleman, B. G., Arger, P. H., Mulhern, C. B., Jr., Endometriosis: clinical and ultrasonic correlation, AJR. American Journal of Roentgenology, 132, 747–9, 1979 | All patients were recruited in this study, had surgically proven endometriosis |
| Corwin, M. T., Gerscovich, E. O., Lamba, R., Wilson, M., McGahan, J. P., Differentiation of ovarian endometriomas from hemorrhagic cysts at MR imaging: utility of the T2 dark spot sign, Radiology, 271, 126–32, 2014 | Using a diagnostic test to diagnose endometriosis has not been addressed in this study. It is about a sign in MRI to distinguish between Endometrioma and haemorrhagic cysts |
| Daniilidis, A., Giannoulis, H., Tantanasis, T., Papathanasiou, K., Loufopoulos, A., Tzafettas, J., Diagnostic laparoscopy, infertility, and endometriosis - 5 Years experience, Gynecological Surgery, 5, 231–234, 2008 | Outcomes not of interest |
| de Kroon, C. D., van der Sandt, H. A., van Houwelingen, J. C., Jansen, F. W., Sonographic assessment of non-malignant ovarian cysts: does sonohistology exist?, Human Reproduction, 19, 2138–43, 2004 | Postmenopausal women included in the analysis |
| Dechaud, H., Ali Ahmed, S. A., Aligier, N., Vergnes, C., Hedon, B., Does transvaginal hydrolaparoscopy render standard diagnostic laparoscopy obsolete for unexplained infertility investigation?, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 94, 97–102, 2001 | Transvaginal hydro laparoscopy compared with conventional laparoscopy; no data for outcomes |
| Delpy, R., Barthet, M., Gasmi, M., Berdah, S., Shojai, R., Desjeux, A., Boubli, L., Grimaud, J. C., Value of endorectal ultrasonography for diagnosing rectovaginal septal endometriosis infiltrating the rectum, Endoscopy, 37, 357–61, 2005 | Not able to calculate 2 by 2 table |
| Dessole, S., Farina, M., Rubattu, G., Cosmi, E., Ambrosini, G., Nardelli, G. B., Sonovaginography is a new technique for assessing rectovaginal endometriosis, Fertility & Sterility, 79, 1023–7, 2003 | Included as one of the studies in the Nisenblat 2016 review |
| do Amaral, V. F., Ferriani, R. A., de Sa, M. F. S., Nogueira, A. A., Silva, J. C. R., de Sa Rosa e Silva, A. C. J., de Moura, M. D., Positive correlation between serum and peritoneal fluid CA-125 levels in women with pelvic endometriosis, Sao Paulo Medical Journal, 124, 223–227, 2006 | It is a case-control study |
| Dogan, M. M., Ugur, M., Soysal, S. K., Soysal, M. E., Ekici, E., Gokmen, O., Transvaginal sonographic diagnosis of ovarian endometrioma, International Journal of Gynaecology & Obstetrics, 52, 145–9, 1996 | Analysis included lesions, not number of participants |
| Doniec, J. M., Kahlke, V., Peetz, F., Schniewind, B., Mundhenke, C., Lohnert, M. S., Kremer, B., Rectal endometriosis: high sensitivity and specificity of endorectal ultrasound with an impact for the operative management, Diseases of the Colon & Rectum, 46, 1667–73, 2003 | Some of the population have confirmed endometriosis and some suspected |
| Dunselman, G. A. J., Vermeulen, N., Becker, C., Calhaz-Jorge, C., D’Hooghe, T., De Bie, B., Heikinheimo, O., Horne, A. W., Kiesel, L., Nap, A., Prentice, A., Saridogan, E., Soriano, D., Nelen, W., ESHRE guideline: Management of women with endometriosis, Human Reproduction, 29, 400–412, 2014 | The individual studies in this publication have been checked for inclusion in the review |
| El Maati, A. A. A., Ibrahim, E. A. G., Mokhtar, F. Z., A two-stage imaging protocol for evaluating women presenting with acute pelvic pain, Egyptian Journal of Radiology and Nuclear Medicine, 44, 923–936, 2013 | The population is women with acute pelvic pain, not suspected endometriosis |
| Ellett, L., Readman, E., Newman, M., McIlwaine, K., Villegas, R., Jagasia, N., Maher, P., Are endometrial nerve fibres unique to endometriosis? A prospective case-control study of endometrial biopsy as a diagnostic test for endometriosis in women with pelvic pain, Human Reproduction, 30, 2808–15, 2015 | Case-control study |
| Eskenazi, B., Warner, M., Bonsignore, L., Olive, D., Samuels, S., Vercellini, P., Validation study of nonsurgical diagnosis of endometriosis, Fertility & Sterility, 76, 929–35, 2001 | Included as one of the studies in the Nisenblat 2016 review |
| Exacoustos, C., Luciano, D., Corbett, B., De Felice, G., Di Feliciantonio, M., Luciano, A., Zupi, E., The uterine junctional zone: a 3-dimensional ultrasound study of patients with endometriosis, American Journal of Obstetrics & Gynecology, 209, 248.e1–7, 2013 | In the study, the relation between thickness of uterine junctional zone and endometriosis has been evaluated. It has not been used as a diagnostic tool. |
| Exacoustos, C., Malzoni, M., Di Giovanni, A., Lazzeri, L., Tosti, C., Petraglia, F., Zupi, E., Ultrasound mapping system for the surgical management of deep infiltrating endometriosis, Fertility & Sterility, 102, 143–150.e2, 2014 | Only women with positive index test underwent surgery) |
| Fedele, L., Bianchi, S., Portuese, A., Borruto, F., Dorta, M., Transrectal ultrasonography in the assessment of rectovaginal endometriosis, Obstetrics & Gynecology, 91, 444–8, 1998 | Included as one of the studies in the Nisenblat 2016 review |
| Federici, D., Muggiasca, M. L., Conti, M., Diagnostic value of laparoscopic evaluation of women with chronic pelvic pain: Our experience and a review of the literature, VALEUR DIAGNOSTIQUE DE L’EXPLORATION LAPAROSCOPIQUE DES FEMMES SOUFFRANT DE DOULEURS PELVIENNES CHRONIQUES: EXPERIENCE PERSONNELLE ET REVUE DE LA LITTERATURE, Acta Endoscopica, 22, 177–186, 1992 | Narrative review |
| Felding, C., Mikkelsen, A. L., Peen, U., Laparoscopy and ultrasound in patients with chronic pelvic pain, Journal of Obstetrics and Gynaecology, 10, 419–422, 1990 | No outcome of interest |
| Ferrero, S., Biscaldi, E., Morotti, M., Venturini, P. L., Remorgida, V., Rollandi, G. A., Valenzano Menada, M., Multidetector computerized tomography enteroclysis vs. rectal water contrast transvaginal ultrasonography in determining the presence and extent of bowel endometriosis, Ultrasound in Obstetrics & Gynecology, 37, 603–13, 2011 | Included as one of the studies in the Nisenblat 2016 review |
| Fiaschetti, V., Crusco, S., Meschini, A., Cama, V., Di Vito, L., Marziali, M., Piccione, E., Calabria, F., Simonetti, G., Deeply infiltrating endometriosis: evaluation of retro-cervical space on MRI after vaginal opacification, European Journal of Radiology, 81, 3638–45, 2012 | Analysis included lesions, not number of participants |
| Foda, A. A., Aal, I. A. A., Role of some biomarkers in chronic pelvic pain for early detection of endometriosis in infertile women, Middle East Fertility Society Journal, 17, 187–194, 2012 | Case-control study |
| Fratelli, N., Scioscia, M., Bassi, E., Musola, M., Minelli, L., Trivella, G., Transvaginal sonography for preoperative assessment of deep endometriosis, Journal of Clinical Ultrasound, 41, 69–75, 2013 | Data for TVS was collected retrospectively |
| Friedman, H., Vogelzang, R. L., Mendelson, E. B., Neiman, H. L., Cohen, M., Endometriosis detection by US with laparoscopic correlation, Radiology, 157, 217–20, 1985 | No data on outcomes |
| Ghezzi, F., Raio, L., Cromi, A., Duwe, D. G., Beretta, P., Buttarelli, M., Mueller, M. D., “Kissing ovaries”: a sonographic sign of moderate to severe endometriosis, Fertility & Sterility, 83, 143–7, 2005 | Included as one of the studies in the Nisenblat 2016 review |
| Goncalves, M. O., Podgaec, S., Dias, J. A., Jr., Gonzalez, M., Abrao, M. S., Transvaginal ultrasonography with bowel preparation is able to predict the number of lesions and rectosigmoid layers affected in cases of deep endometriosis, defining surgical strategy, Human Reproduction, 25, 665–71, 2010 | Included as one of the studies in the Nisenblat 2016 review |
| Gougoutas, C. A., Siegelman, E. S., Hunt, J., Outwater, E. K., Pelvic endometriosis: various manifestations and MR imaging findings, AJR. American Journal of Roentgenology, 175, 353–8, 2000 | Narrative review |
| Grasso, R. F., Di Giacomo, V., Sedati, P., Sizzi, O., Florio, G., Faiella, E., Rossetti, A., Del Vescovo, R., Zobel, B. B., Diagnosis of deep infiltrating endometriosis: accuracy of magnetic resonance imaging and transvaginal 3D ultrasonography, Abdominal Imaging, 35, 716–25, 2010 | Included as one of the studies in the Nisenblat 2016 review |
| Guerriero, S., Ajossa, S., Gerada, M., D’Aquila, M., Piras, B., Melis, G. B., “Tenderness-guided” transvaginal ultrasonography: a new method for the detection of deep endometriosis in patients with chronic pelvic pain, Fertility & Sterility, 88, 1293–7, 2007 | Included as one of the studies in the Nisenblat 2016 review |
| Guerriero, S., Ajossa, S., Gerada, M., Virgilio, B., Angioni, S., Melis, G. B., Diagnostic value of transvaginal ‘tenderness-guided’ ultrasonography for the prediction of location of deep endometriosis, Human Reproduction, 23, 2452–7, 2008 | Included as one of the studies in the Nisenblat 2016 review |
| Guerriero, S., Ajossa, S., Mais, V., Risalvato, A., Lai, M. P., Melis, G. B., The diagnosis of endometriomas using colour Doppler energy imaging, Human Reproduction, 13, 1691–5, 1998 | Analysis included lesions only, not number of participants |
| Guerriero, S., Ajossa, S., Minguez, J. A., Jurado, M., Mais, V., Melis, G. B., Alcazar, J. L., Accuracy of transvaginal ultrasound for diagnosis of deep endometriosis in uterosacral ligaments, rectovaginal septum, vagina and bladder: systematic review and meta-analysis, Ultrasound in Obstetrics & Gynecology, 46, 534–45, 2015 | Single studies were assessed according to inclusion criteria and, if relevant, included |
| Guerriero, S., Ajossa, S., Paoletti, A. M., Mais, V., Angiolucci, M., Melis, G. B., Tumor markers and transvaginal ultrasonography in the diagnosis of endometrioma, Obstetrics & Gynecology, 88, 403–7, 1996 | Included as one of the studies in the Nisenblat 2016 review |
| Guerriero, S., Mais, V., Ajossa, S., Paoletti, A. M., Angiolucci, M., Labate, F., Melis, G. B., The role of endovaginal ultrasound in differentiating endometriomas from other ovarian cysts, Clinical & Experimental Obstetrics & Gynecology, 22, 20–2, 1995 | Analysis included number of lesions, not number of participants |
| Guerriero, S., Mais, V., Ajossa, S., Paoletti, A. M., Angiolucci, M., Melis, G. B., Transvaginal ultrasonography combined with CA-125 plasma levels in the diagnosis of endometrioma, Fertility & Sterility, 65, 293–8, 1996 | Included as one of the studies in the Nisenblat 2016 review |
| Guerriero, S., Mallarini, G., Ajossa, S., Risalvato, A., Satta, R., Mais, V., Angiolucci, M., Melis, G. B., Transvaginal ultrasound and computed tomography combined with clinical parameters and CA-125 determinations in the differential diagnosis of persistent ovarian cysts in premenopausal women, Ultrasound in Obstetrics & Gynecology, 9, 339–43, 1997 | Analysis included number of lesions, not number of participants |
| Guerriero, S., Saba, L., Ajossa, S., Peddes, C., Angiolucci, M., Perniciano, M., Melis, G. B., Alcazar, J. L., Three-dimensional ultrasonography in the diagnosis of deep endometriosis, Human Reproduction, 29, 1189–98, 2014 | Included as one of the studies in the Nisenblat 2016 review |
| Guven, M. A., Bese, T., Demirkiran, F., Comparison of hydrosonography and transvaginal ultrasonography in the detection of intracavitary pathologies in women with abnormal uterine bleeding, International Journal of Gynecological Cancer, 14, 57–63, 2004 | The study population are women with history of abnormal uterine bleeding not women suspected to endometriosis. |
| Harada, T., Kubota, T., Aso, T., Usefulness of CA19–9 versus CA125 for the diagnosis of endometriosis, Fertility and Sterility, 78, 733–739, 2002 | Case-control study |
| Holland, T. K., Cutner, A., Saridogan, E., Mavrelos, D., Pateman, K., Jurkovic, D., Ultrasound mapping of pelvic endometriosis: does the location and number of lesions affect the diagnostic accuracy? A multicentre diagnostic accuracy study, BMC Women’s Health, 13, 43, 2013 | Analysis included number of lesions, not number of participants |
| Holland, T.K., Yazbek, J., Cutner, A., Saridogan, E., Hoo, W.L., Jurkovic, D., Value of transvaginal ultrasound in assessing severity of pelvic endometriosis, Ultrasound in Obstetrics and Gynecology, 36, 241–248, 2010 | Included as one of the studies in the Nisenblat 2016 review |
| Howard, F. M., El-Minawi, A. M., Sanchez, R. A., Conscious pain mapping by laparoscopy in women with chronic pelvic pain, Obstetrics & Gynecology, 96, 934–9, 2000 | The study investigated conscious pain mapping using laparoscopy |
| Hudelist, G., Ballard, K., English, J., Wright, J., Banerjee, S., Mastoroudes, H., Thomas, A., Singer, C. F., Keckstein, J., Transvaginal sonography vs. clinical examination in the preoperative diagnosis of deep infiltrating endometriosis, Ultrasound in Obstetrics & Gynecology, 37, 480–7, 2011 | Included as one of the studies in the Nisenblat 2016 review |
| Hudelist, G., English, J., Thomas, A. E., Tinelli, A., Singer, C. F., Keckstein, J., Diagnostic accuracy of transvaginal ultrasound for non-invasive diagnosis of bowel endometriosis: systematic review and meta-analysis, Ultrasound in Obstetrics & Gynecology, 37, 257–63, 2011 | Individual studies checked for inclusion/exclusion |
| Hudelist, G., Fritzer, N., Staettner, S., Tammaa, A., Tinelli, A., Sparic, R., Keckstein, J., Uterine sliding sign: a simple sonographic predictor for presence of deep infiltrating endometriosis of the rectum, Ultrasound in Obstetrics & Gynecology, 41, 692–5, 2013 | Included as one of the studies in the Nisenblat 2016 review |
| Hudelist, G., Oberwinkler, K. H., Singer, C. F., Tuttlies, F., Rauter, G., Ritter, O., Keckstein, J., Combination of transvaginal sonography and clinical examination for preoperative diagnosis of pelvic endometriosis, Human Reproduction, 24, 1018–24, 2009 | No separate data for imaging test |
| Hudelist, G., Tuttlies, F., Rauter, G., Pucher, S., Keckstein, J., Can transvaginal sonography predict infiltration depth in patients with deep infiltrating endometriosis of the rectum?, Human Reproduction, 24, 1012–7, 2009 | Focus of study was on the depth of invasion of endometriotic lesions |
| Ikeda, F., Bernardini, M. A., Vanni, D., Vasconcelos, A., Pinotti, J. A., Abrao, M. S., A comparison of microlaparoscopy under sedation, microlaparoscopy under general anesthesia and conventional laparoscopy for diagnosis and treatment of pelvic endometriosis in early stages, Fertility and sterility, 77, S21, 2002 | The effectiveness of using a diagnostic tool for diagnosis of endometriosis has not been addressed. |
| Jain, K. A., Friedman, D. L., Pettinger, T. W., Alagappan, R., Jeffrey, R. B., Jr., Sommer, F. G., Adnexal masses: comparison of specificity of endovaginal US and pelvic MR imaging, Radiology, 186, 697–704, 1993 | Not enough data to calculate sensitivity and specificity for 2x2 table |
| Johnson, W. K., Ott, D. J., Chen, M. Y. M., Fayez, J. A., Gelfand, D. W., Efficacy of hysterosalpingography in evaluating endometriosis, Abdominal Imaging, 19, 278–280, 1994 | The study evaluated the effectiveness of hysterosalpingography and laparoscopy-retrospective study |
| Kafali, H., Artuc, H., Demir, N., Use of CA125 fluctuation during the menstrual cycle as a tool in the clinical diagnosis of endometriosis; a preliminary report, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 116, 85–8, 2004 | It is a case-control study |
| Kang, S. B., Chung, H. H., Lee, H. P., Lee, J. Y., Chang, Y. S., Impact of diagnostic laparoscopy on the management of chronic pelvic pain, Surgical Endoscopy, 21, 916–9, 2007 | there was no comparison between laparoscopy and another test |
| Karabacak, O., Tiras, M. B., Taner, M. Z., Guner, H., Yildiz, A., Yildirim, M., Small diameter versus conventional laparoscopy: a prospective, self-controlled study, Human Reproduction, 12, 2399–401, 1997 | Comparison of two types of laparoscopy |
| Kitawaki, J., Ishihara, H., Koshiba, H., Kiyomizu, M., Teramoto, M., Kitaoka, Y., Honjo, H., Usefulness and limits of CA-125 in diagnosis of endometriosis without associated ovarian endometriomas.[Erratum appears in Hum Reprod. 2007 Feb;22(2):627], Human Reproduction, 20, 1999–2003, 2005 | Women enrolled in the study were already diagnosed with endometriosis, adenomyosis and/or leiomyomas |
| Kruger, K., Behrendt, K., Niedobitek-Kreuter, G., Koltermann, K., Ebert, A. D., Location-dependent value of pelvic MRI in the preoperative diagnosis of endometriosis, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 169, 93–8, 2013 | Pelvic MRI retrospectively assessed with histology |
| Kurjak, A., Kupesic, S., Scoring system for prediction of ovarian endometriosis based on transvaginal color and pulsed Doppler sonography, Fertility & Sterility, 62, 81–8, 1994 | Postmenopausal women were included in the analysis, analysis included number of lesions, not number of participants |
| Leon, M., Vaccaro, H., Alcazar, J. L., Martinez, J., Gutierrez, J., Amor, F., Iturra, A., Sovino, H., Extended transvaginal sonography in deep infiltrating endometriosis: use of bowel preparation and an acoustic window with intravaginal gel: preliminary results, Journal of Ultrasound in Medicine, 33, 315–21, 2014 | Included as one of the studies in the Nisenblat 2016 review |
| Leslie, C., Ma, T., McElhinney, B., Leake, R., Stewart, C. J., Is the detection of endometrial nerve fibers useful in the diagnosis of endometriosis?, International Journal of Gynecological Pathology, 32, 149–55, 2013 | No outcome of interest |
| Li, G., Yu, Z., Li, K., The value of FS, NLR, and CA-125 in the diagnosis of endometriosis, International journal of clinical and experimental medicine, 9, 7309–7313, 2016 | Not the population of interest |
| Macer, M. L., Mathur, M., Spektor, M., Gysler, S., Staib, L., Kodaman, P., McCarthy, S., Utility of magnetic resonance imaging in the evaluation of intraoperatively confirmed pelvic adhesions, Journal of Computer Assisted Tomography, 39, 896–900, 2015 | Not the population of interest |
| Maiorana, A., Incandela, D., Giambanco, L., Alio, W., Alio, L., Ultrasound diagnosis of pelvic endometriosis, Journal of Endometriosis, 3, 105–119, 2011 | A narrative review, no QUADAS2 assessment |
| Mais, V., Guerriero, S., Ajossa, S., Angiolucci, M., Paoletti, A. M., Melis, G. B., The efficiency of transvaginal ultrasonography in the diagnosis of endometrioma, Fertility & Sterility, 60, 776–80, 1993 | Analysis include number of lesions, not number of participants |
| Malik, E., Berg, C., Meyhofer-Malik, A., Buchweitz, O., Moubayed, P., Diedrich, K., Fluorescence diagnosis of endometriosis using 5-aminolevulinic acid, Surgical Endoscopy, 14, 452–5, 2000 | The test is not of interest |
| Manganaro, L., Fierro, F., Tomei, A., Irimia, D., Lodise, P., Sergi, M. E., Vinci, V., Sollazzo, P., Porpora, M. G., Delfini, R., Vittori, G., Marini, M., Feasibility of 3.0T pelvic MR imaging in the evaluation of endometriosis, European Journal of Radiology, 81, 1381–7, 2012 | Women in the study already had a diagnosis of endometriosis by transvaginal ultrasound |
| Mangler, M., Medrano, N., Bartley, J., Mechsner, S., Speiser, D., Schneider, A., Kohler, C., Value of diagnostic procedures in rectovaginal endometriosis, Australian & New Zealand Journal of Obstetrics & Gynaecology, 53, 389–94, 2013 | Included as one of the studies in the Nisenblat 2016 review |
| Marasinghe, J. P., Senanayake, H., Saravanabhava, N., Arambepola, C., Condous, G., Greenwood, P., History, pelvic examination findings and mobility of ovaries as a sonographic marker to detect pelvic adhesions with fixed ovaries, Journal of Obstetrics & Gynaecology Research, 40, 785–90, 2014 | TVS was used as a marker of ovarian mobility |
| Mathlouthi, N., Ayed, B. B., Dhouib, M., Chaabene, K., Trabelsi, K., Amouri, H., Guermazi, M., Confrontation ultrasonography-CA125-histology in the managment of ovarian cysts: A prospective study about 77 cases, Tunisie Medicale, 89, 686–692, 2011 | Full-text in French |
| McBride, N., Newman, R. L., Diagnostic laparoscopy, International Journal of Gynaecology & Obstetrics, 15, 556–8, 1978 | No outcome of interest |
| McKinnon, B., Mueller, M. D., Nirgianakis, K., Bersinger, N. A., Comparison of ovarian cancer markers in endometriosis favours HE4 over CA125, Molecular Medicine Reports, 12, 5179–84, 2015 | No data reported to calculate sensitivity |
| Melega, C., Marchesini, F. P., Bellettini, L., Biscontin, S., Flamigni, C., Diagnostic value of laparoscopy in endometriosis and infertility, Journal of Reproductive Medicine, 29, 597–600, 1984 | No outcome of interest |
| Melis, G. B., Ajossa, S., Guerriero, S., Paoletti, A. M., Angiolucci, M., Piras, B., Caffiero, A., Mais, V., Epidemiology and diagnosis of endometriosis, Annals of the New York Academy of Sciences, 734, 352–7, 1994 | Analysis included number of endometriomas, not number of participants |
| Menada, M. V., Remorgida, V., Abbamonte, L. H., Fulcheri, E., Ragni, N., Ferrero, S., Transvaginal ultrasonography combined with water-contrast in the rectum in the diagnosis of rectovaginal endometriosis infiltrating the bowel, Fertility & Sterility, 89, 699–700, 2008 | Population overlap with Menada 2008 (401661) |
| Mezzi, G., Ferrari, S., Arcidiacono, P. G., Di Puppo, F., Candiani, M., Testoni, P. A., Endoscopic rectal ultrasound and elastosonography are useful in flow chart for the diagnosis of deep pelvic endometriosis with rectal involvement, Journal of Obstetrics & Gynaecology Research, 37, 586–90, 2011 | No comparison with surgery |
| Mikami, M., Tanabe, K., Matsuo, K., Miyazaki, Y., Miyazawa, M., Hayashi, M., Asai, S., Ikeda, M., Shida, M., Hirasawa, T., Kojima, N., Sho, R., Iijima, S., Fully-sialylated alpha-chain of complement 4-binding protein: Diagnostic utility for ovarian clear cell carcinoma, Gynecologic Oncology, 139, 520–528, 2015 | Not the population of interest |
| Millischer, A. E., Salomon, L. J., Santulli, P., Borghese, B., Dousset, B., Chapron, C., Fusion imaging for evaluation of deep infiltrating endometriosis: feasibility and preliminary results, Ultrasound in Obstetrics & Gynecology, 46, 109–17, 2015 | No data on surgical diagnosis |
| Miyagi, E., Maruyama, Y., Mogami, T., Numazaki, R., Ikeda, A., Yamamoto, H., Hirahara, F., Comparison of plasma amino acid profile-based index and CA125 in the diagnosis of epithelial ovarian cancers and borderline malignant tumors, International Journal of Clinical Oncology, 1–8, 2016 | Not the population of interest |
| Moore, J., Copley, S., Morris, J., Lindsell, D., Golding, S., Kennedy, S., A systematic review of the accuracy of ultrasound in the diagnosis of endometriosis, Ultrasound in Obstetrics & Gynecology, 20, 630–4, 2002 | Individual studies assessed for inclusion/exclusion |
| Ota, H., Maki, M., Evaluation of autoantibody and CA125 in the diagnosis of endometriosis or adenomyosis, Medical Science Research, 18, 309–310, 1990 | All the participants had known condition. |
| Othman, E. E. D. R., Hornung, D., Al-Hendy, A., Biomarkers of endometriosis, Expert Opinion on Medical Diagnostics, 2, 741–752, 2008 | Narrative review |
| Pascual, M. A., Guerriero, S., Hereter, L., Barri-Soldevila, P., Ajossa, S., Graupera, B., Rodriguez, I., Diagnosis of endometriosis of the rectovaginal septum using introital three-dimensional ultrasonography, Fertility & Sterility, 94, 2761–5, 2010 | Included as one of the studies in the Nisenblat 2016 review |
| Pascual, M. A., Tresserra, F., Lopez-Marin, L., Ubeda, A., Grases, P. J., Dexeus, S., Role of color Doppler ultrasonography in the diagnosis of endometriotic cyst, Journal of Ultrasound in Medicine, 19, 695–9, 2000 | Lesion-level analysis |
| Pastorfide, G., Fong, Y. F., Use of narrowband imaging for the detection of endometriosis, Journal of Minimally Invasive Gynecology, 22, 535, 2015 | No outcome of interest |
| Patel, M. D., Feldstein, V. A., Chen, D. C., Lipson, S. D., Filly, R. A., Endometriomas: diagnostic performance of US.[Erratum appears in Radiology 1999 Dec;213(3):930], Radiology, 210, 739–45, 1999 | Retrospective review of sonograms by two sonologists |
| Patel, M. D., Feldstein, V. A., Filly, R. A., The likelihood ratio of sonographic findings for the diagnosis of hemorrhagic ovarian cysts, Journal of Ultrasound in Medicine, 24, 607–14; quiz 615, 2005 | It is about diagnosis of haemorrhagic ovarian cyst not endometrioma |
| Philip, C. A., Bisch, C., Coulon, A., de Saint-Hilaire, P., Rudigoz, R. C., Dubernard, G., Correlation between three-dimensional rectosonography and magnetic resonance imaging in the diagnosis of rectosigmoid endometriosis: a preliminary study on the first fifty cases, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 187, 35–40, 2015 | MRI was the reference test |
| Piessens, S., Healey, M., Maher, P., Tsaltas, J., Rombauts, L., Can anyone screen for deep infiltrating endometriosis with transvaginal ultrasound?, Australian & New Zealand Journal of Obstetrics & Gynaecology, 54, 462–8, 2014 | Included as one of the studies in the Nisenblat 2016 review |
| Piketty, M., Chopin, N., Dousset, B., Millischer-Bellaische, A. E., Roseau, G., Leconte, M., Borghese, B., Chapron, C., Preoperative work-up for patients with deeply infiltrating endometriosis: transvaginal ultrasonography must definitely be the first-line imaging examination, Human Reproduction, 24, 602–7, 2009 | Included as one of the studies in the Nisenblat 2016 review |
| Preutthipan, S., Hesla, J.S., A comparative study between pelvic ultrasonography and laparoscopy in the detection of pelvic pathology in the initial workup of subfertile women, Journal of the Medical Association of Thailand, 78, 596–599, 1995 | No separated data for endometriosis |
| Redwine, D. B., Ovarian endometriosis: A marker for more extensive pelvic and intestinal disease, Fertility and Sterility, 72, 310–315, 1999 | All the patients have endometriosis |
| Reid, S., Lu, C., Casikar, I., Reid, G., Abbott, J., Cario, G., Chou, D., Kowalski, D., Cooper, M., Condous, G., Prediction of pouch of Douglas obliteration in women with suspected endometriosis using a new real-time dynamic transvaginal ultrasound technique: the sliding sign, Ultrasound in Obstetrics & Gynecology, 41, 685–91, 2013 | Included as one of the studies in the Nisenblat 2016 review |
| Reid, S., Lu, C., Hardy, N., Casikar, I., Reid, G., Cario, G., Chou, D., Almashat, D., Condous, G., Office gel sonovaginography for the prediction of posterior deep infiltrating endometriosis: a multicenter prospective observational study, Ultrasound in Obstetrics & Gynecology, 44, 710–8, 2014 | Included as one of the studies in the Nisenblat 2016 review |
| Ribeiro, H. S., Ribeiro, P. A., Rossini, L., Rodrigues, F. C., Donadio, N., Aoki, T., Double-contrast barium enema and transrectal endoscopic ultrasonography in the diagnosis of intestinal deeply infiltrating endometriosis, Journal of Minimally Invasive Gynecology, 15, 315–20, 2008 | Included as one of the studies in the Nisenblat 2016 review |
| Rosa, E. Silva A. C., Rosa, E. Silva J. C., Ferriani, R. A., Serum CA-125 in the diagnosis of endometriosis, International Journal of Gynaecology & Obstetrics, 96, 206–7, 2007 | Retrospective study. Women included in the study already had a diagnosis of endometriosis prior to CA-125 serum collection |
| Saba, L., Guerriero, S., Sulcis, R., Ajossa, S., Melis, G., Mallarini, G., Agreement and reproducibility in identification of endometriosis using magnetic resonance imaging, Acta Radiologica, 51, 573–80, 2010 | No outcome of interest |
| Saba, L., Guerriero, S., Sulcis, R., Pilloni, M., Ajossa, S., Melis, G., Mallarini, G., MRI and “tenderness guided” transvaginal ultrasonography in the diagnosis of recto-sigmoid endometriosis, Journal of Magnetic Resonance Imaging, 35, 352–60, 2012 | Only women with positive index test underwent surgery |
| Saba, L., Guerriero, S., Sulis, R., Pilloni, M., Ajossa, S., Melis, G., Mallarini, G., Learning curve in the detection of ovarian and deep endometriosis by using Magnetic Resonance: comparison with surgical results, European Journal of Radiology, 79, 237–44, 2011 | The aim of the study was to determine whether diagnostic accuracy is correlated to radiologist expertise |
| Saccardi, C., Cosmi, E., Borghero, A., Tregnaghi, A., Dessole, S., Litta, P., Comparison between transvaginal sonography, saline contrast sonovaginography and magnetic resonance imaging in the diagnosis of posterior deep infiltrating endometriosis, Ultrasound in Obstetrics & Gynecology, 40, 464–9, 2012 | Only women with positive index test underwent surgery |
| Said, T. H., Azzam, A. Z., Prediction of endometriosis by transvaginal ultrasound in reproductive-age women with normal ovarian size, Middle East Fertility Society Journal, 19, 197–207, 2014 | Included as one of the studies in the Nisenblat 2016 review |
| Savelli, L., Manuzzi, L., Coe, M., Mabrouk, M., Di Donato, N., Venturoli, S., Seracchioli, R., Comparison of transvaginal sonography and double-contrast barium enema for diagnosing deep infiltrating endometriosis of the posterior compartment, Ultrasound in Obstetrics & Gynecology, 38, 466–71, 2011 | Included as one of the studies in the Nisenblat 2016 review |
| Savelli, L., Manuzzi, L., Pollastri, P., Mabrouk, M., Seracchioli, R., Venturoli, S., Diagnostic accuracy and potential limitations of transvaginal sonography for bladder endometriosis, Ultrasound in Obstetrics & Gynecology, 34, 595–600, 2009 | Retrospective analysis |
| Scardapane, A., Bettocchi, S., Lorusso, F., Stabile Ianora, A. A., Vimercati, A., Ceci, O., Lasciarrea, M., Angelelli, G., Diagnosis of colorectal endometriosis: contribution of contrast enhanced MR-colonography, European Radiology, 21, 1553–63, 2011 | Comparison of MRI between two radiologists |
| Scardapane, A., Lorusso, F., Scioscia, M., Ferrante, A., Stabile Ianora, A. A., Angelelli, G., Standard high-resolution pelvic MRI vs. low-resolution pelvic MRI in the evaluation of deep infiltrating endometriosis, European Radiology, 24, 2590–6, 2014 | Comparison of MRI carried out by two different radiologists |
| Schenken, R. S., Improving the diagnosis of endometriosis in adolescents, Sexuality, Reproduction and Menopause, 6, 4–8, 2008 | Narrative review |
| Seeber, B., Sammel, M. D., Fan, X., Gerton, G. L., Shaunik, A., Chittams, J., Barnhart, K. T., Panel of markers can accurately predict endometriosis in a subset of patients, Fertility & Sterility, 89, 1073–81, 2008 | It is a case-control study |
| Shen, A., Xu, S., Ma, Y., Guo, H., Li, C., Yang, C., Zou, S., Diagnostic value of serum CA125, CA19–9 and CA15–3 in endometriosis: A meta-analysis, Journal of International Medical Research, 43, 599–609, 2015 | It is about association of biomarkers and stage of endometriosis. No outcome of interest. |
| Sokalska, A., Timmerman, D., Testa, A. C., Van Holsbeke, C., Lissoni, A. A., Leone, F. P., Jurkovic, D., Valentin, L., Diagnostic accuracy of transvaginal ultrasound examination for assigning a specific diagnosis to adnexal masses, Ultrasound in Obstetrics & Gynecology, 34, 462–70, 2009 | Women in the study had postmenopausal status |
| Somigliana, E., Vigano, P., Candiani, M., Felicetta, I., Di Blasio, A. M., Vignali, M., Use of serum-soluble intercellular adhesion molecule-1 as a new marker of endometriosis, Fertility & Sterility, 77, 1028–31, 2002 | Women included in the study already had laparoscopy prior to CA-125 serum collection |
| Somigliana, E., Vigano, P., Tirelli, A. S., Felicetta, I., Torresani, E., Vignali, M., Di Blasio, A. M., Use of the concomitant serum dosage of CA 125, CA 19–9 and interleukin-6 to detect the presence of endometriosis. Results from a series of reproductive age women undergoing laparoscopic surgery for benign gynaecological conditions, Human Reproduction, 19, 1871–6, 2004 | Case-control study |
| Spencer, J. A., Weston, M. J., Imaging in endometriosis, Imaging, 15, 63–71, 2003 | Narrative review |
| Szubert, M., Suzin, J., Wierzbowski, T., Kowalczyk-Amico, K., CA-125 concentration in serum and peritoneal fluid in patients with endometriosis - preliminary results, Archives of Medical Science, 8, 504–8, 2012 | Case-control study |
| Takahashi, K., Nagata, H., Kitao, M., CA-125 in the menstrual blood is an effective marker for diagnosing early stage endometriosis: A preliminary report, Japanese Journal of Fertility and Sterility, 36, 356–359, 1991 | Ultrasound was used to confirm ovulatory day only |
| Takeuchi, M., Matsuzaki, K., Nishitani, H., Susceptibility-weighted MRI of endometrioma: preliminary results, AJR. American Journal of Roentgenology, 191, 1366–70, 2008 | No outcome of interest |
| Theodoridis, T. D., Zepiridis, L., Mikos, T., Grimbizis, G. F., Dinas, K., Athanasiadis, A., Bontis, J. N., Comparison of diagnostic accuracy of transvaginal ultrasound with laparoscopy in the management of patients with adnexal masses, Archives of Gynecology & Obstetrics, 280, 767–73, 2009 | Analysis included lesions, not number of participants |
| Tirlapur, S. A., Daniels, J. P., Khan, K. S., Medal trial collaboration, Chronic pelvic pain: how does noninvasive imaging compare with diagnostic laparoscopy?, Current Opinion in Obstetrics & Gynecology, 27, 445–8, 2015 | This systematic review has not only focused on patients with suspected endometriosis. It is more general about pelvic pain and diagnostic tools |
| Tumedei, U., Ciardelli, V., Paltrinieri, F., Kuria, M. S., Amadori, A., Stefanetti, M., Gori, G., Transvaginal ultrasound in the diagnosis of endometrial abnormalities, Tumori, 87, S15, 2001 | It has focused on endometrial abnormalities not endometriosis |
| Ubaldi, F., Wisanto, A., Camus, M., Tournaye, H., Clasen, K., Devroey, P., The role of transvaginal ultrasonography in the detection of pelvic pathologies in the infertility workup, Human Reproduction, 13, 330–3, 1998 | Included as one of the studies in the Nisenblat 2016 review |
| Valenzano Menada, M., Remorgida, V., Abbamonte, L. H., Nicoletti, A., Ragni, N., Ferrero, S., Does transvaginal ultrasonography combined with water-contrast in the rectum aid in the diagnosis of rectovaginal endometriosis infiltrating the bowel?, Human Reproduction, 23, 1069–75, 2008 | Included as one of the studies in the Nisenblat 2016 review |
| Van den Bosch, T., Vandendael, A., Van Schoubroeck, D., Wranz, P. A. B., Lombard, C. J., Combining vaginal ultrasonography and office endometrial sampling in the diagnosis of endometrial disease in postmenopausal women, Obstetrics and Gynecology, 85, 349–352, 1995 | It is not about endometriosis, it has addressed endometrial diseases |
| Van Holsbeke, C., Van Calster, B., Guerriero, S., Savelli, L., Leone, F., Fischerova, D., Czekierdowski, A., Fruscio, R., Veldman, J., Van de Putte, G., Testa, A. C., Bourne, T., Valentin, L., Timmerman, D., Imaging in gynaecology: How good are we in identifying endometriomas?, Facts Views & Vision in Obgyn, 1, 7–17, 2009 | Population overlap with Van Holsbeke 2010 |
| Van Holsbeke, C., Van Calster, B., Guerriero, S., Savelli, L., Paladini, D., Lissoni, A. A., Czekierdowski, A., Fischerova, D., Zhang, J., Mestdagh, G., Testa, A. C., Bourne, T., Valentin, L., Timmerman, D., Endometriomas: their ultrasound characteristics, Ultrasound in Obstetrics & Gynecology, 35, 730–40, 2010 | Retrospective analysis included postmenopausal women |
| Vimercati, A., Achilarre, M. T., Scardapane, A., Lorusso, F., Ceci, O., Mangiatordi, G., Angelelli, G., Van Herendael, B., Selvaggi, L., Bettocchi, S., Accuracy of transvaginal sonography and contrast-enhanced magnetic resonance-colonography for the presurgical staging of deep infiltrating endometriosis, Ultrasound in Obstetrics & Gynecology, 40, 592–603, 2012 | Analysis included lesions, not number of participants |
| Volpi, E., De Grandis, T., Zuccaro, G., La Vista, A., Sismondi, P., Role of transvaginal sonography in the detection of endometriomata, Journal of Clinical Ultrasound, 23, 163–7, 1995 | Retrospective study |
| Vrachnis, N., Sifakis, S., Samoli, E., Kappou, D., Pavlakis, K., Iliodromiti, Z., Botsis, D., Three-dimensional ultrasound and three-dimensional power Doppler improve the preoperative evaluation of complex benign ovarian lesions, Clinical & Experimental Obstetrics & Gynecology, 39, 474–8, 2012 | No outcome of interest |
| Walsh, J. W., Taylor, K. J., Wasson, J. F., Schwartz, P. E., Rosenfield, A. T., Gray-scale ultrasound in 204 proved gynecologic masses: accuracy and specific diagnostic criteria, Radiology, 130, 391–7, 1979 | No outcome of interest |
| Wang, L., Liu, H. Y., Shi, H. H., Lang, J. H., Sun, W., Urine peptide patterns for non-invasive diagnosis of endometriosis: a preliminary prospective study, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 177, 23–8, 2014 | Biomarker not of interest |
| Weerakiet, S., Wongkularb, A., Rochanawutanon, M., Rojanasakul, A., Transvaginal ultrasonography combined with pelvic examination in the diagnosis of ovarian endometrioma, Journal of the Medical Association of Thailand, 83, 523–8, 2000 | Retrospective study |
| Wessels, J. M., Kay, V. R., Leyland, N. A., Agarwal, S. K., Foster, W. G., Assessing brain-derived neurotrophic factor as a novel clinical marker of endometriosis, Fertility & Sterility, 105, 119–128.e5, 2016 | Not the test of interest |
| Wolfler, M. M., Nagele, F., Kolbus, A., Seidl, S., Schneider, B., Huber, J. C., Tschugguel, W., A predictive model for endometriosis, Human Reproduction, 20, 1702–8, 2005 | Biomarker not of interest |
| Yamashita, Y., Torashima, M., Hatanaka, Y., Harada, M., Higashida, Y., Takahashi, M., Mizutani, H., Tashiro, H., Iwamasa, J., Miyazaki, K., et al.,, Adnexal masses: accuracy of characterization with transvaginal US and precontrast and postcontrast MR imaging, Radiology, 194, 557–65, 1995 | Review of MRI and TVUS by five radiologists |
| Yazbek, J., Helmy, S., Ben-Nagi, J., Holland, T., Sawyer, E., Jurkovic, D., Value of preoperative ultrasound examination in the selection of women with adnexal masses for laparoscopic surgery, Ultrasound in Obstetrics and Gynecology, 30, 883–888, 2007 | The preoperative sonography has not been used to diagnose endometriosis. |
| Zapardiel, I., Gorostidi, M., Ravaggi, A., Allende, M. T., Silveira, M., Abehsera, D., MacUks, R., Utility Serum Marker HE4 for the Differential Diagnosis between Endometriosis and Adnexal Malignancy, International Journal of Gynecological Cancer, 26, 52–55, 2016 | No data on surgical diagnosis |
H.7. Diagnosis – Biomarkers: CA-125
| Study | Reason for Exclusion |
|---|---|
| Abrao, M. S., Podgaec, S., Filho, B. M., Ramos, L. O., Pinotti, J. A., de Oliveira, R. M., The use of biochemical markers in the diagnosis of pelvic endometriosis, Human Reproduction, 12, 2523–7, 1997 | Case-control study |
| Abrao, M. S., Podgaec, S., Pinotti, J. A., de Oliveira, R. M., Tumor markers in endometriosis, International Journal of Gynaecology & Obstetrics, 66, 19–22, 1999 | Case-control study |
| Abu-Musa, A., Takahashi, K., Nagata, H., Yamasaki, H., Mizoguchi, S., Kitao, M., CA-125 in menstrual discharge in patients with chronic pelvic pain, International Journal of Gynaecology & Obstetrics, 37, 111–4, 1992 | The level of CA-125 in menstrual discharge has been assessed |
| Acimovic, M., Vidakovic, S., Milic, N., Jeremic, K., Markovic, M., Milosevic-Djeric, A., Lazovic-Radonjic, G., Survivin and Vegf as Novel Biomarkers in Diagnosis of Endometriosis, Journal of Medical Biochemistry, 35, 63–68, 2016 | No laparoscopy/laparotomy and no histological confirmation |
| Adamyan, L. V., Fanchenko, N. D., Alexeyeva, M. L., Andreyeva Ye, N., Novikov Ye, A., Jahan, I., Hormonal and immunologic methods in the diagnosis and treatment of patients with benign ovarian tumors and endometriotic cysts, International Journal of Fertility, 38, 92–8, 1993 | Not able to calculate 2x2 table |
| Aleem, F., Pennisi, J., Zeitoun, K., Predanic, M., The role of color Doppler in diagnosis of endometriomas, Ultrasound in Obstetrics & Gynecology, 5, 51–4, 1995 | The aim of this study is to describe vascular appearance in endometriomas. No outcome of interest. |
| Anaf, V., El Nakadi, I., De Moor, V., Coppens, E., Zalcman, M., Noel, J. C., Anatomic significance of a positive barium enema in deep infiltrating endometriosis of the large bowel, World Journal of Surgery, 33, 822–7, 2009 | All patients had surgery and DCBE |
| Bagan, P., Berna, P., Assouad, J., Hupertan, V., Le Pimpec Barthes, F., Riquet, M., Value of cancer antigen 125 for diagnosis of pleural endometriosis in females with recurrent pneumothorax, European Respiratory Journal, 31, 140–2, 2008 | The control group are males |
| Balasch, J., Creus, M., Fabregues, F., Carmona, F., Ordi, J., Martinez-Roman, S., Vanrell, J. A., Visible and non-visible endometriosis at laparoscopy in fertile and infertile women and in patients with chronic pelvic pain: a prospective study, Human Reproduction, 11, 387–91, 1996 | Not a diagnostic study |
| Balleyguier, C., Roupret, M., Nguyen, T., Kinkel, K., Helenon, O., Chapron, C., Ureteral endometriosis: the role of magnetic resonance imaging, Journal of the American Association of Gynecologic Laparoscopists, 11, 530–6, 2004 | No outcome of interest. Moreover, only 6 patients were included |
| Barbati, A., Cosmi, E. V., Spaziani, R., Ventura, R., Montanino, G., Serum and peritoneal fluid CA-125 levels in patients with endometriosis, Fertility & Sterility, 61, 438–42, 1994 | Included as one of the studies in the Nisenblat 2016 review |
| Barbieri, R. L., Niloff, J. M., Bast, R. C., Jr., Scaetzl, E., Kistner, R. W., Knapp, R. C., Elevated serum concentrations of CA-125 in patients with advanced endometriosis, Fertility & Sterility, 45, 630–4, 1986 | Postmenopausal women included |
| Barcellos, M. B., Lasmar, B., Lasmar, R., Agreement between the preoperative findings and the operative diagnosis in patients with deep endometriosis, Archives of Gynecology & Obstetrics Arch Gynecol Obstet, 293, 845–50, 2016 | Lesion-level analysis |
| Bazot, M., Gasner, A., Ballester, M., Darai, E., Value of thin-section oblique axial T2-weighted magnetic resonance images to assess uterosacral ligament endometriosis, Human Reproduction, 26, 346–53, 2011 | Retrospective study; one MRI technique compared to conventional technique |
| Bazot, M., Gasner, A., Lafont, C., Ballester, M., Darai, E., Deep pelvic endometriosis: limited additional diagnostic value of postcontrast in comparison with conventional MR images, European Journal of Radiology, 80, e331–9, 2011 | Retrospective study; comparison of post-contrast MRI versus conventional MRI |
| Bedaiwy, M. A., Falcone, T., Laboratory testing for endometriosis, Clinica Chimica Acta, 340, 41–56, 2004 | Narrative review |
| Bedaiwy, M. A., Falcone, T., Sharma, R. K., Goldberg, J. M., Attaran, M., Nelson, D. R., Agarwal, A., Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial, Human Reproduction, 17, 426–31, 2002 | Biomarkers not of interest |
| Belli, P., De Gaetano, A. M., Mirk, P., Speca, S., Valentini, A. L., Uterine adenomyosis and tubal endometriosis: diagnostic imaging, Rays, 23, 693–701, 1998 | Narrative review |
| Benacerraf, B. R., Finkler, N. J., Wojciechowski, C., Knapp, R. C., Sonographic accuracy in the diagnosis of ovarian masses, Journal of Reproductive Medicine for the Obstetrician and Gynecologist, 35, 491–495, 1990 | No outcome of interest |
| Benacerraf, B. R., Groszmann, Y., Sonography should be the first imaging examination done to evaluate patients with suspected endometriosis, Journal of Ultrasound in Medicine, 31, 651–3, 2012 | Narrative review |
| Bilibio, J. P., Souza, C. A., Rodini, G. P., Andreoli, C. G., Genro, V. K., de Conto, E., Cunha-Filho, J. S., Serum prolactin and CA-125 levels as biomarkers of peritoneal endometriosis, Gynecologic & Obstetric Investigation, 78, 45–52, 2014 | Included as one of the studies in the Nisenblat 2016 review |
| Bordin, L., Fiore, C., Dona, G., Andrisani, A., Ambrosini, G., Faggian, D., Plebani, M., Clari, G., Armanini, D., Evaluation of erythrocyte band 3 phosphotyrosine level, glutathione content, CA-125, and human epididymal secretory protein E4 as combined parameters in endometriosis, Fertility & Sterility, 94, 1616–21, 2010 | All the patients have proven endometriosis. |
| Chen, F. P., Soong, Y. K., Lee, N., Lo, S. K., The use of serum CA-125 as a marker for endometriosis in patients with dysmenorrhea for monitoring therapy and for recurrence of endometriosis, Acta Obstetricia et Gynecologica Scandinavica, 77, 665–70, 1998 | Included as one of the studies in the Nisenblat 2016 review |
| Cheng, Y. M., Wang, S. T., Chou, C. Y., Serum CA-125 in preoperative patients at high risk for endometriosis, Obstetrics & Gynecology, 99, 375–80, 2002 | CA-125 has been used for identifying high risk woman not as a diagnostic tool. |
| Cho, S., Cho, H., Nam, A., Kim, H. Y., Choi, Y. S., Park, K. H., Cho, D. J., Lee, B. S., Neutrophil-to-lymphocyte ratio as an adjunct to CA-125 for the diagnosis of endometriosis, Fertility & Sterility, 90, 2073–9, 2008 | It is a case-control study |
| Chudecka-Glaz, A., Cymbaluk-Ploska, A., Luterek-Puszynska, K., Menkiszak, J., Diagnostic usefulness of the Risk of Ovarian Malignancy Algorithm using the electrochemiluminescence immunoassay for HE4 and the chemiluminescence microparticle immunoassay for CA125, Oncology Letters, 12, 3101–3114, 2016 | Women with no suspected endometriosis |
| Chung, M. K., Chung, R. R., Gordon, D., Jennings, C., The evil twins of chronic pelvic pain syndrome: endometriosis and interstitial cystitis, JSLS: Journal of the Society of Laparoendoscopic Surgeons / Society of Laparoendoscopic Surgeons, 6, 311–314, 2002 | No outcome of interest |
| Cohen, L. S., Valle, R. F., Sabbagha, R. E., A comparison of preoperative ultrasound images of surgically proven endometriomas scanned by both transabdominal and transvaginal techniques, Journal of Gynecologic Surgery, 11, 27–32, 1995 | All the patients have surgically confirmed endometriosis |
| Cohen, M. R., Laparoscopy in the diagnosis and management of endometriosis, Journal of Reproductive Medicine, 27, 240–2, 1982 | No outcome of interest |
| Colacurci, N., Fortunato, N., De Franciscis, P., Cardone, A., Relevance of CA-125 in the evaluation of endometriosis, Clinical & Experimental Obstetrics & Gynecology, 23, 150–4, 1996 | Included as one of the studies in the Nisenblat 2016 review |
| Colacurci, N., Fortunato, N., De Franciscis, P., Fratta, M., Cioffi, M., Zarcone, R., Cardone, A., Serum and peritoneal CA-125 levels as diagnostic test for endometriosis, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 66, 41–3, 1996 | Unable to calculate 2x2 table |
| Coleman, B. G., Arger, P. H., Mulhern, C. B., Jr., Endometriosis: clinical and ultrasonic correlation, AJR. American Journal of Roentgenology, 132, 747–9, 1979 | All patients were recruited in this study, had surgically proven endometriosis |
| Corwin, M. T., Gerscovich, E. O., Lamba, R., Wilson, M., McGahan, J. P., Differentiation of ovarian endometriomas from hemorrhagic cysts at MR imaging: utility of the T2 dark spot sign, Radiology, 271, 126–32, 2014 | Using a diagnostic test to diagnose endometriosis has not been addressed in this study. It is about a sign in MRI to distinguish between Endometrioma and haemorrhagic cysts. |
| Daher, R. M. F., Rosa, E. Silva J. C., Poli-Neto, O. B., Candido Dosreis, F. J., Nogueira, A. A., Diagnosis of endometriosis in women with chronic pelvic pain, Clinical and Experimental Obstetrics and Gynecology, 43, 512–515, 2016 | No data for the CA-125 cut-off of >=35 U/ml |
| Daniilidis, A., Giannoulis, H., Tantanasis, T., Papathanasiou, K., Loufopoulos, A., Tzafettas, J., Diagnostic laparoscopy, infertility, and endometriosis - 5 Years experience, Gynecological Surgery, 5, 231–234, 2008 | Outcomes not of interest |
| Dechaud, H., Ali Ahmed, S. A., Aligier, N., Vergnes, C., Hedon, B., Does transvaginal hydrolaparoscopy render standard diagnostic laparoscopy obsolete for unexplained infertility investigation?, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 94, 97–102, 2001 | Transvaginal hydrolaparoscopy compared with conventional laparoscopy; no data for outcomes |
| do Amaral, V. F., Ferriani, R. A., de Sa, M. F. S., Nogueira, A. A., Silva, J. C. R., de Sa Rosa e Silva, A. C. J., de Moura, M. D., Positive correlation between serum and peritoneal fluid CA-125 levels in women with pelvic endometriosis, Sao Paulo Medical Journal, 124, 223–227, 2006 | No data for the CA-125 cut-off of >=35 U/ml |
| Dunselman, G. A. J., Vermeulen, N., Becker, C., Calhaz-Jorge, C., D’Hooghe, T., De Bie, B., Heikinheimo, O., Horne, A. W., Kiesel, L., Nap, A., Prentice, A., Saridogan, E., Soriano, D., Nelen, W., ESHRE guideline: Management of women with endometriosis, Human Reproduction, 29, 400–412, 2014 | The individual studies in this publication have been checked for inclusion in the review |
| El Maati, A. A. A., Ibrahim, E. A. G., Mokhtar, F. Z., A two-stage imaging protocol for evaluating women presenting with acute pelvic pain, Egyptian Journal of Radiology and Nuclear Medicine, 44, 923–936, 2013 | The population is women with acute pelvic pain, not suspected endometriosis |
| Elgafor El Sharkwy, I. A., Combination of non-invasive and semi-invasive tests for diagnosis of minimal to mild endometriosis, Archives of gynecology and obstetrics, 288, 793–7, 2013 | The diagnostic test (IL-6 combined with nerve fibres) which has been used in this study is not matched with the protocol. |
| Ellett, L., Readman, E., Newman, M., McIlwaine, K., Villegas, R., Jagasia, N., Maher, P., Are endometrial nerve fibres unique to endometriosis? A prospective case-control study of endometrial biopsy as a diagnostic test for endometriosis in women with pelvic pain, Human Reproduction, 30, 2808–15, 2015 | Case-control study |
| Exacoustos, C., Luciano, D., Corbett, B., De Felice, G., Di Feliciantonio, M., Luciano, A., Zupi, E., The uterine junctional zone: a 3-dimensional ultrasound study of patients with endometriosis, American Journal of Obstetrics & Gynecology, 209, 248.e1–7, 2013 | In the study, the relation between thickness of uterine junctional zone and endometriosis has been evaluated. It has not been used as a diagnostic tool. |
| Faccioli, N., Manfredi, R., Mainardi, P., Dalla Chiara, E., Spoto, E., Minelli, L., Mucelli, R. P., Barium enema evaluation of colonic involvement in endometriosis, AJR. American Journal of Roentgenology, 190, 1050–4, 2008 | The diagnostic test (Barium enema) which has been used in this study is not matched with the protocol. |
| Fedele, L., Arcaini, L., Vercellini, P., Marchini, M., Baglioni, A., Bianchi, S., Serum Ca-125 concentrations in endometriosis, Acta Europaea Fertilitatis, 20, 137–9, 1989 | Included as one of the studies in the Nisenblat 2016 review |
| Federici, D., Muggiasca, M. L., Conti, M., Diagnostic value of laparoscopic evaluation of women with chronic pelvic pain: Our experience and a review of the literature, VALEUR DIAGNOSTIQUE DE L’EXPLORATION LAPAROSCOPIQUE DES FEMMES SOUFFRANT DE DOULEURS PELVIENNES CHRONIQUES: EXPERIENCE PERSONNELLE ET REVUE DE LA LITTERATURE, Acta Endoscopica, 22, 177–186, 1992 | Narrative review |
| Felding, C., Mikkelsen, A. L., Peen, U., Laparoscopy and ultrasound in patients with chronic pelvic pain, Journal of Obstetrics and Gynaecology, 10, 419–422, 1990 | No outcome of interest |
| Fisk, N. M., Tan, C. E., CA 125 in peritoneal fluid and serum of patients with endometriosis, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 29, 153–8, 1988 | Case-control study |
| Florio, P., Reis, F. M., Torres, P. B., Calonaci, F., Abrao, M. S., Nascimento, L. L., Franchini, M., Cianferoni, L., Petraglia, F., High serum follistatin levels in women with ovarian endometriosis, Human Reproduction, 24, 2600–6, 2009 | No data for the CA-125 cut-off of >=35 U/ml |
| Foda, A. A., Aal, I. A. A., Role of some biomarkers in chronic pelvic pain for early detection of endometriosis in infertile women, Middle East Fertility Society Journal, 17, 187–194, 2012 | Case-control study |
| Fratelli, N., Scioscia, M., Bassi, E., Musola, M., Minelli, L., Trivella, G., Transvaginal sonography for preoperative assessment of deep endometriosis, Journal of Clinical Ultrasound, 41, 69–75, 2013 | Data for TVS was collected retrospectively |
| Friedman, H., Vogelzang, R. L., Mendelson, E. B., Neiman, H. L., Cohen, M., Endometriosis detection by US with laparoscopic correlation, Radiology, 157, 217–20, 1985 | No data on outcomes |
| Gagne, D., Rivard, M., Page, M., Lepine, M., Platon, C., Shazand, K., Hugo, P., Gosselin, D., Development of a nonsurgical diagnostic tool for endometriosis based on the detection of endometrial leukocyte subsets and serum CA-125 levels, Fertility & Sterility, 80, 876–85, 2003 | Included as one of the studies in the Nisenblat 2016 review |
| Gougoutas, C. A., Siegelman, E. S., Hunt, J., Outwater, E. K., Pelvic endometriosis: various manifestations and MR imaging findings, AJR. American Journal of Roentgenology, 175, 353–8, 2000 | Narrative review |
| Guerriero, S., Mais, V., Ajossa, S., Paoletti, A. M., Angiolucci, M., Melis, G. B., Transvaginal ultrasonography combined with CA-125 plasma levels in the diagnosis of endometrioma, Fertility & Sterility, 65, 293–8, 1996 | Included as one of the studies in the Nisenblat 2016 review |
| Guerriero, S., Mallarini, G., Ajossa, S., Risalvato, A., Satta, R., Mais, V., Angiolucci, M., Melis, G. B., Transvaginal ultrasound and computed tomography combined with clinical parameters and CA-125 determinations in the differential diagnosis of persistent ovarian cysts in premenopausal women, Ultrasound in Obstetrics & Gynecology, 9, 339–43, 1997 | The cut-off which has been used in this study is 25 U/ml |
| Gurgan, T., Kisnisci, H., Yarali, H., Aksu, T., Zeyneloglu, H., Develioglu, O., Serum and peritoneal fluid CA-125 levels in early stage endometriosis, Gynecologic & Obstetric Investigation, 30, 105–8, 1990 | The cut-off for CA-125 is 16 U/ml |
| Guven, M. A., Bese, T., Demirkiran, F., Comparison of hydrosonography and transvaginal ultrasonography in the detection of intracavitary pathologies in women with abnormal uterine bleeding, International Journal of Gynecological Cancer, 14, 57–63, 2004 | The study population are women with history of abnormal uterine bleeding not women suspected to endometriosis. |
| Harada, T., Kubota, T., Aso, T., Usefulness of CA19–9 versus CA125 for the diagnosis of endometriosis, Fertility and Sterility, 78, 733–739, 2002 | Included as one of the studies in the Nisenblat 2016 review |
| Hirsch, M., Duffy, J. M. N., Davis, C. J., Plana, Nieves M., Khan, K. S., the International Collaboration to Harmonise, Outcomes, Measures for, Endometriosis, Diagnostic accuracy of cancer antigen 125 for endometriosis: a systematic review and meta-analysis, BJOG: An International Journal of Obstetrics & Gynaecology | Single studies were assessed according to inclusion criteria and, if relevant, included |
| Hompes, P. G., Koninckx, P. R., Kennedy, S., van Kamp, G. F., Verstraeten, R. A., Cornillie, F., Serum CA-125 concentrations during midfollicular phase, a clinically useful and reproducible marker in diagnosis of advanced endometriosis, Clinical Chemistry, 42, 1871–4, 1996 | No outcome of interest has been reported. |
| Hornstein, M. D., Harlow, B. L., Thomas, P. P., Check, J. H., Use of a new CA 125 assay in the diagnosis of endometriosis, Human Reproduction, 10, 932–4, 1995 | Included as one of the studies in the Nisenblat 2016 review |
| Howard, F. M., El-Minawi, A. M., Sanchez, R. A., Conscious pain mapping by laparoscopy in women with chronic pelvic pain, Obstetrics & Gynecology, 96, 934–9, 2000 | The study investigated conscious pain mapping using laparoscopy |
| Ikeda, F., Bernardini, M. A., Vanni, D., Vasconcelos, A., Pinotti, J. A., Abrao, M. S., A comparison of microlaparoscopy under sedation, microlaparoscopy under general anesthesia and conventional laparoscopy for diagnosis and treatment of pelvic endometriosis in early stages, Fertility and sterility, 77, S21, 2002 | The effectiveness of using a diagnostic tool for diagnosis of endometriosis has not been addressed. |
| Ismail, M. A., Rotmensch, J., Mercer, L. J., Block, B. S., Salti, G. I., Holt, J. A., CA-125 in peritoneal fluid from patients with nonmalignant gynecologic disorders, Journal of Reproductive Medicine, 39, 510–2, 1994 | The women without any symptom who went through laparoscopic sterilization have been considered as control group. |
| Johnson, W. K., Ott, D. J., Chen, M. Y. M., Fayez, J. A., Gelfand, D. W., Efficacy of hysterosalpingography in evaluating endometriosis, Abdominal Imaging, 19, 278–280, 1994 | The study evaluated the effectiveness of hysterosalpingography and laparoscopy-retrospective study |
| Kafali, H., Artuc, H., Demir, N., Use of CA125 fluctuation during the menstrual cycle as a tool in the clinical diagnosis of endometriosis; a preliminary report, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 116, 85–8, 2004 | It is a case-control study |
| Kang, S. B., Chung, H. H., Lee, H. P., Lee, J. Y., Chang, Y. S., Impact of diagnostic laparoscopy on the management of chronic pelvic pain, Surgical Endoscopy, 21, 916–9, 2007 | there was no comparison between laparoscopy and another test |
| Karabacak, O., Tiras, M. B., Taner, M. Z., Guner, H., Yildiz, A., Yildirim, M., Small diameter versus conventional laparoscopy: a prospective, self-controlled study, Human Reproduction, 12, 2399–401, 1997 | Comparison of two types of laparoscopy |
| Kitawaki, J., Ishihara, H., Koshiba, H., Kiyomizu, M., Teramoto, M., Kitaoka, Y., Honjo, H., Usefulness and limits of CA-125 in diagnosis of endometriosis without associated ovarian endometriomas.[Erratum appears in Hum Reprod. 2007 Feb;22(2):627], Human Reproduction, 20, 1999–2003, 2005 | No data for the CA-125 cut-off of >=35U/ml |
| Koninckx, P. R., Meuleman, C., Oosterlynck, D., Cornillie, F. J., Diagnosis of deep endometriosis by clinical examination during menstruation and plasma CA-125 concentration, Fertility & Sterility, 65, 280–7, 1996 | Included as one of the studies in the Nisenblat 2016 review |
| Koninckx, P. R., Riittinen, L., Seppala, M., Cornillie, F. J., CA-125 and placental protein 14 concentrations in plasma and peritoneal fluid of women with deeply infiltrating pelvic endometriosis, Fertility & Sterility, 57, 523–30, 1992 | Wrong data and result have been reported |
| Kruger, K., Behrendt, K., Niedobitek-Kreuter, G., Koltermann, K., Ebert, A. D., Location-dependent value of pelvic MRI in the preoperative diagnosis of endometriosis, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 169, 93–8, 2013 | Pelvic MRI retrospectively assessed with histology |
| Kruitwagen, R. F., Thomas, C., Poels, L. G., Koster, A. M., Willemsen, W. N., Rolland, R., High CA-125 concentrations in peritoneal fluid of normal cyclic women with various infertility-related factors as demonstrated with two-step immunoradiometric assay, Fertility & Sterility, 56, 863–9, 1991 | The outcome of interest has not been reported. |
| Lanzone, A., Marana, R., Muscatello, R., Fulghesu, A. M., Dell’Acqua, S., Caruso, A., Mancuso, S., Serum CA-125 levels in the diagnosis and management of endometriosis, Journal of Reproductive Medicine, 36, 603–7, 1991 | Included as one of the studies in the Nisenblat 2016 review |
| Leslie, C., Ma, T., McElhinney, B., Leake, R., Stewart, C. J., Is the detection of endometrial nerve fibers useful in the diagnosis of endometriosis?, International Journal of Gynecological Pathology, 32, 149–55, 2013 | No outcome of interest |
| Li, G., Yu, Z., Li, K., The value of FS, NLR, and CA-125 in the diagnosis of endometriosis, International journal of clinical and experimental medicine, 9, 7309–7313, 2016 | Not the population of interest |
| Macer, M. L., Mathur, M., Spektor, M., Gysler, S., Staib, L., Kodaman, P., McCarthy, S., Utility of magnetic resonance imaging in the evaluation of intraoperatively confirmed pelvic adhesions, Journal of Computer Assisted Tomography, 39, 896–900, 2015 | Not the population of interest |
| Maiorana, A., Cicerone, C., Niceta, M., Alio, L., Evaluation of serum CA 125 levels in patients with pelvic pain related to endometriosis, International Journal of Biological Markers, 22, 200–2, 2007 | Included as one of the studies in the Nisenblat 2016 review |
| Malik, E., Berg, C., Meyhofer-Malik, A., Buchweitz, O., Moubayed, P., Diedrich, K., Fluorescence diagnosis of endometriosis using 5-aminolevulinic acid, Surgical Endoscopy, 14, 452–5, 2000 | The test is not of interest |
| Manganaro, L., Fierro, F., Tomei, A., Irimia, D., Lodise, P., Sergi, M. E., Vinci, V., Sollazzo, P., Porpora, M. G., Delfini, R., Vittori, G., Marini, M., Feasibility of 3.0T pelvic MR imaging in the evaluation of endometriosis, European Journal of Radiology, 81, 1381–7, 2012 | Women in the study already had a diagnosis of endometriosis by transvaginal ultrasound |
| Martinez, S., Garrido, N., Coperias, J. L., Pardo, F., Desco, J., Garcia-Velasco, J. A., Simon, C., Pellicer, A., Serum interleukin-6 levels are elevated in women with minimal-mild endometriosis, Human Reproduction, 22, 836–42, 2007 | Included as one of the studies in the Nisenblat 2016 review |
| Mathlouthi, N., Ayed, B. B., Dhouib, M., Chaabene, K., Trabelsi, K., Amouri, H., Guermazi, M., Confrontation ultrasonography-CA125-histology in the managment of ovarian cysts: A prospective study about 77 cases, Tunisie Medicale, 89, 686–692, 2011 | Full-text in French |
| May, K. E., Conduit-Hulbert, S. A., Villar, J., Kirtley, S., Kennedy, S. H., Becker, C. M., Peripheral biomarkers of endometriosis: a systematic review, Human Reproduction Update, 16, 651–74, 2010 | This systematic review includes papers also regarding other biomarkers. The full texts of individual related studies were retrieved and reviewed. |
| May, K. E., Villar, J., Kirtley, S., Kennedy, S. H., Becker, C. M., Endometrial alterations in endometriosis: a systematic review of putative biomarkers, Human Reproduction Update, 17, 637–53, 2011 | Single studies were assessed for inclusion and, if relevant, included |
| McBride, N., Newman, R. L., Diagnostic laparoscopy, International Journal of Gynaecology & Obstetrics, 15, 556–8, 1978 | No outcome of interest |
| McKinnon, B., Mueller, M. D., Nirgianakis, K., Bersinger, N. A., Comparison of ovarian cancer markers in endometriosis favours HE4 over CA125, Molecular Medicine Reports, 12, 5179–84, 2015 | No data reported to calculate sensitivity |
| Medl, M., Ogris, E., Peters-Engl, C., Mierau, M., Buxbaum, P., Leodolter, S., Serum levels of the tumour-associated trypsin inhibitor in patients with endometriosis, British Journal of Obstetrics & Gynaecology, 104, 78–81, 1997 | Wrong data and result have been reported |
| Melega, C., Marchesini, F. P., Bellettini, L., Biscontin, S., Flamigni, C., Diagnostic value of laparoscopy in endometriosis and infertility, Journal of Reproductive Medicine, 29, 597–600, 1984 | No outcome of interest |
| Mezzi, G., Ferrari, S., Arcidiacono, P. G., Di Puppo, F., Candiani, M., Testoni, P. A., Endoscopic rectal ultrasound and elastosonography are useful in flow chart for the diagnosis of deep pelvic endometriosis with rectal involvement, Journal of Obstetrics & Gynaecology Research, 37, 586–90, 2011 | There was no comparison with surgery |
| Mikami, M., Tanabe, K., Matsuo, K., Miyazaki, Y., Miyazawa, M., Hayashi, M., Asai, S., Ikeda, M., Shida, M., Hirasawa, T., Kojima, N., Sho, R., Iijima, S., Fully-sialylated alpha-chain of complement 4-binding protein: Diagnostic utility for ovarian clear cell carcinoma, Gynecologic Oncology, 139, 520–528, 2015 | Not the population of interest |
| Millischer, A. E., Salomon, L. J., Santulli, P., Borghese, B., Dousset, B., Chapron, C., Fusion imaging for evaluation of deep infiltrating endometriosis: feasibility and preliminary results, Ultrasound in Obstetrics & Gynecology, 46, 109–17, 2015 | No data on surgical diagnosis |
| Miyagi, E., Maruyama, Y., Mogami, T., Numazaki, R., Ikeda, A., Yamamoto, H., Hirahara, F., Comparison of plasma amino acid profile-based index and CA125 in the diagnosis of epithelial ovarian cancers and borderline malignant tumors, International Journal of Clinical Oncology, 1–8, 2016 | Not the population of interest |
| Mohamed, M. L., El Behery, M. M., Mansour, S. A., Comparative study between VEGF-A and CA-125 in diagnosis and follow-up of advanced endometriosis after conservative laparoscopic surgery, Archives of Gynecology & Obstetrics, 287, 77–82, 2013 | Included as one of the studies in the Nisenblat 2016 review |
| Mol, B. W., Bayram, N., Lijmer, J. G., Wiegerinck, M. A., Bongers, M. Y., van der Veen, F., Bossuyt, P. M., The performance of CA-125 measurement in the detection of endometriosis: a metaanalysis, Fertility & Sterility, 70, 1101–8, 1998 | All the studies included in this systematic review could not be included in our systematic review. The full-texts of all individual studies were retrieved and reviewed and related studies were included in our review. |
| Molo, M. W., Kelly, M., Radwanska, E., Binor, Z., Preoperative serum CA-125 and CA-72 in predicting endometriosis in infertility patients, Journal of Reproductive Medicine, 39, 964–6, 1994 | Included as one of the studies in the Nisenblat 2016 review |
| Moloney, M. D., Thornton, J. G., Cooper, E. H., Serum CA 125 antigen levels and disease severity in patients with endometriosis, Obstetrics & Gynecology, 73, 767–9, 1989 | Women had laparoscopically confirmed endometriosis and then CA-125 level has been evaluated. |
| Moretuzzo, R. W., DiLauro, S., Jenison, E., Chen, S. L., Reindollar, R. H., McDonough, P. G., Serum and peritoneal lavage fluid CA-125 levels in endometriosis, Fertility & Sterility, 50, 430–3, 1988 | No outcome of interest |
| Muscatello, R., Cucinelli, F., Fulghesu, A., Lanzone, A., Caruso, A., Mancuso, S., Multiple serum marker assay in the diagnosis of endometriosis, Gynecological Endocrinology, 6, 265–9, 1992 | Included as one of the studies in the Nisenblat 2016 review |
| O’Shaughnessy, A., Check, J. H., Nowroozi, K., Lurie, D., CA 125 levels measured in different phases of the menstrual cycle in screening for endometriosis, Obstetrics & Gynecology, 81, 99–103, 1993 | Wrong data and result have been reported. |
| Ota, H., Maki, M., Evaluation of autoantibody and CA125 in the diagnosis of endometriosis or adenomyosis, Medical Science Research, 18, 309–310, 1990 | All the participants had known condition |
| Othman, E. E. D. R., Hornung, D., Al-Hendy, A., Biomarkers of endometriosis, Expert Opinion on Medical Diagnostics, 2, 741–752, 2008 | Narrative review |
| Ozaksit, G., Caglar, T., Cicek, N., Kuscu, E., Batioglu, S., Gokmen, O., Serum CA 125 levels before, during and after treatment for endometriosis, International Journal of Gynaecology & Obstetrics, 50, 269–73, 1995 | Women had a confirmed diagnosis of endometriosis prior to CA-125 test |
| Paiva, P., Lappas, M., Barker, G., Healey, M., Using symptom scores, lifestyle measures and biochemical markers to create a test for endometriosis, Journal of Endometriosis and Pelvic Pain Disorders, 6, 135–143, 2014 | No outcome of interest |
| Panidis, D., Vlassis, G., Matalliotakis, J., Skiadopoulos, S., Kalogeropoulos, A., Serum levels of the oncofetal antigens CA-125, CA 19–9 and CA 15–3 in patients with endometriosis, Journal of Endocrinological Investigation, 11, 801–804, 1988 | All women who involved in the study have proven endometriosis |
| Pastorfide, G., Fong, Y. F., Use of narrowband imaging for the detection of endometriosis, Journal of Minimally Invasive Gynecology, 22, 535, 2015 | No outcome of interest |
| Patel, M. D., Feldstein, V. A., Chen, D. C., Lipson, S. D., Filly, R. A., Endometriomas: diagnostic performance of US.[Erratum appears in Radiology 1999 Dec;213(3):930], Radiology, 210, 739–45, 1999 | Retrospective review of sonograms by two sonologists |
| Patel, M. D., Feldstein, V. A., Filly, R. A., The likelihood ratio of sonographic findings for the diagnosis of hemorrhagic ovarian cysts, Journal of Ultrasound in Medicine, 24, 607–14; quiz 615, 2005 | It is about diagnosis of haemorrhagic ovarian cyst not endometrioma |
| Patton, P. E., Field, C. S., Harms, R. W., Coulam, C. B., CA-125 levels in endometriosis, Fertility & Sterility, 45, 770–3, 1986 | Included as one of the studies in the Nisenblat 2016 review |
| Philip, C. A., Bisch, C., Coulon, A., de Saint-Hilaire, P., Rudigoz, R. C., Dubernard, G., Correlation between three-dimensional rectosonography and magnetic resonance imaging in the diagnosis of rectosigmoid endometriosis: a preliminary study on the first fifty cases, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 187, 35–40, 2015 | MRI was the reference test |
| Piessens, S., Healey, M., Maher, P., Tsaltas, J., Rombauts, L., Can anyone screen for deep infiltrating endometriosis with transvaginal ultrasound?, Australian & New Zealand Journal of Obstetrics & Gynaecology, 54, 462–8, 2014 | Women included in the study had the ultrasound test after diagnosis of endometriosis by surgery |
| Pittaway, D. E., Douglas, J. W., Serum CA-125 in women with endometriosis and chronic pelvic pain, Fertility & Sterility, 51, 68–70, 1989 | The cut-off for CA-125 is 16 U/ml |
| Pittaway, D. E., Fayez, J. A., The use of CA-125 in the diagnosis and management of endometriosis, Fertility & Sterility, 46, 790–5, 1986 | No separate data for endometriosis |
| Ramos, I. M. L., Podgaec, S., Abrao, M. S., de Oliveira, R., Baracat, E. C., Evaluation of CA-125 and soluble CD-23 in patients with pelvic endometriosis: A case-control study, Revista Da Associacao Medica Brasileira, 58, 26–32, 2012 | Not able to calculate 2x2 table |
| Randall, G. W., Gantt, P. A., Poe-Zeigler, R. L., Bergmann, C. A., Noel, M. E., Strawbridge, W. R., Richardson-Cox, B., Hereford, J. R., Reiff, R. H., Serum antiendometrial antibodies and diagnosis of endometriosis, American Journal of Reproductive Immunology, 58, 374–82, 2007 | The diagnostic test which has been used in this study is not matched with the protocol |
| Redwine, D. B., Ovarian endometriosis: A marker for more extensive pelvic and intestinal disease, Fertility and Sterility, 72, 310–315, 1999 | All the patients have endometriosis |
| Reid, S., Lu, C., Casikar, I., Reid, G., Abbott, J., Cario, G., Chou, D., Kowalski, D., Cooper, M., Condous, G., Prediction of pouch of Douglas obliteration in women with suspected endometriosis using a new real-time dynamic transvaginal ultrasound technique: the sliding sign, Ultrasound in Obstetrics & Gynecology, 41, 685–91, 2013 | It has focused on the pouch of Douglas obliteration not only endometriosis |
| Rosa, E. Silva A. C., Rosa, E. Silva J. C., Ferriani, R. A., Serum CA-125 in the diagnosis of endometriosis, International Journal of Gynaecology & Obstetrics, 96, 206–7, 2007 | Retrospective study. Women included in the study already had a diagnosis of endometriosis prior to CA-125 serum collection |
| Saba, L., Guerriero, S., Sulcis, R., Ajossa, S., Melis, G., Mallarini, G., Agreement and reproducibility in identification of endometriosis using magnetic resonance imaging, Acta Radiologica, 51, 573–80, 2010 | No outcome of interest. |
| Saba, L., Guerriero, S., Sulis, R., Pilloni, M., Ajossa, S., Melis, G., Mallarini, G., Learning curve in the detection of ovarian and deep endometriosis by using Magnetic Resonance: comparison with surgical results, European Journal of Radiology, 79, 237–44, 2011 | The aim of the study was to determine whether diagnostic accuracy is correlated to radiologist expertise |
| Salehpour, S., Sene, A. A., Mehrjerdi, E. K., Akhoond, M. R., The correlation between serum and peritoneal fluid CA125 level in women with pelvic endometriosis, International Journal of Fertility and Sterility, 3, 29–34, 2009 | No data for the CA-125 cut-off >=35U/ml |
| Santulli, P., Streuli, I., Melonio, I., Marcellin, L., M’Baye, M., Bititi, A., Borghese, B., Lafay Pillet, M. C., Chapron, C., Increased serum cancer antigen-125 is a marker for severity of deep endometriosis, Journal of Minimally Invasive Gynecology, 22, 275–84, 2015 | No data for the CA-125 cut-off of >=35U/ml |
| Scardapane, A., Bettocchi, S., Lorusso, F., Stabile Ianora, A. A., Vimercati, A., Ceci, O., Lasciarrea, M., Angelelli, G., Diagnosis of colorectal endometriosis: contribution of contrast enhanced MR-colonography, European Radiology, 21, 1553–63, 2011 | Comparison of MRI between two radiologists |
| Scardapane, A., Lorusso, F., Scioscia, M., Ferrante, A., Stabile Ianora, A. A., Angelelli, G., Standard high-resolution pelvic MRI vs. low-resolution pelvic MRI in the evaluation of deep infiltrating endometriosis, European Radiology, 24, 2590–6, 2014 | Comparison of MRI carried out by two different radiologists |
| Schenken, R. S., Improving the diagnosis of endometriosis in adolescents, Sexuality, Reproduction and Menopause, 6, 4–8, 2008 | Narrative review |
| Seeber, B., Sammel, M. D., Fan, X., Gerton, G. L., Shaunik, A., Chittams, J., Barnhart, K. T., Panel of markers can accurately predict endometriosis in a subset of patients, Fertility & Sterility, 89, 1073–81, 2008 | It is a case-control study |
| Shen, A., Xu, S., Ma, Y., Guo, H., Li, C., Yang, C., Zou, S., Diagnostic value of serum CA125, CA19–9 and CA15–3 in endometriosis: A meta-analysis, Journal of International Medical Research, 43, 599–609, 2015 | It is about association of biomarkers and stage of endometriosis. No outcome of interest. |
| Somigliana, E., Vigano, P., Candiani, M., Felicetta, I., Di Blasio, A. M., Vignali, M., Use of serum-soluble intercellular adhesion molecule-1 as a new marker of endometriosis, Fertility & Sterility, 77, 1028–31, 2002 | Women included in the study already had laparoscopy prior to CA-125 serum collection |
| Somigliana, E., Vigano, P., Tirelli, A. S., Felicetta, I., Torresani, E., Vignali, M., Di Blasio, A. M., Use of the concomitant serum dosage of CA 125, CA 19–9 and interleukin-6 to detect the presence of endometriosis. Results from a series of reproductive age women undergoing laparoscopic surgery for benign gynaecological conditions, Human Reproduction, 19, 1871–6, 2004 | Included as one of the studies in the Nisenblat 2016 review |
| Spencer, J. A., Weston, M. J., Imaging in endometriosis, Imaging, 15, 63–71, 2003 | Narrative review |
| Stowell, S. B., Wiley, C. M., Perez-Reyes, N., Powers, C. N., Cytologic diagnosis of peritoneal fluids. Applicability to the laparoscopic diagnosis of endometriosis, Acta Cytologica, 41, 817–22, 1997 | The diagnostic test in this study is not matched with the protocol. |
| Szubert, M., Suzin, J., Wierzbowski, T., Kowalczyk-Amico, K., CA-125 concentration in serum and peritoneal fluid in patients with endometriosis - preliminary results, Archives of Medical Science, 8, 504–8, 2012 | Case-control study |
| Takahashi, K., Nagata, H., Kitao, M., CA-125 in the menstrual blood is an effective marker for diagnosing early stage endometriosis: A preliminary report, Japanese Journal of Fertility and Sterility, 36, 356–359, 1991 | Ultrasound was used to confirm ovulatory day only |
| Takahashi, K., Nagata, H., Musa, A. A., Shibukawa, T., Yamasaki, H., Kitao, M., Clinical usefulness of CA-125 levels in the menstrual discharge in patients with endometriosis, Fertility & Sterility, 54, 360–2, 1990 | The level of CA-125 has been assessed in the menstrual discharge |
| Takeuchi, M., Matsuzaki, K., Nishitani, H., Susceptibility-weighted MRI of endometrioma: preliminary results, AJR. American Journal of Roentgenology, 191, 1366–70, 2008 | No outcome of interest |
| Tirlapur, S. A., Daniels, J. P., Khan, K. S., Medal trial collaboration, Chronic pelvic pain: how does noninvasive imaging compare with diagnostic laparoscopy?, Current Opinion in Obstetrics & Gynecology, 27, 445–8, 2015 | This systematic review has not only focused on patients with suspected endometriosis. It is more general about pelvic pain and diagnostic tools. |
| Tumedei, U., Ciardelli, V., Paltrinieri, F., Kuria, M. S., Amadori, A., Stefanetti, M., Gori, G., Transvaginal ultrasound in the diagnosis of endometrial abnormalities, Tumori, 87, S15, 2001 | It has focused on endometrial abnormalities not endometriosis |
| Van den Bosch, T., Vandendael, A., Van Schoubroeck, D., Wranz, P. A. B., Lombard, C. J., Combining vaginal ultrasonography and office endometrial sampling in the diagnosis of endometrial disease in postmenopausal women, Obstetrics and Gynecology, 85, 349–352, 1995 | It is not about endometriosis, it has addressed endometrial diseases |
| Vercellini, P., Oldani, S., Felicetta, I., Bramante, T., Rognoni, M. T., Crosignani, P. G., The value of cyst puncture in the differential diagnosis of benign ovarian tumours, Human Reproduction, 10, 1465–9, 1995 | Post-menopausal women incldued |
| Vrachnis, N., Sifakis, S., Samoli, E., Kappou, D., Pavlakis, K., Iliodromiti, Z., Botsis, D., Three-dimensional ultrasound and three-dimensional power Doppler improve the preoperative evaluation of complex benign ovarian lesions, Clinical & Experimental Obstetrics & Gynecology, 39, 474–8, 2012 | No outcome of interest |
| Walsh, J. W., Taylor, K. J., Wasson, J. F., Schwartz, P. E., Rosenfield, A. T., Gray-scale ultrasound in 204 proved gynecologic masses: accuracy and specific diagnostic criteria, Radiology, 130, 391–7, 1979 | No outcome of interest |
| Wang, L., Liu, H. Y., Shi, H. H., Lang, J. H., Sun, W., Urine peptide patterns for non-invasive diagnosis of endometriosis: a preliminary prospective study, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 177, 23–8, 2014 | Biomarker not of interest |
| Wessels, J. M., Kay, V. R., Leyland, N. A., Agarwal, S. K., Foster, W. G., Assessing brain-derived neurotrophic factor as a novel clinical marker of endometriosis, Fertility & Sterility, 105, 119–128.e5, 2016 | Not the test of interest |
| Wild, R. A., Hirisave, V., Bianco, A., Podczaski, E. S., Demers, L. M., Endometrial antibodies versus CA-125 for the detection of endometriosis, Fertility & Sterility, 55, 90–4, 1991 | The cut-off for CA-125 is 16 U/ml |
| Wolfler, M. M., Nagele, F., Kolbus, A., Seidl, S., Schneider, B., Huber, J. C., Tschugguel, W., A predictive model for endometriosis, Human Reproduction, 20, 1702–8, 2005 | Biomarker not of interest |
| Yamashita, Y., Torashima, M., Hatanaka, Y., Harada, M., Higashida, Y., Takahashi, M., Mizutani, H., Tashiro, H., Iwamasa, J., Miyazaki, K., et al.,, Adnexal masses: accuracy of characterization with transvaginal US and precontrast and postcontrast MR imaging, Radiology, 194, 557–65, 1995 | Review of MRI and TVUS by five radiologists |
| Yazbek, J., Helmy, S., Ben-Nagi, J., Holland, T., Sawyer, E., Jurkovic, D., Value of preoperative ultrasound examination in the selection of women with adnexal masses for laparoscopic surgery, Ultrasound in Obstetrics and Gynecology, 30, 883–888, 2007 | The preoperative sonography has not been used to diagnose endometriosis |
| Zapardiel, I., Gorostidi, M., Ravaggi, A., Allende, M. T., Silveira, M., Abehsera, D., MacUks, R., Utility Serum Marker HE4 for the Differential Diagnosis between Endometriosis and Adnexal Malignancy, International Journal of Gynecological Cancer, 26, 52–55, 2016 | No data on surgical diagnosis |
| Zhang, Y., Qiao, C., Li, L., Zhao, X., Li, Y., Serum HE4 is more suitable as a biomarker than CA125 in Chinese women with benign gynecologic disorders, African Health Sciences, 14, 913–8, 2014 | No data to calculate the full 2x2 table |
H.8. Diagnosis – Biomarkers: HE-4
| Study | Reason for Exclusion |
|---|---|
| Abrao, M. S., Goncalves, M. O., Dias, J. A., Jr., Podgaec, S., Chamie, L. P., Blasbalg, R., Comparison between clinical examination, transvaginal sonography and magnetic resonance imaging for the diagnosis of deep endometriosis, Human Reproduction, 22, 3092–7, 2007 | Test not of interest |
| Abrao, M. S., Podgaec, S., Filho, B. M., Ramos, L. O., Pinotti, J. A., de Oliveira, R. M., The use of biochemical markers in the diagnosis of pelvic endometriosis, Human Reproduction, 12, 2523–7, 1997 | Case-control study |
| Abrao, M. S., Podgaec, S., Pinotti, J. A., de Oliveira, R. M., Tumor markers in endometriosis, International Journal of Gynaecology & Obstetrics, 66, 19–22, 1999 | Case-control study |
| Abu-Musa, A., Takahashi, K., Nagata, H., Yamasaki, H., Mizoguchi, S., Kitao, M., CA-125 in menstrual discharge in patients with chronic pelvic pain, International Journal of Gynaecology & Obstetrics, 37, 111–4, 1992 | The level of CA-125 in menstrual discharge has been assessed |
| Acimovic, M., Vidakovic, S., Milic, N., Jeremic, K., Markovic, M., Milosevic-Djeric, A., Lazovic-Radonjic, G., Survivin and Vegf as Novel Biomarkers in Diagnosis of Endometriosis, Journal of Medical Biochemistry, 35, 63–68, 2016 | No laparoscopy/laparotomy and no histological confirmation |
| Alcazar, J. L., Laparte, C., Jurado, M., Lopez-Garcia, G., The role of transvaginal ultrasonography combined with color velocity imaging and pulsed Doppler in the diagnosis of endometrioma, Fertility & Sterility, 67, 487–91, 1997 | Test not of interest |
| Aleem, F., Pennisi, J., Zeitoun, K., Predanic, M., The role of color Doppler in diagnosis of endometriomas, Ultrasound in Obstetrics & Gynecology, 5, 51–4, 1995 | The aim of this study is to describe vascular appearance in endometriomas. No outcome of interest. |
| Al-Jefout, M., Dezarnaulds, G., Cooper, M., Tokushige, N., Luscombe, G. M., Markham, R., Fraser, I. S., Diagnosis of endometriosis by detection of nerve fibres in an endometrial biopsy: a double blind study, Human Reproduction (Oxford, England), 24, 3019–24, 2009 | Not a test that is routinely carried out |
| Anaf, V., El Nakadi, I., De Moor, V., Coppens, E., Zalcman, M., Noel, J. C., Anatomic significance of a positive barium enema in deep infiltrating endometriosis of the large bowel, World Journal of Surgery, 33, 822–7, 2009 | All patients had surgery and DCBE |
| Arrive, L., Hricak, H., Martin, M. C., Pelvic endometriosis: MR imaging, Radiology, 171, 687–92, 1989 | Test not of interest |
| Bagan, P., Berna, P., Assouad, J., Hupertan, V., Le Pimpec Barthes, F., Riquet, M., Value of cancer antigen 125 for diagnosis of pleural endometriosis in females with recurrent pneumothorax, European Respiratory Journal, 31, 140–2, 2008 | The control group are males |
| Balasch, J., Creus, M., Fabregues, F., Carmona, F., Ordi, J., Martinez-Roman, S., Vanrell, J. A., Visible and non-visible endometriosis at laparoscopy in fertile and infertile women and in patients with chronic pelvic pain: a prospective study, Human Reproduction, 11, 387–91, 1996 | Not a diagnostic study |
| Balleyguier, C., Roupret, M., Nguyen, T., Kinkel, K., Helenon, O., Chapron, C., Ureteral endometriosis: the role of magnetic resonance imaging, Journal of the American Association of Gynecologic Laparoscopists, 11, 530–6, 2004 | No outcome of interest. Moreover, only 6 patients were included |
| Barcellos, M. B., Lasmar, B., Lasmar, R., Agreement between the preoperative findings and the operative diagnosis in patients with deep endometriosis, Archives of Gynecology & Obstetrics Arch Gynecol Obstet, 293, 845–50, 2016 | Lesion-level analysis |
| Bazot, M., Gasner, A., Ballester, M., Darai, E., Value of thin-section oblique axial T2-weighted magnetic resonance images to assess uterosacral ligament endometriosis, Human Reproduction, 26, 346–53, 2011 | Retrospective study; one MRI technique compared to conventional technique |
| Bazot, M., Gasner, A., Lafont, C., Ballester, M., Darai, E., Deep pelvic endometriosis: limited additional diagnostic value of postcontrast in comparison with conventional MR images, European Journal of Radiology, 80, e331–9, 2011 | Retrospective study; comparison of post-contrast MRI versus conventional MRI |
| Bedaiwy, M. A., Falcone, T., Laboratory testing for endometriosis, Clinica Chimica Acta, 340, 41–56, 2004 | Narrative review |
| Bedaiwy, M. A., Falcone, T., Sharma, R. K., Goldberg, J. M., Attaran, M., Nelson, D. R., Agarwal, A., Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial, Human Reproduction, 17, 426–31, 2002 | Biomarkers not of interest |
| Belghiti, J., Thomassin-Naggara, I., Zacharopoulou, C., Zilberman, S., Jarboui, L., Bazot, M., Ballester, M., Darai, E., Contribution of Computed Tomography Enema and Magnetic Resonance Imaging to Diagnose Multifocal and Multicentric Bowel Lesions in Patients With Colorectal Endometriosis, Journal of Minimally Invasive Gynecology, 22, 776–84, 2015 | Lesion-level analysis |
| Belli, P., De Gaetano, A. M., Mirk, P., Speca, S., Valentini, A. L., Uterine adenomyosis and tubal endometriosis: diagnostic imaging, Rays, 23, 693–701, 1998 | Narrative review |
| Benacerraf, B. R., Finkler, N. J., Wojciechowski, C., Knapp, R. C., Sonographic accuracy in the diagnosis of ovarian masses, Journal of Reproductive Medicine for the Obstetrician and Gynecologist, 35, 491–495, 1990 | No outcome of interest |
| Benacerraf, B. R., Groszmann, Y., Sonography should be the first imaging examination done to evaluate patients with suspected endometriosis, Journal of Ultrasound in Medicine, 31, 651–3, 2012 | Narrative review |
| Bordin, L., Fiore, C., Dona, G., Andrisani, A., Ambrosini, G., Faggian, D., Plebani, M., Clari, G., Armanini, D., Evaluation of erythrocyte band 3 phosphotyrosine level, glutathione content, CA-125, and human epididymal secretory protein E4 as combined parameters in endometriosis, Fertility & Sterility, 94, 1616–21, 2010 | All the patients have proven endometriosis |
| Cheng, Y. M., Wang, S. T., Chou, C. Y., Serum CA-125 in preoperative patients at high risk for endometriosis, Obstetrics & Gynecology, 99, 375–80, 2002 | CA-125 has been used for identifying high risk woman not as a diagnostic tool. |
| Cho, S., Cho, H., Nam, A., Kim, H. Y., Choi, Y. S., Park, K. H., Cho, D. J., Lee, B. S., Neutrophil-to-lymphocyte ratio as an adjunct to CA-125 for the diagnosis of endometriosis, Fertility & Sterility, 90, 2073–9, 2008 | It is a case-control study |
| Chudecka-Glaz, A., Cymbaluk-Ploska, A., Luterek-Puszynska, K., Menkiszak, J., Diagnostic usefulness of the Risk of Ovarian Malignancy Algorithm using the electrochemiluminescence immunoassay for HE4 and the chemiluminescence microparticle immunoassay for CA125, Oncology Letters, 12, 3101–3114, 2016 | Women with no suspected endometriosis |
| Chung, M. K., Chung, R. R., Gordon, D., Jennings, C., The evil twins of chronic pelvic pain syndrome: endometriosis and interstitial cystitis, JSLS: Journal of the Society of Laparoendoscopic Surgeons / Society of Laparoendoscopic Surgeons, 6, 311–314, 2002 | No outcome of interest |
| Cicinelli, E., Resta, L., Nicoletti, R., Tartagni, M., Marinaccio, M., Bulletti, C., Colafiglio, G., Detection of chronic endometritis at fluid hysteroscopy, Journal of Minimally Invasive Gynecology, 12, 514–518, 2005 | Comparison not of interest |
| Cohen, L. S., Valle, R. F., Sabbagha, R. E., A comparison of preoperative ultrasound images of surgically proven endometriomas scanned by both transabdominal and transvaginal techniques, Journal of Gynecologic Surgery, 11, 27–32, 1995 | All the patients have surgically confirmed endometriosis |
| Cohen, M. R., Laparoscopy in the diagnosis and management of endometriosis, Journal of Reproductive Medicine, 27, 240–2, 1982 | No outcome of interest |
| Colacurci, N., Fortunato, N., De Franciscis, P., Fratta, M., Cioffi, M., Zarcone, R., Cardone, A., Serum and peritoneal CA-125 levels as diagnostic test for endometriosis, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 66, 41–3, 1996 | Case-control study |
| Coleman, B. G., Arger, P. H., Mulhern, C. B., Jr., Endometriosis: clinical and ultrasonic correlation, AJR. American Journal of Roentgenology, 132, 747–9, 1979 | All patients were recruited in this study, had surgically proven endometriosis |
| Corwin, M. T., Gerscovich, E. O., Lamba, R., Wilson, M., McGahan, J. P., Differentiation of ovarian endometriomas from hemorrhagic cysts at MR imaging: utility of the T2 dark spot sign, Radiology, 271, 126–32, 2014 | Using a diagnostic test to diagnose endometriosis has not been addressed in this study. It is about a sign in MRI to distinguish between Endometrioma and haemorrhagic cysts. |
| Daniilidis, A., Giannoulis, H., Tantanasis, T., Papathanasiou, K., Loufopoulos, A., Tzafettas, J., Diagnostic laparoscopy, infertility, and endometriosis - 5 Years experience, Gynecological Surgery, 5, 231–234, 2008 | Outcomes not of interest |
| Dechaud, H., Ali Ahmed, S. A., Aligier, N., Vergnes, C., Hedon, B., Does transvaginal hydrolaparoscopy render standard diagnostic laparoscopy obsolete for unexplained infertility investigation?, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 94, 97–102, 2001 | Transvaginal hydrolaparoscopy compared with conventional laparoscopy; no data for outcomes |
| do Amaral, V. F., Ferriani, R. A., de Sa, M. F. S., Nogueira, A. A., Silva, J. C. R., de Sa Rosa e Silva, A. C. J., de Moura, M. D., Positive correlation between serum and peritoneal fluid CA-125 levels in women with pelvic endometriosis, Sao Paulo Medical Journal, 124, 223–227, 2006 | It is a case-control study |
| Dunselman, G. A. J., Vermeulen, N., Becker, C., Calhaz-Jorge, C., D’Hooghe, T., De Bie, B., Heikinheimo, O., Horne, A. W., Kiesel, L., Nap, A., Prentice, A., Saridogan, E., Soriano, D., Nelen, W., ESHRE guideline: Management of women with endometriosis, Human Reproduction, 29, 400–412, 2014 | The individual studies in this publication have been checked for inclusion in the review |
| El Maati, A. A. A., Ibrahim, E. A. G., Mokhtar, F. Z., A two-stage imaging protocol for evaluating women presenting with acute pelvic pain, Egyptian Journal of Radiology and Nuclear Medicine, 44, 923–936, 2013 | The population is women with acute pelvic pain, not suspected endometriosis |
| Elgafor El Sharkwy, I. A., Combination of non-invasive and semi-invasive tests for diagnosis of minimal to mild endometriosis, Archives of gynecology and obstetrics, 288, 793–7, 2013 | The diagnostic test (IL-6 combined with nerve fibers) which has been used in this study is not matched with the protocol. |
| Ellett, L., Readman, E., Newman, M., McIlwaine, K., Villegas, R., Jagasia, N., Maher, P., Are endometrial nerve fibres unique to endometriosis? A prospective case-control study of endometrial biopsy as a diagnostic test for endometriosis in women with pelvic pain, Human Reproduction, 30, 2808–15, 2015 | Case-control study |
| Exacoustos, C., Luciano, D., Corbett, B., De Felice, G., Di Feliciantonio, M., Luciano, A., Zupi, E., The uterine junctional zone: a 3-dimensional ultrasound study of patients with endometriosis, American Journal of Obstetrics & Gynecology, 209, 248.e1–7, 2013 | In the study, the relation between thickness of uterine junctional zone and endometriosis has been evaluated. It has not been used as a diagnostic tool. |
| Faccioli, N., Manfredi, R., Mainardi, P., Dalla Chiara, E., Spoto, E., Minelli, L., Mucelli, R. P., Barium enema evaluation of colonic involvement in endometriosis, AJR. American Journal of Roentgenology, 190, 1050–4, 2008 | The diagnostic test (Barium enema) which has been used in this study is not matched with the protocol. |
| Federici, D., Muggiasca, M. L., Conti, M., Diagnostic value of laparoscopic evaluation of women with chronic pelvic pain: Our experience and a review of the literature, VALEUR DIAGNOSTIQUE DE L’EXPLORATION LAPAROSCOPIQUE DES FEMMES SOUFFRANT DE DOULEURS PELVIENNES CHRONIQUES: EXPERIENCE PERSONNELLE ET REVUE DE LA LITTERATURE, Acta Endoscopica, 22, 177–186, 1992 | Narrative review |
| Felding, C., Mikkelsen, A. L., Peen, U., Laparoscopy and ultrasound in patients with chronic pelvic pain, Journal of Obstetrics and Gynaecology, 10, 419–422, 1990 | No outcome of interest |
| Fisk, N. M., Tan, C. E., CA 125 in peritoneal fluid and serum of patients with endometriosis, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 29, 153–8, 1988 | Case-control study |
| Foda, A. A., Aal, I. A. A., Role of some biomarkers in chronic pelvic pain for early detection of endometriosis in infertile women, Middle East Fertility Society Journal, 17, 187–194, 2012 | Case-control study |
| Fratelli, N., Scioscia, M., Bassi, E., Musola, M., Minelli, L., Trivella, G., Transvaginal sonography for preoperative assessment of deep endometriosis, Journal of Clinical Ultrasound, 41, 69–75, 2013 | Data for TVS was collected retrospectively |
| Friedman, H., Vogelzang, R. L., Mendelson, E. B., Neiman, H. L., Cohen, M., Endometriosis detection by US with laparoscopic correlation, Radiology, 157, 217–20, 1985 | No data on outcomes |
| Gougoutas, C. A., Siegelman, E. S., Hunt, J., Outwater, E. K., Pelvic endometriosis: various manifestations and MR imaging findings, AJR. American Journal of Roentgenology, 175, 353–8, 2000 | Narrative review |
| Gurgan, T., Kisnisci, H., Yarali, H., Aksu, T., Zeyneloglu, H., Develioglu, O., Serum and peritoneal fluid CA-125 levels in early stage endometriosis, Gynecologic & Obstetric Investigation, 30, 105–8, 1990 | The cut-off for CA-125 is 16 U/ml |
| Guven, M. A., Bese, T., Demirkiran, F., Comparison of hydrosonography and transvaginal ultrasonography in the detection of intracavitary pathologies in women with abnormal uterine bleeding, International Journal of Gynecological Cancer, 14, 57–63, 2004 | The study population are women with history of abnormal uterine bleeding not women suspected to endometriosis. |
| Harada, T., Kubota, T., Aso, T., Usefulness of CA19–9 versus CA125 for the diagnosis of endometriosis, Fertility and Sterility, 78, 733–739, 2002 | Case-control study |
| Hompes, P. G., Koninckx, P. R., Kennedy, S., van Kamp, G. F., Verstraeten, R. A., Cornillie, F., Serum CA-125 concentrations during midfollicular phase, a clinically useful and reproducible marker in diagnosis of advanced endometriosis, Clinical Chemistry, 42, 1871–4, 1996 | No outcome of interest has been reported |
| Hornstein, M. D., Harlow, B. L., Thomas, P. P., Check, J. H., Use of a new CA 125 assay in the diagnosis of endometriosis, Human Reproduction, 10, 932–4, 1995 | The reported result has adjusted for prevalence of endometriosis in the community. This data is not useful for our systematic review. |
| Howard, F. M., El-Minawi, A. M., Sanchez, R. A., Conscious pain mapping by laparoscopy in women with chronic pelvic pain, Obstetrics & Gynecology, 96, 934–9, 2000 | The study investigated conscious pain mapping using laparoscopy |
| Ikeda, F., Bernardini, M. A., Vanni, D., Vasconcelos, A., Pinotti, J. A., Abrao, M. S., A comparison of microlaparoscopy under sedation, microlaparoscopy under general anesthesia and conventional laparoscopy for diagnosis and treatment of pelvic endometriosis in early stages, Fertility and sterility, 77, S21, 2002 | The effectiveness of using a diagnostic tool for diagnosis of endometriosis has not been addressed. |
| Ismail, M. A., Rotmensch, J., Mercer, L. J., Block, B. S., Salti, G. I., Holt, J. A., CA-125 in peritoneal fluid from patients with nonmalignant gynecologic disorders, Journal of Reproductive Medicine, 39, 510–2, 1994 | The women without any symptom who went through laparoscopic sterilization have been considered as control group. |
| Johnson, W. K., Ott, D. J., Chen, M. Y. M., Fayez, J. A., Gelfand, D. W., Efficacy of hysterosalpingography in evaluating endometriosis, Abdominal Imaging, 19, 278–280, 1994 | The study evaluated the effectiveness of hysterosalpingography and laparoscopy-retrospective study |
| Kafali, H., Artuc, H., Demir, N., Use of CA125 fluctuation during the menstrual cycle as a tool in the clinical diagnosis of endometriosis; a preliminary report, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 116, 85–8, 2004 | It is a case-control study |
| Kang, S. B., Chung, H. H., Lee, H. P., Lee, J. Y., Chang, Y. S., Impact of diagnostic laparoscopy on the management of chronic pelvic pain, Surgical Endoscopy, 21, 916–9, 2007 | there was no comparison between laparoscopy and another test |
| Karabacak, O., Tiras, M. B., Taner, M. Z., Guner, H., Yildiz, A., Yildirim, M., Small diameter versus conventional laparoscopy: a prospective, self-controlled study, Human Reproduction, 12, 2399–401, 1997 | Comparison of two types of laparoscopy |
| Kitawaki, J., Ishihara, H., Koshiba, H., Kiyomizu, M., Teramoto, M., Kitaoka, Y., Honjo, H., Usefulness and limits of CA-125 in diagnosis of endometriosis without associated ovarian endometriomas.[Erratum appears in Hum Reprod. 2007 Feb;22(2):627], Human Reproduction, 20, 1999–2003, 2005 | Women enrolled in the study were already diagnosed with endometriosis, adenomyosis and/or leiomyomas |
| Koninckx, P. R., Riittinen, L., Seppala, M., Cornillie, F. J., CA-125 and placental protein 14 concentrations in plasma and peritoneal fluid of women with deeply infiltrating pelvic endometriosis, Fertility & Sterility, 57, 523–30, 1992 | Wrong data and result have been reported. |
| Kruger, K., Behrendt, K., Niedobitek-Kreuter, G., Koltermann, K., Ebert, A. D., Location-dependent value of pelvic MRI in the preoperative diagnosis of endometriosis, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 169, 93–8, 2013 | Pelvic MRI retrospectively assessed with histology |
| Kruitwagen, R. F., Thomas, C., Poels, L. G., Koster, A. M., Willemsen, W. N., Rolland, R., High CA-125 concentrations in peritoneal fluid of normal cyclic women with various infertility-related factors as demonstrated with two-step immunoradiometric assay, Fertility & Sterility, 56, 863–9, 1991 | The outcome of interest has not been reported |
| Leslie, C., Ma, T., McElhinney, B., Leake, R., Stewart, C. J., Is the detection of endometrial nerve fibers useful in the diagnosis of endometriosis?, International Journal of Gynecological Pathology, 32, 149–55, 2013 | Included as one of the studies in Gupta et al. 2016 review |
| Li, G., Yu, Z., Li, K., The value of FS, NLR, and CA-125 in the diagnosis of endometriosis, International journal of clinical and experimental medicine, 9, 7309–7313, 2016 | Not the population of interest |
| Macer, M. L., Mathur, M., Spektor, M., Gysler, S., Staib, L., Kodaman, P., McCarthy, S., Utility of magnetic resonance imaging in the evaluation of intraoperatively confirmed pelvic adhesions, Journal of Computer Assisted Tomography, 39, 896–900, 2015 | Not the population of interest |
| Malik, E., Berg, C., Meyhofer-Malik, A., Buchweitz, O., Moubayed, P., Diedrich, K., Fluorescence diagnosis of endometriosis using 5-aminolevulinic acid, Surgical Endoscopy, 14, 452–5, 2000 | The test is not of interest |
| Manganaro, L., Fierro, F., Tomei, A., Irimia, D., Lodise, P., Sergi, M. E., Vinci, V., Sollazzo, P., Porpora, M. G., Delfini, R., Vittori, G., Marini, M., Feasibility of 3.0T pelvic MR imaging in the evaluation of endometriosis, European Journal of Radiology, 81, 1381–7, 2012 | Women in the study already had a diagnosis of endometriosis by transvaginal ultrasound |
| Martinez, S., Garrido, N., Coperias, J. L., Pardo, F., Desco, J., Garcia-Velasco, J. A., Simon, C., Pellicer, A., Serum interleukin-6 levels are elevated in women with minimal-mild endometriosis, Human Reproduction, 22, 836–42, 2007 | It is a case-control study |
| Mathlouthi, N., Ayed, B. B., Dhouib, M., Chaabene, K., Trabelsi, K., Amouri, H., Guermazi, M., Confrontation ultrasonography-CA125-histology in the managment of ovarian cysts: A prospective study about 77 cases, Tunisie Medicale, 89, 686–692, 2011 | Full-text in French |
| May, K. E., Conduit-Hulbert, S. A., Villar, J., Kirtley, S., Kennedy, S. H., Becker, C. M., Peripheral biomarkers of endometriosis: a systematic review, Human Reproduction Update, 16, 651–74, 2010 | This systematic review includes papers also regarding other biomarkers. The full texts of individual related studies were retrieved and reviewed. |
| May, K. E., Villar, J., Kirtley, S., Kennedy, S. H., Becker, C. M., Endometrial alterations in endometriosis: a systematic review of putative biomarkers, Human Reproduction Update, 17, 637–53, 2011 | Single studies from the review were assessed for inclusion |
| McBride, N., Newman, R. L., Diagnostic laparoscopy, International Journal of Gynaecology & Obstetrics, 15, 556–8, 1978 | No outcome of interest |
| McKinnon, B., Mueller, M. D., Nirgianakis, K., Bersinger, N. A., Comparison of ovarian cancer markers in endometriosis favours HE4 over CA125, Molecular Medicine Reports, 12, 5179–84, 2015 | No data reported to calculate sensitivity |
| Medl, M., Ogris, E., Peters-Engl, C., Mierau, M., Buxbaum, P., Leodolter, S., Serum levels of the tumour-associated trypsin inhibitor in patients with endometriosis, British Journal of Obstetrics & Gynaecology, 104, 78–81, 1997 | Wrong data and result have been reported |
| Melega, C., Marchesini, F. P., Bellettini, L., Biscontin, S., Flamigni, C., Diagnostic value of laparoscopy in endometriosis and infertility, Journal of Reproductive Medicine, 29, 597–600, 1984 | No outcome of interest |
| Mezzi, G., Ferrari, S., Arcidiacono, P. G., Di Puppo, F., Candiani, M., Testoni, P. A., Endoscopic rectal ultrasound and elastosonography are useful in flow chart for the diagnosis of deep pelvic endometriosis with rectal involvement, Journal of Obstetrics & Gynaecology Research, 37, 586–90, 2011 | There was no comparison with surgery |
| Mikami, M., Tanabe, K., Matsuo, K., Miyazaki, Y., Miyazawa, M., Hayashi, M., Asai, S., Ikeda, M., Shida, M., Hirasawa, T., Kojima, N., Sho, R., Iijima, S., Fully-sialylated alpha-chain of complement 4-binding protein: Diagnostic utility for ovarian clear cell carcinoma, Gynecologic Oncology, 139, 520–528, 2015 | Not the population of interest |
| Millischer, A. E., Salomon, L. J., Santulli, P., Borghese, B., Dousset, B., Chapron, C., Fusion imaging for evaluation of deep infiltrating endometriosis: feasibility and preliminary results, Ultrasound in Obstetrics & Gynecology, 46, 109–17, 2015 | No data on surgical diagnosis |
| Miyagi, E., Maruyama, Y., Mogami, T., Numazaki, R., Ikeda, A., Yamamoto, H., Hirahara, F., Comparison of plasma amino acid profile-based index and CA125 in the diagnosis of epithelial ovarian cancers and borderline malignant tumors, International Journal of Clinical Oncology, 1–8, 2016 | Not the population of interest |
| Mol, B. W., Bayram, N., Lijmer, J. G., Wiegerinck, M. A., Bongers, M. Y., van der Veen, F., Bossuyt, P. M., The performance of CA-125 measurement in the detection of endometriosis: a metaanalysis, Fertility & Sterility, 70, 1101–8, 1998 | All the studies included in this systematic review could not be included in our systematic review. The full-texts of all individual studies were retrieved and reviewed and related studies were included in our review. |
| Moloney, M. D., Thornton, J. G., Cooper, E. H., Serum CA 125 antigen levels and disease severity in patients with endometriosis, Obstetrics & Gynecology, 73, 767–9, 1989 | Women had laparoscopically confirmed endometriosis and then CA-125 level has been evaluated. |
| Moretuzzo, R. W., DiLauro, S., Jenison, E., Chen, S. L., Reindollar, R. H., McDonough, P. G., Serum and peritoneal lavage fluid CA-125 levels in endometriosis, Fertility & Sterility, 50, 430–3, 1988 | No outcome of interest |
| O’Shaughnessy, A., Check, J. H., Nowroozi, K., Lurie, D., CA 125 levels measured in different phases of the menstrual cycle in screening for endometriosis, Obstetrics & Gynecology, 81, 99–103, 1993 | Wrong data and result have been reported |
| Ota, H., Maki, M., Evaluation of autoantibody and CA125 in the diagnosis of endometriosis or adenomyosis, Medical Science Research, 18, 309–310, 1990 | All the participants had known condition |
| Othman, E. E. D. R., Hornung, D., Al-Hendy, A., Biomarkers of endometriosis, Expert Opinion on Medical Diagnostics, 2, 741–752, 2008 | Narrative review |
| Ozaksit, G., Caglar, T., Cicek, N., Kuscu, E., Batioglu, S., Gokmen, O., Serum CA 125 levels before, during and after treatment for endometriosis, International Journal of Gynaecology & Obstetrics, 50, 269–73, 1995 | Women had a confirmed diagnosis of endometriosis prior to CA-125 test |
| Paiva, P., Lappas, M., Barker, G., Healey, M., Using symptom scores, lifestyle measures and biochemical markers to create a test for endometriosis, Journal of Endometriosis and Pelvic Pain Disorders, 6, 135–143, 2014 | No outcome of interest |
| Panidis, D., Vlassis, G., Matalliotakis, J., Skiadopoulos, S., Kalogeropoulos, A., Serum levels of the oncofetal antigens CA-125, CA 19–9 and CA 15–3 in patients with endometriosis, Journal of Endocrinological Investigation, 11, 801–804, 1988 | All women who involved in the study have proven endometriosis |
| Pastorfide, G., Fong, Y. F., Use of narrowband imaging for the detection of endometriosis, Journal of Minimally Invasive Gynecology, 22, 535, 2015 | No outcome of interest |
| Patel, M. D., Feldstein, V. A., Chen, D. C., Lipson, S. D., Filly, R. A., Endometriomas: diagnostic performance of US.[Erratum appears in Radiology 1999 Dec;213(3):930], Radiology, 210, 739–45, 1999 | Retrospective review of sonograms by two sonologists |
| Patel, M. D., Feldstein, V. A., Filly, R. A., The likelihood ratio of sonographic findings for the diagnosis of hemorrhagic ovarian cysts, Journal of Ultrasound in Medicine, 24, 607–14; quiz 615, 2005 | It is about diagnosis of haemorrhagic ovarian cyst not endometrioma |
| Patton, P. E., Field, C. S., Harms, R. W., Coulam, C. B., CA-125 levels in endometriosis, Fertility & Sterility, 45, 770–3, 1986 | Women who come for elective sterilization have been also included in this study, while they are not suspected for endometriosis. |
| Philip, C. A., Bisch, C., Coulon, A., de Saint-Hilaire, P., Rudigoz, R. C., Dubernard, G., Correlation between three-dimensional rectosonography and magnetic resonance imaging in the diagnosis of rectosigmoid endometriosis: a preliminary study on the first fifty cases, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 187, 35–40, 2015 | MRI was the reference test |
| Piessens, S., Healey, M., Maher, P., Tsaltas, J., Rombauts, L., Can anyone screen for deep infiltrating endometriosis with transvaginal ultrasound?, Australian & New Zealand Journal of Obstetrics & Gynaecology, 54, 462–8, 2014 | Women included in the study had the ultrasound test after diagnosis of endometriosis by surgery |
| Pittaway, D. E., Douglas, J. W., Serum CA-125 in women with endometriosis and chronic pelvic pain, Fertility & Sterility, 51, 68–70, 1989 | The cut-off for CA-125 is 16 U/ml |
| Polisseni, F., Bambirra, E. A., Camargos, A. F., Detection of chronic endometritis by diagnostic hysteroscopy in asymptomatic infertile patients, Gynecologic & Obstetric Investigation, 55, 205–10, 2003 | Comparison not of interest |
| Randall, G. W., Gantt, P. A., Poe-Zeigler, R. L., Bergmann, C. A., Noel, M. E., Strawbridge, W. R., Richardson-Cox, B., Hereford, J. R., Reiff, R. H., Serum antiendometrial antibodies and diagnosis of endometriosis, American Journal of Reproductive Immunology, 58, 374–82, 2007 | The diagnostic test which has been used in this study is not matched with the protocol |
| Redwine, D. B., Ovarian endometriosis: A marker for more extensive pelvic and intestinal disease, Fertility and Sterility, 72, 310–315, 1999 | All the patients have endometriosis |
| Reid, S., Lu, C., Casikar, I., Reid, G., Abbott, J., Cario, G., Chou, D., Kowalski, D., Cooper, M., Condous, G., Prediction of pouch of Douglas obliteration in women with suspected endometriosis using a new real-time dynamic transvaginal ultrasound technique: the sliding sign, Ultrasound in Obstetrics & Gynecology, 41, 685–91, 2013 | It has focused on the pouch of Douglas obliteration not only endometriosis |
| Rosa, E. Silva A. C., Rosa, E. Silva J. C., Ferriani, R. A., Serum CA-125 in the diagnosis of endometriosis, International Journal of Gynaecology & Obstetrics, 96, 206–7, 2007 | Retrospective study. Women included in the study already had a diagnosis of endometriosis prior to CA-125 serum collection |
| Saba, L., Guerriero, S., Sulcis, R., Ajossa, S., Melis, G., Mallarini, G., Agreement and reproducibility in identification of endometriosis using magnetic resonance imaging, Acta Radiologica, 51, 573–80, 2010 | No outcome of interest. |
| Saba, L., Guerriero, S., Sulis, R., Pilloni, M., Ajossa, S., Melis, G., Mallarini, G., Learning curve in the detection of ovarian and deep endometriosis by using Magnetic Resonance: comparison with surgical results, European Journal of Radiology, 79, 237–44, 2011 | The aim of the study was to determine whether diagnostic accuracy is correlated to radiologist expertise |
| Scardapane, A., Bettocchi, S., Lorusso, F., Stabile Ianora, A. A., Vimercati, A., Ceci, O., Lasciarrea, M., Angelelli, G., Diagnosis of colorectal endometriosis: contribution of contrast enhanced MR-colonography, European Radiology, 21, 1553–63, 2011 | Comparison of MRI between two radiologists |
| Scardapane, A., Lorusso, F., Scioscia, M., Ferrante, A., Stabile Ianora, A. A., Angelelli, G., Standard high-resolution pelvic MRI vs. low-resolution pelvic MRI in the evaluation of deep infiltrating endometriosis, European Radiology, 24, 2590–6, 2014 | Comparison of MRI carried out by two different radiologists |
| Schenken, R. S., Improving the diagnosis of endometriosis in adolescents, Sexuality, Reproduction and Menopause, 6, 4–8, 2008 | Narrative review |
| Seeber, B., Sammel, M. D., Fan, X., Gerton, G. L., Shaunik, A., Chittams, J., Barnhart, K. T., Panel of markers can accurately predict endometriosis in a subset of patients, Fertility & Sterility, 89, 1073–81, 2008 | It is a case-control study |
| Shen, A., Xu, S., Ma, Y., Guo, H., Li, C., Yang, C., Zou, S., Diagnostic value of serum CA125, CA19–9 and CA15–3 in endometriosis: A meta-analysis, Journal of International Medical Research, 43, 599–609, 2015 | It is about association of biomarkers and stage of endometriosis. No outcome of interest. |
| Somigliana, E., Vigano, P., Candiani, M., Felicetta, I., Di Blasio, A. M., Vignali, M., Use of serum-soluble intercellular adhesion molecule-1 as a new marker of endometriosis, Fertility & Sterility, 77, 1028–31, 2002 | Women included in the study already had laparoscopy prior to CA-125 serum collection |
| Somigliana, E., Vigano, P., Tirelli, A. S., Felicetta, I., Torresani, E., Vignali, M., Di Blasio, A. M., Use of the concomitant serum dosage of CA 125, CA 19–9 and interleukin-6 to detect the presence of endometriosis. Results from a series of reproductive age women undergoing laparoscopic surgery for benign gynaecological conditions, Human Reproduction, 19, 1871–6, 2004 | Case-control study |
| Spencer, J. A., Weston, M. J., Imaging in endometriosis, Imaging, 15, 63–71, 2003 | Narrative review |
| Stowell, S. B., Wiley, C. M., Perez-Reyes, N., Powers, C. N., Cytologic diagnosis of peritoneal fluids. Applicability to the laparoscopic diagnosis of endometriosis, Acta Cytologica, 41, 817–22, 1997 | The diagnostic test in this study is not matched with the protocol |
| Szubert, M., Suzin, J., Wierzbowski, T., Kowalczyk-Amico, K., CA-125 concentration in serum and peritoneal fluid in patients with endometriosis - preliminary results, Archives of Medical Science, 8, 504–8, 2012 | Case-control study |
| Takahashi, K., Nagata, H., Kitao, M., CA-125 in the menstrual blood is an effective marker for diagnosing early stage endometriosis: A preliminary report, Japanese Journal of Fertility and Sterility, 36, 356–359, 1991 | Ultrasound was used to confirm ovulatory day only |
| Takahashi, K., Nagata, H., Musa, A. A., Shibukawa, T., Yamasaki, H., Kitao, M., Clinical usefulness of CA-125 levels in the menstrual discharge in patients with endometriosis, Fertility & Sterility, 54, 360–2, 1990 | The level of CA-125 has been assessed in the menstrual discharge |
| Takeuchi, M., Matsuzaki, K., Nishitani, H., Susceptibility-weighted MRI of endometrioma: preliminary results, AJR. American Journal of Roentgenology, 191, 1366–70, 2008 | No outcome of interest |
| Tirlapur, S. A., Daniels, J. P., Khan, K. S., Medal trial collaboration, Chronic pelvic pain: how does noninvasive imaging compare with diagnostic laparoscopy?, Current Opinion in Obstetrics & Gynecology, 27, 445–8, 2015 | This systematic review has not only focused on patients with suspected endometriosis. It is more general about pelvic pain and diagnostic tools. |
| Tumedei, U., Ciardelli, V., Paltrinieri, F., Kuria, M. S., Amadori, A., Stefanetti, M., Gori, G., Transvaginal ultrasound in the diagnosis of endometrial abnormalities, Tumori, 87, S15, 2001 | It has focused on endometrial abnormalities not endometriosis |
| Van den Bosch, T., Vandendael, A., Van Schoubroeck, D., Wranz, P. A. B., Lombard, C. J., Combining vaginal ultrasonography and office endometrial sampling in the diagnosis of endometrial disease in postmenopausal women, Obstetrics and Gynecology, 85, 349–352, 1995 | It is not about endometriosis, it has addressed endometrial diseases |
| Vrachnis, N., Sifakis, S., Samoli, E., Kappou, D., Pavlakis, K., Iliodromiti, Z., Botsis, D., Three-dimensional ultrasound and three-dimensional power Doppler improve the preoperative evaluation of complex benign ovarian lesions, Clinical & Experimental Obstetrics & Gynecology, 39, 474–8, 2012 | No outcome of interest |
| Walsh, J. W., Taylor, K. J., Wasson, J. F., Schwartz, P. E., Rosenfield, A. T., Gray-scale ultrasound in 204 proved gynecologic masses: accuracy and specific diagnostic criteria, Radiology, 130, 391–7, 1979 | No outcome of interest |
| Wang, L., Liu, H. Y., Shi, H. H., Lang, J. H., Sun, W., Urine peptide patterns for non-invasive diagnosis of endometriosis: a preliminary prospective study, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 177, 23–8, 2014 | Biomarker not of interest |
| Wessels, J. M., Kay, V. R., Leyland, N. A., Agarwal, S. K., Foster, W. G., Assessing brain-derived neurotrophic factor as a novel clinical marker of endometriosis, Fertility & Sterility, 105, 119128.e5, 2016 | Not the test of interest |
| Wild, R. A., Hirisave, V., Bianco, A., Podczaski, E. S., Demers, L. M., Endometrial antibodies versus CA-125 for the detection of endometriosis, Fertility & Sterility, 55, 90–4, 1991 | The cut-off for CA-125 is 16 U/ml |
| Wolfler, M. M., Nagele, F., Kolbus, A., Seidl, S., Schneider, B., Huber, J. C., Tschugguel, W., A predictive model for endometriosis, Human Reproduction, 20, 1702–8, 2005 | Biomarker not of interest |
| Yamashita, Y., Torashima, M., Hatanaka, Y., Harada, M., Higashida, Y., Takahashi, M., Mizutani, H., Tashiro, H., Iwamasa, J., Miyazaki, K., et al.,, Adnexal masses: accuracy of characterization with transvaginal US and precontrast and postcontrast MR imaging, Radiology, 194, 557–65, 1995 | Review of MRI and TVUS by five radiologists |
| Yazbek, J., Helmy, S., Ben-Nagi, J., Holland, T., Sawyer, E., Jurkovic, D., Value of preoperative ultrasound examination in the selection of women with adnexal masses for laparoscopic surgery, Ultrasound in Obstetrics and Gynecology, 30, 883–888, 2007 | The preoperative sonography has not been used to diagnose endometriosis |
| Zapardiel, I., Gorostidi, M., Ravaggi, A., Allende, M. T., Silveira, M., Abehsera, D., MacUks, R., Utility Serum Marker HE4 for the Differential Diagnosis between Endometriosis and Adnexal Malignancy, International Journal of Gynecological Cancer, 26, 52–55, 2016 | No data on surgical diagnosis |
| Zhang Y, Qiao C, Li L, Zhao X, Li Y. Serum HE4 is more suitable as a biomarker than CA125 in Chinese women with benign gynecologic disorders. Afr Health Sci, 14(4):913–8, 2014 | Included in the nerve fibres question |
H.9. Diagnosis – Biomarkers: Nerve fibre marker Protein Gene Product 9.5 (PGP 9.5)
| Study | Reason for Exclusion |
|---|---|
| Abrao, M. S., Goncalves, M. O., Dias, J. A., Jr., Podgaec, S., Chamie, L. P., Blasbalg, R., Comparison between clinical examination, transvaginal sonography and magnetic resonance imaging for the diagnosis of deep endometriosis, Human Reproduction, 22, 3092–7, 2007 | Test not of interest |
| Abrao, M. S., Podgaec, S., Filho, B. M., Ramos, L. O., Pinotti, J. A., de Oliveira, R. M., The use of biochemical markers in the diagnosis of pelvic endometriosis, Human Reproduction, 12, 2523–7, 1997 | Case-control study |
| Abrao, M. S., Podgaec, S., Pinotti, J. A., de Oliveira, R. M., Tumor markers in endometriosis, International Journal of Gynaecology & Obstetrics, 66, 19–22, 1999 | Case-control study |
| Abu-Musa, A., Takahashi, K., Nagata, H., Yamasaki, H., Mizoguchi, S., Kitao, M., CA-125 in menstrual discharge in patients with chronic pelvic pain, International Journal of Gynaecology & Obstetrics, 37, 111–4, 1992 | The level of CA-125 in menstrual discharge has been assessed |
| Acimovic, M., Vidakovic, S., Milic, N., Jeremic, K., Markovic, M., Milosevic-Djeric, A., Lazovic-Radonjic, G., Survivin and Vegf as Novel Biomarkers in Diagnosis of Endometriosis, Journal of Medical Biochemistry, 35, 63–68, 2016 | No laparoscopy/laparotomy and no histological confirmation |
| Alcazar, J. L., Laparte, C., Jurado, M., Lopez-Garcia, G., The role of transvaginal ultrasonography combined with color velocity imaging and pulsed Doppler in the diagnosis of endometrioma, Fertility & Sterility, 67, 487–91, 1997 | Test not of interest |
| Aleem, F., Pennisi, J., Zeitoun, K., Predanic, M., The role of color Doppler in diagnosis of endometriomas, Ultrasound in Obstetrics & Gynecology, 5, 51–4, 1995 | The aim of this study is to describe vascular appearance in endometriomas. No outcome of interest. |
| Al-Jefout, M., Dezarnaulds, G., Cooper, M., Tokushige, N., Luscombe, G. M., Markham, R., Fraser, I. S., Diagnosis of endometriosis by detection of nerve fibres in an endometrial biopsy: a double blind study, Human Reproduction (Oxford, England), 24, 3019–24, 2009 | Not a test that is routinely carried out |
| Anaf, V., El Nakadi, I., De Moor, V., Coppens, E., Zalcman, M., Noel, J. C., Anatomic significance of a positive barium enema in deep infiltrating endometriosis of the large bowel, World Journal of Surgery, 33, 822–7, 2009 | All patients had surgery and DCBE |
| Arrive, L., Hricak, H., Martin, M. C., Pelvic endometriosis: MR imaging, Radiology, 171, 687–92, 1989 | Test not of interest |
| Bagan, P., Berna, P., Assouad, J., Hupertan, V., Le Pimpec Barthes, F., Riquet, M., Value of cancer antigen 125 for diagnosis of pleural endometriosis in females with recurrent pneumothorax, European Respiratory Journal, 31, 140–2, 2008 | The control group are males |
| Balasch, J., Creus, M., Fabregues, F., Carmona, F., Ordi, J., Martinez-Roman, S., Vanrell, J. A., Visible and non-visible endometriosis at laparoscopy in fertile and infertile women and in patients with chronic pelvic pain: a prospective study, Human Reproduction, 11, 387–91, 1996 | Not a diagnostic study |
| Balleyguier, C., Roupret, M., Nguyen, T., Kinkel, K., Helenon, O., Chapron, C., Ureteral endometriosis: the role of magnetic resonance imaging, Journal of the American Association of Gynecologic Laparoscopists, 11, 530–6, 2004 | No outcome of interest. Moreover, only 6 patients were included |
| Barcellos, M. B., Lasmar, B., Lasmar, R., Agreement between the preoperative findings and the operative diagnosis in patients with deep endometriosis, Archives of Gynecology & Obstetrics Arch Gynecol Obstet, 293, 845–50, 2016 | Lesion-level analysis |
| Bazot, M., Gasner, A., Ballester, M., Darai, E., Value of thin-section oblique axial T2-weighted magnetic resonance images to assess uterosacral ligament endometriosis, Human Reproduction, 26, 346–53, 2011 | Retrospective study; one MRI technique compared to conventional technique |
| Bazot, M., Gasner, A., Lafont, C., Ballester, M., Darai, E., Deep pelvic endometriosis: limited additional diagnostic value of postcontrast in comparison with conventional MR images, European Journal of Radiology, 80, e331–9, 2011 | Retrospective study; comparison of post-contrast MRI versus conventional MRI |
| Bedaiwy, M. A., Falcone, T., Laboratory testing for endometriosis, Clinica Chimica Acta, 340, 41–56, 2004 | Narrative review |
| Bedaiwy, M. A., Falcone, T., Sharma, R. K., Goldberg, J. M., Attaran, M., Nelson, D. R., Agarwal, A., Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial, Human Reproduction, 17, 426–31, 2002 | Biomarkers not of interest |
| Belghiti, J., Thomassin-Naggara, I., Zacharopoulou, C., Zilberman, S., Jarboui, L., Bazot, M., Ballester, M., Darai, E., Contribution of Computed Tomography Enema and Magnetic Resonance Imaging to Diagnose Multifocal and Multicentric Bowel Lesions in Patients With Colorectal Endometriosis, Journal of Minimally Invasive Gynecology, 22, 776–84, 2015 | Lesion-level analysis |
| Belli, P., De Gaetano, A. M., Mirk, P., Speca, S., Valentini, A. L., Uterine adenomyosis and tubal endometriosis: diagnostic imaging, Rays, 23, 693–701, 1998 | Narrative review |
| Benacerraf, B. R., Finkler, N. J., Wojciechowski, C., Knapp, R. C., Sonographic accuracy in the diagnosis of ovarian masses, Journal of Reproductive Medicine for the Obstetrician and Gynecologist, 35, 491–495, 1990 | No outcome of interest |
| Benacerraf, B. R., Groszmann, Y., Sonography should be the first imaging examination done to evaluate patients with suspected endometriosis, Journal of Ultrasound in Medicine, 31, 651–3, 2012 | Narrative review |
| Bordin, L., Fiore, C., Dona, G., Andrisani, A., Ambrosini, G., Faggian, D., Plebani, M., Clari, G., Armanini, D., Evaluation of erythrocyte band 3 phosphotyrosine level, glutathione content, CA-125, and human epididymal secretory protein E4 as combined parameters in endometriosis, Fertility & Sterility, 94, 1616–21, 2010 | All the patients have proven endometriosis |
| Cheng, Y. M., Wang, S. T., Chou, C. Y., Serum CA-125 in preoperative patients at high risk for endometriosis, Obstetrics & Gynecology, 99, 375–80, 2002 | CA-125 has been used for identifying high risk woman not as a diagnostic tool |
| Cho, S., Cho, H., Nam, A., Kim, H. Y., Choi, Y. S., Park, K. H., Cho, D. J., Lee, B. S., Neutrophil-to-lymphocyte ratio as an adjunct to CA-125 for the diagnosis of endometriosis, Fertility & Sterility, 90, 2073–9, 2008 | It is a case control-study |
| Chudecka-Glaz, A., Cymbaluk-Ploska, A., Luterek-Puszynska, K., Menkiszak, J., Diagnostic usefulness of the Risk of Ovarian Malignancy Algorithm using the electrochemiluminescence immunoassay for HE4 and the chemiluminescence microparticle immunoassay for CA125, Oncology Letters, 12, 3101–3114, 2016 | Women with no suspected endometriosis |
| Chung, M. K., Chung, R. R., Gordon, D., Jennings, C., The evil twins of chronic pelvic pain syndrome: endometriosis and interstitial cystitis, JSLS: Journal of the Society of Laparoendoscopic Surgeons / Society of Laparoendoscopic Surgeons, 6, 311–314, 2002 | No outcome of interest |
| Cicinelli, E., Resta, L., Nicoletti, R., Tartagni, M., Marinaccio, M., Bulletti, C., Colafiglio, G., Detection of chronic endometritis at fluid hysteroscopy, Journal of Minimally Invasive Gynecology, 12, 514–518, 2005 | Comparison not of interest |
| Cohen, L. S., Valle, R. F., Sabbagha, R. E., A comparison of preoperative ultrasound images of surgically proven endometriomas scanned by both transabdominal and transvaginal techniques, Journal of Gynecologic Surgery, 11, 27–32, 1995 | All the patients have surgically confirmed endometriosis. |
| Cohen, M. R., Laparoscopy in the diagnosis and management of endometriosis, Journal of Reproductive Medicine, 27, 240–2, 1982 | No outcome of interest |
| Colacurci, N., Fortunato, N., De Franciscis, P., Fratta, M., Cioffi, M., Zarcone, R., Cardone, A., Serum and peritoneal CA-125 levels as diagnostic test for endometriosis, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 66, 41–3, 1996 | Case-control study |
| Coleman, B. G., Arger, P. H., Mulhern, C. B., Jr., Endometriosis: clinical and ultrasonic correlation, AJR. American Journal of Roentgenology, 132, 747–9, 1979 | All patients were recruited in this study, had surgically proven endometriosis |
| Corwin, M. T., Gerscovich, E. O., Lamba, R., Wilson, M., McGahan, J. P., Differentiation of ovarian endometriomas from hemorrhagic cysts at MR imaging: utility of the T2 dark spot sign, Radiology, 271, 126–32, 2014 | Using a diagnostic test to diagnose endometriosis has not been addressed in this study. It is about a sign in MRI to distinguish between Endometrioma and haemorrhagic cysts. |
| Daniilidis, A., Giannoulis, H., Tantanasis, T., Papathanasiou, K., Loufopoulos, A., Tzafettas, J., Diagnostic laparoscopy, infertility, and endometriosis - 5 Years experience, Gynecological Surgery, 5, 231–234, 2008 | Outcomes not of interest |
| Dechaud, H., Ali Ahmed, S. A., Aligier, N., Vergnes, C., Hedon, B., Does transvaginal hydrolaparoscopy render standard diagnostic laparoscopy obsolete for unexplained infertility investigation?, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 94, 97–102, 2001 | Transvaginal hydrolaparoscopy compared with conventional laparoscopy; no data for outcomes |
| do Amaral, V. F., Ferriani, R. A., de Sa, M. F. S., Nogueira, A. A., Silva, J. C. R., de Sa Rosa e Silva, A. C. J., de Moura, M. D., Positive correlation between serum and peritoneal fluid CA-125 levels in women with pelvic endometriosis, Sao Paulo Medical Journal, 124, 223–227, 2006 | It is a case-control study |
| Dunselman, G. A. J., Vermeulen, N., Becker, C., Calhaz-Jorge, C., D’Hooghe, T., De Bie, B., Heikinheimo, O., Horne, A. W., Kiesel, L., Nap, A., Prentice, A., Saridogan, E., Soriano, D., Nelen, W., ESHRE guideline: Management of women with endometriosis, Human Reproduction, 29, 400–412, 2014 | The individual studies in this publication have been checked for inclusion in the review |
| El Maati, A. A. A., Ibrahim, E. A. G., Mokhtar, F. Z., A two-stage imaging protocol for evaluating women presenting with acute pelvic pain, Egyptian Journal of Radiology and Nuclear Medicine, 44, 923–936, 2013 | The population is women with acute pelvic pain, not suspected endometriosis |
| Elgafor El Sharkwy, I. A., Combination of non-invasive and semi-invasive tests for diagnosis of minimal to mild endometriosis, Archives of gynecology and obstetrics, 288, 793–7, 2013 | The diagnostic test (IL-6 combined with nerve fibers) which has been used in this study is not matched with the protocol |
| Ellett, L., Readman, E., Newman, M., McIlwaine, K., Villegas, R., Jagasia, N., Maher, P., Are endometrial nerve fibres unique to endometriosis? A prospective case-control study of endometrial biopsy as a diagnostic test for endometriosis in women with pelvic pain, Human Reproduction, 30, 2808–15, 2015 | Case-control study |
| Exacoustos, C., Luciano, D., Corbett, B., De Felice, G., Di Feliciantonio, M., Luciano, A., Zupi, E., The uterine junctional zone: a 3-dimensional ultrasound study of patients with endometriosis, American Journal of Obstetrics & Gynecology, 209, 248.e1–7, 2013 | In the study, the relation between thickness of uterine junctional zone and endometriosis has been evaluated. It has not been used as a diagnostic tool. |
| Faccioli, N., Manfredi, R., Mainardi, P., Dalla Chiara, E., Spoto, E., Minelli, L., Mucelli, R. P., Barium enema evaluation of colonic involvement in endometriosis, AJR. American Journal of Roentgenology, 190, 1050–4, 2008 | The diagnostic test (Barium enema) which has been used in this study is not matched with the protocol. |
| Federici, D., Muggiasca, M. L., Conti, M., Diagnostic value of laparoscopic evaluation of women with chronic pelvic pain: Our experience and a review of the literature, VALEUR DIAGNOSTIQUE DE L’EXPLORATION LAPAROSCOPIQUE DES FEMMES SOUFFRANT DE DOULEURS PELVIENNES CHRONIQUES: EXPERIENCE PERSONNELLE ET REVUE DE LA LITTERATURE, Acta Endoscopica, 22, 177–186, 1992 | Narrative review |
| Felding, C., Mikkelsen, A. L., Peen, U., Laparoscopy and ultrasound in patients with chronic pelvic pain, Journal of Obstetrics and Gynaecology, 10, 419–422, 1990 | No outcome of interest. |
| Fisk, N. M., Tan, C. E., CA 125 in peritoneal fluid and serum of patients with endometriosis, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 29, 153–8, 1988 | Case-control study |
| Foda, A. A., Aal, I. A. A., Role of some biomarkers in chronic pelvic pain for early detection of endometriosis in infertile women, Middle East Fertility Society Journal, 17, 187–194, 2012 | Case-control study |
| Fratelli, N., Scioscia, M., Bassi, E., Musola, M., Minelli, L., Trivella, G., Transvaginal sonography for preoperative assessment of deep endometriosis, Journal of Clinical Ultrasound, 41, 69–75, 2013 | Data for TVS was collected retrospectively |
| Friedman, H., Vogelzang, R. L., Mendelson, E. B., Neiman, H. L., Cohen, M., Endometriosis detection by US with laparoscopic correlation, Radiology, 157, 217–20, 1985 | No data on outcomes |
| Gougoutas, C. A., Siegelman, E. S., Hunt, J., Outwater, E. K., Pelvic endometriosis: various manifestations and MR imaging findings, AJR. American Journal of Roentgenology, 175, 353–8, 2000 | Narrative review |
| Gurgan, T., Kisnisci, H., Yarali, H., Aksu, T., Zeyneloglu, H., Develioglu, O., Serum and peritoneal fluid CA-125 levels in early stage endometriosis, Gynecologic & Obstetric Investigation, 30, 105–8, 1990 | The cut-off for CA-125 is 16 U/ml |
| Guven, M. A., Bese, T., Demirkiran, F., Comparison of hydrosonography and transvaginal ultrasonography in the detection of intracavitary pathologies in women with abnormal uterine bleeding, International Journal of Gynecological Cancer, 14, 57–63, 2004 | The study population are women with history of abnormal uterine bleeding not women suspected to endometriosis. |
| Harada, T., Kubota, T., Aso, T., Usefulness of CA19–9 versus CA125 for the diagnosis of endometriosis, Fertility and Sterility, 78, 733–739, 2002 | Case-control study |
| Hompes, P. G., Koninckx, P. R., Kennedy, S., van Kamp, G. F., Verstraeten, R. A., Cornillie, F., Serum CA-125 concentrations during midfollicular phase, a clinically useful and reproducible marker in diagnosis of advanced endometriosis, Clinical Chemistry, 42, 1871–4, 1996 | No outcome of interest has been reported |
| Hornstein, M. D., Harlow, B. L., Thomas, P. P., Check, J. H., Use of a new CA 125 assay in the diagnosis of endometriosis, Human Reproduction, 10, 932–4, 1995 | The reported result has adjusted for prevalence of endometriosis in the community. This data is not useful for our systematic review |
| Howard, F. M., El-Minawi, A. M., Sanchez, R. A., Conscious pain mapping by laparoscopy in women with chronic pelvic pain, Obstetrics & Gynecology, 96, 934–9, 2000 | The study investigated conscious pain mapping using laparoscopy |
| Ikeda, F., Bernardini, M. A., Vanni, D., Vasconcelos, A., Pinotti, J. A., Abrao, M. S., A comparison of microlaparoscopy under sedation, microlaparoscopy under general anesthesia and conventional laparoscopy for diagnosis and treatment of pelvic endometriosis in early stages, Fertility and sterility, 77, S21, 2002 | The effectiveness of using a diagnostic tool for diagnosis of endometriosis has not been addressed. |
| Ismail, M. A., Rotmensch, J., Mercer, L. J., Block, B. S., Salti, G. I., Holt, J. A., CA-125 in peritoneal fluid from patients with nonmalignant gynecologic disorders, Journal of Reproductive Medicine, 39, 510–2, 1994 | The women without any symptom who went through laparoscopic sterilization have been considered as control group |
| Johnson, W. K., Ott, D. J., Chen, M. Y. M., Fayez, J. A., Gelfand, D. W., Efficacy of hysterosalpingography in evaluating endometriosis, Abdominal Imaging, 19, 278–280, 1994 | The study evaluated the effectiveness of hysterosalpingography and laparoscopy-retrospective study |
| Kafali, H., Artuc, H., Demir, N., Use of CA125 fluctuation during the menstrual cycle as a tool in the clinical diagnosis of endometriosis; a preliminary report, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 116, 85–8, 2004 | It is a case-control study |
| Kang, S. B., Chung, H. H., Lee, H. P., Lee, J. Y., Chang, Y. S., Impact of diagnostic laparoscopy on the management of chronic pelvic pain, Surgical Endoscopy, 21, 916–9, 2007 | there was no comparison between laparoscopy and another test |
| Karabacak, O., Tiras, M. B., Taner, M. Z., Guner, H., Yildiz, A., Yildirim, M., Small diameter versus conventional laparoscopy: a prospective, self-controlled study, Human Reproduction, 12, 2399–401, 1997 | Comparison of two types of laparoscopy |
| Kitawaki, J., Ishihara, H., Koshiba, H., Kiyomizu, M., Teramoto, M., Kitaoka, Y., Honjo, H., Usefulness and limits of CA-125 in diagnosis of endometriosis without associated ovarian endometriomas.[Erratum appears in Hum Reprod. 2007 Feb;22(2):627], Human Reproduction, 20, 1999–2003, 2005 | Women enrolled in the study were already diagnosed with endometriosis, adenomyosis and/or leiomyomas |
| Koninckx, P. R., Riittinen, L., Seppala, M., Cornillie, F. J., CA-125 and placental protein 14 concentrations in plasma and peritoneal fluid of women with deeply infiltrating pelvic endometriosis, Fertility & Sterility, 57, 523–30, 1992 | Wrong data and result have been reported. |
| Kruger, K., Behrendt, K., Niedobitek-Kreuter, G., Koltermann, K., Ebert, A. D., Location-dependent value of pelvic MRI in the preoperative diagnosis of endometriosis, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 169, 93–8, 2013 | Pelvic MRI retrospectively assessed with histology |
| Kruitwagen, R. F., Thomas, C., Poels, L. G., Koster, A. M., Willemsen, W. N., Rolland, R., High CA-125 concentrations in peritoneal fluid of normal cyclic women with various infertility-related factors as demonstrated with two-step immunoradiometric assay, Fertility & Sterility, 56, 863–9, 1991 | The outcome of interest has not been reported. |
| Leslie, C., Ma, T., McElhinney, B., Leake, R., Stewart, C. J., Is the detection of endometrial nerve fibers useful in the diagnosis of endometriosis?, International Journal of Gynecological Pathology, 32, 149–55, 2013 | Included as one of the studies in Gupta et al. 2016 review |
| Li, G., Yu, Z., Li, K., The value of FS, NLR, and CA-125 in the diagnosis of endometriosis, International journal of clinical and experimental medicine, 9, 7309–7313, 2016 | Not the population of interest |
| Macer, M. L., Mathur, M., Spektor, M., Gysler, S., Staib, L., Kodaman, P., McCarthy, S., Utility of magnetic resonance imaging in the evaluation of intraoperatively confirmed pelvic adhesions, Journal of Computer Assisted Tomography, 39, 896–900, 2015 | Not the population of interest |
| Malik, E., Berg, C., Meyhofer-Malik, A., Buchweitz, O., Moubayed, P., Diedrich, K., Fluorescence diagnosis of endometriosis using 5-aminolevulinic acid, Surgical Endoscopy, 14, 452–5, 2000 | The test is not of interest |
| Manganaro, L., Fierro, F., Tomei, A., Irimia, D., Lodise, P., Sergi, M. E., Vinci, V., Sollazzo, P., Porpora, M. G., Delfini, R., Vittori, G., Marini, M., Feasibility of 3.0T pelvic MR imaging in the evaluation of endometriosis, European Journal of Radiology, 81, 1381–7, 2012 | Women in the study already had a diagnosis of endometriosis by transvaginal ultrasound |
| Martinez, S., Garrido, N., Coperias, J. L., Pardo, F., Desco, J., Garcia-Velasco, J. A., Simon, C., Pellicer, A., Serum interleukin-6 levels are elevated in women with minimal-mild endometriosis, Human Reproduction, 22, 836–42, 2007 | It is a case-control study |
| Mathlouthi, N., Ayed, B. B., Dhouib, M., Chaabene, K., Trabelsi, K., Amouri, H., Guermazi, M., Confrontation ultrasonography-CA125-histology in the managment of ovarian cysts: A prospective study about 77 cases, Tunisie Medicale, 89, 686–692, 2011 | Full-text in French |
| May, K. E., Conduit-Hulbert, S. A., Villar, J., Kirtley, S., Kennedy, S. H., Becker, C. M., Peripheral biomarkers of endometriosis: a systematic review, Human Reproduction Update, 16, 651–74, 2010 | This systematic review includes papers also regarding other biomarkers. The full texts of individual related studies were retrieved and reviewed. |
| May, K. E., Villar, J., Kirtley, S., Kennedy, S. H., Becker, C. M., Endometrial alterations in endometriosis: a systematic review of putative biomarkers, Human Reproduction Update, 17, 637–53, 2011 | Single studies from the review were assessed for inclusion |
| McBride, N., Newman, R. L., Diagnostic laparoscopy, International Journal of Gynaecology & Obstetrics, 15, 556–8, 1978 | No outcome of interest |
| McKinnon, B., Mueller, M. D., Nirgianakis, K., Bersinger, N. A., Comparison of ovarian cancer markers in endometriosis favours HE4 over CA125, Molecular Medicine Reports, 12, 5179–84, 2015 | No data reported to calculate sensitivity |
| Medl, M., Ogris, E., Peters-Engl, C., Mierau, M., Buxbaum, P., Leodolter, S., Serum levels of the tumour-associated trypsin inhibitor in patients with endometriosis, British Journal of Obstetrics & Gynaecology, 104, 78–81, 1997 | Wrong data and result have been reported. |
| Melega, C., Marchesini, F. P., Bellettini, L., Biscontin, S., Flamigni, C., Diagnostic value of laparoscopy in endometriosis and infertility, Journal of Reproductive Medicine, 29, 597–600, 1984 | No outcome of interest |
| Mezzi, G., Ferrari, S., Arcidiacono, P. G., Di Puppo, F., Candiani, M., Testoni, P. A., Endoscopic rectal ultrasound and elastosonography are useful in flow chart for the diagnosis of deep pelvic endometriosis with rectal involvement, Journal of Obstetrics & Gynaecology Research, 37, 586–90, 2011 | There was no comparison with surgery |
| Mikami, M., Tanabe, K., Matsuo, K., Miyazaki, Y., Miyazawa, M., Hayashi, M., Asai, S., Ikeda, M., Shida, M., Hirasawa, T., Kojima, N., Sho, R., Iijima, S., Fully-sialylated alpha-chain of complement 4-binding protein: Diagnostic utility for ovarian clear cell carcinoma, Gynecologic Oncology, 139, 520–528, 2015 | Not the population of interest |
| Millischer, A. E., Salomon, L. J., Santulli, P., Borghese, B., Dousset, B., Chapron, C., Fusion imaging for evaluation of deep infiltrating endometriosis: feasibility and preliminary results, Ultrasound in Obstetrics & Gynecology, 46, 109–17, 2015 | No data on surgical diagnosis |
| Miyagi, E., Maruyama, Y., Mogami, T., Numazaki, R., Ikeda, A., Yamamoto, H., Hirahara, F., Comparison of plasma amino acid profile-based index and CA125 in the diagnosis of epithelial ovarian cancers and borderline malignant tumors, International Journal of Clinical Oncology, 1–8, 2016 | Not the population of interest |
| Mol, B. W., Bayram, N., Lijmer, J. G., Wiegerinck, M. A., Bongers, M. Y., van der Veen, F., Bossuyt, P. M., The performance of CA-125 measurement in the detection of endometriosis: a metaanalysis, Fertility & Sterility, 70, 1101–8, 1998 | All the studies included in this systematic review could not be included in our systematic review The full-texts of all individual studies were retrieved and reviewed and related studies were included in our review |
| Moloney, M. D., Thornton, J. G., Cooper, E. H., Serum CA 125 antigen levels and disease severity in patients with endometriosis, Obstetrics & Gynecology, 73, 767–9, 1989 | Women had laparoscopically confirmed endometriosis and then CA-125 level has been evaluated |
| Moretuzzo, R. W., DiLauro, S., Jenison, E., Chen, S. L., Reindollar, R. H., McDonough, P. G., Serum and peritoneal lavage fluid CA-125 levels in endometriosis, Fertility & Sterility, 50, 430–3, 1988 | No outcome of interest |
| O’Shaughnessy, A., Check, J. H., Nowroozi, K., Lurie, D., CA 125 levels measured in different phases of the menstrual cycle in screening for endometriosis, Obstetrics & Gynecology, 81, 99–103, 1993 | Wrong data and result have been reported |
| Ota, H., Maki, M., Evaluation of autoantibody and CA125 in the diagnosis of endometriosis or adenomyosis, Medical Science Research, 18, 309–310, 1990 | All the participants had known condition |
| Othman, E. E. D. R., Hornung, D., Al-Hendy, A., Biomarkers of endometriosis, Expert Opinion on Medical Diagnostics, 2, 741–752, 2008 | Narrative review |
| Ozaksit, G., Caglar, T., Cicek, N., Kuscu, E., Batioglu, S., Gokmen, O., Serum CA 125 levels before, during and after treatment for endometriosis, International Journal of Gynaecology & Obstetrics, 50, 269–73, 1995 | Women had a confirmed diagnosis of endometriosis prior to CA-125 test |
| Paiva, P., Lappas, M., Barker, G., Healey, M., Using symptom scores, lifestyle measures and biochemical markers to create a test for endometriosis, Journal of Endometriosis and Pelvic Pain Disorders, 6, 135–143, 2014 | No outcome of interest |
| Panidis, D., Vlassis, G., Matalliotakis, J., Skiadopoulos, S., Kalogeropoulos, A., Serum levels of the oncofetal antigens CA-125, CA 19–9 and CA 15–3 in patients with endometriosis, Journal of Endocrinological Investigation, 11, 801–804, 1988 | All women who involved in the study have proven endometriosis |
| Pastorfide, G., Fong, Y. F., Use of narrowband imaging for the detection of endometriosis, Journal of Minimally Invasive Gynecology, 22, 535, 2015 | No outcome of interest |
| Patel, M. D., Feldstein, V. A., Chen, D. C., Lipson, S. D., Filly, R. A., Endometriomas: diagnostic performance of US.[Erratum appears in Radiology 1999 Dec;213(3):930], Radiology, 210, 739–45, 1999 | Retrospective review of sonograms by two sonologists |
| Patel, M. D., Feldstein, V. A., Filly, R. A., The likelihood ratio of sonographic findings for the diagnosis of hemorrhagic ovarian cysts, Journal of Ultrasound in Medicine, 24, 607–14; quiz 615, 2005 | It is about diagnosis of haemorrhagic ovarian cyst not endometrioma |
| Patton, P. E., Field, C. S., Harms, R. W., Coulam, C. B., CA-125 levels in endometriosis, Fertility & Sterility, 45, 770–3, 1986 | Women who come for elective sterilization have been also included in this study, while they are not suspected for endometriosis |
| Philip, C. A., Bisch, C., Coulon, A., de Saint-Hilaire, P., Rudigoz, R. C., Dubernard, G., Correlation between three-dimensional rectosonography and magnetic resonance imaging in the diagnosis of rectosigmoid endometriosis: a preliminary study on the first fifty cases, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 187, 35–40, 2015 | MRI was the reference test |
| Piessens, S., Healey, M., Maher, P., Tsaltas, J., Rombauts, L., Can anyone screen for deep infiltrating endometriosis with transvaginal ultrasound?, Australian & New Zealand Journal of Obstetrics & Gynaecology, 54, 462–8, 2014 | Women included in the study had the ultrasound test after diagnosis of endometriosis by surgery |
| Pittaway, D. E., Douglas, J. W., Serum CA-125 in women with endometriosis and chronic pelvic pain, Fertility & Sterility, 51, 68–70, 1989 | The cut-off for CA-125 is 16 U/ml |
| Polisseni, F., Bambirra, E. A., Camargos, A. F., Detection of chronic endometritis by diagnostic hysteroscopy in asymptomatic infertile patients, Gynecologic & Obstetric Investigation, 55, 205–10, 2003 | Comparison not of interest |
| Randall, G. W., Gantt, P. A., Poe-Zeigler, R. L., Bergmann, C. A., Noel, M. E., Strawbridge, W. R., Richardson-Cox, B., Hereford, J. R., Reiff, R. H., Serum antiendometrial antibodies and diagnosis of endometriosis, American Journal of Reproductive Immunology, 58, 374–82, 2007 | The diagnostic test which has been used in this study is not matched with the protocol |
| Redwine, D. B., Ovarian endometriosis: A marker for more extensive pelvic and intestinal disease, Fertility and Sterility, 72, 310–315, 1999 | All the patients have endometriosis |
| Reid, S., Lu, C., Casikar, I., Reid, G., Abbott, J., Cario, G., Chou, D., Kowalski, D., Cooper, M., Condous, G., Prediction of pouch of Douglas obliteration in women with suspected endometriosis using a new real-time dynamic transvaginal ultrasound technique: the sliding sign, Ultrasound in Obstetrics & Gynecology, 41, 685–91, 2013 | It has focused on the pouch of Douglas obliteration not only endometriosis |
| Rosa, E. Silva A. C., Rosa, E. Silva J. C., Ferriani, R. A., Serum CA-125 in the diagnosis of endometriosis, International Journal of Gynaecology & Obstetrics, 96, 206–7, 2007 | Retrospective study. Women included in the study already had a diagnosis of endometriosis prior to serum CA-125 collection |
| Saba, L., Guerriero, S., Sulcis, R., Ajossa, S., Melis, G., Mallarini, G., Agreement and reproducibility in identification of endometriosis using magnetic resonance imaging, Acta Radiologica, 51, 573–80, 2010 | No outcome of interest |
| Saba, L., Guerriero, S., Sulis, R., Pilloni, M., Ajossa, S., Melis, G., Mallarini, G., Learning curve in the detection of ovarian and deep endometriosis by using Magnetic Resonance: comparison with surgical results, European Journal of Radiology, 79, 237–44, 2011 | The aim of the study was to determine whether diagnostic accuracy is correlated to radiologist expertise |
| Scardapane, A., Bettocchi, S., Lorusso, F., Stabile Ianora, A. A., Vimercati, A., Ceci, O., Lasciarrea, M., Angelelli, G., Diagnosis of colorectal endometriosis: contribution of contrast enhanced MR-colonography, European Radiology, 21, 1553–63, 2011 | Comparison of MRI between two radiologists |
| Scardapane, A., Lorusso, F., Scioscia, M., Ferrante, A., Stabile Ianora, A. A., Angelelli, G., Standard high-resolution pelvic MRI vs. low-resolution pelvic MRI in the evaluation of deep infiltrating endometriosis, European Radiology, 24, 2590–6, 2014 | Comparison of MRI carried out by two different radiologists |
| Schenken, R. S., Improving the diagnosis of endometriosis in adolescents, Sexuality, Reproduction and Menopause, 6, 4–8, 2008 | Narrative review |
| Seeber, B., Sammel, M. D., Fan, X., Gerton, G. L., Shaunik, A., Chittams, J., Barnhart, K. T., Panel of markers can accurately predict endometriosis in a subset of patients, Fertility & Sterility, 89, 1073–81, 2008 | It is a case-control study |
| Shen, A., Xu, S., Ma, Y., Guo, H., Li, C., Yang, C., Zou, S., Diagnostic value of serum CA125, CA19–9 and CA15–3 in endometriosis: A meta-analysis, Journal of International Medical Research, 43, 599–609, 2015 | It is about association of biomarkers and stage of endometriosis. No outcome of interest. |
| Somigliana, E., Vigano, P., Candiani, M., Felicetta, I., Di Blasio, A. M., Vignali, M., Use of serum-soluble intercellular adhesion molecule-1 as a new marker of endometriosis, Fertility & Sterility, 77, 1028–31, 2002 | Women included in the study already had laparoscopy prior to CA-125 serum collection |
| Somigliana, E., Vigano, P., Tirelli, A. S., Felicetta, I., Torresani, E., Vignali, M., Di Blasio, A. M., Use of the concomitant serum dosage of CA 125, CA 19–9 and interleukin-6 to detect the presence of endometriosis. Results from a series of reproductive age women undergoing laparoscopic surgery for benign gynaecological conditions, Human Reproduction, 19, 1871–6, 2004 | Case-control study |
| Spencer, J. A., Weston, M. J., Imaging in endometriosis, Imaging, 15, 63–71, 2003 | Narrative review |
| Stowell, S. B., Wiley, C. M., Perez-Reyes, N., Powers, C. N., Cytologic diagnosis of peritoneal fluids. Applicability to the laparoscopic diagnosis of endometriosis, Acta Cytologica, 41, 817–22, 1997 | The diagnostic test in this study is not matched with the protocol |
| Szubert, M., Suzin, J., Wierzbowski, T., Kowalczyk-Amico, K., CA-125 concentration in serum and peritoneal fluid in patients with endometriosis - preliminary results, Archives of Medical Science, 8, 504–8, 2012 | Case control study |
| Takahashi, K., Nagata, H., Kitao, M., CA-125 in the menstrual blood is an effective marker for diagnosing early stage endometriosis: A preliminary report, Japanese Journal of Fertility and Sterility, 36, 356–359, 1991 | Ultrasound was used to confirm ovulatory day only |
| Takahashi, K., Nagata, H., Musa, A. A., Shibukawa, T., Yamasaki, H., Kitao, M., Clinical usefulness of CA-125 levels in the menstrual discharge in patients with endometriosis, Fertility & Sterility, 54, 360–2, 1990 | The level of CA-125 has been assessed in the menstrual discharge |
| Takeuchi, M., Matsuzaki, K., Nishitani, H., Susceptibility-weighted MRI of endometrioma: preliminary results, AJR. American Journal of Roentgenology, 191, 1366–70, 2008 | No outcome of interest |
| Tirlapur, S. A., Daniels, J. P., Khan, K. S., Medal trial collaboration, Chronic pelvic pain: how does noninvasive imaging compare with diagnostic laparoscopy?, Current Opinion in Obstetrics & Gynecology, 27, 445–8, 2015 | This systematic review has not only focused on patients with suspected endometriosis. It is more general about pelvic pain and diagnostic tools |
| Tumedei, U., Ciardelli, V., Paltrinieri, F., Kuria, M. S., Amadori, A., Stefanetti, M., Gori, G., Transvaginal ultrasound in the diagnosis of endometrial abnormalities, Tumori, 87, S15, 2001 | It has focused on endometrial abnormalities not endometriosis |
| Van den Bosch, T., Vandendael, A., Van Schoubroeck, D., Wranz, P. A. B., Lombard, C. J., Combining vaginal ultrasonography and office endometrial sampling in the diagnosis of endometrial disease in postmenopausal women, Obstetrics and Gynecology, 85, 349–352, 1995 | It is not about endometriosis, it has addressed endometrial diseases |
| Vrachnis, N., Sifakis, S., Samoli, E., Kappou, D., Pavlakis, K., Iliodromiti, Z., Botsis, D., Three-dimensional ultrasound and three-dimensional power Doppler improve the preoperative evaluation of complex benign ovarian lesions, Clinical & Experimental Obstetrics & Gynecology, 39, 474–8, 2012 | No outcome of interest |
| Walsh, J. W., Taylor, K. J., Wasson, J. F., Schwartz, P. E., Rosenfield, A. T., Gray-scale ultrasound in 204 proved gynecologic masses: accuracy and specific diagnostic criteria, Radiology, 130, 391–7, 1979 | No outcome of interest. |
| Wang, L., Liu, H. Y., Shi, H. H., Lang, J. H., Sun, W., Urine peptide patterns for non-invasive diagnosis of endometriosis: a preliminary prospective study, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 177, 23–8, 2014 | Biomarker not of interest |
| Wessels, J. M., Kay, V. R., Leyland, N. A., Agarwal, S. K., Foster, W. G., Assessing brain-derived neurotrophic factor as a novel clinical marker of endometriosis, Fertility & Sterility, 105, 119128.e5, 2016 | Not the test of interest |
| Wild, R. A., Hirisave, V., Bianco, A., Podczaski, E. S., Demers, L. M., Endometrial antibodies versus CA-125 for the detection of endometriosis, Fertility & Sterility, 55, 90–4, 1991 | The cut-off for CA-125 is 16 U/ml |
| Wolfler, M. M., Nagele, F., Kolbus, A., Seidl, S., Schneider, B., Huber, J. C., Tschugguel, W., A predictive model for endometriosis, Human Reproduction, 20, 1702–8, 2005 | Biomarker not of interest |
| Yamashita, Y., Torashima, M., Hatanaka, Y., Harada, M., Higashida, Y., Takahashi, M., Mizutani, H., Tashiro, H., Iwamasa, J., Miyazaki, K., et al.,, Adnexal masses: accuracy of characterization with transvaginal US and precontrast and postcontrast MR imaging, Radiology, 194, 557–65, 1995 | Review of MRI and TVUS by five radiologists |
| Yazbek, J., Helmy, S., Ben-Nagi, J., Holland, T., Sawyer, E., Jurkovic, D., Value of preoperative ultrasound examination in the selection of women with adnexal masses for laparoscopic surgery, Ultrasound in Obstetrics and Gynecology, 30, 883–888, 2007 | The preoperative sonography has not been used to diagnose endometriosis |
| Zapardiel, I., Gorostidi, M., Ravaggi, A., Allende, M. T., Silveira, M., Abehsera, D., MacUks, R., Utility Serum Marker HE4 for the Differential Diagnosis between Endometriosis and Adnexal Malignancy, International Journal of Gynecological Cancer, 26, 52–55, 2016 | No data on surgical diagnosis |
| Zhang Y, Qiao C, Li L, Zhao X, Li Y. Serum HE4 is more suitable as a biomarker than CA125 in Chinese women with benign gynecologic disorders. Afr Health Sci, 14(4):913–8, 2014 | Included in the nerve fibres question |
H.10. Diagnosis – MRI
| Study | Reason for Exclusion |
|---|---|
| Abrao, M. S., Goncalves, M. O., Dias, J. A., Jr., Podgaec, S., Chamie, L. P., Blasbalg, R., Comparison between clinical examination, transvaginal sonography and magnetic resonance imaging for the diagnosis of deep endometriosis, Human Reproduction, 22, 3092–7, 2007 | Included as one of the studies in the Nisenblat 2016 review |
| Abrao, M. S., Podgaec, S., Filho, B. M., Ramos, L. O., Pinotti, J. A., de Oliveira, R. M., The use of biochemical markers in the diagnosis of pelvic endometriosis, Human Reproduction, 12, 2523–7, 1997 | Case-control study |
| Abrao, M. S., Podgaec, S., Pinotti, J. A., de Oliveira, R. M., Tumor markers in endometriosis, International Journal of Gynaecology & Obstetrics, 66, 19–22, 1999 | Case-control study |
| Abu-Musa, A., Takahashi, K., Nagata, H., Yamasaki, H., Mizoguchi, S., Kitao, M., CA-125 in menstrual discharge in patients with chronic pelvic pain, International Journal of Gynaecology & Obstetrics, 37, 111–4, 1992 | Not MRI, but included for CA-125 |
| Acimovic, M., Vidakovic, S., Milic, N., Jeremic, K., Markovic, M., Milosevic-Djeric, A., Lazovic-Radonjic, G., Survivin and Vegf as Novel Biomarkers in Diagnosis of Endometriosis, Journal of Medical Biochemistry, 35, 63–68, 2016 | No laparoscopy/laparotomy and no histological confirmation |
| Alcazar, J. L., Laparte, C., Jurado, M., Lopez-Garcia, G., The role of transvaginal ultrasonography combined with color velocity imaging and pulsed Doppler in the diagnosis of endometrioma, Fertility & Sterility, 67, 487–91, 1997 | Mixed population: postmenopausal women included; ‘lesion-level’ analysis |
| Aleem, F., Pennisi, J., Zeitoun, K., Predanic, M., The role of color Doppler in diagnosis of endometriomas, Ultrasound in Obstetrics & Gynecology, 5, 51–4, 1995 | The aim of this study is to describe vascular appearance in endometriomas. No outcome of interest. |
| Al-Jefout, M., Dezarnaulds, G., Cooper, M., Tokushige, N., Luscombe, G. M., Markham, R., Fraser, I. S., Diagnosis of endometriosis by detection of nerve fibres in an endometrial biopsy: a double blind study, Human Reproduction (Oxford, England), 24, 3019–24, 2009 | Not MRI, but included for nerve fibres |
| Anaf, V., El Nakadi, I., De Moor, V., Coppens, E., Zalcman, M., Noel, J. C., Anatomic significance of a positive barium enema in deep infiltrating endometriosis of the large bowel, World Journal of Surgery, 33, 822–7, 2009 | All patients had surgery and DCBE |
| Ascher, S. M., Agrawal, R., Bis, K. G., Brown, E. D., Maximovich, A., Markham, S. M., Patt, R. H., Semelka, R. C., Endometriosis: appearance and detection with conventional and contrast-enhanced fat-suppressed spin-echo techniques, Journal of Magnetic Resonance Imaging, 5, 251–7, 1995 | Included as one of the studies in the Nisenblat 2016 review |
| Bahr, A., de Parades, V., Gadonneix, P., Etienney, I., Salet-Lizee, D., Villet, R., Atienza, P., Endorectal ultrasonography in predicting rectal wall infiltration in patients with deep pelvic endometriosis: a modern tool for an ancient disease, Diseases of the Colon & Rectum, 49, 869–75, 2006 | Included for ultrasound review |
| Balasch, J., Creus, M., Fabregues, F., Carmona, F., Ordi, J., Martinez-Roman, S., Vanrell, J. A., Visible and non-visible endometriosis at laparoscopy in fertile and infertile women and in patients with chronic pelvic pain: a prospective study, Human Reproduction, 11, 387–91, 1996 | Not a diagnostic study |
| Balleyguier, C., Roupret, M., Nguyen, T., Kinkel, K., Helenon, O., Chapron, C., Ureteral endometriosis: the role of magnetic resonance imaging, Journal of the American Association of Gynecologic Laparoscopists, 11, 530–6, 2004 | No outcome of interest. Moreover, only 6 patients were included. |
| Barbati, A., Cosmi, E. V., Spaziani, R., Ventura, R., Montanino, G., Serum and peritoneal fluid CA-125 levels in patients with endometriosis, Fertility & Sterility, 61, 438–42, 1994 | Case-control study |
| Barbieri, R. L., Niloff, J. M., Bast, R. C., Jr., Scaetzl, E., Kistner, R. W., Knapp, R. C., Elevated serum concentrations of CA-125 in patients with advanced endometriosis, Fertility & Sterility, 45, 630–4, 1986 | Case-control study |
| Barcellos, M. B., Lasmar, B., Lasmar, R., Agreement between the preoperative findings and the operative diagnosis in patients with deep endometriosis, Archives of Gynecology & Obstetrics Arch Gynecol Obstet, 293, 845–50, 2016 | Lesion-level analysis |
| Bayoglu Tekin, Y., Dede, F. S., What is the success of ultrasonography of benign adnexal masses?, Journal of Obstetrics & Gynaecology Research, 40, 473–8, 2014 | Not MRI, but included for ultrasound |
| Bazot, M., Bornier, C., Dubernard, G., Roseau, G., Cortez, A., Darai, E., Accuracy of magnetic resonance imaging and rectal endoscopic sonography for the prediction of location of deep pelvic endometriosis, Human Reproduction, 22, 1457–63, 2007 | Population overlap with Bazot 2009 |
| Bazot, M., Darai, E., Hourani, R., Thomassin, I., Cortez, A., Uzan, S., Buy, J. N., Deep pelvic endometriosis: MR imaging for diagnosis and prediction of extension of disease, Radiology, 232, 379–89, 2004 | Overlap of population from Bazot 2009 |
| Bazot, M., Detchev, R., Cortez, A., Amouyal, P., Uzan, S., Darai, E., Transvaginal sonography and rectal endoscopic sonography for the assessment of pelvic endometriosis: a preliminary comparison, Human Reproduction, 18, 1686–92, 2003 | Population overlapped with Bazot 2009 |
| Bazot, M., Gasner, A., Ballester, M., Darai, E., Value of thin-section oblique axial T2-weighted magnetic resonance images to assess uterosacral ligament endometriosis, Human Reproduction, 26, 346–53, 2011 | Retrospective selection of cases |
| Bazot, M., Gasner, A., Lafont, C., Ballester, M., Darai, E., Deep pelvic endometriosis: limited additional diagnostic value of postcontrast in comparison with conventional MR images, European Journal of Radiology, 80, e331–9, 2011 | Retrospective selection of cases |
| Bazot, M., Lafont, C., Rouzier, R., Roseau, G., Thomassin-Naggara, I., Darai, E., Diagnostic accuracy of physical examination, transvaginal sonography, rectal endoscopic sonography, and magnetic resonance imaging to diagnose deep infiltrating endometriosis, Fertility & Sterility, 92, 1825–33, 2009 | Included as one of the studies in the Nisenblat 2016 review |
| Bazot, M., Malzy, P., Cortez, A., Roseau, G., Amouyal, P., Darai, E., Accuracy of transvaginal sonography and rectal endoscopic sonography in the diagnosis of deep infiltrating endometriosis, Ultrasound in Obstetrics & Gynecology, 30, 994–1001, 2007 | Overlap with Bazot 2009 |
| Bazot, M., Stivalet, A., Darai, E., Coudray, C., Thomassin Naggara, I., Poncelet, E., Comparison of 3D and 2D FSE T2-weighted MRI in the diagnosis of deep pelvic endometriosis: preliminary results, Clinical Radiology, 68, 47–54, 2013 | Included as one of the studies in the Nisenblat 2016 review |
| Bazot, M., Thomassin, I., Hourani, R., Cortez, A., Darai, E., Diagnostic accuracy of transvaginal sonography for deep pelvic endometriosis, Ultrasound in Obstetrics & Gynecology, 24, 180–5, 2004 | Not MRI, but included for ultrasound |
| Bedaiwy, M. A., Falcone, T., Laboratory testing for endometriosis, Clinica Chimica Acta, 340, 41–56, 2004 | Narrative review |
| Bedaiwy, M. A., Falcone, T., Sharma, R. K., Goldberg, J. M., Attaran, M., Nelson, D. R., Agarwal, A., Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial, Human Reproduction, 17, 426–31, 2002 | Biomarkers not of interest |
| Belghiti, J., Thomassin-Naggara, I., Zacharopoulou, C., Zilberman, S., Jarboui, L., Bazot, M., Ballester, M., Darai, E., Contribution of Computed Tomography Enema and Magnetic Resonance Imaging to Diagnose Multifocal and Multicentric Bowel Lesions in Patients With Colorectal Endometriosis, Journal of Minimally Invasive Gynecology, 22, 776–84, 2015 | Lesion-level analysis |
| Belli, P., De Gaetano, A. M., Mirk, P., Speca, S., Valentini, A. L., Uterine adenomyosis and tubal endometriosis: diagnostic imaging, Rays, 23, 693–701, 1998 | Narrative review |
| Benacerraf, B. R., Finkler, N. J., Wojciechowski, C., Knapp, R. C., Sonographic accuracy in the diagnosis of ovarian masses, Journal of Reproductive Medicine for the Obstetrician and Gynecologist, 35, 491–495, 1990 | No outcome of interest |
| Benacerraf, B. R., Groszmann, Y., Sonography should be the first imaging examination done to evaluate patients with suspected endometriosis, Journal of Ultrasound in Medicine, 31, 651–3, 2012 | Narrative review |
| Bergamini, V., Ghezzi, F., Scarperi, S., Raffaelli, R., Cromi, A., Franchi, M., Preoperative assessment of intestinal endometriosis: A comparison of transvaginal sonography with water-contrast in the rectum, transrectal sonography, and barium enema, Abdominal Imaging, 35, 732–6, 2010 | Not MRI, but included for ultrasound |
| Biscaldi, E., Ferrero, S., Leone Roberti Maggiore, U., Remorgida, V., Venturini, P. L., Rollandi, G. A., Multidetector computerized tomography enema versus magnetic resonance enema in the diagnosis of rectosigmoid endometriosis, European Journal of Radiology, 83, 261–7, 2014 | Included as one of the studies in the Nisenblat 2016 review |
| Boog, G., Penot, P., Momber, A., Ultrasound as a diagnostic aid in endometriosis, Contributions to Gynecology & Obstetrics, 16, 119–24, 1987 | retrospective selection of cases |
| Bordin, L., Fiore, C., Dona, G., Andrisani, A., Ambrosini, G., Faggian, D., Plebani, M., Clari, G., Armanini, D., Evaluation of erythrocyte band 3 phosphotyrosine level, glutathione content, CA-125, and human epididymal secretory protein E4 as combined parameters in endometriosis, Fertility & Sterility, 94, 1616–21, 2010 | All the patients have proven endometriosis |
| Camagna, O., Dhainaut, C., Dupuis, O., Soncini, E., Martin, B., Palazzo, L., Chosidow, D., Madelenat, P., [Surgical management of rectovaginal septum endometriosis from a continuous series of 50 cases], Gynecologie, Obstetrique & Fertilite, 32, 199–209, 2004 | Full text in French |
| Carbognin, G., Girardi, V., Pinali, L., Raffaelli, R., Bergamini, V., Pozzi Mucelli, R., Assessment of pelvic endometriosis: correlation of US and MRI with laparoscopic findings, Radiologia Medica, 111, 687–701, 2006 | Analysis included lesions, not number of participants |
| Chamie, L. P., Blasbalg, R., Goncalves, M. O., Carvalho, F. M., Abrao, M. S., de Oliveira, I. S., Accuracy of magnetic resonance imaging for diagnosis and preoperative assessment of deeply infiltrating endometriosis, International Journal of Gynaecology & Obstetrics, 106, 198–201, 2009 | Included as one of the studies in the Nisenblat 2016 review |
| Chapron, C., Vieira, M., Chopin, N., Balleyguier, C., Barakat, H., Dumontier, I., Roseau, G., Fauconnier, A., Foulot, H., Dousset, B., Accuracy of rectal endoscopic ultrasonography and magnetic resonance imaging in the diagnosis of rectal involvement for patients presenting with deeply infiltrating endometriosis, Ultrasound in Obstetrics & Gynecology, 24, 175–9, 2004 | Retrospective selection of cases |
| Chen, F. P., Soong, Y. K., Lee, N., Lo, S. K., The use of serum CA-125 as a marker for endometriosis in patients with dysmenorrhea for monitoring therapy and for recurrence of endometriosis, Acta Obstetricia et Gynecologica Scandinavica, 77, 665–70, 1998 | Not MRI, but included for CA125 |
| Cheng, Y. M., Wang, S. T., Chou, C. Y., Serum CA-125 in preoperative patients at high risk for endometriosis, Obstetrics & Gynecology, 99, 375–80, 2002 | CA-125 has been used for identifying high risk woman not as a diagnostic tool |
| Cho, S., Cho, H., Nam, A., Kim, H. Y., Choi, Y. S., Park, K. H., Cho, D. J., Lee, B. S., Neutrophil-to-lymphocyte ratio as an adjunct to CA-125 for the diagnosis of endometriosis, Fertility & Sterility, 90, 2073–9, 2008 | It is a case-control study |
| Chung, M. K., Chung, R. R., Gordon, D., Jennings, C., The evil twins of chronic pelvic pain syndrome: endometriosis and interstitial cystitis, JSLS: Journal of the Society of Laparoendoscopic Surgeons / Society of Laparoendoscopic Surgeons, 6, 311–314, 2002 | No outcome of interest |
| Cicinelli, E., Resta, L., Nicoletti, R., Tartagni, M., Marinaccio, M., Bulletti, C., Colafiglio, G., Detection of chronic endometritis at fluid hysteroscopy, Journal of Minimally Invasive Gynecology, 12, 514–518, 2005 | Not MRI, but included for hysteroscopy |
| Cohen, L. S., Valle, R. F., Sabbagha, R. E., A comparison of preoperative ultrasound images of surgically proven endometriomas scanned by both transabdominal and transvaginal techniques, Journal of Gynecologic Surgery, 11, 27–32, 1995 | All the patients have surgically confirmed endometriosis. |
| Cohen, M. R., Laparoscopy in the diagnosis and management of endometriosis, Journal of Reproductive Medicine, 27, 240–2, 1982 | No outcome of interest |
| Colacurci, N., Fortunato, N., De Franciscis, P., Cardone, A., Relevance of CA-125 in the evaluation of endometriosis, Clinical & Experimental Obstetrics & Gynecology, 23, 150–4, 1996 | Not MRI, but included for CA125 |
| Colacurci, N., Fortunato, N., De Franciscis, P., Fratta, M., Cioffi, M., Zarcone, R., Cardone, A., Serum and peritoneal CA-125 levels as diagnostic test for endometriosis, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 66, 41–3, 1996 | Case-control study |
| Coleman, B. G., Arger, P. H., Mulhern, C. B., Jr., Endometriosis: clinical and ultrasonic correlation, AJR. American Journal of Roentgenology, 132, 747–9, 1979 | All patients were recruited in this study, had surgically proven endometriosis |
| Corwin, M. T., Gerscovich, E. O., Lamba, R., Wilson, M., McGahan, J. P., Differentiation of ovarian endometriomas from hemorrhagic cysts at MR imaging: utility of the T2 dark spot sign, Radiology, 271, 126–32, 2014 | Using a diagnostic test to diagnose endometriosis has not been addressed in this study. It is about a sign in MRI to distinguish between Endometrioma and haemorrhagic cysts. |
| Daniilidis, A., Giannoulis, H., Tantanasis, T., Papathanasiou, K., Loufopoulos, A., Tzafettas, J., Diagnostic laparoscopy, infertility, and endometriosis - 5 Years experience, Gynecological Surgery, 5, 231–234, 2008 | Outcomes not of interest |
| de Kroon, C. D., van der Sandt, H. A., van Houwelingen, J. C., Jansen, F. W., Sonographic assessment of non-malignant ovarian cysts: does sonohistology exist?, Human Reproduction, 19, 2138–43, 2004 | Not MRI, but included for ultrasound |
| Dechaud, H., Ali Ahmed, S. A., Aligier, N., Vergnes, C., Hedon, B., Does transvaginal hydrolaparoscopy render standard diagnostic laparoscopy obsolete for unexplained infertility investigation?, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 94, 97–102, 2001 | Transvaginal hydrolaparoscopy compared with conventional laparoscopy; no data for outcomes |
| Delpy, R., Barthet, M., Gasmi, M., Berdah, S., Shojai, R., Desjeux, A., Boubli, L., Grimaud, J. C., Value of endorectal ultrasonography for diagnosing rectovaginal septal endometriosis infiltrating the rectum, Endoscopy, 37, 357–61, 2005 | unable to construct 2 × 2 tables |
| Dessole, S., Farina, M., Rubattu, G., Cosmi, E., Ambrosini, G., Nardelli, G. B., Sonovaginography is a new technique for assessing rectovaginal endometriosis, Fertility & Sterility, 79, 1023–7, 2003 | Not MRI, but included for ultrasound |
| do Amaral, V. F., Ferriani, R. A., de Sa, M. F. S., Nogueira, A. A., Silva, J. C. R., de Sa Rosa e Silva, A. C. J., de Moura, M. D., Positive correlation between serum and peritoneal fluid CA-125 levels in women with pelvic endometriosis, Sao Paulo Medical Journal, 124, 223–227, 2006 | It is a case-control study |
| Dogan, M. M., Ugur, M., Soysal, S. K., Soysal, M. E., Ekici, E., Gokmen, O., Transvaginal sonographic diagnosis of ovarian endometrioma, International Journal of Gynaecology & Obstetrics, 52, 145–9, 1996 | ‘Lesion-level’ analysis |
| Dunselman, G. A. J., Vermeulen, N., Becker, C., Calhaz-Jorge, C., D’Hooghe, T., De Bie, B., Heikinheimo, O., Horne, A. W., Kiesel, L., Nap, A., Prentice, A., Saridogan, E., Soriano, D., Nelen, W., ESHRE guideline: Management of women with endometriosis, Human Reproduction, 29, 400–412, 2014 | The individual studies in this publication have been checked for inclusion in the review |
| El Maati, A. A. A., Ibrahim, E. A. G., Mokhtar, F. Z., A two-stage imaging protocol for evaluating women presenting with acute pelvic pain, Egyptian Journal of Radiology and Nuclear Medicine, 44, 923–936, 2013 | The population is women with acute pelvic pain, not suspected endometriosis |
| Elgafor El Sharkwy, I. A., Combination of non-invasive and semiinvasive tests for diagnosis of minimal to mild endometriosis, Archives of gynecology and obstetrics, 288, 793–7, 2013 | The diagnostic test (IL-6 combined with nerve fibres) which has been used in this study is not matched with the protocol |
| Ellett, L., Readman, E., Newman, M., McIlwaine, K., Villegas, R., Jagasia, N., Maher, P., Are endometrial nerve fibres unique to endometriosis? A prospective case-control study of endometrial biopsy as a diagnostic test for endometriosis in women with pelvic pain, Human Reproduction, 30, 2808–15, 2015 | Case-control study |
| Eskenazi, B., Warner, M., Bonsignore, L., Olive, D., Samuels, S., Vercellini, P., Validation study of nonsurgical diagnosis of endometriosis, Fertility & Sterility, 76, 929–35, 2001 | Not MRI, but included for ultrasound |
| Exacoustos, C., Luciano, D., Corbett, B., De Felice, G., Di Feliciantonio, M., Luciano, A., Zupi, E., The uterine junctional zone: a 3-dimensional ultrasound study of patients with endometriosis, American Journal of Obstetrics & Gynecology, 209, 248.e1–7, 2013 | In the study, the relation between thickness of uterine junctional zone and endometriosis has been evaluated. It has not been used as a diagnostic tool. |
| Exacoustos, C., Malzoni, M., Di Giovanni, A., Lazzeri, L., Tosti, C., Petraglia, F., Zupi, E., Ultrasound mapping system for the surgical management of deep infiltrating endometriosis, Fertility & Sterility, 102, 143–150.e2, 2014 | Not MRI, but included for ultrasound |
| Faccioli, N., Foti, G., Manfredi, R., Mainardi, P., Spoto, E., Ruffo, G., Minelli, L., Mucelli, R. P., Evaluation of colonic involvement in endometriosis: double-contrast barium enema vs. magnetic resonance imaging, Abdominal Imaging, 35, 414–21, 2010 | ‘Lesion-level’ analysis |
| Faccioli, N., Manfredi, R., Mainardi, P., Dalla Chiara, E., Spoto, E., Minelli, L., Mucelli, R. P., Barium enema evaluation of colonic involvement in endometriosis, AJR. American Journal of Roentgenology, 190, 1050–4, 2008 | Retrospective selection of cases; ‘lesion-level’ analysis |
| Fedele, L., Arcaini, L., Vercellini, P., Marchini, M., Baglioni, A., Bianchi, S., Serum Ca-125 concentrations in endometriosis, Acta Europaea Fertilitatis, 20, 137–9, 1989 | Not MRI, but included for CA-125 |
| Fedele, L., Bianchi, S., Portuese, A., Borruto, F., Dorta, M., Transrectal ultrasonography in the assessment of rectovaginal endometriosis, Obstetrics & Gynecology, 91, 444–8, 1998 | Not MRI, but included for ultrasound |
| Federici, D., Muggiasca, M. L., Conti, M., Diagnostic value of laparoscopic evaluation of women with chronic pelvic pain: Our experience and a review of the literature, VALEUR DIAGNOSTIQUE DE L’EXPLORATION LAPAROSCOPIQUE DES FEMMES SOUFFRANT DE DOULEURS PELVIENNES CHRONIQUES: EXPERIENCE PERSONNELLE ET REVUE DE LA LITTERATURE, Acta Endoscopica, 22, 177–186, 1992 | Narrative review |
| Felding, C., Mikkelsen, A. L., Peen, U., Laparoscopy and ultrasound in patients with chronic pelvic pain, Journal of Obstetrics and Gynaecology, 10, 419–422, 1990 | No outcome of interest |
| Ferrero, S., Biscaldi, E., Morotti, M., Venturini, P. L., Remorgida, V., Rollandi, G. A., Valenzano Menada, M., Multidetector computerized tomography enteroclysis vs. rectal water contrast transvaginal ultrasonography in determining the presence and extent of bowel endometriosis, Ultrasound in Obstetrics & Gynecology, 37, 603–13, 2011 | Not MRI, but included for ultrasound |
| Fiaschetti, V., Crusco, S., Meschini, A., Cama, V., Di Vito, L., Marziali, M., Piccione, E., Calabria, F., Simonetti, G., Deeply infiltrating endometriosis: evaluation of retro-cervical space on MRI after vaginal opacification, European Journal of Radiology, 81, 3638–45, 2012 | Lesion-level analysis |
| Fisk, N. M., Tan, C. E., CA 125 in peritoneal fluid and serum of patients with endometriosis, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 29, 153–8, 1988 | Case-control study |
| Foda, A. A., Aal, I. A. A., Role of some biomarkers in chronic pelvic pain for early detection of endometriosis in infertile women, Middle East Fertility Society Journal, 17, 187–194, 2012 | Case-control study |
| Fratelli, N., Scioscia, M., Bassi, E., Musola, M., Minelli, L., Trivella, G., Transvaginal sonography for preoperative assessment of deep endometriosis, Journal of Clinical Ultrasound, 41, 69–75, 2013 | Data for TVS was collected retrospectively |
| Friedman, H., Vogelzang, R. L., Mendelson, E. B., Neiman, H. L., Cohen, M., Endometriosis detection by US with laparoscopic correlation, Radiology, 157, 217–20, 1985 | No data on outcomes |
| Goncalves, M. O., Podgaec, S., Dias, J. A., Jr., Gonzalez, M., Abrao, M. S., Transvaginal ultrasonography with bowel preparation is able to predict the number of lesions and rectosigmoid layers affected in cases of deep endometriosis, defining surgical strategy, Human Reproduction, 25, 665–71, 2010 | Not MRI, but included for ultrasound |
| Gougoutas, C. A., Siegelman, E. S., Hunt, J., Outwater, E. K., Pelvic endometriosis: various manifestations and MR imaging findings, AJR. American Journal of Roentgenology, 175, 353–8, 2000 | Narrative review |
| Grasso, R. F., Di Giacomo, V., Sedati, P., Sizzi, O., Florio, G., Faiella, E., Rossetti, A., Del Vescovo, R., Zobel, B. B., Diagnosis of deep infiltrating endometriosis: accuracy of magnetic resonance imaging and transvaginal 3D ultrasonography, Abdominal Imaging, 35, 716–25, 2010 | Included as one of the studies in the Nisenblat 2016 review |
| Guerriero, S., Ajossa, S., Gerada, M., Virgilio, B., Angioni, S., Melis, G. B., Diagnostic value of transvaginal ‘tenderness-guided’ ultrasonography for the prediction of location of deep endometriosis, Human Reproduction, 23, 2452–7, 2008 | Not MRI, but included for ultrasound |
| Guerriero, S., Ajossa, S., Mais, V., Risalvato, A., Lai, M. P., Melis, G. B., The diagnosis of endometriomas using colour Doppler energy imaging, Human Reproduction, 13, 1691–5, 1998 | Not MRI, but included for ultrasound |
| Guerriero, S., Ajossa, S., Minguez, J. A., Jurado, M., Mais, V., Melis, G. B., Alcazar, J. L., Accuracy of transvaginal ultrasound for diagnosis of deep endometriosis in uterosacral ligaments, rectovaginal septum, vagina and bladder: systematic review and meta-analysis, Ultrasound in Obstetrics & Gynecology, 46, 534–45, 2015 | Not MRI, but included for ultrasound |
| Guerriero, S., Ajossa, S., Paoletti, A. M., Mais, V., Angiolucci, M., Melis, G. B., Tumor markers and transvaginal ultrasonography in the diagnosis of endometrioma, Obstetrics & Gynecology, 88, 403–7, 1996 | Not MRI, but included for ultrasound |
| Guerriero, S., Mais, V., Ajossa, S., Paoletti, A. M., Angiolucci, M., Labate, F., Melis, G. B., The role of endovaginal ultrasound in differentiating endometriomas from other ovarian cysts, Clinical & Experimental Obstetrics & Gynecology, 22, 20–2, 1995 | Not MRI, but included for ultrasound |
| Guerriero, S., Mais, V., Ajossa, S., Paoletti, A. M., Angiolucci, M., Melis, G. B., Transvaginal ultrasonography combined with CA-125 plasma levels in the diagnosis of endometrioma, Fertility & Sterility, 65, 293–8, 1996 | Not MRI, but included for ultrasound |
| Guerriero, S., Mallarini, G., Ajossa, S., Risalvato, A., Satta, R., Mais, V., Angiolucci, M., Melis, G. B., Transvaginal ultrasound and computed tomography combined with clinical parameters and CA-125 determinations in the differential diagnosis of persistent ovarian cysts in premenopausal women, Ultrasound in Obstetrics & Gynecology, 9, 339–43, 1997 | Not MRI, but included for ultrasound |
| Guerriero, S., Saba, L., Ajossa, S., Peddes, C., Angiolucci, M., Perniciano, M., Melis, G. B., Alcazar, J. L., Three-dimensional ultrasonography in the diagnosis of deep endometriosis, Human Reproduction, 29, 1189–98, 2014 | Not MRI, but included for ultrasound |
| Gurgan, T., Kisnisci, H., Yarali, H., Aksu, T., Zeyneloglu, H., Develioglu, O., Serum and peritoneal fluid CA-125 levels in early stage endometriosis, Gynecologic & Obstetric Investigation, 30, 105–8, 1990 | Not MRI, but included for CA-125 |
| Guven, M. A., Bese, T., Demirkiran, F., Comparison of hydrosonography and transvaginal ultrasonography in the detection of intracavitary pathologies in women with abnormal uterine bleeding, International Journal of Gynecological Cancer, 14, 57–63, 2004 | The study population are women with history of abnormal uterine bleeding not women suspected to endometriosis |
| Ha, H. K., Lim, Y. T., Kim, H. S., Suh, T. S., Song, H. H., Kim, S. J., Diagnosis of pelvic endometriosis: fat-suppressed T1-weighted vs conventional MR images, AJR. American Journal of Roentgenology, 163, 127–31, 1994 | Included as one of the studies in the Nisenblat 2016 review |
| Harada, T., Kubota, T., Aso, T., Usefulness of CA19–9 versus CA125 for the diagnosis of endometriosis, Fertility and Sterility, 78, 733–739, 2002 | Case-control study |
| Holland, T. K., Cutner, A., Saridogan, E., Mavrelos, D., Pateman, K., Jurkovic, D., Ultrasound mapping of pelvic endometriosis: does the location and number of lesions affect the diagnostic accuracy? A multicentre diagnostic accuracy study, BMC Women’s Health, 13, 43, 2013 | Not MRI, but included for ultrasound |
| Hompes, P. G., Koninckx, P. R., Kennedy, S., van Kamp, G. F., Verstraeten, R. A., Cornillie, F., Serum CA-125 concentrations during midfollicular phase, a clinically useful and reproducible marker in diagnosis of advanced endometriosis, Clinical Chemistry, 42, 1871–4, 1996 | Not MRI, but included for CA-125 |
| Hornstein, M. D., Harlow, B. L., Thomas, P. P., Check, J. H., Use of a new CA 125 assay in the diagnosis of endometriosis, Human Reproduction, 10, 932–4, 1995 | Diagnosis of endometriosis was made prior to serum collection for CA-125 |
| Hottat, N., Larrousse, C., Anaf, V., Noel, J. C., Matos, C., Absil, J., Metens, T., Endometriosis: contribution of 3.0-T pelvic MR imaging in preoperative assessment-initial results, Radiology, 253, 126–34, 2009 | Included as one of the studies in the Nisenblat 2016 review |
| Howard, F. M., El-Minawi, A. M., Sanchez, R. A., Conscious pain mapping by laparoscopy in women with chronic pelvic pain, Obstetrics & Gynecology, 96, 934–9, 2000 | The study investigated conscious pain mapping using laparoscopy |
| Hudelist, G., Ballard, K., English, J., Wright, J., Banerjee, S., Mastoroudes, H., Thomas, A., Singer, C. F., Keckstein, J., Transvaginal sonography vs. clinical examination in the preoperative diagnosis of deep infiltrating endometriosis, Ultrasound in Obstetrics & Gynecology, 37, 480–7, 2011 | Not MRI, but included for ultrasound |
| Hudelist, G., English, J., Thomas, A. E., Tinelli, A., Singer, C. F., Keckstein, J., Diagnostic accuracy of transvaginal ultrasound for non-invasive diagnosis of bowel endometriosis: systematic review and meta-analysis, Ultrasound in Obstetrics & Gynecology, 37, 257–63, 2011 | Individual studies checked for inclusion/exclusion |
| Hudelist, G., Oberwinkler, K. H., Singer, C. F., Tuttlies, F., Rauter, G., Ritter, O., Keckstein, J., Combination of transvaginal sonography and clinical examination for preoperative diagnosis of pelvic endometriosis, Human Reproduction, 24, 1018–24, 2009 | No separate data for imaging test |
| Hudelist, G., Tuttlies, F., Rauter, G., Pucher, S., Keckstein, J., Can transvaginal sonography predict infiltration depth in patients with deep infiltrating endometriosis of the rectum?, Human Reproduction, 24, 1012–7, 2009 | Focus on depth of invasion of endometriotic lesions |
| Ikeda, F., Bernardini, M. A., Vanni, D., Vasconcelos, A., Pinotti, J. A., Abrao, M. S., A comparison of microlaparoscopy under sedation, microlaparoscopy under general anesthesia and conventional laparoscopy for diagnosis and treatment of pelvic endometriosis in early stages, Fertility and sterility, 77, S21, 2002 | The effectiveness of using a diagnostic tool for diagnosis of endometriosis has not been addressed. |
| Ismail, M. A., Rotmensch, J., Mercer, L. J., Block, B. S., Salti, G. I., Holt, J. A., CA-125 in peritoneal fluid from patients with nonmalignant gynecologic disorders, Journal of Reproductive Medicine, 39, 510–2, 1994 | No outcome of interest |
| Jain, K. A., Friedman, D. L., Pettinger, T. W., Alagappan, R., Jeffrey, R. B., Jr., Sommer, F. G., Adnexal masses: comparison of specificity of endovaginal US and pelvic MR imaging, Radiology, 186, 697–704, 1993 | ‘Lesion-level’ analysis |
| Johnson, W. K., Ott, D. J., Chen, M. Y. M., Fayez, J. A., Gelfand, D. W., Efficacy of hysterosalpingography in evaluating endometriosis, Abdominal Imaging, 19, 278–280, 1994 | The study evaluated the effectiveness of hysterosalpingography and laparoscopy-retrospective study |
| Kafali, H., Artuc, H., Demir, N., Use of CA125 fluctuation during the menstrual cycle as a tool in the clinical diagnosis of endometriosis; a preliminary report, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 116, 85–8, 2004 | It is a case-control study |
| Kang, S. B., Chung, H. H., Lee, H. P., Lee, J. Y., Chang, Y. S., Impact of diagnostic laparoscopy on the management of chronic pelvic pain, Surgical Endoscopy, 21, 916–9, 2007 | there was no comparison between laparoscopy and another test |
| Karabacak, O., Tiras, M. B., Taner, M. Z., Guner, H., Yildiz, A., Yildirim, M., Small diameter versus conventional laparoscopy: a prospective, self-controlled study, Human Reproduction, 12, 2399–401, 1997 | Comparison of two types of laparoscopy |
| Kinkel, K., Chapron, C., Balleyguier, C., Fritel, X., Dubuisson, J. B., Moreau, J. F., Magnetic resonance imaging characteristics of deep endometriosis, Human Reproduction, 14, 1080–6, 1999 | ‘Lesion-level’ analysis |
| Kitawaki, J., Ishihara, H., Koshiba, H., Kiyomizu, M., Teramoto, M., Kitaoka, Y., Honjo, H., Usefulness and limits of CA-125 in diagnosis of endometriosis without associated ovarian endometriomas.[Erratum appears in Hum Reprod. 2007 Feb;22(2):627], Human Reproduction, 20, 1999–2003, 2005 | Women enrolled in the study were already diagnosed with endometriosis, adenomyosis and/or leiomyomas |
| Koninckx, P. R., Meuleman, C., Oosterlynck, D., Cornillie, F. J., Diagnosis of deep endometriosis by clinical examination during menstruation and plasma CA-125 concentration, Fertility & Sterility, 65, 280–7, 1996 | Women had laparoscopy prior to CA-125 |
| Koninckx, P. R., Riittinen, L., Seppala, M., Cornillie, F. J., CA-125 and placental protein 14 concentrations in plasma and peritoneal fluid of women with deeply infiltrating pelvic endometriosis, Fertility & Sterility, 57, 523–30, 1992 | CA-125 |
| Kruger, K., Behrendt, K., Niedobitek-Kreuter, G., Koltermann, K., Ebert, A. D., Location-dependent value of pelvic MRI in the preoperative diagnosis of endometriosis, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 169, 93–8, 2013 | ‘Lesion-level’ analysis |
| Kruitwagen, R. F., Thomas, C., Poels, L. G., Koster, A. M., Willemsen, W. N., Rolland, R., High CA-125 concentrations in peritoneal fluid of normal cyclic women with various infertilityrelated factors as demonstrated with two-step immunoradiometric assay, Fertility & Sterility, 56, 863–9, 1991 | The aim of the study was to identify CA-125 concentrations, women were not suspected of endometriosis |
| Kurjak, A., Kupesic, S., Scoring system for prediction of ovarian endometriosis based on transvaginal color and pulsed Doppler sonography, Fertility & Sterility, 62, 81–8, 1994 | No a test of interest |
| Lanzone, A., Marana, R., Muscatello, R., Fulghesu, A. M., Dell’Acqua, S., Caruso, A., Mancuso, S., Serum CA-125 levels in the diagnosis and management of endometriosis, Journal of Reproductive Medicine, 36, 603–7, 1991 | CA-125 |
| Leon, M., Vaccaro, H., Alcazar, J. L., Martinez, J., Gutierrez, J., Amor, F., Iturra, A., Sovino, H., Extended transvaginal sonography in deep infiltrating endometriosis: use of bowel preparation and an acoustic window with intravaginal gel: preliminary results, Journal of Ultrasound in Medicine, 33, 315–21, 2014 | Not a test of interest |
| Leslie, C., Ma, T., McElhinney, B., Leake, R., Stewart, C. J., Is the detection of endometrial nerve fibers useful in the diagnosis of endometriosis?, International Journal of Gynecological Pathology, 32, 149–55, 2013 | No outcome of interest |
| Li, G., Yu, Z., Li, K., The value of FS, NLR, and CA-125 in the diagnosis of endometriosis, International journal of clinical and experimental medicine, 9, 7309–7313, 2016 | Not the population of interest |
| Macer, M. L., Mathur, M., Spektor, M., Gysler, S., Staib, L., Kodaman, P., McCarthy, S., Utility of magnetic resonance imaging in the evaluation of intraoperatively confirmed pelvic adhesions, Journal of Computer Assisted Tomography, 39, 896–900, 2015 | Not the population of interest |
| Maiorana, A., Cicerone, C., Niceta, M., Alio, L., Evaluation of serum CA 125 levels in patients with pelvic pain related to endometriosis, International Journal of Biological Markers, 22, 200–2, 2007 | CA-125 |
| Maiorana, A., Incandela, D., Giambanco, L., Alio, W., Alio, L., Ultrasound diagnosis of pelvic endometriosis, Journal of Endometriosis, 3, 105–119, 2011 | A narrative review |
| Mais, V., Guerriero, S., Ajossa, S., Angiolucci, M., Paoletti, A. M., Melis, G. B., The efficiency of transvaginal ultrasonography in the diagnosis of endometrioma, Fertility & Sterility, 60, 776–80, 1993 | ‘Lesion-level’ analysis |
| Malik, E., Berg, C., Meyhofer-Malik, A., Buchweitz, O., Moubayed, P., Diedrich, K., Fluorescence diagnosis of endometriosis using 5-aminolevulinic acid, Surgical Endoscopy, 14, 452–5, 2000 | The test is not of interest |
| Manganaro, L., Fierro, F., Tomei, A., Irimia, D., Lodise, P., Sergi, M. E., Vinci, V., Sollazzo, P., Porpora, M. G., Delfini, R., Vittori, G., Marini, M., Feasibility of 3.0T pelvic MR imaging in the evaluation of endometriosis, European Journal of Radiology, 81, 1381–7, 2012 | Included as one of the studies in the Nisenblat 2016 review |
| Manganaro, L., Vittori, G., Vinci, V., Fierro, F., Tomei, A., Lodise, P., Sollazzo, P., Sergi, M. E., Bernardo, S., Ballesio, L., Marini, M., Porpora, M. G., Beyond laparoscopy: 3-T magnetic resonance imaging in the evaluation of posterior cul-de-sac obliteration, Magnetic Resonance Imaging, 30, 1432–8, 2012 | Included as one of the studies in the Nisenblat 2016 review |
| Marasinghe, J. P., Senanayake, H., Saravanabhava, N., Arambepola, C., Condous, G., Greenwood, P., History, pelvic examination findings and mobility of ovaries as a sonographic marker to detect pelvic adhesions with fixed ovaries, Journal of Obstetrics & Gynaecology Research, 40, 785–90, 2014 | Aim of study was to look at mobility of ovaries as a marker of endometriosis |
| Mathlouthi, N., Ayed, B. B., Dhouib, M., Chaabene, K., Trabelsi, K., Amouri, H., Guermazi, M., Confrontation ultrasonography-CA125-histology in the managment of ovarian cysts: A prospective study about 77 cases, Tunisie Medicale, 89, 686–692, 2011 | Full-text in French |
| May, K. E., Conduit-Hulbert, S. A., Villar, J., Kirtley, S., Kennedy, S. H., Becker, C. M., Peripheral biomarkers of endometriosis: a systematic review, Human Reproduction Update, 16, 651–74, 2010 | Individual studies checked for inclusion/exclusion |
| McBride, N., Newman, R. L., Diagnostic laparoscopy, International Journal of Gynaecology & Obstetrics, 15, 556–8, 1978 | No outcome of interest |
| McKinnon, B., Mueller, M. D., Nirgianakis, K., Bersinger, N. A., Comparison of ovarian cancer markers in endometriosis favours HE4 over CA125, Molecular Medicine Reports, 12, 5179–84, 2015 | No data reported to calculate sensitivity |
| Medeiros, L. R., Rosa, M. I., Silva, B. R., Reis, M. E., Simon, C. S., Dondossola, E. R., da Cunha Filho, J. S., Accuracy of magnetic resonance in deeply infiltrating endometriosis: a systematic review and meta-analysis, Archives of Gynecology & Obstetrics, 291, 611–21, 2015 | Single studies in the review were assessed for inclusion |
| Medl, M., Ogris, E., Peters-Engl, C., Mierau, M., Buxbaum, P., Leodolter, S., Serum levels of the tumour-associated trypsin inhibitor in patients with endometriosis, British Journal of Obstetrics & Gynaecology, 104, 78–81, 1997 | The tumour-associated trypsin inhibitors |
| Melega, C., Marchesini, F. P., Bellettini, L., Biscontin, S., Flamigni, C., Diagnostic value of laparoscopy in endometriosis and infertility, Journal of Reproductive Medicine, 29, 597–600, 1984 | No outcome of interest |
| Melis, G. B., Ajossa, S., Guerriero, S., Paoletti, A. M., Angiolucci, M., Piras, B., Caffiero, A., Mais, V., Epidemiology and diagnosis of endometriosis, Annals of the New York Academy of Sciences, 734, 352–7, 1994 | Analysis include lesions, not number of participants |
| Menada, M. V., Remorgida, V., Abbamonte, L. H., Fulcheri, E., Ragni, N., Ferrero, S., Transvaginal ultrasonography combined with water-contrast in the rectum in the diagnosis of rectovaginal endometriosis infiltrating the bowel, Fertility & Sterility, 89, 699–700, 2008 | Not a test of interest |
| Mezzi, G., Ferrari, S., Arcidiacono, P. G., Di Puppo, F., Candiani, M., Testoni, P. A., Endoscopic rectal ultrasound and elastosonography are useful in flow chart for the diagnosis of deep pelvic endometriosis with rectal involvement, Journal of Obstetrics & Gynaecology Research, 37, 586–90, 2011 | There was no comparison with surgery |
| Millischer, A. E., Salomon, L. J., Santulli, P., Borghese, B., Dousset, B., Chapron, C., Fusion imaging for evaluation of deep infiltrating endometriosis: feasibility and preliminary results, Ultrasound in Obstetrics & Gynecology, 46, 109–17, 2015 | No data or surgical diagnosis |
| Miyagi, E., Maruyama, Y., Mogami, T., Numazaki, R., Ikeda, A., Yamamoto, H., Hirahara, F., Comparison of plasma amino acid profile-based index and CA125 in the diagnosis of epithelial ovarian cancers and borderline malignant tumors, International Journal of Clinical Oncology, 1–8, 2016 | Not the population of interest |
| Mol, B. W., Bayram, N., Lijmer, J. G., Wiegerinck, M. A., Bongers, M. Y., van der Veen, F., Bossuyt, P. M., The performance of CA125 measurement in the detection of endometriosis: a metaanalysis, Fertility & Sterility, 70, 1101–8, 1998 | CA-125 |
| Molo, M. W., Kelly, M., Radwanska, E., Binor, Z., Preoperative serum CA-125 and CA-72 in predicting endometriosis in infertility patients, Journal of Reproductive Medicine, 39, 964–6, 1994 | CA-125 |
| Moloney, M. D., Thornton, J. G., Cooper, E. H., Serum CA 125 antigen levels and disease severity in patients with endometriosis, Obstetrics & Gynecology, 73, 767–9, 1989 | Women had laparoscopically confirmed endometriosis |
| Moore, J., Copley, S., Morris, J., Lindsell, D., Golding, S., Kennedy, S., A systematic review of the accuracy of ultrasound in the diagnosis of endometriosis, Ultrasound in Obstetrics & Gynecology, 20, 630–4, 2002 | Individual studies checked for inclusion/exclusion |
| Moretuzzo, R. W., DiLauro, S., Jenison, E., Chen, S. L., Reindollar, R. H., McDonough, P. G., Serum and peritoneal lavage fluid CA-125 levels in endometriosis, Fertility & Sterility, 50, 430–3, 1988 | No outcome of interest |
| Muscatello, R., Cucinelli, F., Fulghesu, A., Lanzone, A., Caruso, A., Mancuso, S., Multiple serum marker assay in the diagnosis of endometriosis, Gynecological Endocrinology, 6, 265–9, 1992 | No outcome of interest |
| O’Shaughnessy, A., Check, J. H., Nowroozi, K., Lurie, D., CA 125 levels measured in different phases of the menstrual cycle in screening for endometriosis, Obstetrics & Gynecology, 81, 99–103, 1993 | CA-125. |
| Ota, H., Maki, M., Evaluation of autoantibody and CA125 in the diagnosis of endometriosis or adenomyosis, Medical Science Research, 18, 309–310, 1990 | All the participants had known condition. |
| Othman, E. E. D. R., Hornung, D., Al-Hendy, A., Biomarkers of endometriosis, Expert Opinion on Medical Diagnostics, 2, 741–752, 2008 | Narrative review |
| Ozaksit, G., Caglar, T., Cicek, N., Kuscu, E., Batioglu, S., Gokmen, O., Serum CA 125 levels before, during and after treatment for endometriosis, International Journal of Gynaecology & Obstetrics, 50, 269–73, 1995 | Women had a confirmed diagnosis of endometriosis prior to CA-125 test |
| Panidis, D., Vlassis, G., Matalliotakis, J., Skiadopoulos, S., Kalogeropoulos, A., Serum levels of the oncofetal antigens CA125, CA 19–9 and CA 15–3 in patients with endometriosis, Journal of Endocrinological Investigation, 11, 801–804, 1988 | All women who involved in the study have proven endometriosis |
| Pascual, M. A., Guerriero, S., Hereter, L., Barri-Soldevila, P., Ajossa, S., Graupera, B., Rodriguez, I., Diagnosis of endometriosis of the rectovaginal septum using introital three-dimensional ultrasonography, Fertility & Sterility, 94, 2761–5, 2010 | Not a test of interest |
| Pascual, M. A., Tresserra, F., Lopez-Marin, L., Ubeda, A., Grases, P. J., Dexeus, S., Role of color Doppler ultrasonography in the diagnosis of endometriotic cyst, Journal of Ultrasound in Medicine, 19, 695–9, 2000 | Data not reported properly |
| Pastorfide, G., Fong, Y. F., Use of narrowband imaging for the detection of endometriosis, Journal of Minimally Invasive Gynecology, 22, 535, 2015 | No outcome of interest |
| Patel, M. D., Feldstein, V. A., Chen, D. C., Lipson, S. D., Filly, R. A., Endometriomas: diagnostic performance of US.[Erratum appears in Radiology 1999 Dec;213(3):930], Radiology, 210, 739–45, 1999 | retrospective selection of cases; ‘lesion-level’ analysis |
| Patel, M. D., Feldstein, V. A., Filly, R. A., The likelihood ratio of sonographic findings for the diagnosis of hemorrhagic ovarian cysts, Journal of Ultrasound in Medicine, 24, 607–14; quiz 615, 2005 | It is about diagnosis of haemorrhagic ovarian cyst not endometrioma |
| Patton, P. E., Field, C. S., Harms, R. W., Coulam, C. B., CA-125 levels in endometriosis, Fertility & Sterility, 45, 770–3, 1986 | CA-125 |
| Philip, C. A., Bisch, C., Coulon, A., de Saint-Hilaire, P., Rudigoz, R. C., Dubernard, G., Correlation between three-dimensional rectosonography and magnetic resonance imaging in the diagnosis of rectosigmoid endometriosis: a preliminary study on the first fifty cases, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 187, 35–40, 2015 | MRI was the reference test |
| Piessens, S., Healey, M., Maher, P., Tsaltas, J., Rombauts, L., Can anyone screen for deep infiltrating endometriosis with transvaginal ultrasound?, Australian & New Zealand Journal of Obstetrics & Gynaecology, 54, 462–8, 2014 | Women included in the study had the ultrasound test after diagnosis of endometriosis by surgery |
| Piketty, M., Chopin, N., Dousset, B., Millischer-Bellaische, A. E., Roseau, G., Leconte, M., Borghese, B., Chapron, C., Preoperative work-up for patients with deeply infiltrating endometriosis: transvaginal ultrasonography must definitely be the first-line imaging examination, Human Reproduction, 24, 602–7, 2009 | Women had histological confirmation of deep infiltrating endometriosis |
| Pittaway, D. E., Douglas, J. W., Serum CA-125 in women with endometriosis and chronic pelvic pain, Fertility & Sterility, 51, 68–70, 1989 | CA-125 |
| Pittaway, D. E., Fayez, J. A., The use of CA-125 in the diagnosis and management of endometriosis, Fertility & Sterility, 46, 790–5, 1986 | CA-125 |
| Polisseni, F., Bambirra, E. A., Camargos, A. F., Detection of chronic endometritis by diagnostic hysteroscopy in asymptomatic infertile patients, Gynecologic & Obstetric Investigation, 55, 205–10, 2003 | Not a test of interest |
| Preutthipan, S., Hesla, J.S., A comparative study between pelvic ultrasonography and laparoscopy in the detection of pelvic pathology in the initial workup of subfertile women, Journal of the Medical Association of Thailand, 78, 596–599, 1995 | No separate data for endometriosis for analysis |
| Randall, G. W., Gantt, P. A., Poe-Zeigler, R. L., Bergmann, C. A., Noel, M. E., Strawbridge, W. R., Richardson-Cox, B., Hereford, J. R., Reiff, R. H., Serum antiendometrial antibodies and diagnosis of endometriosis, American Journal of Reproductive Immunology, 58, 374–82, 2007 | The diagnostic test which has been used in this study is not matched with the protocol |
| Redwine, D. B., Ovarian endometriosis: A marker for more extensive pelvic and intestinal disease, Fertility and Sterility, 72, 310–315, 1999 | All the patients have endometriosis |
| Reid, S., Lu, C., Casikar, I., Reid, G., Abbott, J., Cario, G., Chou, D., Kowalski, D., Cooper, M., Condous, G., Prediction of pouch of Douglas obliteration in women with suspected endometriosis using a new real-time dynamic transvaginal ultrasound technique: the sliding sign, Ultrasound in Obstetrics & Gynecology, 41, 685–91, 2013 | Not a test of interest |
| Reid, S., Lu, C., Hardy, N., Casikar, I., Reid, G., Cario, G., Chou, D., Almashat, D., Condous, G., Office gel sonovaginography for the prediction of posterior deep infiltrating endometriosis: a multicenter prospective observational study, Ultrasound in Obstetrics & Gynecology, 44, 710–8, 2014 | Not a test of interest |
| Ribeiro, H. S., Ribeiro, P. A., Rossini, L., Rodrigues, F. C., Donadio, N., Aoki, T., Double-contrast barium enema and transrectal endoscopic ultrasonography in the diagnosis of intestinal deeply infiltrating endometriosis, Journal of Minimally Invasive Gynecology, 15, 315–20, 2008 | Not the test of interest |
| Rosa, E. Silva A. C., Rosa, E. Silva J. C., Ferriani, R. A., Serum CA-125 in the diagnosis of endometriosis, International Journal of Gynaecology & Obstetrics, 96, 206–7, 2007 | Retrospective study. Women included in the study already had a diagnosis of endometriosis prior to CA-125 serum collection |
| Saba, L., Guerriero, S., Sulcis, R., Ajossa, S., Melis, G., Mallarini, G., Agreement and reproducibility in identification of endometriosis using magnetic resonance imaging, Acta Radiologica, 51, 573–80, 2010 | No the outcome of interest |
| Saba, L., Guerriero, S., Sulcis, R., Pilloni, M., Ajossa, S., Melis, G., Mallarini, G., MRI and “tenderness guided” transvaginal ultrasonography in the diagnosis of recto-sigmoid endometriosis, Journal of Magnetic Resonance Imaging, 35, 352–60, 2012 | Only women with positive index test had surgery |
| Saba, L., Guerriero, S., Sulis, R., Pilloni, M., Ajossa, S., Melis, G., Mallarini, G., Learning curve in the detection of ovarian and deep endometriosis by using Magnetic Resonance: comparison with surgical results, European Journal of Radiology, 79, 237–44, 2011 | The aim of the study was to determine whether diagnostic accuracy is correlated to radiologist expertise |
| Saccardi, C., Cosmi, E., Borghero, A., Tregnaghi, A., Dessole, S., Litta, P., Comparison between transvaginal sonography, saline contrast sonovaginography and magnetic resonance imaging in the diagnosis of posterior deep infiltrating endometriosis, Ultrasound in Obstetrics & Gynecology, 40, 464–9, 2012 | Only women with positive index test had surgery |
| Said, T. H., Azzam, A. Z., Prediction of endometriosis by transvaginal ultrasound in reproductive-age women with normal ovarian size, Middle East Fertility Society Journal, 19, 197–207, 2014 | Not a test of interest |
| Savelli, L., Manuzzi, L., Coe, M., Mabrouk, M., Di Donato, N., Venturoli, S., Seracchioli, R., Comparison of transvaginal sonography and double-contrast barium enema for diagnosing deep infiltrating endometriosis of the posterior compartment, Ultrasound in Obstetrics & Gynecology, 38, 466–71, 2011 | Not the test of interest |
| Savelli, L., Manuzzi, L., Pollastri, P., Mabrouk, M., Seracchioli, R., Venturoli, S., Diagnostic accuracy and potential limitations of transvaginal sonography for bladder endometriosis, Ultrasound in Obstetrics & Gynecology, 34, 595–600, 2009 | Not MRI, but included for ultrasound |
| Sayasneh, A., Kaijser, J., Preisler, J., Smith, A. A., Raslan, F., Johnson, S., Husicka, R., Ferrara, L., Stalder, C., Ghaem-Maghami, S., Timmerman, D., Bourne, T., Accuracy of ultrasonography performed by examiners with varied training and experience in predicting specific pathology of adnexal masses, Ultrasound in Obstetrics & Gynecology, 45, 605–12, 2015 | Not MRI, but included for ultrasound |
| Scardapane, A., Bettocchi, S., Lorusso, F., Stabile Ianora, A. A., Vimercati, A., Ceci, O., Lasciarrea, M., Angelelli, G., Diagnosis of colorectal endometriosis: contribution of contrast enhanced MR-colonography, European Radiology, 21, 1553–63, 2011 | Comparison of MRI between two radiologists |
| Scardapane, A., Lorusso, F., Bettocchi, S., Moschetta, M., Fiume, M., Vimercati, A., Pepe, M. L., Angelelli, G., Stabile Ianora, A. A., Deep pelvic endometriosis: accuracy of pelvic MRI completed by MR colonography, Radiologia Medica, 118, 323–38, 2013 | ‘Lesion-level’ analysis |
| Scardapane, A., Lorusso, F., Scioscia, M., Ferrante, A., Stabile Ianora, A. A., Angelelli, G., Standard high-resolution pelvic MRI vs. low-resolution pelvic MRI in the evaluation of deep infiltrating endometriosis, European Radiology, 24, 2590–6, 2014 | Comparison of MRI carried out by two different radiologists |
| Schenken, R. S., Improving the diagnosis of endometriosis in adolescents, Sexuality, Reproduction and Menopause, 6, 4–8, 2008 | Narrative review |
| Seeber, B., Sammel, M. D., Fan, X., Gerton, G. L., Shaunik, A., Chittams, J., Barnhart, K. T., Panel of markers can accurately predict endometriosis in a subset of patients, Fertility & Sterility, 89, 1073–81, 2008 | It is a case-control study |
| Shen, A., Xu, S., Ma, Y., Guo, H., Li, C., Yang, C., Zou, S., Diagnostic value of serum CA125, CA19–9 and CA15–3 in endometriosis: A meta-analysis, Journal of International Medical Research, 43, 599–609, 2015 | It is about association of biomarkers and stage of endometriosis. No outcome of interest. |
| Sherif, M. F., Badawy, M. E., Elkholi, D. G. E. Y., Accuracy of magnetic resonance imaging in diagnosis of deeply infiltrating endometriosis, Egyptian Journal of Radiology and Nuclear Medicine, 46, 159–165, 2015 | Unclear how outcomes were obtained, data for each of the tests not available from the paper. Also, description of sites may have overlap, unclear classification of endometriosis sites |
| Sokalska, A., Timmerman, D., Testa, A. C., Van Holsbeke, C., Lissoni, A. A., Leone, F. P., Jurkovic, D., Valentin, L., Diagnostic accuracy of transvaginal ultrasound examination for assigning a specific diagnosis to adnexal masses, Ultrasound in Obstetrics & Gynecology, 34, 462–70, 2009 | Not MRI, but included for ultrasound |
| Somigliana, E., Vigano, P., Candiani, M., Felicetta, I., Di Blasio, A. M., Vignali, M., Use of serum-soluble intercellular adhesion molecule-1 as a new marker of endometriosis, Fertility & Sterility, 77, 1028–31, 2002 | Women included in the study already had laparoscopy prior to CA-125 serum collection |
| Somigliana, E., Vigano, P., Tirelli, A. S., Felicetta, I., Torresani, E., Vignali, M., Di Blasio, A. M., Use of the concomitant serum dosage of CA 125, CA 19–9 and interleukin-6 to detect the presence of endometriosis. Results from a series of reproductive age women undergoing laparoscopic surgery for benign gynaecological conditions, Human Reproduction, 19, 1871–6, 2004 | Case-control study |
| Spencer, J. A., Weston, M. J., Imaging in endometriosis, Imaging, 15, 63–71, 2003 | Narrative review |
| Stowell, S. B., Wiley, C. M., Perez-Reyes, N., Powers, C. N., Cytologic diagnosis of peritoneal fluids. Applicability to the laparoscopic diagnosis of endometriosis, Acta Cytologica, 41, 817–22, 1997 | The diagnostic test in this study is not matched with the protocol |
| Stratton, P., Winkel, C., Premkumar, A., Chow, C., Wilson, J., Hearns-Stokes, R., Heo, S., Merino, M., Nieman, L. K., Diagnostic accuracy of laparoscopy, magnetic resonance imaging, and histopathologic examination for the detection of endometriosis, Fertility & Sterility, 79, 1078–85, 2003 | Included as one of the studies in the Nisenblat 2016 review |
| Sugimura, K., Okizuka, H., Imaoka, I., Kaji, Y., Takahashi, K., Kitao, M., Ishida, T., Pelvic endometriosis: detection and diagnosis with chemical shift MR imaging, Radiology, 188, 435–8, 1993 | Included as one of the studies in the Nisenblat 2016 review |
| Szubert, M., Suzin, J., Wierzbowski, T., Kowalczyk-Amico, K., CA-125 concentration in serum and peritoneal fluid in patients with endometriosis - preliminary results, Archives of Medical Science, 8, 504–8, 2012 | Case-control study |
| Takahashi, K., Nagata, H., Kitao, M., CA-125 in the menstrual blood is an effective marker for diagnosing early stage endometriosis: A preliminary report, Japanese Journal of Fertility and Sterility, 36, 356–359, 1991 | Ultrasound was used to confirm ovulatory day only |
| Takahashi, K., Nagata, H., Musa, A. A., Shibukawa, T., Yamasaki, H., Kitao, M., Clinical usefulness of CA-125 levels in the menstrual discharge in patients with endometriosis, Fertility & Sterility, 54, 360–2, 1990 | Not MRI, but included for CA125 |
| Takahashi, K., Okada, S., Ozaki, T., Kitao, M., Sugimura, K., Diagnosis of pelvic endometriosis by magnetic resonance imaging using “fat-saturation” technique, Fertility & Sterility, 62, 973–7, 1994 | Population appears to overlap with Sigumura 1993 (which is included in the review) |
| Takeuchi, H., Kuwatsuru, R., Kitade, M., Sakurai, A., Kikuchi, I., Shimanuki, H., Kinoshita, K., A novel technique using magnetic resonance imaging jelly for evaluation of rectovaginal endometriosis, Fertility & Sterility, 83, 442–7, 2005 | Included as one of the studies in the Nisenblat 2016 review |
| Takeuchi, M., Matsuzaki, K., Nishitani, H., Susceptibility-weighted MRI of endometrioma: preliminary results, AJR. American Journal of Roentgenology, 191, 1366–70, 2008 | No outcome of interest |
| Theodoridis, T. D., Zepiridis, L., Mikos, T., Grimbizis, G. F., Dinas, K., Athanasiadis, A., Bontis, J. N., Comparison of diagnostic accuracy of transvaginal ultrasound with laparoscopy in the management of patients with adnexal masses, Archives of Gynecology & Obstetrics, 280, 767–73, 2009 | Not MRI, but included for ultrasound |
| Thomeer, M. G., Steensma, A. B., van Santbrink, E. J., Willemssen, F. E., Wielopolski, P. A., Hunink, M. G., Spronk, S., Laven, J. S., Krestin, G. P., Can magnetic resonance imaging at 3.0-Tesla reliably detect patients with endometriosis? Initial results, Journal of Obstetrics & Gynaecology Research, 40, 1051–8, 2014 | Included as one of the studies in the Nisenblat 2016 review |
| Tirlapur, S. A., Daniels, J. P., Khan, K. S., Medal trial collaboration, Chronic pelvic pain: how does noninvasive imaging compare with diagnostic laparoscopy?, Current Opinion in Obstetrics & Gynecology, 27, 445–8, 2015 | This systematic review has not only focused on patients with suspected endometriosis. It is more general about pelvic pain and diagnostic tools. |
| Togashi, K., Nishimura, K., Kimura, I., Tsuda, Y., Yamashita, K., Shibata, T., Nakano, Y., Konishi, J., Konishi, I., Mori, T., Endometrial cysts: diagnosis with MR imaging, Radiology, 180, 73–8, 1991 | A mixed population - some women are postmenopausal (age range 9 to 85 yrs.) |
| Tumedei, U., Ciardelli, V., Paltrinieri, F., Kuria, M. S., Amadori, A., Stefanetti, M., Gori, G., Transvaginal ultrasound in the diagnosis of endometrial abnormalities, Tumori, 87, S15, 2001 | It has focused on endometrial abnormalities not endometriosis |
| Valenzano Menada, M., Remorgida, V., Abbamonte, L. H., Nicoletti, A., Ragni, N., Ferrero, S., Does transvaginal | Not MRI, but included for ultrasound ultrasonography combined with water-contrast in the rectum aid in the diagnosis of rectovaginal endometriosis infiltrating the bowel?, Human Reproduction, 23, 1069–75, 2008 |
| Van den Bosch, T., Vandendael, A., Van Schoubroeck, D., Wranz, P. A. B., Lombard, C. J., Combining vaginal ultrasonography and office endometrial sampling in the diagnosis of endometrial disease in postmenopausal women, Obstetrics and Gynecology, 85, 349–352, 1995 | It is not about endometriosis, it has addressed endometrial diseases |
| Van Holsbeke, C., Van Calster, B., Guerriero, S., Savelli, L., Leone, F., Fischerova, D., Czekierdowski, A., Fruscio, R., Veldman, J., Van de Putte, G., Testa, A. C., Bourne, T., Valentin, L., Timmerman, D., Imaging in gynaecology: How good are we in identifying endometriomas?, Facts Views & Vision in Obgyn, 1, 7–17, 2009 | Not MRI, but included for ultrasound |
| Vercellini, P., Oldani, S., Felicetta, I., Bramante, T., Rognoni, M. T., Crosignani, P. G., The value of cyst puncture in the differential diagnosis of benign ovarian tumours, Human Reproduction, 10, 1465–9, 1995 | Not MRI, but included for CA125 |
| Vimercati, A., Achilarre, M. T., Scardapane, A., Lorusso, F., Ceci, O., Mangiatordi, G., Angelelli, G., Van Herendael, B., Selvaggi, L., Bettocchi, S., Accuracy of transvaginal sonography and contrastenhanced magnetic resonance-colonography for the presurgical staging of deep infiltrating endometriosis, Ultrasound in Obstetrics & Gynecology, 40, 592–603, 2012 | Not a test of interest |
| Volpi, E., De Grandis, T., Zuccaro, G., La Vista, A., Sismondi, P., Role of transvaginal sonography in the detection of endometriomata, Journal of Clinical Ultrasound, 23, 163–7, 1995 | Not MRI, but included for ultrasound |
| Vrachnis, N., Sifakis, S., Samoli, E., Kappou, D., Pavlakis, K., Iliodromiti, Z., Botsis, D., Three-dimensional ultrasound and three-dimensional power Doppler improve the preoperative evaluation of complex benign ovarian lesions, Clinical & Experimental Obstetrics & Gynecology, 39, 474–8, 2012 | No outcome of interest; no data for endometriosis |
| Walsh, J. W., Taylor, K. J., Wasson, J. F., Schwartz, P. E., Rosenfield, A. T., Gray-scale ultrasound in 204 proved gynecologic masses: accuracy and specific diagnostic criteria, Radiology, 130, 391–7, 1979 | No outcome of interest |
| Wang, L., Liu, H. Y., Shi, H. H., Lang, J. H., Sun, W., Urine peptide patterns for non-invasive diagnosis of endometriosis: a preliminary prospective study, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 177, 23–8, 2014 | Biomarker not of interest |
| Weerakiet, S., Wongkularb, A., Rochanawutanon, M., Rojanasakul, A., Transvaginal ultrasonography combined with pelvic examination in the diagnosis of ovarian endometrioma, Journal of the Medical Association of Thailand, 83, 523–8, 2000 | Not MRI, but included for ultrasound |
| Wessels, J. M., Kay, V. R., Leyland, N. A., Agarwal, S. K., Foster, W. G., Assessing brain-derived neurotrophic factor as a novel clinical marker of endometriosis, Fertility & Sterility, 105, 119–128.e5, 2016 | Not the test of interest |
| Wild, R. A., Hirisave, V., Bianco, A., Podczaski, E. S., Demers, L. M., Endometrial antibodies versus CA-125 for the detection of endometriosis, Fertility & Sterility, 55, 90–4, 1991 | Not MRI, but included for CA125 |
| Wolfler, M. M., Nagele, F., Kolbus, A., Seidl, S., Schneider, B., Huber, J. C., Tschugguel, W., A predictive model for endometriosis, Human Reproduction, 20, 1702–8, 2005 | Biomarker not of interest |
| Wykes, C. B., Clark, T. J., Khan, K. S., Accuracy of laparoscopy in the diagnosis of endometriosis: A systematic quantitative review, BJOG: An International Journal of Obstetrics and Gynaecology, 111, 1204–1212, 2004 | Not MRI, but included for Laparoscopy |
| Yamashita, Y., Torashima, M., Hatanaka, Y., Harada, M., Higashida, Y., Takahashi, M., Mizutani, H., Tashiro, H., Iwamasa, J., Miyazaki, K., et al.,, Adnexal masses: accuracy of characterization with transvaginal US and precontrast and postcontrast MR imaging, Radiology, 194, 557–65, 1995 | Review of MRI and TVUS by five radiologists |
| Yazbek, J., Helmy, S., Ben-Nagi, J., Holland, T., Sawyer, E., Jurkovic, D., Value of preoperative ultrasound examination in the selection of women with adnexal masses for laparoscopic surgery, Ultrasound in Obstetrics and Gynecology, 30, 883–888, 2007 | The preoperative sonography has not been used to diagnose endometriosis. |
| Zanardi, R., Del Frate, C., Zuiani, C., Bazzocchi, M., Staging of pelvic endometriosis based on MRI findings versus laparoscopic classification according to the American Fertility Society, Abdominal Imaging, 28, 733–42, 2003 | No data to calculate specificity |
| Zapardiel, I., Gorostidi, M., Ravaggi, A., Allende, M. T., Silveira, M., Abehsera, D., MacUks, R., Utility Serum Marker HE4 for the Differential Diagnosis between Endometriosis and Adnexal Malignancy, International Journal of Gynecological Cancer, 26, 52–55, 2016 | No data on surgical diagnosis |
| Zhang, Y., Qiao, C., Li, L., Zhao, X., Li, Y., Serum HE4 is more suitable as a biomarker than CA125 in Chinese women with benign gynecologic disorders, African Health Sciences, 14, 913–8, 2014 | Not MRI, but included for CA125 |
H.11. Diagnosis – Surgical diagnosis with or without histological confirmation
| Study | Reason for Exclusion |
|---|---|
| Abrao, M. S., Podgaec, S., Filho, B. M., Ramos, L. O., Pinotti, J. A., de Oliveira, R. M., The use of biochemical markers in the diagnosis of pelvic endometriosis, Human Reproduction, 12, 2523–7, 1997 | Case-control study |
| Abrao, M. S., Podgaec, S., Pinotti, J. A., de Oliveira, R. M., Tumor markers in endometriosis, International Journal of Gynaecology & Obstetrics, 66, 19–22, 1999 | Case-control study |
| Abu-Musa, A., Takahashi, K., Nagata, H., Yamasaki, H., Mizoguchi, S., Kitao, M., CA-125 in menstrual discharge in patients with chronic pelvic pain, International Journal of Gynaecology & Obstetrics, 37, 111–4, 1992 | The level of CA-125 in menstrual discharge has been assessed |
| Acimovic, M., Vidakovic, S., Milic, N., Jeremic, K., Markovic, M., Milosevic-Djeric, A., Lazovic-Radonjic, G., Survivin and Vegf as Novel Biomarkers in Diagnosis of Endometriosis, Journal of Medical Biochemistry, 35, 63–68, 2016 | No laparoscopy/laparotomy and no histological confirmation |
| Aleem, F., Pennisi, J., Zeitoun, K., Predanic, M., The role of color Doppler in diagnosis of endometriomas, Ultrasound in Obstetrics & Gynecology, 5, 51–4, 1995 | The aim of this study is to describe vascular appearance in endometriomas. No outcome of interest |
| Anaf, V., El Nakadi, I., De Moor, V., Coppens, E., Zalcman, M., Noel, J. C., Anatomic significance of a positive barium enema in deep infiltrating endometriosis of the large bowel, World Journal of Surgery, 33, 822–7, 2009 | All patients had surgery and DCBE |
| Bagan, P., Berna, P., Assouad, J., Hupertan, V., Le Pimpec Barthes, F., Riquet, M., Value of cancer antigen 125 for diagnosis of pleural endometriosis in females with recurrent pneumothorax, European Respiratory Journal, 31, 140–2, 2008 | The control group are males. |
| Balleyguier, C., Roupret, M., Nguyen, T., Kinkel, K., Helenon, O., Chapron, C., Ureteral endometriosis: the role of magnetic resonance imaging, Journal of the American Association of Gynecologic Laparoscopists, 11, 530–6, 2004 | No outcome of interest. Moreover, only 6 patients were included. |
| Barcellos, M. B., Lasmar, B., Lasmar, R., Agreement between the preoperative findings and the operative diagnosis in patients with deep endometriosis, Archives of Gynecology & Obstetrics Arch Gynecol Obstet, 293, 845–50, 2016 | Lesion-level analysis |
| Bazot, M., Gasner, A., Ballester, M., Darai, E., Value of thin-section oblique axial T2-weighted magnetic resonance images to assess uterosacral ligament endometriosis, Human Reproduction, 26, 346–53, 2011 | Retrospective study; one MRI technique compared to conventional technique |
| Bazot, M., Gasner, A., Lafont, C., Ballester, M., Darai, E., Deep pelvic endometriosis: limited additional diagnostic value of postcontrast in comparison with conventional MR images, European Journal of Radiology, 80, e331–9, 2011 | Retrospective study; comparison of post-contrast MRI versus conventional MRI |
| Bedaiwy, M. A., Falcone, T., Laboratory testing for endometriosis, Clinica Chimica Acta, 340, 41–56, 2004 | Narrative review |
| Bedaiwy, M. A., Falcone, T., Sharma, R. K., Goldberg, J. M., Attaran, M., Nelson, D. R., Agarwal, A., Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial, Human Reproduction, 17, 426–31, 2002 | Biomarkers not of interest |
| Belghiti, J., Thomassin-Naggara, I., Zacharopoulou, C., Zilberman, S., Jarboui, L., Bazot, M., Ballester, M., Darai, E., Contribution of Computed Tomography Enema and Magnetic Resonance Imaging to Diagnose Multifocal and Multicentric Bowel Lesions in Patients With Colorectal Endometriosis, Journal of Minimally Invasive Gynecology, 22, 776–84, 2015 | Lesion-level analysis |
| Belli, P., De Gaetano, A. M., Mirk, P., Speca, S., Valentini, A. L., Uterine adenomyosis and tubal endometriosis: diagnostic imaging, Rays, 23, 693–701, 1998 | Narrative review |
| Benacerraf, B. R., Finkler, N. J., Wojciechowski, C., Knapp, R. C., Sonographic accuracy in the diagnosis of ovarian masses, Journal of Reproductive Medicine for the Obstetrician and Gynecologist, 35, 491–495, 1990 | No outcome of interest |
| Benacerraf, B. R., Groszmann, Y., Sonography should be the first imaging examination done to evaluate patients with suspected endometriosis, Journal of Ultrasound in Medicine, 31, 651–3, 2012 | Narrative review |
| Bordin, L., Fiore, C., Dona, G., Andrisani, A., Ambrosini, G., Faggian, D., Plebani, M., Clari, G., Armanini, D., Evaluation of erythrocyte band 3 phosphotyrosine level, glutathione content, CA-125, and human epididymal secretory protein E4 as combined parameters in endometriosis, Fertility & Sterility, 94, 1616–21, 2010 | All the patients have proven endometriosis |
| Buchweitz, O., Staebler, A., Tio, J., Kiesel, L., Detection of peritoneal endometriotic lesions by autofluorescence laparoscopy, American Journal of Obstetrics & Gynecology, 195, 949–54, 2006 | Not entirely clear but it looks like laparoscopy in white light mode was the reference standard |
| Cheng, Y. M., Wang, S. T., Chou, C. Y., Serum CA-125 in preoperative patients at high risk for endometriosis, Obstetrics & Gynecology, 99, 375–80, 2002 | CA-125 has been used for identifying high risk woman not as a diagnostic tool |
| Cho, S., Cho, H., Nam, A., Kim, H. Y., Choi, Y. S., Park, K. H., Cho, D. J., Lee, B. S., Neutrophil-to-lymphocyte ratio as an adjunct to CA-125 for the diagnosis of endometriosis, Fertility & Sterility, 90, 2073–9, 2008 | It is a case-control study |
| Chung, M. K., Chung, R. R., Gordon, D., Jennings, C., The evil twins of chronic pelvic pain syndrome: endometriosis and interstitial cystitis, JSLS: Journal of the Society of Laparoendoscopic Surgeons / Society of Laparoendoscopic Surgeons, 6, 311–314, 2002 | Irrelevant comparison; includes post-menopausal women |
| Cohen, L. S., Valle, R. F., Sabbagha, R. E., A comparison of preoperative ultrasound images of surgically proven endometriomas scanned by both transabdominal and transvaginal techniques, Journal of Gynecologic Surgery, 11, 27–32, 1995 | All the patients have surgically confirmed endometriosis. |
| Cohen, M. R., Laparoscopy in the diagnosis and management of endometriosis, Journal of Reproductive Medicine, 27, 240–2, 1982 | No outcome of interest |
| Colacurci, N., Fortunato, N., De Franciscis, P., Fratta, M., Cioffi, M., Zarcone, R., Cardone, A., Serum and peritoneal CA-125 levels as diagnostic test for endometriosis, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 66, 41–3, 1996 | Case control study |
| Coleman, B. G., Arger, P. H., Mulhern, C. B., Jr., Endometriosis: clinical and ultrasonic correlation, AJR. American Journal of Roentgenology, 132, 747–9, 1979 | All patients were recruited in this study, had surgically proven endometriosis |
| Corwin, M. T., Gerscovich, E. O., Lamba, R., Wilson, M., McGahan, J. P., Differentiation of ovarian endometriomas from hemorrhagic cysts at MR imaging: utility of the T2 dark spot sign, Radiology, 271, 126–32, 2014 | Using a diagnostic test to diagnose endometriosis has not been addressed in this study. It is about a sign in MRI to distinguish between Endometrioma and haemorrhagic cysts. |
| Daniilidis, A., Giannoulis, H., Tantanasis, T., Papathanasiou, K., Loufopoulos, A., Tzafettas, J., Diagnostic laparoscopy, infertility, and endometriosis - 5 Years experience, Gynecological Surgery, 5, 231–234, 2008 | Outcomes not of interest |
| Dechaud, H., Ali Ahmed, S. A., Aligier, N., Vergnes, C., Hedon, B., Does transvaginal hydrolaparoscopy render standard diagnostic laparoscopy obsolete for unexplained infertility investigation?, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 94, 97–102, 2001 | Transvaginal hydrolaparoscopy compared with conventional laparoscopy; no data for outcomes |
| do Amaral, V. F., Ferriani, R. A., de Sa, M. F. S., Nogueira, A. A., Silva, J. C. R., de Sa Rosa e Silva, A. C. J., de Moura, M. D., Positive correlation between serum and peritoneal fluid CA-125 levels in women with pelvic endometriosis, Sao Paulo Medical Journal, 124, 223–227, 2006 | It is a case-control study |
| Donnez, J., Nisolle, M., Smoes, P., Gillet, N., Beguin, S., Casanas-Roux, F., Peritoneal endometriosis and “endometriotic” nodules of the rectovaginal septum are two different entities, Fertility & Sterility, 66, 362–8, 1996 | Not relevant comparison |
| Dunselman, G. A. J., Vermeulen, N., Becker, C., Calhaz-Jorge, C., D’Hooghe, T., De Bie, B., Heikinheimo, O., Horne, A. W., Kiesel, L., Nap, A., Prentice, A., Saridogan, E., Soriano, D., Nelen, W., ESHRE guideline: Management of women with endometriosis, Human Reproduction, 29, 400–412, 2014 | The individual studies in this publication have been checked for inclusion in the review |
| El Maati, A. A. A., Ibrahim, E. A. G., Mokhtar, F. Z., A two-stage imaging protocol for evaluating women presenting with acute pelvic pain, Egyptian Journal of Radiology and Nuclear Medicine, 44, 923–936, 2013 | The population is women with acute pelvic pain, not suspected endometriosis |
| Elgafor El Sharkwy, I. A., Combination of non-invasive and semi-invasive tests for diagnosis of minimal to mild endometriosis, Archives of gynecology and obstetrics, 288, 793–7, 2013 | The diagnostic test (IL-6 combined with nerve fibres) which has been used in this study is not matched with the protocol. |
| Ellett, L., Readman, E., Newman, M., McIlwaine, K., Villegas, R., Jagasia, N., Maher, P., Are endometrial nerve fibres unique to endometriosis? A prospective case-control study of endometrial biopsy as a diagnostic test for endometriosis in women with pelvic pain, Human Reproduction, 30, 2808–15, 2015 | Case-control study |
| Exacoustos, C., Luciano, D., Corbett, B., De Felice, G., Di Feliciantonio, M., Luciano, A., Zupi, E., The uterine junctional zone: a 3-dimensional ultrasound study of patients with endometriosis, American Journal of Obstetrics & Gynecology, 209, 248.e1–7, 2013 | In the study, the relation between thickness of uterine junctional zone and endometriosis has been evaluated. It has not been used as a diagnostic tool. |
| Faccioli, N., Manfredi, R., Mainardi, P., Dalla Chiara, E., Spoto, E., Minelli, L., Mucelli, R. P., Barium enema evaluation of colonic involvement in endometriosis, AJR. American Journal of Roentgenology, 190, 1050–4, 2008 | The diagnostic test (Barium enema) which has been used in this study is not matched with the protocol. |
| Federici, D., Muggiasca, M. L., Conti, M., Diagnostic value of laparoscopic evaluation of women with chronic pelvic pain: Our experience and a review of the literature, VALEUR DIAGNOSTIQUE DE L’EXPLORATION LAPAROSCOPIQUE DES FEMMES SOUFFRANT DE DOULEURS PELVIENNES CHRONIQUES: EXPERIENCE PERSONNELLE ET REVUE DE LA LITTERATURE, Acta Endoscopica, 22, 177–186, 1992 | Narrative review |
| Felding, C., Mikkelsen, A. L., Peen, U., Laparoscopy and ultrasound in patients with chronic pelvic pain, Journal of Obstetrics and Gynaecology, 10, 419–422, 1990 | No outcome of interest |
| Fisk, N. M., Tan, C. E., CA 125 in peritoneal fluid and serum of patients with endometriosis, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 29, 153–8, 1988 | Case-control study |
| Foda, A. A., Aal, I. A. A., Role of some biomarkers in chronic pelvic pain for early detection of endometriosis in infertile women, Middle East Fertility Society Journal, 17, 187–194, 2012 | Case-control study |
| Fratelli, N., Scioscia, M., Bassi, E., Musola, M., Minelli, L., Trivella, G., Transvaginal sonography for preoperative assessment of deep endometriosis, Journal of Clinical Ultrasound, 41, 69–75, 2013 | Data for TVS was collected retrospectively |
| Friedman, H., Vogelzang, R. L., Mendelson, E. B., Neiman, H. L., Cohen, M., Endometriosis detection by US with laparoscopic correlation, Radiology, 157, 217–20, 1985 | No data on outcomes |
| Gougoutas, C. A., Siegelman, E. S., Hunt, J., Outwater, E. K., Pelvic endometriosis: various manifestations and MR imaging findings, AJR. American Journal of Roentgenology, 175, 353–8, 2000 | Narrative review |
| Gurgan, T., Kisnisci, H., Yarali, H., Aksu, T., Zeyneloglu, H., Develioglu, O., Serum and peritoneal fluid CA-125 levels in early stage endometriosis, Gynecologic & Obstetric Investigation, 30, 105–8, 1990 | The cut-off for CA-125 is 16 U/ml |
| Guven, M. A., Bese, T., Demirkiran, F., Comparison of hydrosonography and transvaginal ultrasonography in the detection of intracavitary pathologies in women with abnormal uterine bleeding, International Journal of Gynecological Cancer, 14, 57–63, 2004 | The study population are women with history of abnormal uterine bleeding not women suspected to endometriosis |
| Harada, T., Kubota, T., Aso, T., Usefulness of CA19–9 versus CA125 for the diagnosis of endometriosis, Fertility and Sterility, 78, 733–739, 2002 | Case-control study |
| Hayata, T., Matsuki, S., Miyakawa, I., Low rate of histological confirmation of macroscopic endometriotic lesions, International Journal of Gynaecology & Obstetrics, 47, 167–8, 1994 | A letter, no description of the population, not sufficient data |
| Hompes, P. G., Koninckx, P. R., Kennedy, S., van Kamp, G. F., Verstraeten, R. A., Cornillie, F., Serum CA-125 concentrations during midfollicular phase, a clinically useful and reproducible marker in diagnosis of advanced endometriosis, Clinical Chemistry, 42, 1871–4, 1996 | No outcome of interest has been reported |
| Hornstein, M. D., Harlow, B. L., Thomas, P. P., Check, J. H., Use of a new CA 125 assay in the diagnosis of endometriosis, Human Reproduction, 10, 932–4, 1995 | The reported result has adjusted for prevalence of endometriosis in the community. This data is not useful for our systematic review. |
| Howard, F. M., El-Minawi, A. M., Sanchez, R. A., Conscious pain mapping by laparoscopy in women with chronic pelvic pain, Obstetrics & Gynecology, 96, 934–9, 2000 | Not relevant comparison |
| Ikeda, F., Bernardini, M. A., Vanni, D., Vasconcelos, A., Pinotti, J. A., Abrao, M. S., A comparison of microlaparoscopy under sedation, microlaparoscopy under general anesthesia and conventional laparoscopy for diagnosis and treatment of pelvic endometriosis in early stages, Fertility and sterility, 77, S21, 2002 | The effectiveness of using a diagnostic tool for diagnosis of endometriosis has not been addressed |
| Ismail, M. A., Rotmensch, J., Mercer, L. J., Block, B. S., Salti, G. I., Holt, J. A., CA-125 in peritoneal fluid from patients with nonmalignant gynecologic disorders, Journal of Reproductive Medicine, 39, 510–2, 1994 | The women without any symptom who went through laparoscopic sterilization have been considered as control group |
| Johnson, W. K., Ott, D. J., Chen, M. Y. M., Fayez, J. A., Gelfand, D. W., Efficacy of hysterosalpingography in evaluating endometriosis, Abdominal Imaging, 19, 278–280, 1994 | The study evaluated the effectiveness of hysterosalpingography and laparoscopy-retrospective study |
| Kafali, H., Artuc, H., Demir, N., Use of CA125 fluctuation during the menstrual cycle as a tool in the clinical diagnosis of endometriosis; a preliminary report, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 116, 85–8, 2004 | It is a case-control study |
| Kang, S. B., Chung, H. H., Lee, H. P., Lee, J. Y., Chang, Y. S., Impact of diagnostic laparoscopy on the management of chronic pelvic pain, Surgical Endoscopy, 21, 916–9, 2007 | there was no comparison between laparoscopy and another test |
| Karabacak, O., Tiras, M. B., Taner, M. Z., Guner, H., Yildiz, A., Yildirim, M., Small diameter versus conventional laparoscopy: a prospective, self-controlled study, Human Reproduction, 12, 2399–401, 1997 | Comparison of two types of laparoscopy |
| Kitawaki, J., Ishihara, H., Koshiba, H., Kiyomizu, M., Teramoto, M., Kitaoka, Y., Honjo, H., Usefulness and limits of CA-125 in diagnosis of endometriosis without associated ovarian endometriomas.[Erratum appears in Hum Reprod. 2007 Feb;22(2):627], Human Reproduction, 20, 1999–2003, 2005 | Women enrolled in the study were already diagnosed with endometriosis, adenomyosis and/or leiomyomas |
| Koninckx, P. R., Riittinen, L., Seppala, M., Cornillie, F. J., CA-125 and placental protein 14 concentrations in plasma and peritoneal fluid of women with deeply infiltrating pelvic endometriosis, Fertility & Sterility, 57, 523–30, 1992 | Wrong data and result have been reported |
| Kruger, K., Behrendt, K., Niedobitek-Kreuter, G., Koltermann, K., Ebert, A. D., Location-dependent value of pelvic MRI in the preoperative diagnosis of endometriosis, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 169, 93–8, 2013 | Pelvic MRI retrospectively assessed with histology |
| Kruitwagen, R. F., Thomas, C., Poels, L. G., Koster, A. M., Willemsen, W. N., Rolland, R., High CA-125 concentrations in peritoneal fluid of normal cyclic women with various infertilityrelated factors as demonstrated with two-step immunoradiometric assay, Fertility & Sterility, 56, 863–9, 1991 | The outcome of interest has not been reported |
| Leslie, C., Ma, T., McElhinney, B., Leake, R., Stewart, C. J., Is the detection of endometrial nerve fibers useful in the diagnosis of endometriosis?, International Journal of Gynecological Pathology, 32, 149–55, 2013 | No outcome of interest |
| Li, G., Yu, Z., Li, K., The value of FS, NLR, and CA-125 in the diagnosis of endometriosis, International journal of clinical and experimental medicine, 9, 7309–7313, 2016 | Not the population of interest |
| Macer, M. L., Mathur, M., Spektor, M., Gysler, S., Staib, L., Kodaman, P., McCarthy, S., Utility of magnetic resonance imaging in the evaluation of intraoperatively confirmed pelvic adhesions, Journal of Computer Assisted Tomography, 39, 896–900, 2015 | Not the population of interest |
| Manganaro, L., Fierro, F., Tomei, A., Irimia, D., Lodise, P., Sergi, M. E., Vinci, V., Sollazzo, P., Porpora, M. G., Delfini, R., Vittori, G., Marini, M., Feasibility of 3.0T pelvic MR imaging in the evaluation of endometriosis, European Journal of Radiology, 81, 1381–7, 2012 | Women in the study already had a diagnosis of endometriosis by transvaginal ultrasound |
| Martin, D. C., Hubert, G. D., Vander Zwaag, R., el-Zeky, F. A., Laparoscopic appearances of peritoneal endometriosis, Fertility & Sterility, 51, 63–7, 1989 | No outcome of interest |
| Martinez, S., Garrido, N., Coperias, J. L., Pardo, F., Desco, J., Garcia-Velasco, J. A., Simon, C., Pellicer, A., Serum interleukin-6 levels are elevated in women with minimal-mild endometriosis, Human Reproduction, 22, 836–42, 2007 | It is a case-control study |
| Mathlouthi, N., Ayed, B. B., Dhouib, M., Chaabene, K., Trabelsi, K., Amouri, H., Guermazi, M., Confrontation ultrasonography-CA125-histology in the managment of ovarian cysts: A prospective study about 77 cases, Tunisie Medicale, 89, 686–692, 2011 | Full-text in French |
| May, K. E., Conduit-Hulbert, S. A., Villar, J., Kirtley, S., Kennedy, S. H., Becker, C. M., Peripheral biomarkers of endometriosis: a systematic review, Human Reproduction Update, 16, 651–74, 2010 | This systematic review includes papers also regarding other biomarkers. The full texts of individual related studies were retrieved and reviewed. |
| McBride, N., Newman, R. L., Diagnostic laparoscopy, International Journal of Gynaecology & Obstetrics, 15, 556–8, 1978 | No outcome of interest |
| McKinnon, B., Mueller, M. D., Nirgianakis, K., Bersinger, N. A., Comparison of ovarian cancer markers in endometriosis favours HE4 over CA125, Molecular Medicine Reports, 12, 5179–84, 2015 | No data reported to calculate sensitivity |
| Medl, M., Ogris, E., Peters-Engl, C., Mierau, M., Buxbaum, P., Leodolter, S., Serum levels of the tumour-associated trypsin inhibitor in patients with endometriosis, British Journal of Obstetrics & Gynaecology, 104, 78–81, 1997 | Wrong data and result have been reported. |
| Melega, C., Marchesini, F. P., Bellettini, L., Biscontin, S., Flamigni, C., Diagnostic value of laparoscopy in endometriosis and infertility, Journal of Reproductive Medicine, 29, 597–600, 1984 | No outcome of interest |
| Mezzi, G., Ferrari, S., Arcidiacono, P. G., Di Puppo, F., Candiani, M., Testoni, P. A., Endoscopic rectal ultrasound and elastosonography are useful in flow chart for the diagnosis of deep pelvic endometriosis with rectal involvement, Journal of Obstetrics & Gynaecology Research, 37, 586–90, 2011 | There was no comparison with surgery |
| Mikami, M., Tanabe, K., Matsuo, K., Miyazaki, Y., Miyazawa, M., Hayashi, M., Asai, S., Ikeda, M., Shida, M., Hirasawa, T., Kojima, N., Sho, R., Iijima, S., Fully-sialylated alpha-chain of complement 4-binding protein: Diagnostic utility for ovarian clear cell carcinoma, Gynecologic Oncology, 139, 520–528, 2015 | Not the population of interest |
| Millischer, A. E., Salomon, L. J., Santulli, P., Borghese, B., Dousset, B., Chapron, C., Fusion imaging for evaluation of deep infiltrating endometriosis: feasibility and preliminary results, Ultrasound in Obstetrics & Gynecology, 46, 109–17, 2015 | No data on surgical diagnosis |
| Miyagi, E., Maruyama, Y., Mogami, T., Numazaki, R., Ikeda, A., Yamamoto, H., Hirahara, F., Comparison of plasma amino acid profile-based index and CA125 in the diagnosis of epithelial ovarian cancers and borderline malignant tumors, International Journal of Clinical Oncology, 1–8, 2016 | Not the population of interest |
| Mol, B. W., Bayram, N., Lijmer, J. G., Wiegerinck, M. A., Bongers, M. Y., van der Veen, F., Bossuyt, P. M., The performance of CA-125 measurement in the detection of endometriosis: a meta-analysis, Fertility & Sterility, 70, 1101–8, 1998 | All the studies included in this systematic review could not be included in our systematic review. The full-texts of all individual studies were retrieved and reviewed and related studies were included in our review. |
| Moloney, M. D., Thornton, J. G., Cooper, E. H., Serum CA 125 antigen levels and disease severity in patients with endometriosis, Obstetrics & Gynecology, 73, 767–9, 1989 | Women had laparoscopically confirmed endometriosis and then CA-125 level has been evaluated |
| Moretuzzo, R. W., DiLauro, S., Jenison, E., Chen, S. L., Reindollar, R. H., McDonough, P. G., Serum and peritoneal lavage fluid CA-125 levels in endometriosis, Fertility & Sterility, 50, 430–3, 1988 | No outcome of interest |
| Nezhat, F., Allan, C. J., Nezhat, C., Martin, D. C., Nonvisualized endometriosis at laparoscopy, International Journal of Fertility, 36, 340–3, 1991 | Not possible to extract data |
| Nisolle, M., Casanas-Roux, F., Anaf, V., Mine, J. M., Donnez, J., Morphometric study of the stromal vascularization in peritoneal endometriosis, Fertility & Sterility, 59, 681–4, 1993 | A morphometric study |
| O’Shaughnessy, A., Check, J. H., Nowroozi, K., Lurie, D., CA 125 levels measured in different phases of the menstrual cycle in screening for endometriosis, Obstetrics & Gynecology, 81, 99–103, 1993 | Wrong data and result have been reported |
| Ota, H., Maki, M., Evaluation of autoantibody and CA125 in the diagnosis of endometriosis or adenomyosis, Medical Science Research, 18, 309–310, 1990 | All the participants had known condition |
| Othman, E. E. D. R., Hornung, D., Al-Hendy, A., Biomarkers of endometriosis, Expert Opinion on Medical Diagnostics, 2, 741–752, 2008 | Narrative review |
| Ozaksit, G., Caglar, T., Cicek, N., Kuscu, E., Batioglu, S., Gokmen, O., Serum CA 125 levels before, during and after treatment for endometriosis, International Journal of Gynaecology & Obstetrics, 50, 269–73, 1995 | Women had a confirmed diagnosis of endometriosis prior to CA-125 test |
| Paiva, P., Lappas, M., Barker, G., Healey, M., Using symptom scores, lifestyle measures and biochemical markers to create a test for endometriosis, Journal of Endometriosis and Pelvic Pain Disorders, 6, 135–143, 2014 | No outcome of interest |
| Panidis, D., Vlassis, G., Matalliotakis, J., Skiadopoulos, S., Kalogeropoulos, A., Serum levels of the oncofetal antigens CA-125, CA 19–9 and CA 15–3 in patients with endometriosis, Journal of Endocrinological Investigation, 11, 801–804, 1988 | All women who involved in the study have proven endometriosis |
| Pastorfide, G., Fong, Y. F., Use of narrowband imaging for the detection of endometriosis, Journal of Minimally Invasive Gynecology, 22, 535, 2015 | No outcome of interest |
| Patel, M. D., Feldstein, V. A., Chen, D. C., Lipson, S. D., Filly, R. A., Endometriomas: diagnostic performance of US.[Erratum appears in Radiology 1999 Dec;213(3):930], Radiology, 210, 739–45, 1999 | Retrospective review of sonograms by two sonologists |
| Patel, M. D., Feldstein, V. A., Filly, R. A., The likelihood ratio of sonographic findings for the diagnosis of hemorrhagic ovarian cysts, Journal of Ultrasound in Medicine, 24, 607–14; quiz 615, 2005 | It is about diagnosis of haemorrhagic ovarian cyst not endometrioma |
| Patton, P. E., Field, C. S., Harms, R. W., Coulam, C. B., CA-125 levels in endometriosis, Fertility & Sterility, 45, 770–3, 1986 | Women who come for elective sterilization have been also included in this study, while they are not suspected for endometriosis. |
| Philip, C. A., Bisch, C., Coulon, A., de Saint-Hilaire, P., Rudigoz, R. C., Dubernard, G., Correlation between three-dimensional rectosonography and magnetic resonance imaging in the diagnosis of rectosigmoid endometriosis: a preliminary study on the first fifty cases, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 187, 35–40, 2015 | MRI was the reference test |
| Piessens, S., Healey, M., Maher, P., Tsaltas, J., Rombauts, L., Can anyone screen for deep infiltrating endometriosis with transvaginal ultrasound?, Australian & New Zealand Journal of Obstetrics & Gynaecology, 54, 462–8, 2014 | Women included in the study had the ultrasound test after diagnosis of endometriosis by surgery |
| Pittaway, D. E., Douglas, J. W., Serum CA-125 in women with endometriosis and chronic pelvic pain, Fertility & Sterility, 51, 68–70, 1989 | The cut-off for CA-125 is 16 U/ml |
| Portuondo, J. A., Herran, C., Echanojauregui, A. D., Riego, A. G., Peritoneal flushing and biopsy in laparoscopically diagnosed endometriosis, Fertility & Sterility, 38, 538–41, 1982 | Not relevant comparison |
| Punnonen, R., Diagnostic gynecologic laparoscopy-analysis of 1226 cases, Asia-Oceania Journal of Obstetrics & Gynaecology, 9, 199–202, 1983 | No pathology |
| Randall, G. W., Gantt, P. A., Poe-Zeigler, R. L., Bergmann, C. A., Noel, M. E., Strawbridge, W. R., Richardson-Cox, B., Hereford, J. R., Reiff, R. H., Serum antiendometrial antibodies and diagnosis of endometriosis, American Journal of Reproductive Immunology, 58, 374–82, 2007 | The diagnostic test which has been used in this study is not matched with the protocol |
| Redwine, D. B., Ovarian endometriosis: A marker for more extensive pelvic and intestinal disease, Fertility and Sterility, 72, 310–315, 1999 | All the patients have endometriosis |
| Reid, S., Lu, C., Casikar, I., Reid, G., Abbott, J., Cario, G., Chou, D., Kowalski, D., Cooper, M., Condous, G., Prediction of pouch of Douglas obliteration in women with suspected endometriosis using a new real-time dynamic transvaginal ultrasound technique: the sliding sign, Ultrasound in Obstetrics & Gynecology, 41, 685–91, 2013 | It has focused on the pouch of Douglas obliteration not only endometriosis |
| Rosa, E. Silva A. C., Rosa, E. Silva J. C., Ferriani, R. A., Serum CA-125 in the diagnosis of endometriosis, International Journal of Gynaecology & Obstetrics, 96, 206–7, 2007 | Retrospective study. Women included in the study already had a diagnosis of endometriosis prior to CA-125 serum collection. |
| Saba, L., Guerriero, S., Sulcis, R., Ajossa, S., Melis, G., Mallarini, G., Agreement and reproducibility in identification of endometriosis using magnetic resonance imaging, Acta Radiologica, 51, 573–80, 2010 | No outcome of interest |
| Saba, L., Guerriero, S., Sulis, R., Pilloni, M., Ajossa, S., Melis, G., Mallarini, G., Learning curve in the detection of ovarian and deep endometriosis by using Magnetic Resonance: comparison with surgical results, European Journal of Radiology, 79, 237–44, 2011 | The aim of the study was to determine whether diagnostic accuracy is correlated to radiologist expertise |
| Samuelsson, S., Sjovall, A., On the diagnostic value of laparoscopy in ovarian endometriosis, Acta Obstetricia et Gynecologica Scandinavica, 47, 350–360, 1968 | No pathology |
| Scardapane, A., Bettocchi, S., Lorusso, F., Stabile Ianora, A. A., Vimercati, A., Ceci, O., Lasciarrea, M., Angelelli, G., Diagnosis of colorectal endometriosis: contribution of contrast enhanced MR-colonography, European Radiology, 21, 1553–63, 2011 | Comparison of MRI between two radiologists |
| Scardapane, A., Lorusso, F., Scioscia, M., Ferrante, A., Stabile Ianora, A. A., Angelelli, G., Standard high-resolution pelvic MRI vs. low-resolution pelvic MRI in the evaluation of deep infiltrating endometriosis, European Radiology, 24, 2590–6, 2014 | Comparison of MRI carried out by two different radiologists |
| Schenken, R. S., Improving the diagnosis of endometriosis in adolescents, Sexuality, Reproduction and Menopause, 6, 4–8, 2008 | Narrative review |
| Seeber, B., Sammel, M. D., Fan, X., Gerton, G. L., Shaunik, A., Chittams, J., Barnhart, K. T., Panel of markers can accurately predict endometriosis in a subset of patients, Fertility & Sterility, 89, 1073–81, 2008 | It is a case-control study |
| Shen, A., Xu, S., Ma, Y., Guo, H., Li, C., Yang, C., Zou, S., Diagnostic value of serum CA125, CA19–9 and CA15–3 in endometriosis: A meta-analysis, Journal of International Medical Research, 43, 599–609, 2015 | It is about association of biomarkers and stage of endometriosis. No outcome of interest. |
| Somigliana, E., Vigano, P., Candiani, M., Felicetta, I., Di Blasio, A. M., Vignali, M., Use of serum-soluble intercellular adhesion molecule-1 as a new marker of endometriosis, Fertility & Sterility, 77, 1028–31, 2002 | Women included in the study already had laparoscopy prior to CA-125 serum collection |
| Somigliana, E., Vigano, P., Tirelli, A. S., Felicetta, I., Torresani, E., Vignali, M., Di Blasio, A. M., Use of the concomitant serum dosage of CA 125, CA 19–9 and interleukin-6 to detect the presence of endometriosis. Results from a series of reproductive age women undergoing laparoscopic surgery for benign gynaecological conditions, Human Reproduction, 19, 1871–6, 2004 | Case-control study |
| Spencer, J. A., Weston, M. J., Imaging in endometriosis, Imaging, 15, 63–71, 2003 | Narrative review |
| Stegmann, B. J., Funk, M. J., Sinaii, N., Hartmann, K. E., Segars, J., Nieman, L. K., Stratton, P., A logistic model for the prediction of endometriosis, Fertility & Sterility, 91, 51–5, 2009 | It is about prediction of endometriosis |
| Stowell, S. B., Wiley, C. M., Perez-Reyes, N., Powers, C. N., Cytologic diagnosis of peritoneal fluids. Applicability to the laparoscopic diagnosis of endometriosis, Acta Cytologica, 41, 817–22, 1997 | The diagnostic test in this study is not matched with the protocol |
| Stratton, P., Winkel, C., Premkumar, A., Chow, C., Wilson, J., Hearns-Stokes, R., Heo, S., Merino, M., Nieman, L. K., Diagnostic accuracy of laparoscopy, magnetic resonance imaging, and histopathologic examination for the detection of endometriosis, Fertility & Sterility, 79, 1078–85, 2003 | Not relevant comparison |
| Szubert, M., Suzin, J., Wierzbowski, T., Kowalczyk-Amico, K., CA-125 concentration in serum and peritoneal fluid in patients with endometriosis - preliminary results, Archives of Medical Science, 8, 504–8, 2012 | Case-control study |
| Takahashi, K., Nagata, H., Kitao, M., CA-125 in the menstrual blood is an effective marker for diagnosing early stage endometriosis: A preliminary report, Japanese Journal of Fertility and Sterility, 36, 356–359, 1991 | Ultrasound was used to confirm ovulatory day only |
| Takahashi, K., Nagata, H., Musa, A. A., Shibukawa, T., Yamasaki, H., Kitao, M., Clinical usefulness of CA-125 levels in the menstrual discharge in patients with endometriosis, Fertility & Sterility, 54, 360–2, 1990 | The level of CA-125 has been assessed in the menstrual discharge |
| Takeuchi, M., Matsuzaki, K., Nishitani, H., Susceptibility-weighted MRI of endometrioma: preliminary results, AJR. American Journal of Roentgenology, 191, 1366–70, 2008 | No outcome of interest |
| Tirlapur, S. A., Daniels, J. P., Khan, K. S., Medal trial collaboration, Chronic pelvic pain: how does noninvasive imaging compare with diagnostic laparoscopy?, Current Opinion in Obstetrics & Gynecology, 27, 445–8, 2015 | This systematic review has not only focused on patients with suspected endometriosis. It is more general about pelvic pain and diagnostic tools. |
| Tumedei, U., Ciardelli, V., Paltrinieri, F., Kuria, M. S., Amadori, A., Stefanetti, M., Gori, G., Transvaginal ultrasound in the diagnosis of endometrial abnormalities, Tumori, 87, S15, 2001 | It has focused on endometrial abnormalities not endometriosis. |
| Ueki, M., Saeki, M., Tsurunaga, T., Ueda, M., Ushiroyama, N., Sugimoto, O., Visual findings and histologic diagnosis of pelvic endometriosis under laparoscopy and laparotomy, International Journal of Fertility & Menopausal Studies, 40, 248–53, 1995 | Post-menopausal women included |
| Van den Bosch, T., Vandendael, A., Van Schoubroeck, D., Wranz, P. A. B., Lombard, C. J., Combining vaginal ultrasonography and office endometrial sampling in the diagnosis of endometrial disease in postmenopausal women, Obstetrics and Gynecology, 85, 349–352, 1995 | It is not about endometriosis, it has addressed endometrial diseases |
| Vercellini, P., Fedele, L., Molteni, P., Arcaini, L., Bianchi, S., Candiani, G. B., Laparoscopy in the diagnosis of gynecologic chronic pelvic pain, International Journal of Gynaecology & Obstetrics, 32, 261–5, 1990 | No pathology |
| Vrachnis, N., Sifakis, S., Samoli, E., Kappou, D., Pavlakis, K., Iliodromiti, Z., Botsis, D., Three-dimensional ultrasound and three-dimensional power Doppler improve the preoperative evaluation of complex benign ovarian lesions, Clinical & Experimental Obstetrics & Gynecology, 39, 474–8, 2012 | No outcome of interest |
| Walsh, J. W., Taylor, K. J., Wasson, J. F., Schwartz, P. E., Rosenfield, A. T., Gray-scale ultrasound in 204 proved gynecologic masses: accuracy and specific diagnostic criteria, Radiology, 130, 391–7, 1979 | No outcome of interest |
| Wang, L., Liu, H. Y., Shi, H. H., Lang, J. H., Sun, W., Urine peptide patterns for non-invasive diagnosis of endometriosis: a preliminary prospective study, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 177, 23–8, 2014 | Biomarker not of interest |
| Wessels, J. M., Kay, V. R., Leyland, N. A., Agarwal, S. K., Foster, W. G., Assessing brain-derived neurotrophic factor as a novel clinical marker of endometriosis, Fertility & Sterility, 105, 119–128.e5, 2016 | Not the test of interest |
| Wild, R. A., Hirisave, V., Bianco, A., Podczaski, E. S., Demers, L. M., Endometrial antibodies versus CA-125 for the detection of endometriosis, Fertility & Sterility, 55, 90–4, 1991 | The cut-off for CA-125 is 16 U/ml |
| Wolfler, M. M., Nagele, F., Kolbus, A., Seidl, S., Schneider, B., Huber, J. C., Tschugguel, W., A predictive model for endometriosis, Human Reproduction, 20, 1702–8, 2005 | Biomarker not of interest |
| Wykes, C. B., Clark, T. J., Khan, K. S., Accuracy of laparoscopy in the diagnosis of endometriosis: A systematic quantitative review, BJOG: An International Journal of Obstetrics and Gynaecology, 111, 1204–1212, 2004 | Single studies included in the review were assessed for inclusion |
| Yamashita, Y., Torashima, M., Hatanaka, Y., Harada, M., Higashida, Y., Takahashi, M., Mizutani, H., Tashiro, H., Iwamasa, J., Miyazaki, K., et al.,, Adnexal masses: accuracy of characterization with transvaginal US and precontrast and postcontrast MR imaging, Radiology, 194, 557–65, 1995 | Review of MRI and TVUS by five radiologists |
| Yazbek, J., Helmy, S., Ben-Nagi, J., Holland, T., Sawyer, E., Jurkovic, D., Value of preoperative ultrasound examination in the selection of women with adnexal masses for laparoscopic surgery, Ultrasound in Obstetrics and Gynecology, 30, 883–888, 2007 | The preoperative sonography has not been used to diagnose endometriosis |
H.12. Staging Systems
| Study | Reason for Exclusion |
|---|---|
| Classification of endometriosis, Fertility and sterility, 32, 633, 1979 | Narrative review |
| Acosta, A. A., Buttram, V. C., Jr., Besch, P. K., Malinak, L. R., Franklin, R. R., Vanderheyden, J. D., A proposed classification of pelvic endometriosis, Obstetrics & Gynecology, 42, 19–25, 1973 | A classification system has been proposed but its effectiveness has not been evaluated |
| Anonymous, Classification of endometriosis. The American Fertility Society, Fertility & Sterility, 32, 633–4, 1979 | Letter |
| Bardis, N., Pistofidis, G. A., Chatzirafail, V., Balinakos, P., Filippidis, M., Enzian Scoring System (ESS) for the assessment of pelvic pain in women with deep comparison between the American Fertility Society (AFS) scoring system versus the infiltrating endometriosis, Gynecological Surgery, 6, S160, 2009 | Surgical outcomes not evaluated |
| Bassil Lasmar, R., Simoes Abraao, M., Lasmar, R. B., Leon Dewilde, R., Simplified approach to the treatment of endometriosis - ECO system, Minerva Ginecologica, 64, 331–335, 2012 | It has focused on development of a classification system while the effectiveness of the system has not been evaluated |
| Bauer, E., Widschwendter, P., Stuck, D., Gundelach, T., Wulff, C., Janni, W., Hancke, K., Endometriosis Health Profile scores and their association with surgical diagnosis in premenopausal women, Journal of Endometriosis, 5, S31-S32, 2013 | The effectiveness of using staging systems to guide treatment has not been assessed |
| Beecham, C. T., Classification of endometriosis, Obstetrics & Gynecology, 28, 437, 1966 | Editorial/letter |
| Borase, H., Hillman-Cooper, C., Khan, A., Reddy, K., Endometriosis infertility index (EFI) - A retrospective analysis of the use of this new tool in the management of infertile women with endometriosis, Human Fertility, 14, 23–24, 2011 | The clinical and cost-effectiveness of using staging system has not been evaluated. |
| Boujenah, J., Bonneau, C., Hugues, J. N., Sifer, C., Poncelet, C., External validation of the Endometriosis Fertility Index in a French population, Fertility & Sterility, 104, 119–123.e1, 2015 | The effectiveness of using staging system to guide the treatment has not been addressed |
| Boujenah, J., Hugues, J. N., Sifer, C., Bricou, A., Cedrin-Durnerin, I., Sonigo, C., Monforte, M., Poncelet, C., Endometriosis Fertility Index, or classification of the American Society of Reproductive Medicine for postoperative endometriosis patients with infertility: Which is more relevant?, Gynecologie Obstetrique Fertilite, 43, 806–809, 2015 | Foreign Language Paper. It is unclear from the abstract whether this paper reports on a primary study. |
| Buttram Jr, V. C., Classification of endometriosis, Contributions to Gynecology and Obstetrics, 16, 73–83, 1987 | Narrative review |
| Candiani, G. B., Vercellini, P., Fedele, L., Clinical staging and therapeutic choices in endometriosis, New Trends in Gynaecology and Obstetrics, 2, 379–386, 1986 | Narrative review |
| Chapron, C., Fauconnier, A., Dubuisson, J.B., Barakat, H., Vieira, M., Breart, G., Deep infiltrating endometriosis: relation between severity of dysmenorrhoea and extent of disease, Human Reproduction, 18, 760–766, 2003 | There is no comparison group and the effectiveness of using staging system has not been assessed |
| Choi, B. R., Jeon, Y. E., Kim, H. Y., Seo, S. K., Choi, Y. S., Cho, S., Lee, B. S., Prognostic value of the revised American fertility society classification system and preoperative serum CA-125 level for the first recurrence of advanced endometriosis after conservative laparoscopy, Fertility and sterility, 1), S220, 2012 | Clinical effectiveness of the staging systems to guide treatment decisions was not assessed |
| Chopin, N., Vieira, M., Borghese, B., Foulot, H., Dousset, B., Coste, J., Mignon, A., Fauconnier, A., Chapron, C., Operative management of deeply infiltrating endometriosis: results on pelvic pain symptoms according to a surgical classification, Journal of Minimally Invasive Gynecology, 12, 106–12, 2005 | Clinical effectiveness of the staging systems has not been assessed |
| Coccia, M. E., Rizzello, F., Palagiano, A., Scarselli, G., Long-term follow-up after laparoscopic treatment for endometriosis: multivariate analysis of predictive factors for recurrence of endometriotic lesions and pain, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 157, 78–83, 2011 | The intervention has not used staging system. There is no comparison group and no outcome of interest. |
| Di Paola, V., Manfredi, R., Castelli, F., Negrelli, R., Mehrabi, S., Pozzi Mucelli, R., Detection and localization of deep endometriosis by means of MRI and correlation with the ENZIAN score, European Journal of Radiology, 84, 568–74, 2015 | The clinical and cost-effectiveness of using staging systems has not been evaluated |
| Dmowski, W. P., Visual assessment of peritoneal implants for staging endometriosis: do number and cumulative size of lesions reflect the severity of a systemic disease?, Fertility & Sterility, 47, 382–4, 1987 | Narrative review |
| Elsheikh, A., Milingos, S., Loutradis, D., Kallipolitis, G., Michalas, S., Endometriosis and reproductive disorders, Annals of the New York Academy of Sciences, 997, 247–54, 2003 | It is focused on the relationship between severity of endometriosis and pregnancy rate after surgery. It has not used the staging system to guide treatment. |
| Emilio, P., Control of pelvic pain and quality of life following treatment of symptomatic endometriosis, Journal of Psychosomatic Obstetrics and Gynecology, 31, 21, 2010 | Not looking at staging systems to guide treatment decisions |
| Fasciani, A., Repetti, F., Binda, G. A., Puntoni, M., Meroni, M. G., Bocci, G., Endometriosis Index: A software-derived score to predict the presence and severity of the disease, Journal of Endometriosis, 2, 79–86, 2010 | Data on surgical outcomes not provided. |
| Fedele, L., Parazzini, F., Bianchi, S., Arcaini, L., Candiani, G. B., Stage and localization of pelvic endometriosis and pain, Fertility & Sterility, 53, 155–8, 1990 | Clinical effectiveness of the staging systems has not been assessed |
| Gillett, W. R., Lamont, J. M., Peek, J. C., Herbison, G. P., Effect of severity of endometriosis on prioritisation for infertility treatment in New Zealand, Human Reproduction, 28, i245-i246, 2013 | The study has addressed the severity of endometriosis and pregnancy rate. It has not evaluated the effectiveness of classification systems. |
| Guzick, D. S., Bross, D. S., Rock, J. A., Assessing the efficacy of The American Fertility Society’s classification of endometriosis: application of a dose-response methodology, Fertility & Sterility, 38, 171–6, 1982 | The effectiveness of using staging systems has not been assessed |
| Haas, D., Chvatal, R., Habelsberger, A., Wurm, P., Schimetta, W., Oppelt, P., Comparison of revised American Fertility Society and ENZIAN staging: a critical evaluation of classifications of endometriosis on the basis of our patient population, Fertility & Sterility, 95, 1574–8, 2011 | The effectiveness of the staging systems has not been addressed |
| Haas, D., Chvatal, R., Wurm, P., Habelsberger, A., Oppelt, P., Endometriosis between AFS and ENZIAN: A critical assessment of classification systems for endometriosis staging in an own patient group, Archives of gynecology and obstetrics, 282, S175, 2010 | The effectiveness of using staging systems to guide treatment has not been assessed |
| Haas, D., Oppelt, P., Shebl, O., Shamiyeh, A., Schimetta, W., Mayer, R., Enzian classification: does it correlate with clinical symptoms and the rASRM score?, Acta Obstetricia et Gynecologica Scandinavica, 92, 562–6, 2013 | There is no comparison group. The intervention has not used staging system to guide treatment |
| Haas, D., Oppelt, P., Shebl, O., Shamiyeha, A., Schimetta, W., Mayer, R., Enzian classification: Does it correlate with clinical symptoms and the rASRM score?, Journal of Endometriosis, 5, S39, 2013 | The effectiveness of using staging systems to guide treatment has not been assessed |
| Haas, D., Wurm, P., Shamiyeh, A., Shebl, O., Chvatal, R., Oppelt, P., Efficacy of the revised Enzian classification: a retrospective analysis. Does the revised Enzian classification solve the problem of duplicate classification in rASRM and Enzian?, Archives of Gynecology & Obstetrics, 287, 941–5, 2013 | The effectiveness of using staging system to guide treatment has not been assessed |
| Hackethal, A., Luck, C., Konrad, L., Muenstedt, K., Tinneberg, H. R., Oehmke, F., Deep infiltrating endometriosis is frequent in all stages of endometriosis and the depth of infiltration influences surgical parameters proportionally, Journal of Endometriosis, 2, 205–212, 2010 | No information about outcomes after surgery. |
| Hancke, K., Friedl, T., Widschwendter, P., Stuck, D., Gundelach, T., Janni, W., Bauer, E., Endometriosis health profile (EHP-30) scores and their association with surgical diagnosis in premenopausal women, Human Reproduction, 29, i208-i209, 2014 | Not using staging systems to guide treatment decisions |
| Hassa, H., What is the problem with the current classification system and how can we improve it?, Journal of Endometriosis, 4 (3), 131–132, 2012 | Literature review of different staging systems |
| Hoshiai, H., Ishikawa, M., Sawatari, Y., Noda, K., Fukaya, T., Laparoscopic evaluation of the onset and progression of endometriosis, American Journal of Obstetrics and Gynecology, 169, 714–719, 1993 | The effectiveness of the staging systems has not been assessed |
| Jayakrishnan, N., Predicting the reproductive outcome in endometriosis-a comparison between EFI and AFS scores, Human Reproduction, 30, i54, 2015 | Study does not use staging systems to guide treatment decisions |
| Kistner, R. W., Siegler, A. M., Behrman, S. J., Suggested classification for endometriosis: relationship to infertility, Fertility & Sterility, 28, 1008–10, 1977 | Narrative review |
| Li, X., Tang, H., The value of endometriosis fertility index in predicting the pregnancy outcome after laparoscopy for minimal or mild endometriosis associated infertility, International Journal of Gynecology and Obstetrics, 131, E293, 2015 | Correlation of stages within a single classification to an outcome. Not used to guide treatment decisions |
| Malinak, L. R., Infertility and endometriosis operative technique, clinical staging, and prognosis, Clinical Obstetrics & Gynecology, 23, 925–35, 1980 | The effectiveness of using staging systems has not been assessed |
| Momoeda, M., Taketani, Y., Terakawa, N., Hoshiai, H., Tanaka, K., Tsutsumi, O., Osuga, Y., Maruyama, M., Harada, T., Obata, K., Hayashi, K., Is endometriosis really associated with pain?, Gynecologic & Obstetric Investigation, 54 Suppl 1, 18–21; discussion 21–3, 2002 | The effectiveness of using staging systems has not been addressed |
| Muse, K., Clinical manifestations and classification of endometriosis, Clinical Obstetrics & Gynecology, 31, 813–22, 1988 | It is a narrative review article explaining the clinical presentations of endometriosis and classification system |
| Nezhat, C., Nezhat, F., Nezhat, C., Seidman, D. S., Classification of endometriosis. Improving the classification of endometriotic ovarian cysts, Human Reproduction, 9, 2212–3, 1994 | It is a debate about classification of endometriosis not a study evaluating the effectiveness of using staging systems |
| Palmisano, G. P., Adamson, G. D., Lamb, E. J., Can staging systems for endometriosis based on anatomic location and lesion type predict pregnancy rates?, International Journal of Fertility & Menopausal Studies, 38, 241–9, 1993 | The effectiveness of using endometriosis to guide the treatment has not been evaluated |
| Pistofidis, G. A., Bardis, N. S., Koukoura, O. G., Balinakos, P. M., Filippidis, M. S., Comparison of the Enzian Scoring system with the American Fertility Society scoring system for the assessment of pelvic pain in women with deep infiltrating endometriosis, Journal of Minimally Invasive Gynecology, 1), S27, 2010 | Pelvic pain and severity of the disease according to the scoring systems have been evaluated. Effectiveness of the staging systems to guide the treatment has not been assessed. |
| Pop-Trajkovic, S., Popovic, J., Antic, V., Radovic, D., Stefanovic, M., Vukomanovic, P., Stages of endometriosis: does it affect in vitro fertilization outcome.[Erratum appears in Taiwan J Obstet Gynecol. 2015 Dec;54(6):806 Note: Stavanovic, Milan [Corrected to Stefanovic, Milan]], Taiwanese Journal of Obstetrics & Gynecology, 53, 224–6, 2014 | Does not compare staging classification systems. Only looks at treatment outcomes for one system. |
| Porpora, M.G., Koninckx, P.R., Piazze, J., Natili, M., Colagrande, S., Cosmi, E.V., Correlation between endometriosis and pelvic pain, Journal of the American Association of Gynecologic Laparoscopists, 6, 429–434, 1999 | The effectiveness of the staging systems has not been assessed |
| Renner, S., Rix, S., Lermann, J., Thiel, F., Oppelt, P., Beckmann, M. W., Fasching, P., Pain as risk factor for recurrence in patients with endometriosis, Gynecological Surgery, 8, S38, 2011 | It has addressed pain as a risk factor for recurrence. The effectiveness of the staging systems has not been assessed. |
| Sun, A., Han, M., A proposed clinical classification of pelvic endometriosis, Proceedings of the Chinese Academy of Medical Sciences & the Peking Union Medical College, 5, 163–7, 1990 | The effectiveness of using staging system has not been assessed |
| Szendei, G., Hernadi, Z., Devenyi, N., Csapo, Z., Is there any correlation between stages of endometriosis and severity of chronic pelvic pain? Possibilities of treatment, Gynecological Endocrinology, 21, 93–100, 2005 | The relationship between pain and the severity of endometriosis has been assessed. The effectiveness of using staging system has not been addressed. |
| Tomassetti, C., Geysenbergh, B., Meuleman, C., Fieuws, S., D’Hooghe, T., External validation of the EFI (Endometriosis Fertility Index) staging system for predicting non-ART pregnancy after endometriosis surgery, Human Reproduction, 27, 2012 | The effectiveness of using staging system has not been assessed |
| Vercellini, P., Fedele, L., Aimi, G., De Giorgi, O., Consonni, D., Crosignani, P. G., Reproductive performance, pain recurrence and disease relapse after conservative surgical treatment for endometriosis: the predictive value of the current classification system, Human Reproduction, 21, 2679–85, 2006 | The research question is focused on association of the classification system and clinical outcomes after the surgery not the effectiveness of using staging systems |
| Vercellini, P., Fedele, L., Aimi, G., Pietropaolo, G., Consonni, D., Crosignani, P. G., Association between endometriosis stage, lesion type, patient characteristics and severity of pelvic pain symptoms: a multivariate analysis of over 1000 patients, Human Reproduction, 22, 266–71, 2007 | The effectiveness of using staging system has not been assessed |
| Vercellini, P., Trespidi, L., De Giorgi, O., Cortesi, I., Parazzini, F., Crosignani, P. G., Endometriosis and pelvic pain: relation to disease stage and localization, Fertility & Sterility, 65, 299–304, 1996 | It has focused on relation between stages of endometriosis and Pelvic pain not using staging system to guide the treatment |
| Wang, W., Li, R., Fang, T., Huang, L., Ouyang, N., Wang, L., Zhang, Q., Yang, D., Endometriosis fertility index score maybe more accurate for predicting the outcomes of in vitro fertilisation than r-AFS classification in women with endometriosis, Reproductive Biology & Endocrinology, 11, 112, 2013 | The effectiveness of staging system has not been evaluated. The study has addressed the predictive value of the staging system in IVF outcome after surgery. |
| Yun, B. H., Jeon, Y. E., Chon, S. J., Park, J. H., Seo, S. K., Cho, S., Choi, Y. S., Lee, J. S., Lee, B. S., The prognostic value of individual adhesion scores from the revised American fertility society classification system for recurrent endometriosis, Yonsei medical journal, 56, 1079–1086, 2015 | The study has not evaluated the effectiveness of using staging systems |
| Zeng, C., Xu, J. N., Zhou, Y., Zhou, Y. F., Zhu, S. N., Xue, Q., Reproductive performance after surgery for endometriosis: predictive value of the revised American Fertility Society classification and the endometriosis fertility index, Gynecologic & Obstetric Investigation, 77, 180–5, 2014 | It has addressed the predictive value of staging system for pregnancy rate. The effectiveness of using staging systems has not been evaluated. |
| Zhang, X., Liu, C., Fu, J., Feng, X., Huang, W., Li, X., Predictive value of endometriosis fertility index (EFI) for natural pregnancy rate after laparoscopy treatment in Chinese women with endometriosis associated infertility, International Journal of Gynecology and Obstetrics, 131, E229, 2015 | The effectiveness of using staging systems to guide the treatment has not been assessed |
H.13. Pharmacological management – Analgesics
| Reference | Reason for Exclusion |
|---|---|
| Allen, Claire, Hopewell, Sally, Prentice, Andrew, Gregory, Daisy, Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis, Cochrane Database of Systematic Reviews, -, 2010 | Checked for relevant RCTs and data from one RCT (Kauppila 1985) is included in preference to the data presented in this Cochrane systematic review |
| Brown, J., Farquhar, C., Endometriosis: an overview of Cochrane Reviews, Cochrane Database of Systematic Reviews, 3, CD009590, 2014 | Overview of Cochrane Reviews. The one relevant Cochrane review (Allen 2010) was checked for relevant RCTs and excluded |
| Cheong, Y. C., Smotra, G., Williams, A. C., Non-surgical interventions for the management of chronic pelvic pain, Cochrane Database of Systematic Reviews, 3, CD008797, 2014 | No analgesic treatment investigated |
| Cobellis, L., Razzi, S., De Simone, S., Sartini, A., Fava, A., Danero, S., Gioffre, W., Mazzini, M., Petraglia, F. The treatment with a COX-2 specific inhibitor is effective in the management of pain related to endometriosis. European Journal of Obstetrics, Gynecology, & Reproductive Biology, 116, 100–2, 2004 | Rofecoxib effect was investigated. The drug was withdrawn from the marketplace on the basis of the safety in November 2004, therefore inappropriate for inclusion. |
| Ferrero, S., Remorgida, V., Venturini, P. L., Current pharmacotherapy for endometriosis, Expert Opinion on Pharmacotherapy, 11, 1123–34, 2010 | Narrative review |
| Howard, F. M., An evidence-based medicine approach to the treatment of endometriosis-associated chronic pelvic pain: placebo-controlled studies, Journal of the American Association of Gynecologic Laparoscopists, 7, 477–88, 2000 | No analgesic treatment investigated |
| Kauppila, A., Puolakka, J., Ylikorkala, O., Prostaglandin biosynthesis inhibitors and endometriosis, Prostaglandins, 18, 655–61, 1979 | Data analysis was flawed: data were not presented per women and pairing within each treatment group not taken into account |
| Koninckx, P. R., Craessaerts, M., Timmerman, D., Cornillie, F., Kennedy, S., Anti-TNF-alpha treatment for deep endometriosis-associated pain: a randomized placebo-controlled trial, Human Reproduction, 23, 2017–23, 2008 | No analgesic treatment investigated |
| Leanza, V., Ciotta, L., Bellanca, S., Leanza, G., Medical therapy for endometriosis: A literature review, Giornale Italiano di Ostetricia e Ginecologia, 37, 71–76, 2015 | Narrative review with no analgesic treatment investigated |
| Lu, D., Song, H., Shi, G., Anti-TNF-alpha treatment for pelvic pain associated with endometriosis, The Cochrane database of systematic reviews, 3, CD008088-, 2013 | No analgesic treatment investigated |
| Setala, M., Hurskainen, R., Kauko, M., Kujansuu, E., Tiitinen, A., Vuorma, S., Makela, M., Treatment of pain caused by endometriosis (Structured abstract), 2015 | A short report with no data |
| Vercellini, P., Crosignani, P. G., Somigliana, E., Berlanda, N., Barbara, G., Fedele, L., Medical treatment for rectovaginal endometriosis: what is the evidence?, Human Reproduction, 24, 2504–14, 2009 | Only hormonal treatment investigated |
| Won, H. R., Abbott, J., Optimal management of chronic cyclical pelvic pain: An evidence-based and pragmatic approach, International Journal of Women’s Health, 2, 263–277, 2010 | Narrative review |
H.14. Pharmacological management – Neuromodulators
| Reference | Reason for Exclusion |
|---|---|
| Ali, A. F., Farid, L., Fouad, M., Faird, M. A., Endometriosis medical therapy from (2010–2013) a systematic review, Journal of Endometriosis, 5, S68-S69, 2013 | A conference abstract |
| Andrews, J., Yunker, A., Reynolds, W. S., Likis, F. E., Sathe, N. A., Jerome, R. N., Noncyclic chronic pelvic pain therapies for women: comparative effectiveness (Structured abstract), 2015 | Population not in line with protocol |
| Api, M., Surgery for endometriosis related pain, Journal of Endometriosis, 4 (3), 133, 2012 | Abstract of narrative reviews |
| Arnold, J., Barcena de Arellano, M. L., Buttner, A., Vercellino, G. F., Chiantera, V., Schneider, A., Mechsner, S., Neuroendocrine modulations of the sensory and sympathetic nerve fibre imbalance in peritoneal endometriosis, Human Reproduction, 27, 2012 | Analysis of sensory nerve fibres rather than analysis of women with endometriosis |
| Bahat, P. Y., Neuraltherapy for treatment of endometriosis, Journal of the Turkish German Gynecology Association, 17, S119-S120, 2016 | Abstract of a cohort study of neuromodulation for endometriosis. No full paper available. |
| Barcena de Arellano, M. L., Arnold, J., Vercellino, G. F., Chiantera, V., Schneider, A., Mechsner, S., Endometriosis-associated neurotrophic properties promote sensory outgrowth, Human Reproduction, 27, 2012 | Intervention does not meet the protocol |
| Bazarra-Fernandez, A., Endometriosis pain and infertility, Journal fur Reproduktionsmedizin und Endokrinologie, 7 (4), 299, 2010 | Abstract of review |
| Bignardi, Tommaso, Khong, SuYen, Lam, Alan, Excisional versus ablative surgery for peritoneal endometriosis, Cochrane Database of Systematic Reviews, -, 2011 | Protocol |
| Blake, C. D., Dinmore, R. C., Kerr, R. K., Surgical Treatment of Endometriosis, Rocky Mountain Medical Journal, 60, 29–30, 1963 | Intervention not in line with protocol |
| Carter, J. E., Laparoscopic presacral neurectomy utilizing contact-tip Nd: YAG laser, The Keio journal of medicine, 45, 332–335, 1996 | Intervention not in line with protocol |
| Centre for Reviews and Dissemination, The evidence for the management of endometriosis (Structured abstract), Database of Abstracts of Reviews of Effects, 2015 | Review |
| Centre for Reviews and Dissemination, Surgical management of endometriosis (Structured abstract), Database of Abstracts of Reviews of Effects, 2015 | Intervention did not meet protocol |
| Centre for Reviews and Dissemination, Individual patient data meta-analysis of randomized evidence to assess the effectiveness of laparoscopic uterosacral nerve ablation in chronic pelvic pain (Structured abstract), Database of Abstracts of Reviews of Effects, 2015 | Intervention did not meet protocol |
| Chen, F. P., Soong, Y. K., The efficacy and complications of laparoscopic presacral neurectomy in pelvic pain, Obstetrics & Gynecology, 90, 974–7, 1997 | Intervention not in line with protocol |
| Cheong, Y., William Stones, R., Chronic pelvic pain: aetiology and therapy, Best Practice & Research in Clinical Obstetrics & Gynaecology, 20, 695–711, 2006 | Population not in line with protocol |
| Corson, S. L., Woodland, M., Frishman, G., Batzer, F. R., Gocial, B., Maislin, G., Treatment of endometriosis with a Nd:YAG tissue-contact laser probe via laparoscopy, International Journal of Fertility, 34, 284–8, 1989 | Intervention is not in line with protocol |
| Costello, M.F., Abbott, J., Katz, S., Vancaillie, T., Wilson, S., A prospective, randomized, double-blind, placebo-controlled trial of multimodal intraoperative analgesia for laparoscopic excision of endometriosis, Fertility and Sterility, 94, 436–443, 2010 | Intervention not in line with protocol |
| Daniels, J., Gray, R., Hills, R. K., Latthe, P., Buckley, L., Gupta, J., Selman, T., Adey, E., Xiong, T., Champaneria, R., Lilford, R., Khan, K. S., Laparoscopic uterosacral nerve ablation for alleviating chronic pelvic pain: A randomized controlled trial, JAMA - Journal of the American Medical Association, 302, 955–961, 2009 | Intervention not in line with protocol |
| Dover, R. W., Pooley, A. Haines P. Sutton C. J. G., Prospective randomised, double-blind trial of laparoscopic laser uterine nerve ablation in the treatment of pelvic pain associated with endometriosis. A provisional report, Gynaecological Endoscopy Abstract from the 6th Annual Congress of the European Society for Gynaecological Endoscopy, Birmingham, UK. 6, 45, 1997 | Intervention does not meet the inclusion criteria |
| Dover, R. W., Pooley, A., Haines, P., Sutton, C. J. G., Prospective, randomised, double-blind controlled trial of laparoscopic laser uterine nerve ablation in the treatment of pelvic pain associated with endometriosis, Abstract from the 7th Congress of the European Society for Gynaecological Endoscopy. Lausanne, 9, 1998 | Intervention not in line with the protocol |
| Dover, R. W., Pooley, A., Hanines, P., Sutton, C. J. G., A prospective randomised double-blind trial of laparoscopic laser uterine nerve ablation in the treatment of pelvic pain associated with endometriosis: a provisional report, British journal of obstetrics and gynaecology, 105, 48, 1998 | Intervention not in line with protocol |
| Duffy, M. N. James, Arambage, Kirana, Correa, J. S. Frederico, Olive, David, Farquhar, Cindy, Garry, Ray, Barlow, David H., Jacobson, Tal Z., Laparoscopic surgery for endometriosis, Cochrane Database of Systematic Reviews, 2014 | Intervention did not meet the inclusion criteria of the review |
| El-Din Shawki, H., The efficacy of laparoscopic uterosacral nerve ablation (LUNA) in the treatment of unexplained chronic pelvic pain: A randomized controlled trial, Gynecological surgery, 8, 31–39, 2011 | Intervention not in line with protocol |
| Evans, S., Moalem-Taylor, G., Tracey, D. J., Pain and endometriosis, Pain, 132, S22-S25, 2007 | Review |
| Ewen, S. P., Sutton, C. J. G., A combined approach for painful heavy periods: Laparoscopic laser uterine nerve ablation and endometrial resection, Gynaecological Endoscopy, 3, 167–168, 1994 | Intervention not in line with protocol |
| Freier, A., Pelvic Neurectomy in Gynecology, Obstetrics & Gynecology, 25, 48–55, 1965 | Intervention not in line with protocol |
| Gelbaya, T. A., El-Halwagy, H. E., Focus on primary care: chronic pelvic pain in women, Obstetrical & Gynecological Survey, 56, 757–64, 2001 | Narrative review |
| Gordon, S. J., Maher, P. J., Hiscock, R., The effect of intraperitoneal ropivacaine on pain after laparoscopic excision of endometriosis, Journal of the American Association of Gynecologic Laparoscopists, 9, 29–34, 2002 | Treatment of post-operative pain rather than general pain management |
| Jacobs, W. M., Conner, J. S., Rogers, S. F., Presacral neurectomy, American Journal of Obstetrics & Gynecology, 85, 437–9, 1963 | Intervention not in protocol |
| Johnson, N. P., Farquhar, C. M., Crossley, S., Yu, Y., Van Peperstraten, A. M., Sprecher, M., Suckling, J., A double-blind randomised controlled trial of laparoscopic uterine nerve ablation for women with chronic pelvic pain, BJOG: An International Journal of Obstetrics & Gynaecology, 111, 950–9, 2004 | Intervention not in line with protocol |
| Johnson, N., Wilson, M., Farquhar, C., Surgical pelvic neuroablation for chronic pelvic pain: A systematic review, Gynaecological Endoscopy, 9, 351–361, 2000 | Intervention not in line with protocol |
| Khan, K. S., Khan, S. F., Nwosu, C. R., Dwarakanath, L. S., Chien, P. F. W., Laparoscopic uterosacral nerve ablation in chronic pelvic pain: An overview, Gynaecological Endoscopy, 8, 257–265, 1999 | Intervention not in line with protocol |
| Latthe, P. M., Proctor, M. L., Farquhar, C. M., Johnson, N., Khan, K. S., Surgical interruption of pelvic nerve pathways in dysmenorrhea: a systematic review of effectiveness, Acta Obstetricia et Gynecologica Scandinavica, 86, 4–15, 2007 | Intervention not in line with protocol |
| Papasakelariou, C., Long-term results of laparoscopic uterosacral nerve ablation, Gynaecological Endoscopy, 5, 177–179, 1996 | Intervention not in line with protocol |
| Proctor, M. L., Latthe, P. M., Farquhar, C. M., Khan, K. S., Johnson, N. P., Surgical interruption of pelvic nerve pathways for primary and secondary dysmenorrhoea, Cochrane Database of Systematic Reviews, CD001896, 2005 | Intervention not in line with protocol |
| Proctor, Michelle, Latthe, Pallavi, Farquhar, Cindy, Khan, Khalid, Johnson, Neil, Surgical interruption of pelvic nerve pathways for primary and secondary dysmenorrhoea, Cochrane Database of Systematic Reviews, -, 2010 | Intervention not in line with protocol |
| Soares, S. R., Martinez-Varea, A., Hidalgo-Mora, J. J., Pellicer, A., Pharmacologic therapies in endometriosis: a systematic review, Fertility & Sterility, 98, 529–55, 2012 | Intervention not in line with protocol |
| Sutton, C. J. G., Ewen, S. P., Whitelaw, N., Haines, P., Prospective, randomized, double-blind, controlled trial of laser laparoscopy in the treatment of pelvic pain associated with minimal, mild, and moderate endometriosis, Fertility and Sterility, 62, 696–700, 1994 | Intervention is not in line with protocol |
| Sutton, C., Pooley, A. S., Jones, K. D., Dover, R. W., Haines, P., A prospective, randomized, double-blind controlled trial of laparoscopic uterine nerve ablation in the treatment of pelvic pain associated with endometriosis, Gynaecological Endoscopy, 10, 217–22, 2001 | Intervention not in line with protocol |
| Tjaden, B., Schlaff, W. D., Kimball, A., Rock, J. A., The efficacy of presacral neurectomy for the relief of midline dysmenorrhea, Obstetrics & Gynecology, 76, 89–91, 1990 | Intervention not in line with protocol |
| Vercellini, P., De Giorgi, O., Pisacreta, A., Pesole, A. P., Vicentini, S., Crosignani, P. G., Surgical management of endometriosis, Best Practice & Research in Clinical Obstetrics & Gynaecology, 14, 501–23, 2000 | intervention not in line with protocol |
| Vercellini, P., Fedele, L., Bianchi, S., Candiani, G. B., Pelvic denervation for chronic pain associated with endometriosis: fact or fancy?, American Journal of Obstetrics & Gynecology, 165, 745–9, 1991 | Intervention not in line with protocol |
| Whitlow, B. J., Lovell, D., Maher, R., Wright, J. T., A double-blind trial of hypogastric nerve block for postoperative pain relief following laparoscopic excision of endometriosis, Gynecological surgery, 2, 5–6, 2005 | Publication focuses on postoperative pain, rather than general pain management |
| Wilson, M. L., Farquhar, C. M., Sinclair, O. J., Johnson, N. P., Surgical interruption of pelvic nerve pathways for primary and secondary dysmenorrhoea, Cochrane Database of Systematic Reviews, CD001896, 2000 | Population does not meet the inclusion criteria |
| Zullo, F., Palomba, S., Zupi, E., Russo, T., Morelli, M., Cappiello, F., Mastrantonio, P., Effectiveness of presacral neurectomy in women with severe dysmenorrhea caused by endometriosis who were treated with laparoscopic conservative surgery: a 1-year prospective randomized double-blind controlled trial, American Journal of Obstetrics & Gynecology, 189, 5–10, 2003 | Intervention not in line with protocol |
| Zullo, F., Palomba, S., Zupi, E., Russo, T., Morelli, M., Sena, T., Pellicano, M., Mastrantonio, P., Long-term effectiveness of presacral neurectomy for the treatment of severe dysmenorrhea due to endometriosis, Journal of the American Association of Gynecologic Laparoscopists, 11, 23–8, 2004 | Intervention not in line with protocol |
| Zullo, F., Pellicano, M., De Stefano, R., Mastrantonio, P., Mencaglia, L., Stampini, A., Zupi, E., Busacca, M., Efficacy of laparoscopic pelvic denervation in central-type chronic pelvic pain: A multicenter study, Journal of Gynecologic Surgery, 12, 35–40, 1996 | Intervention not in line with protocol |
H.15. Pharmacological, non-pharmacological, surgical and combination management strategies (NMA and pairwise comparisons and fertility (NMA))
| Study | Reason for Exclusion |
|---|---|
| Abbott, J., Hawe, J., Hunter, D., Holmes, M., Finn, P., Garry, R., Sowter, M. C., Laparoscopic treatment of endometriosis improved pain and quality of life, but there was also a strong placebo effect, Evidence-based Obstetrics and Gynecology, 7, 139–140, 2005 | Review article of Abbott 2004 |
| Abu Hashim, H., Gonadotrophin-releasing hormone analogues and endometriosis: current strategies and new insights, Gynecological Endocrinology, 28, 314–21, 2012 | Systematic review - included studies checked for relevance to the protocol |
| Abu Hashim, H., El Rakhawy, M., Abd Elaal, I., Randomized comparison of superovulation with letrozole vs. clomiphene citrate in an IUI program for women with recently surgically treated minimal to mild endometriosis, Acta Obstetricia et Gynecologica Scandinavica, 91, 338–45, 2012 | Comparison is not relevant to protocol |
| Acien, P., Quereda, F., Campos, A., Gomez-Torres, M.J., Velasco, I., Gutierrez, M., Use of intraperitoneal interferon alpha-2b therapy after conservative surgery for endometriosis and postoperative medical treatment with depot gonadotropin-releasing hormone analog: a randomized clinical trial, Fertility and Sterility, 78, 705–711, 2002 | No outcomes of interest reported |
| Adamson, G. D., Kwei, L., Edgren, R. A., Pain of endometriosis: effects of nafarelin and danazol therapy, International Journal of Fertility & Menopausal Studies, 39, 215–7, 1994 | No outcomes of interest |
| Adamson, G.D., Nelson, H.P., Medical and surgical treatment of endometriosis, Endocrinologist, 6, 384–391, 1996 | Review |
| Agarwal, S. K., Daniels, A., Drosman, S. R., Udoff, L., Foster, W. G., Pike, M. C., Spicer, D. V., Daniels, J. R., Treatment of Endometriosis with the GnRHa Deslorelin and Add-Back Estradiol and Supplementary Testosterone, BioMed Research International, 2015, 934164, 2015 | Treatment not included in protocol |
| Ahn, A. C., Schnyer, R., Conboy, L., Laufer, M. R., Wayne, P. M., Electrodermal measures of Jing-Well points and their clinical relevance in endometriosis-related chronic pelvic pain, Journal of Alternative & Complementary Medicine, 15, 1293–305, 2009 | Insufficient data reported for the inclusion in the review |
| Aisaka, K., Morioka, H., Watanabe, T., Nishihira, M., Takiaki, F., Trial of long term Gn-RH agonist administration for the treatment of endometriosis with estrogen-progestrogen add back therapy, Fertility and sterility, 70, S259, 1998 | Study not randomised |
| Aisaka, K., Nakagawa, K., Uesato, T., Miwa, A., Koshino, T., Ooka, F., Nishihira, M., Sadatsuki, M., Liang, S., Kaibara, M., Mori, H., Effectiveness of long term GN-RH agonist administration for treatment of endometriosis combined with estrogen-progestogen add back therapy, XVI FIGO World Congress of O & G, 4, 2000 | Conference abstract: insufficient information |
| Al Kadri, H., Hassan, S., Al-Fozan, H. M., Hajeer, A., Hormone therapy for endometriosis and surgical menopause, Cochrane Database of Systematic Reviews, CD005997, 2009 | Both included RCTs (Fedele 1999 and Matorras 2002) already checked for relevance to the protocol and review |
| Alborzi, S., Ghotbi, S., Parsanezhad, M. E., Dehbashi, S., Alborzi, S., Alborzi, M., Pentoxifylline therapy after laparoscopic surgery for different stages of endometriosis: a prospective, double-blind, randomized, placebo-controlled study, Journal of Minimally Invasive Gynecology, 14, 54–8, 2007 | Pentoxifylline intervention is not relevant to protocol |
| Alborzi, S., Momtahan, M., Parsanezhad, M. E., Dehbashi, S., Zolghadri, J., Alborzi, S., A prospective, randomized study comparing laparoscopic ovarian cystectomy versus fenestration and coagulation in patients with endometriomas, Fertility & Sterility, 82, 1633–7, 2004 | Included in a systematic review which is already included (Hart 2011) |
| Alborzi, S., Ravanbakhsh, R., Parsanezhad, M. E., Alborzi, M., Alborzi, S., Dehbashi, S., A comparison of follicular response of ovaries to ovulation induction after laparoscopic ovarian cystectomy or fenestration and coagulation versus normal ovaries in patients with endometrioma, Fertility & Sterility, 88, 507–9, 2007 | Fertility treatment |
| Ali, A. F. Farid L. A. Fouad M. Omar E. D., Continuous oral contraception and Leuprolidein the treatment of Endometriosis associated pelvic pain, Journal of Endometriosis, 5, 2013 | No relevant comparison |
| Al-Inany, H., Houston, B., Farquhar, C., Abousetta, A., Postoperative application of LNG-IUD for symptomatic endometriosis, Human Reproduction, 28, 2013 | Insufficient information to extract data |
| Al-Inany, H., Wahba, A., Abousetta, A., Is dienogest effective in postoperative management of endometriosis compared to GNRH a?, International Journal of Gynecological Cancer, 23, 1054, 2013 | No relevant comparison |
| Alkatout, I., Mettler, L., Beteta, C., Hedderich, J., Jonat, W., Schollmeyer, T., Salmassi, A., Combined surgical and hormone therapy for endometriosis is the most effective treatment: prospective, randomized, controlled trial, Journal of Minimally Invasive Gynecology, 20, 473–81, 2013 | Report of the same study as Mettler 2014. Checked for any further relevant outcomes before exclusion |
| Almassinokiani, F., Mehdizadeh, A., Sariri, E., Rezaei, M., Almasi, A., Akbari, H., Pazouki, A., Solaymani-Dodaran, M., Asadollah, S., Amirkhani, J., Chaichian, S., Vahdat, M., Moosavi, A., Ashouri, M., Tamannaei, Z., Efects of simvastatin in prevention of pain recurrences after surgery for endometriosis, Medical Science Monitor, 19, 534–539, 2013 | No relevant comparison |
| Angioni, S., Cofelice, V., Sedda, F., Loi, E. S., Multinu, F., Pontis, A., Melis, G. B., Progestins for symptomatic endometriosis: Results of clinical studies, Current Drug Therapy, 10, 91–104, 2015 | All studies in review assessed for inclusion/exclusion |
| Angioni, S., Pontis, A., Dessole, M., Surico, D., De Cicco Nardone, C., Melis, I., Pain control and quality of life after laparoscopic en-block resection of deep infiltrating endometriosis (DIE) vs. incomplete surgical treatment with or without GnRHa administration after surgery, Archives of Gynecology & Obstetrics, 291, 363–70, 2015 | Comparison not relevant to protocol |
| Anonymous, Gestrinone versus a gonadotropin-releasing hormone agonist for the treatment of pelvic pain associated with endometriosis: a multicenter, randomized, double-blind study. Gestrinone Italian Study Group, Fertility & Sterility, 66, 911–9, 1996 | No relevant comparison |
| Audebert, A., Descamps, P., Marret, H., Ory-Lavollee, L., Bailleul, F., Hamamah, S., Pre or post-operative medical treatment with nafarelin in stage III-IV endometriosis: a French multicenter study, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 79, 145–8, 1998 | Data for pain outcomes use incorrect denominators and correct data cannot be determined |
| Audebert, A., Lucas, C., Joubert-Collin, M., Efficacy and safety of slow-release leuprorelin 3, 75 mg compared to Danazol treatment. <ORIGINAL> EFFICACITE ET TOLERANCE DE LA LEUPRORELINE 3, 75 MG A LIBERATION PROLONGEE DANS LE TRAITEMENT DE 1’ENDOMETRIOSE EN COMPARAISON AU DANAZOL, References En Gynecologie Obstetrique, 5, 49–57, 1997 | Study not in English. Details reported in Cochrane review |
| Bartley, J., Ebert, A. D., Schweppe, K. H., A safety and efficacy study on long term treatment with Letrozole after GnRH A down-regulation in premenopausal patients with moderate and severe endometriosis, Human Reproduction, 29, i196-i197, 2014 | Insufficient numerical details reported |
| Batioglu, S., Haberal, A., Celikkanat, H., Comparison of GnRH agonist administration before and after laparoscopic drainage of endometriomas, Journal of Gynecologic Surgery, 13, 17–21, 1997 | Randomisation of women within the study but unit of analysis is endometrioma |
| Bayoglu Tekin, Y., Dilbaz, B., Altinbas, S. K., Dilbaz, S., Postoperative medical treatment of chronic pelvic pain related to severe endometriosis: levonorgestrel-releasing intrauterine system versus gonadotropin-releasing hormone analogue, Fertility & Sterility, 95, 492–6, 2011 | No relevant comparison (post surgical hormonal treatment comparison) |
| Benschop, Laura, Farquhar, Cindy, van der Poel, Nicolien, Heineman, Jan Maas, Interventions for women with endometrioma prior to assisted reproductive technology, Cochrane Database of Systematic Reviews, -, 2012 | No intervention of interest for this review: medical treatments and combined surgical treatments |
| Beretta, P., Franchi, M., Ghezzi, F., Busacca, M., Zupi, E., Bolis, P., Randomized clinical trial of two laparoscopic treatments of endometriomas: cystectomy versus drainage and coagulation, Fertility & Sterility, 70, 1176–80, 1998 | Included in a systematic review which is already included (Hart 2011) |
| Bergquist, C., Effects of nafarelin versus danazol on lipids and calcium metabolism, American Journal of Obstetrics and Gynecology, 162, 589–591, 1990 | No outcomes of interest reported |
| Bergqvist, A., Theorell, T., Changes in quality of life after hormonal treatment of endometriosis, Acta Obstetricia et Gynecologica Scandinavica, 80, 628–37, 2001 | Already included in Brown 2012 systematic review |
| Bianchi, S., Agnoli, B., Sgherzi, M. R., Candiani, M., Busacca, M., Effect of three-month treatment with Danazol after laparoscopic surgery for stage III-IV endometriosis: a randomized clinical trial, Fertility and sterility. S22 23p, 1997 | No relevant comparison (post surgical hormonal treatment comparison) |
| Bonocher, C. M., Montenegro, M. L., Rosa, E. Silva J. C., Ferriani, R. A., Meola, J., Endometriosis and physical exercises: a systematic review, Reproductive Biology & Endocrinology, 12, 4, 2014 | Not RCT |
| Bromham, D. R., Booker, M. W., Rose, G. L., Wardle, P. G., Newton, J. R., A multicentre comparative study of gestrinone and danazol in the treatment of endometriosis, Journal of Obstetrics and Gynaecology, 15, 188–94, 1995 | No relevant comparison (gestrinone is not available in the UK) |
| Burry, K.A., Patton, P.E., Illingworth, D.R., Metabolic changes during medical treatment of endometriosis: nafarelin acetate versus danazol.[Erratum appears in Am J Obstet Gynecol 1989 Dec;161(6 Pt 1):1755], American Journal of Obstetrics and Gynecology, 160, 1454–1459, 1989 | Not full text article |
| Cagnacci, A., Tirelli, A., Cannoletta, M., Pirillo, D., Volpe, A., Effect on insulin sensitivity of Implanon vs. GnRH agonist in women with endometriosis, Contraception, 72, 443–6, 2005 | No outcomes of interest reported |
| Carbonell, J. L., Riveron, A. M., Leonard, Y., Gonzalez, J., Heredia, B., Sanchez, C., Mifepristone 2.5, 5, 10 mg versus placebo in the treatment of endometriosis, Journal of Reproductive Health and Medicine, 2, 17–25, 2016 | Treatment not included in protocol |
| Carpenter, S. E., Tjaden, B., Rock, J. A., Kimball, A., The effect of regular exercise on women receiving danazol for treatment of endometriosis, International Journal of Gynaecology & Obstetrics, 49, 299–304, 1995 | Not the outcome of interest |
| Carr, B., Giudice, L., Dmowski, W. P., O’Brien, C., Jiang, P., Burke, J., Jimenez, R., Hass, S., Fuldeore, M., Chwalisz, K., Elagolix, an oral GnRH antagonist for endometriosisassociated pain: A randomized controlled study, Journal of Endometriosis, 5, 105–115, 2013 | Length of follow up is not within protocol (8 weeks) |
| Centre for Reviews and Dissemination, Surgical management of endometriosis (Structured abstract), Database of Abstracts of Reviews of Effects, 2015 | Duplicate of old article previously reviewed |
| Centre for Reviews and Dissemination, Effectiveness and safety of different laparoscopic surgeries for ovarian endometrioma: a systematic review (Provisional abstract), Database of Abstracts of Reviews of Effects, 2015 | Duplicate of article already assessed for inclusion/exclusion |
| Centre for Reviews and Dissemination, Effectiveness of conservative surgery and adjunctive hormone suppression therapy versus surgery alone in the treatment of symptomatic endometriosis: a systematic review with meta-analysis (Provisional abstract), Database of Abstracts of Reviews of Effects, 2015 | All studies included in study have already been assessed for inclusion/exclusion |
| Centre for Reviews and Dissemination, Dyspareunia and quality of sex life after surgical excision of endometriosis: a systematic review (Provisional abstract), Database of Abstracts of Reviews of Effects, 2015 | All studies included in study have already been assessed for inclusion/exclusion |
| Centre for Reviews and Dissemination, Excisional surgery versus ablative surgery for ovarian endometriomata: a Cochrane Review (Structured abstract), Database of Abstracts of Reviews of Effects, 2015 | All studies included in study have already been assessed for inclusion/exclusion |
| Centre for Reviews and Dissemination, Analysis of the levonorgestrel-releasing intrauterine system in women with endometriosis (Provisional abstract), Database of Abstracts of Reviews of Effects, 2015 | All studies included in study have already been assessed for inclusion/exclusion |
| Chang, S. P., Ng, H. T., A randomized comparative study of the effect of leuprorelin acetate depot and danazol in the treatment of endometriosis, Chung Hua i Hsueh Tsa Chih - Chinese Medical Journal, 57, 431–7, 1996 | Details reported in Cochrane review |
| Chang, F.H., Chou, H.H., Soong, Y.K., Chang, M.Y., Lee, C.L., Lai, Y.M., Efficacy of isotopic 13CO2 laser laparoscopic evaporation in the treatment of infertile patients with minimal and mild endometriosis: a life table cumulative pregnancy rates study, Journal of the American Association of Gynecologic Laparoscopists, 4, 219–223, 1997 | Not randomised |
| Charles, C., Muneyyirci-Delale, O., Sinaii, N., Dalloul, M., Stratton, P., Effect of lupron vs norethindrone treatment on lipid profile of women with symptomatic endometriosis, Fertility and Sterility, 1), e161, 2015 | Insufficient numerical details reported |
| Cheewadhanaraks, S., Choksuchat, C., Dhanaworavibul, K., Liabsuetrakul, T., Postoperative depot medroxyprogesterone acetate versus continuous oral contraceptive pills in the treatment of endometriosis-associated pain: a randomized comparative trial, Gynecologic & Obstetric Investigation, 74, 151–6, 2012 | Comparison of pharmacological treatments after surgery |
| Cheewadhanaraks, S., Peeyananjarassri, K., Choksuchat, C., Dhanaworavibul, K., Choobun, T., Bunyapipat, S., Interval of injections of intramuscular depot medroxyprogesterone acetate in the long-term treatment of endometriosisassociated pain: a randomized comparative trial, Gynecologic and Obstetric Investigation, 68, 116–121, 2009 | No relevant comparison (dose comparison) |
| Chen, M., Zhang, H., Li, J., Dong, G. R., [Clinical observation on acupuncture combined with acupoint sticking therapy for treatment of dysmenorrhea caused by endometriosis], Zhongguo zhen jiu [Chinese acupuncture & moxibustion], 30, 725–8, 2010 | Chinese language |
| Chen, S. H., Li, Z. A., Du, X. P., Robot-assisted versus conventional laparoscopic surgery in the treatment of advanced stage endometriosis: a meta-analysis, Clinical & Experimental Obstetrics & Gynecology, 43, 422–6, 2016 | Study of endometrial cancer |
| Cheng, M. H., Yu, B. K. J., Chang, S. P., Wang, P. H., A randomized, parallel, comparative study of the efficacy and safety of nafarelin versus danazol in the treatment of endometriosis in Taiwan, Journal of the Chinese Medical Association, 68, 307–314, 2005 | Relevant data included from Brown 2010 Cochrane systematic review |
| Cheong, Y. C., Smotra, G., Williams, A. C., Non-surgical interventions for the management of chronic pelvic pain, Cochrane Database of Systematic Reviews, 3, CD008797, 2014 | Women with a diagnosis of pelvic congestion syndrome or adhesions and pain not due to endometriosis. |
| Chwalisz, K., Mattia-Goldberg, C., Lee, M., Elger, W., Edmonds, A., Treatment of endometriosis with the novel selective progesterone receptor modulator (SPRM) asoprisnil, Fertility and sterility, 82, S83–84, 2004 | Conference abstract: insufficient information |
| Cirkel, U., Ochs, H., Schneider, H. P., A randomized, comparative trial of triptorelin depot (D-Trp6-LHRH) and danazol in the treatment of endometriosis, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 59, 61–9, 1995 | Details of scale (outcome) not reported) |
| Cirkel, U., Schweppe, K. W., Ochs, H., Schneider, H. P., Effect of LH-RH agonist therapy in the treatment of endometriosis (German experience), Progress in Clinical & Biological Research, 225, 189–99, 1986 | Not a RCT |
| Claesson, B., Bergquist, C., Clinical experience treating endometriosis with nafarelin, Journal of Reproductive Medicine, 34, 1025–8, 1989 | No outcomes of interest reported |
| Cosson, M., Querleu, D., Donnez, J., Madelenat, P., Konincks, P., Audebert, A., Manhes, H., Dienogest is as effective as triptorelin in the treatment of endometriosis after laparoscopic surgery: results of a prospective, multicenter, randomized study, Fertility and Sterility, 77, 684–692, 2002 | Not the comparison of interest (dienogest alone vs triptorelin) |
| Crosignani, P. G., Gastaldi, A., Lombardi, P. L., Montemagno, U., Vignali, M., Serra, G. B., Stella, C., Leuprorelin acetate depot vs danazol in the treatment of endometriosis: results of an open multicentre trial, Clinical Therapeutics, 14 Suppl A, 29–36, 1992 | Relevant numerical data cannot be extracted (narrative representation) |
| Cucinella, G., Granese, R., Calagna, G., Svelato, A., Saitta, S., Tonni, G., De Franciscis, P., Colacurci, N., Perino, A., Oral contraceptives in the prevention of endometrioma recurrence: does the different progestins used make a difference?, Archives of Gynecology & Obstetrics, 288, 821–7, 2013 | Insufficient data reported for inclusion in the review |
| Daniels, J., Gray, R., Hills, R. K., Latthe, P., Buckley, L., Gupta, J., Selman, T., Adey, E., Xiong, T., Champaneria, R., Lilford, R., Khan, K. S., Luna Trial Collaboration, Laparoscopic uterosacral nerve ablation for alleviating chronic pelvic pain: a randomized controlled trial, JAMA, 302, 955–61, 2009 | Majority of women did not have endometriosis |
| Daniels, J., Middleton, L., Gennard, L., Tryposkiadis, K., Leighton, L., Bhattacharya, S., Preventing recurrence of endometriosis by means of long-acting progestogen therapy: The PRE-EMPT pilot study, Bipolar Disorders, 18, 225, 2016 | Preliminary results only - no outcomes of interest reported |
| Davis, C. J., McMillan, L., Pain in endometriosis: effectiveness of medical and surgical management, Current Opinion in Obstetrics & Gynecology, 15, 507–12, 2003 | Review |
| Dawood, M. Y., Ramos, J., Khan-Dawood, F. S., Depot leuprolide acetate versus danazol for treatment of pelvic endometriosis: changes in vertebral bone mass and serum estradiol and calcitonin, Fertility & Sterility, 63, 1177–83, 1995 | No outcomes of interest reported |
| Dawood, M. Y., Spellacy, W. N., Dmowski, W. P., Gambrell, R. D., Jr., Greenblatt, R. B., Girard, Y., Lemay, A., Mishell, D. R., Jr., Nagamani, M., Pepperell, R. J., et al., A comparison of the efficacy and safety of buserelin vs danazol in the treatment of endometriosis. Protocol 310 Study Group, Progress in Clinical & Biological Research, 323, 253–67, 1990 | No outcomes of interest reported |
| de Sa Rosa e Silva, A. C., Rosa e Silva, J. C., Nogueira, A. A., Petta, C. A., Abrao, M. S., Ferriani, R. A., The levonorgestrel-releasing intrauterine device reduces CA-125 serum levels in patients with endometriosis, Fertility & Sterility, 86, 742–4, 2006 | No outcomes of interest reported |
| Deans, R., Hawe, J., Hunter, D., Garry, R., Holmes, M., Abbott, J., A double-blind RCT of surgical excision of endometriosis: Secondary outcomes, Gynecological surgery, 6, S86, 2009 | Abstract only |
| Deaton, J.L., Gibson, M., Blackmer, K.M., Nakajima, S.T., Badger, G.J., Brumsted, J.R., A randomized, controlled trial of clomiphene citrate and intrauterine insemination in couples with unexplained infertility or surgically corrected endometriosis, Fertility and Sterility, 54, 1083–1088, 1990 | No relevant comparison |
| Demirol, A., Guven, S., Baykal, C., Gurgan, T., Effect of endometrioma cystectomy on IVF outcome: a prospective randomized study, Reproductive Biomedicine Online, 12, 639–643, 2006 | Fertility treatment |
| Detorakis, S. Protopapas A. Louradou D. Giannoulis G. Chatzipapas I. Loutradis D., Bipolar energy for ovarian hemostasis in endometrioma surgery: During, after, or not at all?: Presentation of 3 different cystectomy techniques compared in an ongoing rct, Gynecological Surgery, 11 Suppl 1, 54–5, 2014 | Article is a protocol |
| D’Hooghe, T., Dunselman, G. A. J., Saridogan, E., Kiesel, L., Guideline Development Group, E., Vermeulen, N., Treatment of endometriosis-associated pain according to the 2014 eshre guidelines, Gynecological surgery, 1), 260–261, 2014 | Conference abstract |
| Di Donato, N. Bertoldo V. Vicenzi C. Benfenati A. Giovanardi G. Leonardi D. Monti G. Seracchioli R., The role of ovaropexy on reducing post-surgical ovarian adhesions in women with severe endometriosis: A randomized, controlled study, Journal of Minimally Invasive Gynecology, 20 Suppl 1, S38, 2013 | No outcomes of interest reported |
| Dicker, D., Goldman, J.A., Levy, T., Feldberg, D., Ashkenazi, J., The impact of long-term gonadotropin-releasing hormone analogue treatment on preclinical abortions in patients with severe endometriosis undergoing in vitro fertilization-embryo transfer, Fertility and Sterility, 57, 597–600, 1992 | All participants had priori IVF treatment |
| Ding, Z., Lian, F., Traditional Chinese medical herbs staged therapy in infertile women with endometriosis: A clinical study, International Journal of Clinical and Experimental Medicine, 8, 14085–14089, 2015 | Not relevant as mifepristone is only licensed for termination of pregnancy and available in big dose of 200mg in th UK |
| DiVasta, A. D. Feldman H. A. Gallagher J. S. Laufer M. R. Hornstein M. D. Gordon C. M., The effect of hormonal add-back therapy in adolescents treated with a gonadotropin releasing hormone (GNRH) agonist for endometriosis: A randomized trial, Journal of Adolescent Health, 56 Suppl 1, S24, 2015 | Conference abstract: insufficient information |
| DiVasta, A. D., Feldman, H. A., Sadler Gallagher, J., Stokes, N. A., Laufer, M. R., Hornstein, M. D., Gordon, C. M., Hormonal Add-Back Therapy for Females Treated With Gonadotropin-Releasing Hormone Agonist for Endometriosis: A Randomized Controlled Trial, Obstetrics & Gynecology, 126, 617–27, 2015 | Not included in NMA; Interventions not relevant for pairwise analysis |
| Dmowski, W. P., Kapetanakis, E., Scommegna, A., Variable effects of danazol on endometriosis at 4 low-dose levels, Obstetrics & Gynecology, 59, 408–15, 1982 | No relevant comparison (dose comparison) |
| Dmowski, W.P., Radwanska, E., Binor, Z., Tummon, I., Pepping, P., Ovarian suppression induced with Buserelin or danazol in the management of endometriosis: a randomized, comparative study, Fertility and Sterility, 51, 395–400, 1989 | Sample size of subfertile participants too small |
| Dodin, S., Lemay, A., Maheux, R., Dumont, M., Turcot Lemay, L., Bone mass in endometriosis patients treated with GnRH agonist implant or danazol, Obstetrics and gynecology, 77, 410–5, 1991 | No outcomes of interest reported |
| Donnez, J., Dewart, P. J., Hedon, B., Perino, A., Schindler, A. E., Blumberg, J., Querleu, D., Equivalence of the 3-month and 28-day formulations of triptorelin with regard to achievement and maintenance of medical castration in women with endometriosis, Fertility & Sterility, 81, 297–304, 2004 | No outcomes of interest reported |
| Donnez, J., Nisolle, M., Clerckx, F., Casanas, F., Evaluation of preoperative use of danazol, gestrinone, lynestrenol, buserelin spray and buserelin implant, in the treatment of endometriosis associated infertility, Progress in Clinical and Biological Research, 323, 427–442, 1990 | Patients not randomised |
| Donnez, J., Nisolle, M., Gillerot, S., Anaf, V., Clerckx-Braun, F., Casanas-Roux, F., Ovarian endometrial cysts: the role of gonadotropin-releasing hormone agonist and/or drainage, Fertility and Sterility, 62, 63–66, 1994 | No outcomes of interest reported |
| Donnez, J., Nisolle-Pochet, M., Clerckx-Braun, F., Sandow, J., Casanas-Roux, F., Administration of nasal Buserelin as compared with subcutaneous Buserelin implant for endometriosis, Fertility and Sterility, 52, 27–30, 1989 | No relevant comparison (dose comparison) |
| Duffy, James M., Johnson, Neil, Ahmad, Gaity, Watson, Andrew, Postoperative procedures for improving fertility following pelvic reproductive surgery, Cochrane Database of Systematic Reviews, -, 2009 | Cochrane review - Studies are not of patients with endometriosis |
| Emilio, P., Control of pelvic pain and quality of life following treatment of symptomatic endometriosis, Journal of Psychosomatic Obstetrics and Gynecology, 31, 21, 2010 | Conference abstract |
| Falcone, T., Goldberg, J.M., Miller, K.F., Endometriosis: Medical and surgical intervention, Current Opinion in Obstetrics and Gynecology, 8, 178–183, 1996 | Review |
| Faustmann, T., Seitz, C., Marr, J., Gerlinger, C., Strowitzki, T., Safety of dienogest for the treatment of endometriosis: A 24-week, randomised, open-label trial versus leuprolide acetate, International Journal of Gynecology and Obstetrics, 107, S179-, 2009 | Conference abstract: insufficient information |
| Fedele, L., Arcaini, L., Bianchi, S., Baglioni, A., Vercellini, P., Comparison of cyproterone acetate and danazol in the treatment of pelvic pain associated with endometriosis, Obstetrics & Gynecology, 73, 1000–4, 1989 | Cyproterone acetate not included in review; Study not included in NMA and so cannot provide indirect information |
| Fedele, L., Bianchi, S., Bocciolone, L., Di Nola, G., Franchi, D., Buserelin acetate in the treatment of pelvic pain associated with minimal and mild endometriosis: a controlled study, Fertility & Sterility, 59, 516–21, 1993 | Participants’ primary presentation was subfertility; No relevant outcomes assessed |
| Fedele, L., Bianchi, S., Montefusco, S., Frontino, G., Carmignani, L., A gonadotropin-releasing hormone agonist versus a continuous oral contraceptive pill in the treatment of bladder endometriosis, Fertility and sterility, 90, 183–4, 2008 | No outcomes of interest reported |
| Fedele, L., Bianchi, S., Raffaelli, R., Zanconato, G., Comparison of transdermal estradiol and tibolone for the treatment of oophorectomized women with deep residual endometriosis, Maturitas, 32, 189–193, 1999 | No outcomes of interest |
| Fedele, L., Bianchi, S., Viezzoli, T., Arcaini, L., Candiani, G.B., Gestrinone versus danazol in the treatment of endometriosis, Fertility and Sterility, 51, 781–785, 1989 | No relevant comparison (gestrinone is not available in the UK) |
| Federici, D., Brambilla, T., Lacelli, B., Arcaini, L., Motta, G., Agarossi, A., Muggiasca, L., Conti, M., Pain relief after combined medical and laparoscopic conservative treatment of stage Ill-IV endometriosis: A comparison with medical therapy, Minimally Invasive Therapy and Allied Technologies, 5, 547–54, 1996 | Study has not been randomised |
| Felix Wong, W. S., Danforn Lim, C. E., Hormonal treatment for endometriosis associated pelvic pain, Iranian Journal of Reproductive Medicine Iran, 9, 163–70, 2011 | All studies included in study have already been assessed for inclusion/exclusion |
| Ferrero, S., Abbamonte, L. H., Parisi, M., Ragni, N., Remorgida, V., Dyspareunia and quality of sex life after laparoscopic excision of endometriosis and postoperative administration of triptorelin, Fertility & Sterility, 87, 227–9, 2007 | Not a RCT |
| Ferrero, S., Camerini, G., Seracchioli, R., Ragni, N., Venturini, P. L., Remorgida, V., Letrozole combined with norethisterone acetate compared with norethisterone acetate alone in the treatment of pain symptoms caused by endometriosis, Human Reproduction, 24, 3033–41, 2009 | Not a RCT |
| Ferrero, S., Venturini, P. L., Gillott, D. J., Remorgida, V., Letrozole and norethisterone acetate versus letrozole and triptorelin in the treatment of endometriosis related pain symptoms: a randomized controlled trial, Reproductive Biology & Endocrinology, 9, 88, 2011 | Treatment not connected to NMA network |
| Fjerbaek, A., Knudsen, U. B., Endometriosis, dysmenorrhea and diet-what is the evidence?, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 132, 140–7, 2007 | Review - RCTs discussed in this paper have been included |
| Franssen, A. M., van der Heijden, P. F., Thomas, C. M., Doesburg, W. H., Willemsen, W. N., Rolland, R., On the origin and significance of serum CA-125 concentrations in 97 patients with endometriosis before, during, and after buserelin acetate, nafarelin, or danazol, Fertility & Sterility, 57, 974–9, 1992 | Study design does not match the inclusion criteria |
| Freundl, G., Godtke, K., Gnoth, C., Godehardt, E., Kienle, E., Steroidal ‘add-back’ therapy in patients treated with GnRH agonists, Gynecologic & Obstetric Investigation, 45 Suppl 1, 22–30; discussion 35, 1998 | No outcomes of interest |
| Fritzer, N., Hudelist, G., Love is a pain? Quality of sex life after surgical resection of endometriosis: A review, European Journal of Obstetrics Gynecology and Reproductive Biology., 31, 2016 | Study contains insufficient detail on methods and population |
| Fritzer, N., Tammaa, A., Salzer, H., Hudelist, G., Dyspareunia and quality of sex life after surgical excision of endometriosis: a systematic review, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 173, 1–6, 2014 | Systematic review of non-comparative studies |
| Frontino, G., Vercellini, P., De Giorgi, O., Aimi, G., Zaina, B., Crosignani, P. G., Levonorgestrel-releasing intrauterine device (Lng-IUD) versus expectant management after conservative surgery for symptomatic endometriosis. A pilot study, Fertility and sterility, 77 Suppl 1, S25–26, 2002 | Conference abstract: insufficient information |
| Fukushima, M., Changes in bone mineral content following hormone treatment for endometriosis, International Journal of Gynaecology & Obstetrics, 50 Suppl 1, S17–22, 1995 | No outcomes of interest reported |
| Fukushima, M., Shindo, M., Sato, K., Hormone treatment related bone mineral content changes in Japanese women with endometriosis, Asia-Oceania Journal of Obstetrics & Gynaecology, 19, 299–307, 1993 | No outcomes of interest reported |
| Garry, R., Abbott, J., A placebo-controlled randomised controlled trial of laparoscopic excision of endometriosis, European Journal of Obstetrics & Gynecology and Reproductive Biology, 123, S8, 2005 | Abstract only |
| Gelbaya, T. A., El-Halwagy, H. E., Focus on primary care: chronic pelvic pain in women, Obstetrical & Gynecological Survey, 56, 757–64, 2001 | Population is not endometriosis |
| Georgievska, J., Sapunov, S., Cekovska, S., Vasilevska, K., Effect of two laparoscopic techniques for treatment of ovarian endometrioma on ovarian reserve, Medicinski Arhiv, 69, 88–90, 2015 | Not RCT |
| Ghahiri, A., Najafian, A., Ghasemi, M., Najafian, A., Comparison study on effectiveness of pentoxifyllin with LD to prevent recurrent endometriosis, Iranian Journal of Reproductive Medicine, 10, 219–22, 2012 | No relevant comparison |
| Giannini, A., Palla, G., Goglia, L., Genazzani, A. R., Genazzani, A., Simoncini, T., Effects of preoperative and perioperative administration of wobenzym vital on minimal-mild endometriosis, Journal of Endometriosis, 7, 71–77, 2015 | No data reported for outcomes of interest |
| Gnoth, C. H., Godtke, K., Freundl, G., Godehardt, E., Kienle, E., Effects of add-back therapy on bone mineral density and pyridinium crosslinks in patients with endometriosis treated with gonadotropin-releasing hormone agonists, Gynecologic & Obstetric Investigation, 47, 37–41, 1999 | No outcomes of interest reported |
| Goncalves, F. C., Andres, M. P., Passman, L. J., Goncalves, M. O., Podgaec, S., A systematic review of ultrasonography-guided transvaginal aspiration of recurrent ovarian endometrioma, International Journal of Gynaecology & Obstetrics, 134, 3–7, 2016 | All studies included in study have already been assessed for inclusion/exclusion |
| Gong, L., Zhang, S., Han, Y., Long, Q., Zou, S., Cao, Y., Initiation of GnRH agonist treatment on 3–5 days postoperatively in endometriosis patients: A randomized controlled trial, Journal of Clinical Pharmacology, 55, 848–853, 2015 | Treatment not connected to NMA network |
| Gregoriou, O., Konidaris, S., Vitoratos, N., Papadias, C., Papoulias, I., Chryssicopoulos, A., Gonadotropin-releasing hormone analogue plus hormone replacement therapy for the treatment of endometriosis: A randomized controlled trial, International journal of fertility and women’s medicine, 42, 406–411, 1997 | Relevant numerical data cannot be extracted (graphical and narrative representation) |
| Grimes, David A., Jones, B. LaShawn, Lopez, Laureen M., Schulz, Kenneth F., Oral contraceptives for functional ovarian cysts, Cochrane Database of Systematic Reviews, 2014 | Women do not have suspected/confirmed endometriosis |
| Gupta, JK, Daniels, JP, Middleton, LJ, Pattison, HM, Prileszky, G, Roberts, TE, Sanghera, S, Barton, P, Gray, R, Kai, J, A randomised controlled trial of the clinical effectiveness and cost-effectiveness of the levonorgestrel-releasing intrauterine system in primary care against standard treatment for menorrhagia: the ECLIPSE trial (Structured abstract), Health Technology Assessment Database, 2016 | Women do not have endometriosis |
| Halbe, H. W., Nakamura, M. S., Da Silveira, G. P., Carvalho, W. P., Updating the clinical experience in endometriosis-the Brazilian perspective, British Journal of Obstetrics & Gynaecology, 102 Suppl 12, 17–21, 1995 | Within-class comparison in NMA. No information added |
| Hamid, A. M., Madkour, W. A., Moawad, A., Elzaher, M. A., Roberts, M. P., Does cabergoline help in decreasing endometrioma size compared to LHRH agonist? A prospective randomized study, Archives of Gynecology & Obstetrics, 290, 677–82, 2014 | No relevant comparison |
| Han, Y., Zou, S. E., Long, Q. Q., Zhang, S. F., The incidence and characteristics of uterine bleeding during postoperative GnRH agonist treatment combined with estrogen-progestogen add-back therapy in endometriosis patients of reproductive age, International journal of clinical and experimental medicine, 6, 583–8, 2013 | Comparison of pharmacological treatments after surgery. |
| Hardcastle, R. J., A randomised, single-blind clinical trial to investigate the effectiveness of bipolar versus monopolar diathermy treatment on pain symptoms for women with newly diagnosed superficial endometriosis: The set study (superficial endometriosis treatment), Journal of Minimally Invasive Gynecology, 1), S176-S177, 2015 | Trial still awaiting results |
| Harrison, R. F., Barry-Kinsella, C., Efficacy of medroxyprogesterone treatment in infertile women with endometriosis: a prospective, randomized, placebo-controlled study, Fertility & Sterility, 74, 24–30, 2000 | Medroxyprogesterone acetate dose is greater than that specified in the British National Formulary |
| Hefni, M. A., Apoola, A., Omran, O., Comparison between medical treatment by GnRH analogue (goserelin) and conservative surgery by laparoscopic diathermy for the management of endometriosis, Gynaecological Endoscopy, 7, 37–41, 1998 | No outcomes of interest reported |
| Heinrichs, W. L., Henzl, M. R., Human issues and medical economics of endometriosis. Three- vs. six-month GnRHagonist therapy, Journal of Reproductive Medicine, 43, 299–308, 1998 | Narrative review |
| Henzl, M. R., Monroe, S. E., Nafarelin: a new medical therapy for endometriosis, Progress in clinical and biological research, 323, 343–55, 1990 | Study already included in Brown 2010 Cochrane review |
| Henzl, M.R., Corson, S.L., Moghissi, K., Buttram, V.C., Berqvist, C., Jacobson, J., Administration of nasal nafarelin as compared with oral danazol for endometriosis. A multicenter double-blind comparative clinical trial, New England Journal of Medicine, 318, 485–489, 1988 | No outcomes of interest |
| Hornstein, M. D., Gleason, R. E., Barbieri, R. L., A randomized double-blind prospective trial of two doses of gestrinone in the treatment of endometriosis, Fertility & Sterility, 53, 237–41, 1990 | No relevant comparison (gestrinone is not available in the UK) |
| Hornstein, M. D., Hemmings, R., Yuzpe, A. A., LeRoy Heinrichs, W., Use of nafarelin versus placebo after reductive laparoscopic surgery for endometriosis, Fertility and sterility, 68, 860–864, 1997 | Included within Furness 2011 Cochrane review. Full text checked for any further outcomes before exclusion. No relevant outcomes were reported |
| Hornstein, M. D., Yuzpe, A. A., Burry, K. A., Heinrichs, L. R., Buttram, V. L., Jr., Orwoll, E. S., Prospective randomized double-blind trial of 3 versus 6 months of nafarelin therapy for endometriosis associated pelvic pain, Fertility & Sterility, 63, 955–62, 1995 | No relevant comparison (treatment duration) |
| Hornstein, M. D., Yuzpe, A. A., Burry, K. A., Heinrichs, L. R., Buttram, V. L., Orwoll, E. S., Prospective randomized double-blind trial of 3 versus 6 months of nafarelin therapy for endometriosis associated pelvic pain, Fertility and sterility, 63, 955–62, 1995 | No relevant comparison (treatment duration) |
| Howard, F. M., An evidence-based medicine approach to the treatment of endometriosis-associated chronic pelvic pain: placebo-controlled studies, Journal of the American Association of Gynecologic Laparoscopists, 7, 477–88, 2000 | Narrative review |
| Howell, R., Edmonds, D.K., Dowsett, M., Crook, D., Lees, B., Stevenson, J.C., Gonadotropin-releasing hormone analogue (goserelin) plus hormone replacement therapy for the treatment of endometriosis: a randomized controlled trial, Fertility and Sterility, 64, 474–481, 1995 | Study adds no information to NMA network |
| Hurst, B. S., Gardner, S. C., Tucker, K. E., Awoniyi, C. A., Schlaff, W. D., Delayed oral estradiol combined with leuprolide increases endometriosis-related pain, Journal of the Society of Laparoendoscopic Surgeons, 4, 97–101, 2000 | Sample size too small (N=13) |
| Irahara, M., Uemura, H., Yasui, T., Kinoshita, H., Yamada, M., Tezuka, M., Kiyokawa, M., Kamada, M., Aono, T., Efficacy of every-other-day administration of conjugated equine estrogen and medroxyprogesterone acetate on gonadotropin-releasing hormone agonists treatment in women with endometriosis, Gynecologic & Obstetric Investigation, 52, 217–22, 2001 | No outcomes of interest reported |
| Jacobs, L., Field, C., Thie, J., Coulam, C., Treatment of endometriosis with the GnRH agonist naferelin acetate, International journal of fertility, 36, 30–5, 1991 | No study sample size: < 10 participants |
| Jacobson, Tal Z., Duffy, M. N. James, Barlow, David H., Farquhar, Cindy, Koninckx, Philippe R., Olive, David, Laparoscopic surgery for subfertility associated with endometriosis, Cochrane Database of Systematic Reviews, 2014 | This review has been replaced by a review entitled ‘Laparoscopic surgery for endometriosis’, published in issue 4 of The Cochrane Library, 2014 |
| Jarrell, J., Mohindra, R., Ross, S., Taenzer, P., Brant, R., Laparoscopy and reported pain among patients with endometriosis, Journal of Obstetrics & Gynaecology Canada: JOGC, 27, 477–85, 2005 | Included in a systematic review which is already included (Duffy 2014) |
| Jin, X., Ruiz Beguerie, J., Laparoscopic surgery for subfertility related to endometriosis: a meta-analysis, Taiwanese Journal of Obstetrics & Gynecology, 53, 303–8, 2014 | Systematic review of non-randomised studies |
| Jin, Y. B., Sun, Z. L., Jin, H. F., [Randomized controlled study on ear-electroacupuncture treatment of endometriosis-induced dysmenorrhea in patients], Zhen ci yan jiu [Acupuncture research], 34, 188–92, 2009 | Chinese language |
| Johnson, N. P., Farquhar, C. M., Crossley, S., Yu, Y., Van Peperstraten, A. M., Sprecher, M., Suckling, J., A double-blind randomised controlled trial of laparoscopic uterine nerve ablation for women with chronic pelvic pain, BJOG: An International Journal of Obstetrics & Gynaecology, 111, 950–9, 2004 | Population includes many women without endometriosis |
| Kauppila, A., Telimaa, S., Ronnberg, L., Vuori, J., Placebo-controlled study on serum concentrations of CA-125 before and after treatment of endometriosis with danazol or high-dose medroxyprogesterone acetate alone or after surgery, Fertility & Sterility, 49, 37–41, 1988 | No outcomes of interest reported |
| Kitade, M., Kikuchi, I., Kumakiri, J., Mastuoka, S., Takeda, S., An open-label, randomized, comparative study of the efficacy and safety of preoperative GNRH agonist therapy for laparoscopic myomectomy, Gynecological Surgery, 7, S87, 2010 | Conference abstract: insufficient information |
| Kohler, G., Faustmann, T. A., Gerlinger, C., Seitz, C., Mueck, A. O., A dose-ranging study to determine the efficacy and safety of 1, 2, and 4mg of dienogest daily for endometriosis, International journal of gynaecology and obstetrics, 108, 21–5, 2010 | No relevant comparison (dose comparison) |
| Lagana, A. S., Cucinella, G., Calagna, G., Pinelli, M., Adile, G., Perino, A., Granese, R., Control of symptoms relapse after conservative surgery for endometriosis: Advantages of using dienogest plus estradiol valerate, Journal of Endometriosis, 5, 2013 | Data not reported for outcomes of interest |
| Lalchandani, S., Baxter, A., Phillips, K., Is helium thermal coagulator therapy for the treatment of women with minimal to moderate endometriosis cost-effective? A prospective randomised controlled trial, Gynecological Surgery, 2, 255–258, 2005 | No outcomes of interest reported |
| Lalchandani, S., Baxter, A., Phillips, K., A prospective randomised comparison of laparoscopic treatment and treatment with gonadotrophin releasing hormone analogue in patients with mild to moderate endometriosis, International Journal of Obstetrics & Gynecology, 83, 48, 2003 | Preliminary report of Lalchandani 2005 (ID: 370702) |
| Lee, D. Y., Lee, J. Y., Seo, J. W., Yoon, B. K., Choi, D., Gonadotropin-releasing hormone agonist with add-back treatment is as effective and tolerable as dienogest in preventing pain recurrence after laparoscopic surgery for endometriosis, Archives of Gynecology & Obstetrics, 294, 1257–1263, 2016 | Non-randomised trial |
| Lemay, A., Maheux, R., Huot, C., Blanchet, J., Faure, N., Efficacy of intranasal or subcutaneous luteinizing hormone-releasing hormone agonist inhibition of ovarian function in the treatment of endometriosis, American Journal of Obstetrics and Gynecology, 158, 233–236, 1988 | No relevant comparison (dose comparison) |
| Lewis, M., Baker, V., Nezhat, C., The impact on ovarian reserve after laparoscopic ovarian cystectomy versus three-stage management in patients with endometriomas: A prospective randomized study, Fertility and sterility, 94, e81e82, 2010 | Letter to editor |
| Li, L, Ceng, Y, Administration of mifepristone followed by laparoscopic surgery for ovarian endometriosis cyst:a 35 cases-clinical observation, Matern Child Health Care Chin, 22, 3446–7, 2007 | Not a RCT |
| Li, Z., Zhang, H. Y., Zhu, Y. J., Hu, Y. J., Qu, P. P., A randomized study comparing the side effects and hormonal status of triptorelin and leuprorelin following conservative laparoscopic surgery for ovarian endometriosis in Chinese women, European Journal of Obstetrics, Gynecology, and Reproductive Biology, 183, 164–168, 2014 | Comparison of pharmacological treatments after conservative surgery |
| Lim, P. S., Hasnur, C. H., Nirmala, K., Natasha, M. N., Oma, M. H., A pilot study: Short term danazol in adjunct with GNRH agonist to reduce flare ups for treatment of endometriosis, Journal of obstetrics and gynaecology research, 41, 2015 | No outcomes of interest reported |
| Lindsay, P. C., Shaw, R. W., Bennink, H. J., Kicovic, P., The effect of add-back treatment with tibolone (Livial) on patients treated with the gonadotropin-releasing hormone agonist triptorelin (Decapeptyl), Fertility & Sterility, 65, 342–8, 1996 | No outcomes of interest |
| Loverro, G., Santillo, V., Pansini, M., Lorusso, F., Depalo, R., Selvaggi, L., Are GnRH agonists helpful in the therapy of endometriosis after surgical treatment?, Human Reproduction (Oxford, England), 16, 96, 2001 | Included within Furness 2011 Cochrane review. Full text (conference abstract) checked for any further relevant outcomes before exclusion. |
| Low, R. A., Roberts, A. D., Lees, D. A., A comparative study of various dosages of danazol in the treatment of endometriosis, British Journal of Obstetrics & Gynaecology, 91, 167–71, 1984 | No relevant comparison (dose comparison) |
| Lund, I., Lundeberg, T., Is acupuncture effective in the treatment of pain in endometriosis?, Journal of Pain Research, 9, 157–165, 2016 | A narrative review |
| Makarainen, L., Ronnberg, L., Kauppila, A., Medroxyprogesterone acetate supplementation diminishes the hypoestrogenic side effects of gonadotropin-releasing hormone agonist without changing its efficacy in endometriosis, Fertility & Sterility, 65, 29–34, 1996 | Relevant numerical data cannot be extracted (graphical and narrative representation) |
| Maouris, P., Psudomenopause Treatment for Endometriosis: The Endocrine Effects of Danazol Compared with the use of the LH-RH Agonist Goserelin, Journal of Obstetrics and Gynaecology, 11, 123–7, 1991 | No relevant outcomes reported |
| Marqui, A. B., Evaluation of endometriosis-associated pain and influence of conventional treatment: a systematic review, Revista Da Associacao Medica Brasileira, 61, 507–18, 2015 | All studies included in study have already been assessed for inclusion/exclusion |
| Matta, W., Shaw, R., A comparative study between buserelin and danazol in the treatment of endometriosis, British Journal of Clinical Practice, 40, 69–72, 1988 | No relevant outcomes reported |
| Meden-Vrtovec, H., Treatment of laparoscopically confirmed endometriosis with danazol, British Journal of Clinical Practice, 43, 161–6, 1989 | Study not randomised |
| Medhurst, R, Endometriosis and its management using homeopathy, Journal - Australian Traditional-Medicine Society, 18, 155–6., 2012 | Description of various herbs |
| Meissner, K., Schweizer-Arau, A., Limmer, A., Preibisch, C., Popovici, R. M., Lange, I., de Oriol, B., Beissner, F., Psychotherapy With Somatosensory Stimulation for Endometriosis-Associated Pain: A Randomized Controlled Trial, Obstetrics & Gynecology, 128, 1134–1142, 2016 | Not a specific generalizable intervention |
| Melin, A. S., Lundholm, C., Malki, N., Swahn, M. L., Sparen, P., Bergqvist, A., Hormonal and surgical treatments for endometriosis and risk of epithelial ovarian cancer, Acta Obstetricia et Gynecologica Scandinavica, 92, 546–54, 2013 | Case-control study evaluating cancer risk |
| Mendes, C., Dias, L., Klajner, R., Montero, T., Pereira, M., Prevalence of the reduction of symptoms and endometriotic lesions in patients using dienogest 2 mg (continuous use) compared to other treatments for endometriosis, International Journal of Gynecology and Obstetrics, 131, E381, 2015 | Systematic review - insufficient detail reported (conference abstract) |
| Mettler, L., Beteta, C., Alkatout, I., Salmassi, A., Prospective randomized controlled study (Canadian task force classification) on hormonal or operative therapy of endometriosis-who wins the battle, Human Reproduction, 29, 2014 | Results for treatments not presented separately |
| Michalopoulos, G., Makris, V., Daniilidis, A., Sardeli, C., Dinas, K., Giannoulis, C., Loufopoulos, P. D., Surgical treatment of endometriosis, Current Women’s Health Reviews, 8, 131–137, 2012 | Narrative review |
| Miller, J. D., Leuprolide acetate for the treatment of endometriosis, Progress in Clinical & Biological Research, 323, 337–41, 1990 | Insufficient numerical details of results reported |
| Miller, J. D., Quantification of endometriosis-associated pain and quality of life during the stimulatory phase of gonadotropin-releasing hormone agonist therapy: a double-blind, randomized, placebo-controlled trial, American Journal of Obstetrics & Gynecology, 182, 1483–8, 2000 | Outcome measurement period too short (4 weeks) |
| Minaguchi, H., Uemura, T., Shirasu, K., Clinical study on finding optimal dose of a potent LHRH agonist (buserelin) for the treatment of endometriosis-multicenter trial in Japan, Progress in Clinical & Biological Research, 225, 211–25, 1986 | No relevant comparison (dose comparison) |
| Moghissi, K. S., Corson, S. L., Buttram, V., Henzl, M. R., Evaluation of a GnRH Agonist (Nafarelin) versus Danazol for Treatment of Endometriosis, Contributions to gynecology and obstetrics, 16, 1987 | Results not reported numerically. Non-validated pain scale used |
| Moghissi, K. S., Schlaff, W. D., Olive, D. L., Skinner, M. A., Yin, H., Goserelin acetate (Zoladex) with or without hormone replacement therapy for the treatment of endometriosis, Fertility & Sterility, 69, 1056–62, 1998 | Relevant numerical data cannot be extracted (graphical and narrative representation) |
| Montanino, G., Porpora, M. G., Montanino Oliva, M., Gulemi, L., Boninfante, M., Cosmi, E. V., Laparoscopic treatment of ovarian endometrioma. One year follow-up, Clinical & Experimental Obstetrics & Gynecology, 23, 70–2, 1996 | Study not randomised |
| Moore, E. E., Harger, J. H., Rock, J. A., Archer, D. F., Management of pelvic endometriosis with low-dose danazol, Fertility & Sterility, 36, 15–9, 1981 | No relevant comparison (dose comparison) |
| Morgante, G., Ditto, A., La Marca, A., De Leo, V., Low-dose danazol after combined surgical and medical therapy reduces the incidence of pelvic pain in women with moderate and severe endometriosis, Human Reproduction, 14, 2371–4, 1999 | Comparison of pharmacological treatments after laparoscopic surgery |
| Morita, M., Yano, Y., Sukegawa, Y., Ishizuka, J., Takita, M., The use of danazol in women with endometriosis-associated infertility and pain for laparoscopic surgery, Gynaecological Endoscopy, 6, 28, 1997 | Insufficient details on patient charactersitics |
| Moscarini, M., Milazzo, G. N., Assorgi, C., Pacchiarotti, A., Caserta, D., Ovarian stripping versus cystectomy: Recurrence of endometriosis and pregnancy rate, Archives of gynecology and obstetrics, 290, 163–7, 2014 | Non-RCT |
| Mossa, B., Ebano, V., Tucci, S., Rega, C., Dolce, E., Frega, A., Marziani, R., Laparoscopic surgery for the management of ovarian endometriomas, Medical Science Monitor, 16, MT45–50, 2010 | Two different laparoscopic excision techniques compared |
| Moustafa, M. M., Elnasharty, M. A. A., Systematic review of the outcome associated with the different surgical treatment of bowel and rectovaginal endometriosis, Gynecological Surgery, 11, 37–52, 2014 | Systematic review included non-randomised studies |
| Muneyyirci-Delale, O., Charles, C., Sinaii, N., Dalloul, M., Stratton, P., Improvement in endometriosis-related pelvic pain with leuprolide or norethindrone treatment, Fertility and Sterility, 1), e163-e164, 2015 | Insufficient numerical details reported |
| Muzii, L., Achilli, C., Bergamini, V., Candiani, M., Garavaglia, E., Lazzeri, L., Lecce, F., Maiorana, A., Maneschi, F., Marana, R., Perandini, A., Porpora, M. G., Seracchioli, R., Spagnolo, E., Vignali, M., Benedetti Panici, P., Comparison between the stripping technique and the combined excisional/ablative technique for the treatment of bilateral ovarian endometriomas: a multicentre RCT, Human Reproduction, 31, 339–44, 2016 | Mixed population - women have either pain or infertility. Results are not reported by subgroup |
| Muzii, L., Achilli, C., Bergamini, V., Candiani, M., Garavaglia, E., Lazzeri, L., Lecce, F., Maiorana, A., Maneschi, F., Marana, R., Perandini, A., Porpora, M. G., Seracchioli, R., Spagnolo, E., Vignali, M., Benedetti Panici, P., Comparison between the stripping technique and the combined excisional/ablative technique for the treatment of bilateral ovarian endometriomas: A multicentre RCT, Human reproduction (Oxford, England), 31, 339–44, 2015 | Too few women presenting with pain |
| Muzii, L., Bellati, F., Palaia, I., Plotti, F., Manci, N., Zullo, M. A., Angioli, R., Panici, P. B. Laparoscopic stripping of endometriomas: a randomized trial on different surgical techniques. Part I: clinical results, Human Reproduction, 20, 1981–6, 2005 | No outcomes of interest |
| Muzii, L., Di Tucci, C., Achilli, C., Di Donato, V., Musella, A., Palaia, I., Panici, P. B., Continuous versus cyclic oral contraceptives after laparoscopic excision of ovarian endometriomas: a systematic review and metaanalysis, American Journal of Obstetrics & Gynecology, 214, 203–11, 2016 | All studies included in study have already been assessed for inclusion/exclusion |
| Muzii, L., Maneschi, F., Marana, R., Porpora, M. G., Zupi, E., Bellati, F., Angioli, R., Benedetti Panici, P., Oral estroprogestins after laparoscopic surgery to excise endometriomas: continuous or cyclic administration? Results of a multicenter randomized study, Journal of Minimally Invasive Gynecology, 18, 173–8, 2011 | Comparison of pharmacological treatments after laparoscopic surgery |
| Muzii, L., Marana, R., Caruana, P., Mancuso, S., The impact of preoperative gonadotropin-releasing hormone agonist treatment on laparoscopic excision of ovarian endometriotic cysts, Fertility & Sterility, 65, 1235–7, 1996 | Not a RCT |
| Nesbitt-Hawes, E. M., Campbell, N., Maley, P. E., Won, H., Hooshmand, D., Henry, A., Ledger, W., Abbott, J. A., The Surgical Treatment of Severe Endometriosis Positively Affects the Chance of Natural or Assisted Pregnancy Postoperatively, BioMed Research International, 2015, 438790, 2015 | Non-RCT |
| Nezhat, C. H., Nezhat, F., Borhan, S., Seidman, D. S., Nezhat, C. R., Is hormonal treatment efficacious in the management of ovarian cysts in women with histories of endometriosis?, Human Reproduction, 11, 874–7, 1996 | Study only randomised for first 6 weeks - duration too short |
| Ng, J. W., Chwalisz, K., Carter, D., Williams, L. A., Klein, C. E., Dose-dependent suppression of gonadotropins and ovarian hormones by elagolix in healthy premenopausal females, Reproductive Sciences Reprod Sci, 1), 330A–331A, 2016 | No numerical details reported |
| Nieto, A., Tacuri, C., Serra, M., Keller, J., Cortes-Prieto, J., Long term follow-up of endometriosis after two different therapies (Gestrinone and Buserelin), Clinical and Experimental Obstetrics and Gynecology, 23, -204, 1996 | Gestrinone not included in review protocol |
| Noble, A. D., Letchworth, A. T., Medical treatment of endometriosis: a comparative trial, Postgraduate Medical Journal, 55 Suppl 5, 37–9, 1979 | Fertility only relevant outcome. Not all participants were infertile |
| Nowroozi, K., Chase, J. S., Check, J. H., Wu, C. H., The importance of laparoscopic coagulation of mild endometriosis in infertile women, International Journal of Fertility, 32, 442–4, 1987 | No intervention of interest; effect of fulguration of endometriotic implants evaluated |
| Orwoll, E. S., Yuzpe, A. A., Burry, K. A., Heinrichs, L., Buttram, V. C., Jr., Hornstein, M. D., Nafarelin therapy in endometriosis: long-term effects on bone mineral density, American Journal of Obstetrics & Gynecology, 171, 1221–5, 1994 | No relevant outcome |
| Pabuccu, Onalan, G., Goktolga, U., Kucuk, T., Orhon, E., Ceyhan, T., Aspiration of ovarian endometriomas before intracytoplasmic sperm injection, Fertility and sterility, 82, 705–11, 2004 | Fertility treatment |
| Pabuccu, R., Onalan, G., Kaya, C., GnRH agonist and antagonist protocols for stage I-II endometriosis and endometrioma in in vitro fertilization/intracytoplasmic sperm injection cycles, Fertility and Sterility, 88, 832–839, 2007 | Fertility treatment |
| Palagiano, A., Capuano, V., Medical treatment of endometriosis: Comparative study between leuprolide ac. and danazol. <ORIGINAL> TERAPIA MEDICA DELL’ENDOMETRIOSI: STUDIO COMPARATIVO FRA IL LEUPROLIDE ACETATO ED IL DANAZOLO, Minerva Ginecol, 46, 173–7, 1994 | Study not in English. Details reported in Cochrane review |
| Parazzini, F., Ablation of lesions or no treatment in minimal-mild endometriosis in infertile women: a randomized trial. Gruppo Italiano per lo Studio dell’Endometriosi, Human Reproduction, 14, 1332–4, 1999 | No intervention of interest; combined surgical treatments |
| Park, H. J., Koo, Y. A., Yoon, B. K., Choi, D., Postoperative long-term maintenance therapy with oral contraceptives after gonadotropin-releasing hormone analog treatment in women with ovarian endometrioma, Journal of Minimally Invasive Gynecology, 16, 34–9, 2009 | Retrospective study |
| Pattanittum, Porjai, Kunyanone, Naowarat, Brown, Julie, Sangkomkamhang, Ussanee S., Barnes, Joanne, Seyfoddin, Vahid, Marjoribanks, Jane, Dietary supplements for dysmenorrhoea, Cochrane Database of Systematic Reviews, 2016 | Women do not have endometriosis |
| Pierce, S. J., Gazvani, M. R., Farquharson, R. G., Long-term use of gonadotropin-releasing hormone analogs and hormone replacement therapy in the management of endometriosis: a randomized trial with a 6-year follow-up, Fertility & Sterility, 74, 964–8, 2000 | Not a RCT (“partially randomized”) |
| Radosa, M.P., Bernardi, T.S., Georgiev, I., Diebolder, H., Camara, O., Runnebaum, I.B., Coagulation versus excision of primary superficial endometriosis: a 2-year follow-up, European Journal of Obstetrics Gynecology and Reproductive Biology, 150, 195–198, 2010 | Non-RCT |
| Regidor, P.A., Regidor, M., Schmidt, M., Ruwe, B., Lubben, G., Fortig, P., Kienle, E., Schindler, A.E., Prospective randomized study comparing the GnRH-agonist leuprorelin acetate and the gestagen lynestrenol in the treatment of severe endometriosis, Gynecological Endocrinology, 15, 202–209, 2001 | Lynestrenol not included in review protocol |
| Rickes, D., Nickel, I., Kropf, S., Kleinstein, J., Increased pregnancy rates after ultralong postoperative therapy with gonadotropin-releasing hormone analogs in patients with endometriosis, Fertility and Sterility, 78, 757–762, 2002 | No relevant comparison (post surgical hormonal treatment comparison) |
| Riley, K. A., Benton, A. S., Deimling, T. A., Kunselman, A. R., Harkins, G. J., Robotic surgical management of endometriosis: A prospective randomized trial, Journal of Minimally Invasive Gynecology, 23 (7 Supplement 1), S106, 2016 | Abstract - insufficient details reported |
| Roghaei, M. A., Tehrany, H. G., Taherian, A., Koleini, N., Effects of Letrozole compared with Danazol on patients with confirmed endometriosis: A randomized clinical trial, International Journal of Fertility and Sterility, 4, 67–72, 2010 | All women had cauterisation |
| Roghaei, M., Ghasemi Tehrani, H., Taherian, A. A., Comparing the effects of letrozole with danazole in patients with endometriosis: A randomized clinical trial, Iranian Journal of Reproductive Medicine, 8, 75–76, 2010 | Insufficient numerical details reported |
| Roman, H., Huet, E., Bridoux, V., Khalil, H., Darai, E., Collinet, P., Tuech, J. J., Colorectal resection versus rectal conservative surgery in the management of rectal endometriosis: Preliminary results-of endore randomized trial, Surgical Endoscopy and Other Interventional Techniques, 30, S25, 2016 | No outcomes of interest |
| Roshni, P., Suneetha Susan Cleave, A., Suresh, P. K., Complementary and alternative medicine (CAM) therapies for management of pain related to endometriosis, International Research Journal of Pharmacy, 3, 30–34, 2012 | A narrative review of various complementary and alternative medicines. |
| Rubi-Klein, K., Kucera-Sliutz, E., Nissel, H., Bijak, M., Stockenhuber, D., Fink, M., Wolkenstein, E., Is acupuncture in addition to conventional medicine effective as pain treatment for endometriosis? A randomised controlled cross-over trial, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 153, 90–3, 2010 | Insufficient data reported for the inclusion in the review. |
| Scarpellini, F., Sbracia, M., Aromatase Inhibitor plus GnRH analogue in the treatment of patient with ovarian endometriosis recurrence after surgery: A controlled trial, Human Reproduction Hum Reprod, 29, i11, 2014 | Women given IVF |
| Schweizer-Arau, A., Popoici, R., Preibisch, C., Beissner, F., Meissner, K., Treatment of recurrent endometriosis induced pa in combing psychotherapy and acupuncture (SART). First results from a randomized controlled study with follow-up, Journal of Endometriosis, 5, S21, 2013 | Conference abstract |
| Schwertner, A., Conceicao Dos Santos, C. C., Costa, G. D., Deitos, A., De Souza, A., De Souza, I. C. C., Torres, I. L. S., Da Cunha Filho, J. S. L., Caumo, W., Efficacy of melatonin in the treatment of endometriosis: A phase II, randomized, double-blind, placebo-controlled trial, Pain, 154, 874–881, 2013 | Not relevant comparison |
| Seiler, J.C., Gidwani, G., Ballard, L., Laparoscopic cauterization of endometriosis for fertility: a controlled study, Fertility and Sterility, 46, 1098–1100, 1986 | No intervention of interest for this review |
| Seracchioli, R., Mabrouk, M., Manuzzi, L., Vicenzi, C., Frasca, C., Elmakky, A., Venturoli, S., Post-operative use of oral contraceptive pills for prevention of anatomical relapse or symptom-recurrence after conservative surgery for endometriosis, Human Reproduction, 24, 2729–35, 2009 | Narrative systematic review. Included studies checked for relevance before exclusion. |
| Sesti, F., Capozzolo, T., Pietropolli, A., Bollea, M., Piccione, E., Postoperative dietary supplementation with omega-3 fatty acids and antioxidants after conservative surgery for symptomatic endometriosis, International Journal of Gynecology and Obstetrics, 107, S630, 2009 | Conference abstract |
| Shaw, R., Garry, R., McMillan, L., Sutton, C., Wood, S., Harrison, R., Das, R., A prospective randomized open study comparing goserelin (Zoladex) plus surgery and surgery alone in the management of ovarian endometriomas, Gynaecological Endoscopy, 10, 151–7, 2001 | The comparison is not relevant to the protocol |
| Shaw, R.W., Matta, W., Reversible pituitary ovarian suppression induced by an LHRH agonist in the treatment of endometriosis-comparison of two dose regimens, Clinical Reproduction and Fertility, 4, 329–336, 1986 | No relevant comparison (dose comparison) |
| Shawki, O., Hamza, H., Sattar, M., Mild endometriosis, to treat or not treat: randomized controlled trial comparing diagnostic laparoscopy with no further treatment versus post-operative Zoladex in cases with infertility associated with stage I, II endometriosis, Fertility and sterility, 77, S13, 2002 | Relevant outcomes reported in NMA |
| Shohayeb, A., Wahba, A., Abousetta, A., Al-inany, H., Is dienogest effective in postoperative management of endometriosis compared to GnRH a, Human Reproduction, 28, 2013 | Conference abstract: insufficient information |
| Sillem, M., Parviz, M., Woitge, H. W., Kiesel, L., Ulrich, U., von Holst, T., Runnebaum, B., Ziegler, R., Seibel, M. J., Add-back medrogestone does not prevent bone loss in premenopausal women treated with goserelin, Experimental & Clinical Endocrinology & Diabetes, 107, 379–85, 1999 | No outcomes of interest reported |
| Skrzypulec, V., Walaszek, A., Drosdzol, A., Nowosielski, K., Piela, B., Rozmus-Warcholinska, W., Influence of GnRH analogue on the intensification of endometriosis symptoms and infertility treatment. [Polish], Wiadomosci lekarskie (Warsaw, Poland:, 1960) 57, 301–4, 2004 | Study not in English |
| Smith, Caroline A., Armour, Mike, Zhu, Xiaoshu, Li, Xun, Lu, Yong Zhi, Song, Jing, Acupuncture for dysmenorrhoea, Cochrane Database of Systematic Reviews, 2016 | Women do not have endometriosis |
| Soong, Y.K., Chang, F.H., Chou, H.H., Chang, M.Y., Lee, C.L., Lai, Y.M., Chang, S.Y., Life table analysis of pregnancy rates in women with moderate or severe endometriosis comparing danazol therapy after carbon dioxide laser laparoscopy plus electrocoagulation or laparotomy plus electrocoagulation versus danazol therapy only, Journal of the American Association of Gynecologic Laparoscopists, 4, 225–230, 1997 | Study reported estimated cumulative pregnancy rates |
| Soysal, S., Soysal, M.E., Ozer, S., Gul, N., Gezgin, T., The effects of post-surgical administration of goserelin plus anastrozole compared to goserelin alone in patients with severe endometriosis: a prospective randomized trial, Human Reproduction, 19, 160–167, 2004 | Comparison of pharmacological treatments after surgery |
| Stones, R. W., Mountfield, J., Interventions for treating chronic pelvic pain in women, Cochrane Database of Systematic Reviews, CD000387, 2000 | Women with chronic pelvic pain with a diagnosis of pelvic congestion syndrome and not endometriosis. |
| Stratton, P., Sinaii, N., Segars, J., Koziol, D., Wesley, R., Zimmer, C., Winkel, C., Nieman, L. K., Return of chronic pelvic pain from endometriosis after raloxifene treatment: a randomized controlled trial, Obstetrics & Gynecology, 111, 88–96, 2008 | Intervention (raloxifene) is not relevant to the protocol and provides no additional information |
| Strowitzki, T., Faustmann, T., Gerlinger, C., Schumacher, U., Ahlers, C., Seitz, C., Safety and tolerability of dienogest in endometriosis: pooled analysis from the European clinical study program, International Journal of Women’s Health, 7, 393–401, 2015 | Dienogest not included in review protocol |
| Strowitzki, T., Marr, J., Gerlinger, C., Faustmann, T., Seitz, C., Detailed analysis of a randomized, multicenter, comparative trial of dienogest versus leuprolide acetate in endometriosis, International Journal of Gynaecology & Obstetrics, 117, 228–33, 2012 | Relevant numerical data cannot be extracted (graphical and narrative representation) |
| Sun, Y. Z., Chen, H. L., [Controlled study on Shu-Mu point combination for treatment of endometriosis], Zhongguo zhen jiu [Chinese acupuncture & moxibustion], 26, 863–5, 2006 | Chinese language |
| Surrey, E. S., Hornstein, M. D., Prolonged GnRH agonist and add-back therapy for symptomatic endometriosis: long-term follow-up, Obstetrics & Gynecology, 99, 709–19, 2002 | No outcomes of interest |
| Surrey, E. S., Judd, H. L., Reduction of vasomotor symptoms and bone mineral density loss with combined norethindrone and long-acting gonadotropin-releasing hormone agonist therapy of symptomatic endometriosis: a prospective randomized trial, Journal of Clinical Endocrinology & Metabolism, 75, 558–63, 1992 | No relevant outcomes reported |
| Surrey, E.S., Silverberg, K.M., Surrey, M.W., Schoolcraft, W.B., Effect of prolonged gonadotropin-releasing hormone agonist therapy on the outcome of in vitro fertilization-embryo transfer in patients with endometriosis, Fertility and Sterility, 78, 699–704, 2002 | All participants had IVF treatment |
| Sutton, C. J., Pooley, A. S., Ewen, S. P., Haines, P., Follow-up report on a randomized controlled trial of laser laparoscopy in the treatment of pelvic pain associated with minimal to moderate endometriosis, Fertility & Sterility, 68, 1070–4, 1997 | Included in a systematic review which is already included (Duffy 2014) |
| Tahara, M., Matsuoka, T., Yokoi, T., Tasaka, K., Kurachi, H., Murata, Y., Treatment of endometriosis with a decreasing dosage of a gonadotropin-releasing hormone agonist (nafarelin): a pilot study with low-dose agonist therapy (“draw-back” therapy), Fertility & Sterility, 73, 799–804, 2000 | No relevant comparison |
| Takaesu, Y. Nishi H. Sasaki T. Kojima J. Sagawa Y. Isaka K., Dienogest compared with gonadotrophin-releasing hormone agonist after conservative surgery for endometriosis: A randomized controlled trial, Journal of Minimally Invasive Gynecology, 20 Suppl 1, S28, 2013 | Not an RCT |
| Takaesu, Y., Nishi, H., Kojima, J., Sasaki, T., Nagamitsu, Y., Kato, R., Isaka, K., Dienogest compared with gonadotropinreleasing hormone agonist after conservative surgery for endometriosis, Journal of Obstetrics and Gynaecology Research, 42, 1152–1158, 2016 | Dienogest was not the drug of interest |
| Takenaka, M., Yano, R., Hiraku, Y., Shibata, M., Hatano, K., Yamamoto, S., Sato, K., Yamamoto, K., Morishige, K. I., Exploratory study of pre-surgical medications with dienogest or leuprorelin in laparoscopic cystectomy of endometrial cysts, Journal of obstetrics and gynaecology research, 41, 1234–1239, 2015 | Not included in NMA; Comparison of pharmacological treatments before surgery |
| Tanmahasamut, P., Rattanachaiyanont, M., Angsuwathana, S., Techatraisak, K., Indhavivadhana, S., Leerasiri, P., Postoperative levonorgestrel-releasing intrauterine system for pelvic endometriosis-related pain: a randomized controlled trial, Obstetrics & Gynecology, 119, 519–26, 2012 | No relevant comparison (post surgical hormonal treatment comparison) |
| Taskin, O., Yalcinoglu, A.I., Kucuk, S., Uryan, I., Buhur, A., Burak, F., Effectiveness of tibolone on hypoestrogenic symptoms induced by goserelin treatment in patients with endometriosis, Fertility and Sterility, 67, 40–45, 1997 | No relevant outcomes |
| Telimaa, S., Danazol and medroxyprogesterone acetate inefficacious in the treatment of infertility in endometriosis, Fertility & Sterility, 50, 872–5, 1988 | N<10 and surgery pharma / pharma alone results not presented separately |
| Telimaa, S., Apter, D., Reinila, M., Ronnberg, L., Kauppila, A., Placebo-controlled comparison of hormonal and biochemical effects of danazol and high-dose medroxyprogesterone acetate, European Journal of Obstetrics, Gynecology, & Reproductive Biology, 36, 97–105, 1990 | No outcomes of interest reported |
| Telimaa, S., Ronnberg, L., Kauppila, A., Placebo-controlled comparison of danazol and high-dose medroxyprogesterone acetate in the treatment of endometriosis after conservative surgery, Gynecological Endocrinology, 1, 363–71, 1987 | No relevant outcomes reported |
| Thomas, E. J., Cooke, I. D., Impact of gestrinone on the course of asymptomatic endometriosis, British Medical Journal Clinical Research Ed., 294, 272–4, 1987 | Comparison is not relevant (gestrinone); Study not included in NMA |
| Thomassen, H., Berthelsen, H. G., Treatment of endometriosis with progestogens, Danish Medical Bulletin, 13, 33–5, 1966 | Study not randomised |
| Tsai, Y.L., Hwang, J.L., Loo, T.C., Cheng, W.C., Chuang, J., Seow, K.M., Short-term postoperative GnRH analogue or danazol treatment after conservative surgery for stage III or IV endometriosis before ovarian stimulation: a prospective, randomized study, Journal of Reproductive Medicine, 49, 955–959, 2004 | Patients are undergoing ovarian stimulation |
| Tummon, I. S., Ali, A., Pepping, M. E., Radwanska, E., Binor, Z., Dmowski, W. P., Bone mineral density in women with endometriosis before and during ovarian suppression with gonadotropin-releasing hormone agonists or danazol, Fertility & Sterility, 49, 792–6, 1988 | No relevant outcomes reported |
| Tummon, I.S., Pepping, M.E., Binor, Z., Radwanska, E., Dmowski, W.P., A randomized, prospective comparison of endocrine changes induced with intranasal leuprolide or danazol for treatment of endometriosis, Fertility and Sterility, 51, 390–394, 1989 | N = 15 (too small for inclusion) |
| Var, T., Batioglu, S., Tonguc, E., Kahyaoglu, I., The effect of laparoscopic ovarian cystectomy versus coagulation in bilateral endometriomas on ovarian reserve as determined by antral follicle count and ovarian volume: a prospective randomized study, Fertility and Sterility, 95, 2247–2250, 2011 | No relevant outcomes |
| Vercellini, P., Chapron, C., De Giorgi, O., Consonni, D., Frontino, G., Crosignani, P. G., Coagulation or excision of ovarian endometriomas?, American Journal of Obstetrics & Gynecology, 188, 606–10, 2003 | Systematic includes nonrandomised studies |
| Vercellini, P., Crosignani, P. G., Fadini, R., Radici, E., Belloni, C., Sismondi, P., A gonadotrophin-releasing hormone agonist compared with expectant management after conservative surgery for symptomatic endometriosis, British Journal of Obstetrics & Gynaecology, 106, 672–7, 1999 | No relevant comparison (post surgical hormonal treatment comparison) |
| Vercellini, P., Crosignani, P. G., Somigliana, E., Berlanda, N., Barbara, G., Fedele, L., Medical treatment for rectovaginal endometriosis: what is the evidence?, Human Reproduction, 24, 2504–14, 2009 | Systematic review – included studies checked for relevance |
| Vercellini, P., D. E. Matteis S, Somigliana, E., Buggio, L., Frattaruolo, M. P., Fedele, L., Long-term adjuvant therapy for the prevention of postoperative endometrioma recurrence: a systematic review and meta-analysis, Acta Obstetricia et Gynecologica Scandinavica, 92, 8–16, 2013 | Systematic review - relevant RCTs already included/excluded |
| Vercellini, P., De Giorgi, O., Mosconi, P., Stellato, G., Vicentini, S., Crosignani, P. G., Cyproterone acetate versus a continuous monophasic oral contraceptive in the treatment of recurrent pelvic pain after conservative surgery for symptomatic endometriosis, Fertility & Sterility, 77, 52–61, 2002 | Cyproterone acetate is not listed in the BNF |
| Vercellini, P., Frattaruolo, M. P., Somigliana, E., Jones, G. L., Consonni, D., Alberico, D., Fedele, L., Surgical versus low-dose progestin treatment for endometriosis-associated severe deep dyspareunia II: effect on sexual functioning, psychological status and health-related quality of life, Human Reproduction, 28, 1221–30, 2013 | Non-RCT |
| Vercellini, P., Frontino, G., De Giorgi, O., Aimi, G., Zaina, B., Crosignani, P. G., Comparison of a levonorgestrel-releasing intrauterine device versus expectant management after conservative surgery for symptomatic endometriosis: a pilot study, Fertility & Sterility, 80, 305–9, 2003 | No relevant comparison (post surgical hormonal treatment comparison) |
| Vercellini, P., Pietropaolo, G., De Giorgi, O., Pasin, R., Chiodini, A., Crosignani, P. G., Treatment of symptomatic rectovaginal endometriosis with an estrogen-progestogen combination versus low-dose norethindrone acetate, Fertility & Sterility, 84, 1375–87, 2005 | Hormonal formulation not used in clinical practice. Population has post-surgical pain |
| Vercellini, P., Somigliana, E., Consonni, D., Frattaruolo, M. P., De Giorgi, O., Fedele, L., Surgical versus medical treatment for endometriosis-associated severe deep dyspareunia: I. Effect on pain during intercourse and patient satisfaction, Human Reproduction, 27, 3450–9, 2012 | Not a RCT |
| Vercellini, P., Somigliana, E., Vigano, P., De Matteis, S., Barbara, G., Fedele, L., Post-operative endometriosis recurrence: a plea for prevention based on pathogenetic, epidemiological and clinical evidence, Reproductive Biomedicine Online, 21, 259–65, 2010 | Review |
| Vercellini, P., Trespidi, L., Colombo, A., Vendola, N., Marchini, M., Crosignani, P.G., A gonadotropin-releasing hormone agonist versus a low-dose oral contraceptive for pelvic pain associated with endometriosis, Fertility and Sterility, 60, 75–79, 1993 | Study already included in Davis 2007 systematic review |
| Vercellini, P., Trespidi, L., Panazza, S., Bramante, T., Mauro, F., Crosignani, P.G., Very low dose danazol for relief of endometriosis-associated pelvic pain: A pilot study, Fertility and Sterility, 62, 1136–1142, 1994 | Very low dose of danazol not used in practice |
| Weng, Q., Ding, Z. M., Lv, X. L., Yang, D. X., Song, Y. Z., Wang, F. F., Ye, Y. H., Qu, F., Chinese medicinal plants for advanced endometriosis after conservative surgery: a prospective, multi-center and controlled trial, International journal of clinical and experimental medicine, 8, 11307–11, 2015 | No relevant outcomes reported |
| Wheeler, J. M., Knittle, J. D., Miller, J. D., Depot leuprolide versus danazol in treatment of women with symptomatic endometriosis. I. Efficacy results, American Journal of Obstetrics & Gynecology, 167, 1367–71, 1992 | Other study (Wheeler 1993) detailing this RCT has been included already |
| Whitehouse, R. W., Adams, J. E., Bancroft, K., Vaughan-Williams, C. A., Elstein, M., The effects of nafarelin and danazol on vertebral trabecular bone mass in patients with endometriosis, Clinical Endocrinology, 33, 365–73, 1990 | No outcomes of interest reported |
| Whitelaw, N., Haines, P., Ewen, S., Sutton, C., Assessing the efficacy of laser laparoscopy in the treatment of endometriosis, Journal of obstetrics and gynaecology, 13, 486, 1993 | Insufficient study/participant details provided |
| Winkel, C.A., Scialli, A.R., Medical and surgical therapies for pain associated with endometriosis, Journal of Women’s Health and Gender-Based Medicine, 10, 137-Based, 2001 | Review |
| Witt, C. M., A pilot study testing the feasibility of Japanese-style acupuncture for endometriosis-related pelvic pain in adolescents and young women, Focus on Alternative and Complementary Therapies, 14, 36–37, 2009 | Insufficient information to extract data |
| Wong, A. Y., Tang, L., An open and randomized study comparing the efficacy of standard danazol and modified triptorelin regimens for postoperative disease management of moderate to severe endometriosis, Fertility & Sterility, 81, 1522–7, 2004 | No relevant comparison (post surgical hormonal treatment comparison) |
| Worthington, M., Irvine, L.M., Crook, D., Lees, B., Shaw, R.W., Stevenson, J.C., A randomized comparative study of the metabolic effects of two regimens of gestrinone in the treatment of endometriosis, Fertility and Sterility, 59, 522–526, 1993 | No relevant comparison (dose comparison) |
| Wright, S., Valdes, C.T., Dunn, R.C., Franklin, R.R., Short-term Lupron or danazol therapy for pelvic endometriosis, Fertility and Sterility, 63, 504–507, 1995 | No relevant outcomes reported |
| Yang, D. X., Ma, W. G., Qu, F., Ma, B. Z., Comparative study on the efficacy of Yiweining and Gestrinone for post-operational treatment of stage III endometriosis, Chinese Journal of Integrative Medicine, 12, 218–20, 2006 | No relevant comparison (post surgical hormonal treatment comparison); Not included in NMA |
| Yang, Y., Zhao, R., Hao, Z., Li, L., Xu, C., Cui, Y., Effects of danchi decoction on P450arom, survivin of eutopic endometrium of patients with endometriosis after conservative surgery, African Journal of Traditional, Complementary and Alternative Medicines, 12, 65–71, 2015 | No outcomes of interest |
| Yeung, P., Jr., Tu, F., Bajzak, K., Lamvu, G., Guzovsky, O., Agnelli, R., Peavey, M., Winer, W., Albee, R., Sinervo, K., A pilot feasibility multicenter study of patients after excision of endometriosis, Journal of the Society of Laparoendoscopic Surgeons, 17, 88–94, 2013 | Non-comparative study |
| Zhang, Y. X., Effect of mifepristone in the different treatments of endometriosis, Clinical and experimental obstetrics & gynecology, 43, 350–3, 2016 | Study uses mifepristone (antiprogestogen) which the Committee were not interested in making recommendations and does not provide indirect evidence in the NMA |
| Zhao, R. H., Hao, Z. P., Zhang, Y., Lian, F. M., Sun, W. W., Liu, Y., Wang, R., Long, L., Cheng, L., Ding, Y. F., Song, D. R., Meng, Q. W., Wang, A. M., Controlling the recurrence of pelvic endometriosis after a conservative operation: comparison between Chinese herbal medicine and western medicine, Chinese Journal of Integrative Medicine, 19, 820–5, 2013 | No relevant comparison (post surgical treatment comparison); Not included in NMA |
| Zhao, R. H., Liu, Y., Tan, Y., Hao, Z. P., Meng, Q. W., Wang, R., Long, D., Ding, Y. F., Song, D. R., Xu, C., Ren, Z. Z., Yang, Y. H., Wang, A. M., Chinese medicine improves postoperative quality of life in endometriosis patients: a randomized controlled trial, Chinese Journal of Integrative Medicine, 19, 15–21, 2013 | One comparison group was administered GnRHa or gestrinone. Gestrinone is not available in the UK. |
| Zhao, S. Z., Kellerman, L. A., Francisco, C. A., Wong, J. M., Impact of nafarelin and leuprolide for endometriosis on quality of life and subjective clinical measures, Journal of Reproductive Medicine, 44, 1000–6, 1999 | QoL scale not validated; No other outcomes of interest |
| Zheng, Q., Mao, H., Xu, Y., Zhao, J., Wei, X., Liu, P., Can postoperative GnRH agonist treatment prevent endometriosis recurrence? A meta-analysis, Archives of gynecology and obstetrics, 294, 201–207, 2016 | All studies included in study have already been assessed for inclusion/exclusion |
| Zhu, X., Hamilton, K. D., McNicol, E. D., Acupuncture for pain in endometriosis, Cochrane Database of Systematic Reviews, CD007864, 2011 | Paper from this review included in the review. |
| Zou, S., Long, Q., Zhang, S., Han, Y., Zhang, W., Oral continuous combined 0.5 mg estradiol valerate and 5 mg dydrogesterone as daily add-back therapy during postoperative GnRH agonist treatment for endometriosis in Chinese women, International journal of clinical and experimental medicine, 6, 67–73, 2013 | No outcomes of interest |
| Zullo, F., Venturella, R., Mocciaro, R., Cappiello, F., Morelli, M., Letrozole vs. Clomiphene citrate plus IUI for women recently surgically treated for severe or recurrent endometriosis: A randomized controlled trial, Journal of Minimally Invasive Gynecology, 19 Suppl 1, S48, 2012 | Conference abstract: insufficient information |
| Zupi, E., Marconi, D., Sbracia, M., Zullo, F., De Vivo, B., Exacustos, C., Sorrenti, G., Add-back therapy in the treatment of endometriosis-associated pain, Fertility & Sterility, 82, 1303–8, 2004 | No relevant comparison (post surgical hormonal treatment comparison); Not included in NMA |
H.16. Hysterectomy with or without oophorectomy
| Reference | Reason for exclusion |
|---|---|
| Anonymous, ACOG criteria set. Quality evaluation and improvement in practice: Abdominal hysterectomy with or without adnexectomy for endometriosis. Number 27, October 1997. Committee on Quality Assessment. American College of Obstetricians and Gynecologists, International Journal of Gynaecology & Obstetrics, 60, 92–3, 1998 | Questionnaire/criteria for hysterectomy for women with endometriosis |
| Baig, S., Lyons, T. L., Stepanian, A. A., 12 Year follow up of 1000 laparoscopic supracervical hysterectomies at a single center, Journal of Minimally Invasive Gynecology, 1), S160, 2010 | There was no information about population (e.g., age), all women underwent laparoscopic supracervical hysterectomy, no comparator group |
| Bedaiwy, M. A., Abdel Rahman, M. Y., Chapman, M., Frasure, H., Mahajan, S., von Gruenigen, V. E., Hurd, W., Zanotti, K., Robotic-assisted hysterectomy for the management of severe endometriosis: A retrospective review of short-term surgical outcomes, Journal of the Society of Laparoendoscopic Surgeons, 17, 95–99, 2013 | The comparison was hysterectomy plus unilateral or hysterectomy plus bilateral oophorectomy. This did not meet the PICO for the review protocol. |
| Brudie, L. A., Gaia, G., Ahmad, S., Finkler, N. J., Bigsby, G. E. th, Ghurani, G. B., Kendrick, J. E. th, Rakowski, J. A., Groton, J. H., Holloway, R. W., Peri-operative outcomes of patients with stage IV endometriosis undergoing robotic-assisted laparoscopic surgery, Journal of Robotic Surgery, 6, 317–22, 2012 | Results are not provided for hysterectomy separately from hysterectomy oophorectomy. |
| Centre for Reviews and Dissemination, Surgical management of endometriosis (Structured abstract), Database of Abstracts of Reviews of Effects, 2015 | Structured abstract and commentary from DARE. Original review was 346981, which was excluded. |
| Chalermchockchareonkit, A., Tekasakul, P., Chaisilwattana, P., Sirimai, K., Wahab, N., Laparoscopic hysterectomy versus abdominal hysterectomy for severe pelvic endometriosis, International Journal of Gynecology and Obstetrics, 116, 109–111, 2012 | Study investigated laparoscopic hysterectomy vs abdominal hysterectomy for severe pelvic endometriosis, but no indication of oophorectomy in either group. Did not meet PICO |
| Chandakas, S., Hill, N., Erian, J., A multicentered series of over 1000 laparoscopic subtotal hysterectomies in the UK and Greece: The new approach to hysterectomy, Gynecological Surgery, 6, S187-S188, 2009 | Abstract did not provide all data for outcomes, only 21% of the population had endometriosis. Authors were investigating the efficacy of laparoscopic subtotal hysterectomy, no comparison group |
| Chien, H., Matsumoto, T., Saeki, A., Oku, H., Total laparoscopi retrograde hysterectomy for extensive endomeriosis with complete obliteration of the posterior cul-de-sac, Journal of Minimally Invasive Gynecology, 1), S99-S100, 2012 | The study investigated the use of different techniques for total laparoscopic hysterectomy. |
| Chu, C. M., Chang-Jackson, S. C., Nezhat, F. R., Retrospective study assessing laparoscopic versus robotic assisted laparoscopic treatment of severe endometriosis, Journal of Minimally Invasive Gynecology, 1), S101, 2011 | Two different technologies were compared for hysterectomy but individual treatment groups not reported |
| Clayton, R. D., Hawe, J. A., Love, J. C., Wilkinson, N., Garry, R., Recurrent pain after hysterectomy and bilateral salpingo-oophorectomy for endometriosis: Evaluation of laparoscopic excision of residual endometriosis, British Journal of Obstetrics and Gynaecology, 106, 740–744, 1999 | 5 consecutive women who had undergone hysterectomy and bilateral oophorectomy (without symptom relief) prior to start of study. They were then managed by laparoscopic excision of residual endometriosis. |
| Coronado, C., Franklin, R. R., Lotze, E. C., Bailey, H. R., Valdes, C. T., Surgical treatment of symptomatic colorectal endometriosis, Fertility and Sterility, 53, 411–416, 1990 | The intervention investigated in the study was full thickness resection of the colon for the treatment of deep colorectal endometriosis. Also, the study design did not match the protocol |
| Dave, A., Dabelea, V., Intraoperative and immediate postoperative outcomes after robotic hysterectomy in a community hospital: A review of 78 consecutive cases, Journal of Minimally Invasive Gynecology, 1), S205-S206, 2014 | This study was not a comparative study (case series) |
| Duffy, M. N. James, Arambage, Kirana, Correa, J. S. Frederico, Olive, David, Farquhar, Cindy, Garry, Ray, Barlow, David H., Jacobson, Tal Z., Laparoscopic surgery for endometriosis, Cochrane Database of Systematic Reviews, 2014 | Interventions of interest were not included in the Cochrane review. |
| Jihad, D., Fritz, J., Outcome of total laparoscopic hysterectomy, Gynecological Surgery, 8, S137, 2011 | Only investigated the safety of total laparoscopic hysterectomy in majority cases of uterine leiomyomas (51%), adenomyosis (15%), endometrial hyperplasia (13%), intraepithelial neoplasia (12%), and endometrial polyps (7%). |
| Johnson, N., Endometriosis, Clinical Evidence, 2326–39, 2005 | This review did not include studies that matched the PICO of the protocol for our review |
| Kayani, S. I., Pundir, J., Omanwa, K., Quality of life after total laparoscopic hysterectomy: a one-year follow-up study, Minerva Ginecologica, 68, 412–7, 2016 | Hysterectomy for benign conditions. Not specifically endometriosis. |
| Lieng, M., Lomo, A. B., Qvigstad, E., Long-term outcomes following laparoscopic and abdominal supracervical hysterectomies, Obstetrics & Gynecology International, 2010, 989127, 2010 | The study compared laparoscopic and abdominal supracervical hysterectomy, no indication of oophorectomy in either group. |
| Lieng, M., Qvigstad, E., Istre, O., Langebrekke, A., Ballard, K., Long-term outcomes following laparoscopic supracervical hysterectomy, BJOG: An International Journal of Obstetrics and Gynaecology, 115, 1605–1610, 2008 | All women in the study had laparoscopic supracervical hysterectomy (no oophorectomy group) |
| MacDonald, S. R., Klock, S. C., Milad, M. P., Long-term outcome of nonconservative surgery (hysterectomy) for endometriosis-associated pain in women <30 years old, American Journal of Obstetrics & Gynecology, 180, 1360–3, 1999 | Comparison groups were not of interest (hysterectomy stratified by age) |
| Maher, P. J., Wood, E. C., Hill, D. J., Lolatgis, N. A., Laparoscopically assisted hysterectomy, Medical Journal of Australia, 156, 316–8, 1992 | Only 17 participants in the study, with only one intervention (laparoscopic hysterectomy). Only one participant had endometriosis. |
| Malhas, R., Cole, J., Kumar, M., Outcome of laparoscopic hysterectomy in the UK: A retrospective study, BJOG: An International Journal of Obstetrics and Gynaecology, 121, 49, 2014 | Unclear if women had endometriosis. Two women had total abdominal hysterectomy, and majority of women had laparoscopic hysterectomy. |
| Marqueta, L., Munoz, L., Tejerizo, A., Lopez, G., Lorenzo, E., Munoz, J. L., Jimenez, J. S., Multidisciplinary approach in the management of deep infiltrating endometriosis. 5 years follow up, Journal of Minimally Invasive Gynecology, 1), S126, 2012 | Only one woman had hysterectomy only out of 92 patients. |
| Martin, D. C., Hysterectomy for treatment of pain associated with endometriosis, Journal of Minimally Invasive Gynecology, 13, 566–72, 2006 | Narrative review |
| McCoubrey, A., Hunter, D., Khosraviani, K., Surgical management of recto-sigmoidal endometriosis, Gynecological Surgery, 1), S52-S53, 2012 | Only 18 women total in study, there were no comparison groups. |
| McNamee, K. M., Anagnostopoulos, A., McCormack, J., Hawe, J., Total and subtotal laparoscopic hysterectomy can safely reduce total abdominal hysterectomy rates, BJOG: An International Journal of Obstetrics and Gynaecology, 120, 397–398, 2013 | Cases in the study were of mixed ages (26–85years), without subgroups. Only 20% of the cases had endometriosis, without any subgroup data. |
| Mehra, G., Hotchandani, M., Khatri, I. B., Verma, M., Mehra, S., Surgical complications of laparoscopic hysterectomy-a review of large single-centre series in India, BJOG: An International Journal of Obstetrics and Gynaecology, 121, 67, 2014 | Population was not stratified according to condition, intervention was laparoscopic hysterectomy, no comparator group. |
| Mills, C. W., Abdominal Hysterectomy-Indications and Technique, The Journal of abdominal surgery, 31, 37–40, 1964 | Narrative review of abdominal hysterectomy technique |
| Mills, W. G., Endometriosis, Nursing Times, 61, 9–11, 1965 | Narrative review of endometriosis followed by description of three individual cases. |
| Miranda, C.S., Carvajal, A.R., Complications of operative gynecological laparoscopy, Journal of the Society of Laparoendoscopic Surgeons, 7, 53–58, 2003 | Study design did not match the PICO for the review |
| Miranda, C.S., Carvajal, A.R., Escobar, P., Complications of operative laparoscopy, Gynaecological Endoscopy, 9, 161–165, 2000 | Study design did not meet the PICO for the review protocol |
| Mohan, S., Crouch, N., Amin, T., Chilcott, I., Watson, N., Kothari, A., Outcomes of laparoscopic hysterectomy-at introduction and 3 years, Gynecological Surgery, 8, S138, 2011 | Study investigated women who had laparoscopic hysterectomy only. No other comparator group. |
| Murtada, R., Meza, C., Centini, G., Castellano, J., Afors, K., Wattiez, A., Long-term outcomes after hysterectomy for pelvic pain attributed to endometriosis, Gynecological Surgery, 1), 102–103, 2014 | No information about intervention/comparator was reported. |
| Nathorst-Boos, J., Fuchs, T., von Schoultz, B., Consumer’s attitude to hysterectomy. The experience of 678 women, Acta Obstetricia et Gynecologica Scandinavica, 71, 230–4, 1992 | Unclear about which group had hysterectomy plus oophorectomy. |
| Nezhat, C., Kho, K., Robot-assisted laparoscopic hysterectomy utilizing the 5 mm daVinci system, Journal of Minimally Invasive Gynecology, 1), S36, 2010 | Study looked at the daVinci system (robotic-assisted laparoscopic hysterectomy) |
| Nezhat, F., Mahdavi, A., Nagarsheth, N. P., Total laparoscopic radical hysterectomy and pelvic lymphadenectomy using harmonic shears, Journal of Minimally Invasive Gynecology, 13, 20–25, 2006 | Intervention did not match the protocol for our review. There was no comparator group, Only one patient out of 7 had endometriosis |
| Niblock, K., Johnston, K., Morgan, D., McCracken, G., A reviewofmajor complications associated with 832 operative gynaecological laparoscopies, Gynecological Surgery, 1), S1-S2, 2012 | Only 16% of the cases had laparoscopic excisions for endometriosis, and did not include the comparisons for our review |
| Nichols, P., Miligkos, D., Di Fabio, F., Moors, A., Surgery for deep infiltrating endometriosis is associated with long-term improvement of pain and quality of life: A prospective study from a joint gyne/colorectal team, Colorectal Disease, 16, 207, 2014 | The population included women with severe endometriosis who had either undergone hysterectomy or just uni/bilateral oophorectomy |
| Nisolle, M., Nervo, P., Brichant, G., Foidart, J. M., Is there a place for hysterectomy in endometriotic pelvic pain?, International Journal of Gynecology and Obstetrics, 107, S60, 2009 | Narrative abstract |
| O’Brien, S., Munro, K., Vyas, S., Audit of clinical outcomes from total laparoscopic hysterectomies at Southmead Hospital, Bristol, September 2009–2013, BJOG: An International Journal of Obstetrics and Gynaecology, 121, 3–4, 2014 | Abstract did not report information on population, and there was no comparator group. |
| Ojeda, V. J., The pathology of hysterectomy specimens, New Zealand Medical Journal, 89, 169–171, 1979 | No indication of endometriosis |
| Okaro, E. O., Jones, K. D., Sutton, C., Long term outcome following laparoscopic supracervical hysterectomy, British Journal of Obstetrics and Gynaecology, 108, 1017–1020, 2001 | There was no comparator in the study. Only 4 women had endometriosis from histology. Analysis of patient case records |
| Oshinowo, A. E., Noam Smorgick-Rosenbaum, N., Advincula, A., As-Sanie, S., Robot-assisted hysterectomies for advanced endometriosis, Journal of Minimally Invasive Gynecology, 1), S4, 2012 | Comparing two technical interventions for hysterectomy, did not meet our review protocol |
| Ouahba, J., Madelenat, P., Poncelet, C., Transient abdominal ovariopexy for adhesion prevention in patients who underwent surgery for severe pelvic endometriosis, Fertility and Sterility, 82, 1407–1411, 2004 | Outcomes not of interest, subgroups for population not reported in study |
| Ozdemir, E., Ozturk, U., Celen, S., Sucak, A., Gunel, M., Guney, G., Imamoglu, M. A., Danisman, A. N., Iatrogenic urinary tract system injuries in obstetrics and gynecology operations, European Urology, Supplements, 9 (6), 566, 2010 | Population was not endometriosis |
| Parsons, L., Conservative surgical management of external endometriosis, Obstetrics & Gynecology, 32, 576–9, 1968 | Narrative editorial comment |
| Ranney, B., Endometriosis. 3. Complete operations. Reasons, sequelae, treatment, American Journal of Obstetrics & Gynecology, 109, 1137–44, 1971 | All women with endometriosis had hysterectomy plus salpingooophorectomy. There was no comparison with women who had hysterectomy alone |
| Ranney, B., Endometriosis. I. Conservative operations, American Journal of Obstetrics & Gynecology, 107, 743–53, 1970 | Women who had endometriosis had hysterectomy only, there was no comparison group of hysterectomy plus oophorectomy |
| Reddy, S., Rock, J. A., Treatment of endometriosis, Clinical Obstetrics & Gynecology, 41, 387–92, 1998 | Narrative review |
| Sirota, I., Mrkaic, A., Apostol, R., Nezhat, F., Comparison of long term outcomes in robotic versus conventional laparoscopy for treatment of advanced-stage endometriosis: Which is the preferred discipline?, Journal of Minimally Invasive Gynecology, 1), S39, 2014 | Study looked at comparison of two techniques for robotic versus conventional laparoscopy |
| Smith, T., The surgical treatment of endometriosis, Clinics in Obstetrics & Gynaecology, 5, 557–70, 1978 | Narrative review |
| Taskiran, C., Oktem, O., Turkgeldi, E., Celik, S., Urman, B., Type 3 like total laparoscopic hysterectomy because of endometriosis, Journal of Minimally Invasive Gynecology, 1), S31, 2013 | Narrative abstract |
| Tran, K. T., Kuijpers, H. C., Willemsen, W. N., Bulten, H., Surgical treatment of symptomatic rectosigmoid endometriosis, European Journal of Surgery, 162, 139–41, 1996 | Hysterectomy and oophorectomy was reported as separate groups. |
| Vercellini, P., De Giorgi, O., Pisacreta, A., Pesole, A. P., Vicentini, S., Crosignani, P. G., Surgical management of endometriosis, Best Practice & Research in Clinical Obstetrics & Gynaecology, 14, 501–23, 2000 | Intervention included pre-sacral neuroectomy and uterosacral ligament resection |
| Winkel, C.A., Scialli, A.R., Medical and surgical therapies for pain associated with endometriosis, Journal of Women’s Health and Gender-Based Medicine, 10, 137-Based, 2001 | No relevant outcomes |
H.17. Management strategies to improve spontaneous pregnancy rates
H.18. Economic evidence
| Study | Reason for Exclusion |
|---|---|
| Allaire, C., MacRae, G. S., Nishi, C., Chen, I. Hospital-related costs for endometriosis in Canada | Costs only |
| Araujo, D., Passos, R. B. F., Souza, C. P. R., Silva, A. P., Marques, M. Cost effectiveness analysis of goserelin empiric therapy for deep endometriosis treatment | Costs only |
| Attilia, B. K., Griffiths, A. N., Penketh, R. J. Regression analysis of predicted and actual operating duration for advanced laparoscopic excisional endometriosis surgery | Costs only |
| Banta, H. D. The cost-effectiveness of 10 selected applications in minimally invasive therapy | No conclusions reached in endometriosis section |
| Becker, I., Parlayan, S., Baumgarten, C., Dakkak, R., Rosenow, G., Von Kleinsorgen, C., Halis, G., Fuhr, N., Ebert, A. D. Inpatient costs for women with deep infiltrating endometriosis: A comparison of data from the years 2006 and 2007 of the Deutsche Endometriosezentrum Berlin (DEZB) Stufe III | Costs only |
| Bostrom, P., Lovkvist, L., Edlund, M., Olovsson, M. Burden of illness in women with endometriosis | Burden of illness |
| Bostrom, P., Lovkvist, L., Gustafsson, M., Alexandersson, O., Bruse, C., Liffner, C., Holmberg, J., Edlund, M., Olovsson, M. Cost of illness in women with endometriosis | Costs only |
| Brandes, I., Kleine-Budde, K., Halis, G. Quality of life results from the EndoCost study | Quality of Life only |
| Choi, S. E., Lim, E. A., Park, J. H., Lee, M. K., Jung, S. W., Cho, H. Y. Economic evaluation of dienogest for endometriosis in the context of Korea national health insurance | Abstract only |
| Chvatal, R., Reichert, B., Renner, S., Oppelt, P. Cost of inpatient treatment for endometriosis in Germany: An analysis based on the G-DRG-coding | Costs only |
| De Graaff, A. A., D’Hooghe, T. M., Dunselman, G. A., Dirksen, C. D., Hummelshoj, L., Werf EndoCost Consortium, Simoens, S. The significant effect of endometriosis on physical, mental and social wellbeing: results from an international cross-sectional survey | Quality of Life |
| D’Hooghe, T., Dirksen, C. D., Dunselman, G. A. J., De Graaff, A., EndoCost Consortium, W. E. R. F., Simoens, S. The costs of endometriosis: It’s the economy, stupid | Costs only |
| Ebert, A. D., Rosenow, G., Kruger, K., Liehr, R. M., Adam, U., Braunig, P., Haselmann, J., Freitag, A., Papadopolous, T., Von Kleinsorgen, C. Development of centres of excellence for endometriosis - The Berlin experiences | No HE data |
| Ferracini, M., Nakada, C. P. Cost minimization analysis of the dienogest use in patients with endometris under Brazilian public and private perspective | Costs only |
| Ferracini, M., Nakada, C. P. Cost minimization analysis of the dienogest use in patients with endometris under Brazilian public and private perspective | No numerical analysis |
| Fuldeore, M., Chwalisz, K., Marx, S., Wu, N., Boulanger, L., Ma, L., Lamothe, K. Surgical procedures and their cost estimates among women with newly diagnosed endometriosis: a US database study | Costs only |
| Fuldeore, M., Yang, H., Du, E. X., Soliman, A. M., Wu, E. Q., Winkel, C. Healthcare utilization and costs in women diagnosed with endometriosis before and after diagnosis: a longitudinal analysis of claims databases | Costs only |
| Fuldeore, M., Wu, N., Boulanger, L., Chwalisz, K., Marx, S. Prevalence rate and direct cost of surgical procedures among women with newly diagnosed endometriosis | Costs only |
| Gao, X., Outley, J., Botteman, M., Spalding, J., Simon, J. A., Pashos, C. L. Economic burden of endometriosis | Systematic review |
| Glasser, M. The clinical and economic benefits of GnRH agonist in treating endometriosis | No numerical analysis |
| Heinrichs, W. L., Henzl, M. R. Human issues and medical economics of endometriosis. Three- vs. six-month GnRH-agonist therapy | Quality of Life only |
| Hummelshoj, L. Worldwide studies have proven the challenge of endometriosis, its impact, and global costs | Abstract only |
| Hummelshoj, L., Nnoaham, K. E., Zondervan, K. T., Jenkinson, C., Webster, P., Kennedy, S. H. Life impact and life planning for women with endometriosis | Trial protocol |
| Jia, S.Z., Leng, J.H., Shi, J.H., Sun, P.R., Lang, J.H. Health-related quality of life in women with endometriosis: A systematic review | Systematic review |
| Klein, S., D’Hooghe, T., Meuleman, C., Dirksen, C., Dunselman, G., Simoens, S. What is the societal burden of endometriosis-associated symptoms? a prospective Belgian study | Costs only |
| Knight, C., Colligs, A., Lipinski, J. A budget impact analysis of dienogest in treating endometriosis associated pelvic pain in Germany | Abstract only |
| Koltermann, K. C., Mpinou, L. E., Niedobitek-Kreuter, G., Kruger, K., Thiel-Moder, U., Mechsner, S., Ebert, A. D. Symptomatic and asymptomatic bowel endometriosis in health economic focus in Germany | Could not retrieve |
| Lei, L. Economic burden of surgery on endometriosis | Costs only |
| Levy, A. R., Osenenko, K. M., Lozano-Ortega, G., Sambrook, R., Jeddi, M., Belisle, S., Reid, R. L. Economic burden of surgically confirmed endometriosis in Canada | Costs only |
| Long, C. Y., Fang, J. H., Chen, W. C., Su, J. H., Hsu, S. C. Comparison of total laparoscopic hysterectomy and laparoscopically assisted vaginal hysterectomy | Endometriosis costs not given |
| Luciano, A. A., Lowney, J., Jacobs, S. L. Endoscopic treatment of endometriosis-associated infertility. Therapeutic, economic and social benefits | Costs only |
| Lyttle-Nguessan, C., Campbell, E. S. Cost-effectiveness of early detection of endometriosis: A systematic review | Economic costs not considered (no opportunity cost) |
| Marmarali, B., Deger, C., Memis, S. A., Parali, E., Sumer, F., Karakeben, K., Kayadibinli, M. Cost effectiveness comparison between dienogest and gonadotropin-releasing hormone analogs in Turkey | Abstract only |
| Mirkin, D., Murphy-Barron, C., Iwasaki, K. Actuarial analysis of private payer administrative claims data for women with endometriosis | Costs only |
| Naughton, M. J., McBee, W. L. Health-related quality of life after hysterectomy | Endometriosis costs not given |
| Nnoaham, K. E., Hummelshoj, L., Webster, P., d’Hooghe, T., de Cicco Nardone, F., de Cicco Nardone, C., Jenkinson, C., Kennedy, S. H., Zondervan, K. T., World Endometriosis Research Foundation Global Study of Women’s Health, consortium Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries | Duplicate |
| Oehmke, F., Weyand, J., Hackethal, A., Konrad, L., Omwandho, C., Tinneberg, H. R. Impact of endometriosis on quality of life: a pilot study | Quality of Life |
| Oppelt, P., Chavtal, R., Haas, D., Reichert, B., Wagner, S., Muller, A., Lermann, J. H., Renner, S. P. Costs of in-patient treatment for endometriosis in Germany 2006: An analysis based on the G-DRG-Coding | Costs only |
| Parali, E., Deger, C., Marmarali, B., Memis, S. A., Sumer, F., Karakeben, K., Kayadibinli, M. Effects of different clinical practices of laparoscopic surgery for endometriosis treatment on cost of therapy | Costs only |
| Piniazhko, O., Zalis’ka, O., Vernikovskyy, I. The prevalence and cost of illness in women with endometriosis in Ukraine | No HE information |
| Redwine, D. B., Koning, M., Sharpe, D. R. Laparoscopically assisted transvaginal segmental resection of the rectosigmoid colon for endometriosis | Costs only |
| Sacher, F., Fritsch, M., Schulze-Rath, R., Xia, F., Law, A. A retrospective cohort study of women who have had a diagnosis of endometriosis at discharge in a hospital database in the us to characterize subentities of the disease | Abstract only |
| Schindler, A. E. Oral hormonal contraceptives and endometriosis | Not HE |
| Simoens, S., Dunselman, G., Dirksen, C., Hummelshoj, L., Bokor, A., Brandes, I., Brodszky, V., Canis, M., Colombo, G. L., DeLeire, T., Falcone, T., Graham, B., Halis, G., Horne, A., Kanj, O., Kjer, J. J., Kristensen, J., Lebovic, D., Mueller, M., Vigano, P., Wullschleger, M., D’Hooghe, T. The burden of endometriosis: costs and quality of life of women with endometriosis and treated in referral centres.[Erratum appears in Hum Reprod. 2014 Sep;29(9):2073] | Abstract only |
| Simoens, S., Hummelshoj, L., D’Hooghe, T. Endometriosis: cost estimates and methodological perspective | Costs only |
| Simoens, S., Hummelshoj, L., Dunselman, G., Brandes, I., Dirksen, C., D’Hooghe, T., EndoCost, Consortium Endometriosis cost assessment (the EndoCost study): a cost-of-illness study protocol | Protocol only |
| Simoens, S., Hummelshoj, L., Dunselman, G., Dirksen, C., Endocost Consortium, W., D’Hooghe, T. The burden of endometriosis: Costs and quality of life of women with endometriosis treated in referral centres | Abstract only |
| Simoens, S., Meuleman, C., D’Hooghe, T. Non-health-care costs associated with endometriosis | QoL metric not appropriate for NICE analysis |
| Sugimura, K., Imaoka, I., Okizuka, H. Pelvic endometriosis: impact of magnetic resonance imaging on treatment decisions and costs | Costs only |
| Tselos, E., Whitlow, B. Patient level information costing systems (PLICS): Could be used to get right tariffs for endometriosis cases? | Abstract only |
| Vercellini, P., Frattaruolo, M. P., Somigliana, E., Jones, G. L., Consonni, D., Alberico, D., Fedele, L. Surgical versus lowdose progestin treatment for endometriosis-associated severe deep dyspareunia II: effect on sexual functioning, psychological status and health-related quality of life | Quality of Life only |
| Vercellini, P., Somigliana, E., Vigano, P., Abbiati, A., Daguati, R., Crosignani, P.G. Endometriosis: current and future medical therapies | Modelling information only |
| Wasiak, R., Hjalte, F., Ragnarson Tennvall, G., Olovsson, M. Cost of illness for endometriosis in sweden | Costs only |
| Wasiak, R., Manson, S., Ryan, J., Petri, J. C. Treatment and cost for patients with endometriosis in the United Kingdom | Costs only |
| Winkel, C. A. Modeling of medical and surgical treatment costs of chronic pelvic pain: new paradigms for making clinical decisions | Chronic pelvic pain |
| Wong, A. Y., Tang, L. An open and randomized study comparing the efficacy of standard danazol and modified triptorelin regimens for postoperative disease management of moderate to severe endometriosis | Quality of Life |
| Wullschleger, M. F., Imboden, S., Wanner, J., Mueller, M. D. Minimally invasive surgery when treating endometriosis has a positive effect on health and on quality of work life of affected women | QoL metric not appropriate for NICE analysis |
| Zhao, S. Z., Wong, J. M., Davis, M. B., Gersh, G. E., Johnson, K. E. The cost of inpatient endometriosis treatment: An analysis based on the healthcare cost and utilization project nationwide inpatient sample | Costs only |
- Specialist services
- Timing of interventions: association between duration of symptoms before laparoscopy and treatment outcomes
- Signs and symptoms of endometriosis (monitoring and referral)
- Information and support
- Risk of cancer of reproductive organs
- Diagnosis – Ultrasound
- Diagnosis – Biomarkers: CA-125
- Diagnosis – Biomarkers: HE-4
- Diagnosis – Biomarkers: Nerve fibre marker Protein Gene Product 9.5 (PGP 9.5)
- Diagnosis – MRI
- Diagnosis – Surgical diagnosis with or without histological confirmation
- Staging Systems
- Pharmacological management – Analgesics
- Pharmacological management – Neuromodulators
- Pharmacological, non-pharmacological, surgical and combination management strategies (NMA and pairwise comparisons and fertility (NMA))
- Hysterectomy with or without oophorectomy
- Management strategies to improve spontaneous pregnancy rates
- Economic evidence
- Excluded studies - Endometriosis: diagnosis and managementExcluded studies - Endometriosis: diagnosis and management
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