LOC100000823 disks large homolog 4 [Danio rerio (zebrafish)] - Gene

Summary

Gene symbol: LOC100000823
Gene description: disks large homolog 4
See related: Ensembl:ENSDARG00000041926
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dlg4
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (68527359..68754844, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (67756907..67984499, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

G39939 (e-PCR)
- UniSTS:49161

z43319 (e-PCR), detects polymorphism
- UniSTS:238740

Z4299 (e-PCR)
- UniSTS:14514

G46918 (e-PCR)
- UniSTS:107713

Homology

NCBI Orthologs

Orthologs from OrthoDB

General protein information

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Preferred Names: disks large homolog 4

Names: discs large MAGUK scaffold protein 4; discs, large homolog 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

68527359..68754844 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009302021.4 → XP_009300296.1 disks large homolog 4 isoform X4

UniProtKB/TrEMBL

A0A8M3B029

Conserved Domains (8) summary

smart00072
Location:595 → 763

GuKc; Guanylate kinase homologues

smart00228
Location:205 → 294

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG0265
Location:343 → 436

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:113 → 197

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:584 → 763

Guanylate_kin; Guanylate kinase

pfam10600
Location:305 → 360

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:10 → 112

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

cl17036
Location:478 → 543

SH3; Src Homology 3 domain superfamily
XM_009302020.4 → XP_009300295.1 disks large homolog 4 isoform X3

UniProtKB/TrEMBL

A0A8M3B301

Conserved Domains (8) summary

smart00072
Location:599 → 767

GuKc; Guanylate kinase homologues

smart00228
Location:209 → 298

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG0265
Location:347 → 440

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:117 → 201

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:588 → 767

Guanylate_kin; Guanylate kinase

pfam10600
Location:309 → 364

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:15 → 116

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

cl17036
Location:482 → 547

SH3; Src Homology 3 domain superfamily
XM_009302019.4 → XP_009300294.1 disks large homolog 4 isoform X2

UniProtKB/TrEMBL

A0A8M3ASY7

Related

ENSDARP00000048431.8, ENSDART00000048432.8

Conserved Domains (8) summary

smart00072
Location:605 → 773

GuKc; Guanylate kinase homologues

smart00228
Location:215 → 304

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG0265
Location:353 → 446

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:123 → 207

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:594 → 773

Guanylate_kin; Guanylate kinase

pfam10600
Location:315 → 370

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:39 → 122

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

cl17036
Location:488 → 553

SH3; Src Homology 3 domain superfamily
XM_009302018.4 → XP_009300293.1 disks large homolog 4 isoform X1

UniProtKB/TrEMBL

A0A8M3BA19

Conserved Domains (8) summary

smart00072
Location:624 → 792

GuKc; Guanylate kinase homologues

smart00228
Location:234 → 323

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG0265
Location:372 → 465

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:142 → 226

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:613 → 792

Guanylate_kin; Guanylate kinase

pfam10600
Location:334 → 389

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:39 → 141

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

cl17036
Location:507 → 572

SH3; Src Homology 3 domain superfamily
XM_009302023.4 → XP_009300298.1 disks large homolog 4 isoform X5

UniProtKB/TrEMBL

A0A8M3ASX4

Conserved Domains (8) summary

smart00072
Location:542 → 710

GuKc; Guanylate kinase homologues

smart00228
Location:152 → 241

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG0265
Location:290 → 383

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:60 → 144

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:531 → 710

Guanylate_kin; Guanylate kinase

pfam10600
Location:252 → 307

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:31 → 59

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

cl17036
Location:425 → 490

SH3; Src Homology 3 domain superfamily