kif2c kinesin family member 2C [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kif2cprovided by ZNC
Official Full Name: kinesin family member 2Cprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070912-298
See related: Ensembl:ENSDARG00000076228 AllianceGenome:ZFIN:ZDB-GENE-070912-298
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch211-61f14.1
Summary: Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Acts upstream of or within hematopoietic stem cell homeostasis. Predicted to be part of kinesin complex. Predicted to be active in centrosome; microtubule; and spindle. Orthologous to human KIF2C (kinesin family member 2C). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (33926921..33950610)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (33943711..33966754)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of kif2c, A Gene Related to ALL Relapse, in Embryonic Hematopoiesis in Zebrafish.
Title: Role of kif2c, A Gene Related to ALL Relapse, in Embryonic Hematopoiesis in Zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromosome segregation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hematopoietic stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in spindle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kinesin-like protein KIF2C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114593.1 → NP_001108065.1 kinesin-like protein KIF2C

See identical proteins and their annotated locations for NP_001108065.1

Status: PROVISIONAL

Source sequence(s)

BC155585

UniProtKB/TrEMBL

A0A8M1NHQ3, A9JRA8

Related

ENSDARP00000099090.1, ENSDART00000111430.2

Conserved Domains (2) summary

cd01367
Location:256 → 584

KISc_KIF2_like; Kinesin motor domain, KIF2-like group

pfam00225
Location:262 → 585

Kinesin; Kinesin motor domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

33926921..33950610

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005163472.4 → XP_005163529.1 kinesin-like protein KIF2C isoform X1

UniProtKB/TrEMBL

A0A8M2BAP1, B0S7G2

Related

ENSDARP00000102193.3, ENSDART00000109849.5

Conserved Domains (2) summary

cd01367
Location:267 → 595

KISc_KIF2_like; Kinesin motor domain, KIF2-like group

pfam00225
Location:273 → 596

Kinesin; Kinesin motor domain