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TSPAN32 tetraspanin 32 [ Homo sapiens (human) ]

Gene ID: 10077, updated on 2-Nov-2024

Summary

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Official Symbol
TSPAN32provided by HGNC
Official Full Name
tetraspanin 32provided by HGNC
Primary source
HGNC:HGNC:13410
See related
Ensembl:ENSG00000064201 MIM:603853; AllianceGenome:HGNC:13410
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ART1; PHMX; PHEMX; TSSC6
Summary
This gene, which is a member of the tetraspanin superfamily, is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4, escapes imprinting. This gene may play a role in malignancies and diseases that involve this region, and it is also involved in hematopoietic cell function. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Expression
Biased expression in bone marrow (RPKM 10.4), spleen (RPKM 4.1) and 5 other tissues See more
Orthologs
mouse all
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Genomic context

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See TSPAN32 in Genome Data Viewer
Location:
11p15.5
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (2302013..2318204)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (2391457..2407521)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (2323243..2339434)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:2198066-2198912 Neighboring gene microRNA 4686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:2225905-2226503 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:2233643-2234213 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:2235935-2236495 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:2244593-2245167 Neighboring gene achaete-scute family bHLH transcription factor 2 Neighboring gene Sharpr-MPRA regulatory region 3604 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:2327147-2327814 Neighboring gene chromosome 11 open reading frame 21 Neighboring gene uncharacterized LOC124902612 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:2333788-2334393 Neighboring gene NANOG hESC enhancer GRCh37_chr11:2349809-2350310 Neighboring gene RNA, U6 small nuclear 878, pseudogene Neighboring gene CD81 antisense RNA 1 Neighboring gene ribosomal protein L26 pseudogene 30

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Altered Expression of TSPAN32 during B Cell Activation and Systemic Lupus Erythematosus. Fagone P, et al. Genes (Basel), 2021 Jun 18. PMID 34207245, Free PMC Article
  2. Tumor cell growth arrest caused by subchromosomal transferable DNA fragments from chromosome 11. Koi M, et al. Science, 1993 Apr 16. PMID 8469989
  3. Modulation of Tetraspanin 32 (TSPAN32) Expression in T Cell-Mediated Immune Responses and in Multiple Sclerosis. Lombardo SD, et al. Int J Mol Sci, 2019 Sep 4. PMID 31487788, Free PMC Article
  4. Molecular characterisation of mouse and human TSSC6: evidence that TSSC6 is a genuine member of the tetraspanin superfamily and is expressed specifically in haematopoietic organs. Robb L, et al. Biochim Biophys Acta, 2001 Nov 11. PMID 11718897
  5. Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting. Lee MP, et al. Hum Mol Genet, 1999 Apr. PMID 10072438

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Altered Expression of TSPAN32 during B Cell Activation and Systemic Lupus Erythematosus.
    Title: Altered Expression of TSPAN32 during B Cell Activation and Systemic Lupus Erythematosus.
  2. TSPAN32 mRNA level is significantly reduced in CD4 T cells of multiple sclerosis patients.
    Title: Modulation of Tetraspanin 32 (TSPAN32) Expression in T Cell-Mediated Immune Responses and in Multiple Sclerosis.
  3. In the absence of both CD37 and Tssc6, immune function is further altered when compared with CD37- or Tssc6-deficient transgenic mice, demonstrating a complementary role for these two molecules in cellular immunity.
    Title: A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
EBI GWAS Catalog
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

  • D11S1318 (e-PCR), detects polymorphism

Homology

Clone Names

  • FLJ17158, FLJ97586, MGC22455

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in T cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
 PubMed 
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to protozoan IEA
Inferred from Electronic Annotation
more info
  
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of myeloid dendritic cell activation IEA
Inferred from Electronic Annotation
more info
  
involved_in platelet aggregation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of defense response to virus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
part_of integrin alphaIIb-beta3 complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tetraspanin-32
Names
pan-hematopoietic expression protein
protein Phemx
tumor-suppressing STF cDNA 6
tumor-suppressing subchromosomal transferable fragment cDNA 6
tumor-suppressing subtransferable candidate 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139022.3 → NP_620591.3  tetraspanin-32

    See identical proteins and their annotated locations for NP_620591.3

    Status: REVIEWED

    Source sequence(s)
    AA701395, AC129929, AY039001, BG506933
    Consensus CDS
    CCDS7733.1
    UniProtKB/Swiss-Prot
    Q96KX4, Q96QS1, Q9HC50, Q9HC51, Q9Y5U1
    UniProtKB/TrEMBL
    D3YTD1
    Related
    ENSP00000182290.5, ENST00000182290.9
    Conserved Domains (2) summary
    cd03153
    Location:113 → 195
    PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:11 → 223
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    2302013..2318204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519822.2 → XP_011518124.1  tetraspanin-32 isoform X11

    Related
    ENSP00000370513.3, ENST00000381121.7
    Conserved Domains (2) summary
    cd03153
    Location:148 → 230
    PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:46 → 258
    Tetraspannin; Tetraspanin family

  2. XM_011519818.4 → XP_011518120.4  tetraspanin-32 isoform X6

    Related
    ENSP00000482901.1, ENST00000612299.4

  3. XM_005252719.5 → XP_005252776.1  tetraspanin-32 isoform X2

    Conserved Domains (2) summary
    cd03153
    Location:148 → 230
    PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:46 → 258
    Tetraspannin; Tetraspanin family

  4. XM_011519815.4 → XP_011518117.4  tetraspanin-32 isoform X5

  5. XM_005252720.5 → XP_005252777.1  tetraspanin-32 isoform X12

    UniProtKB/TrEMBL
    B4DQ90
    Conserved Domains (2) summary
    cd03153
    Location:148 → 217
    PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:46 → 196
    Tetraspannin; Tetraspanin family

  6. XM_047426215.1 → XP_047282171.1  tetraspanin-32 isoform X16

    Related
    ENST00000461200.5

  7. XM_047426212.1 → XP_047282168.1  tetraspanin-32 isoform X14

  8. XM_047426209.1 → XP_047282165.1  tetraspanin-32 isoform X7

  9. XM_011519819.2 → XP_011518121.1  tetraspanin-32 isoform X7

    UniProtKB/TrEMBL
    D3YTD1
    Conserved Domains (2) summary
    cd03153
    Location:83 → 165
    PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:36 → 193
    Tetraspannin; Tetraspanin family

  10. XM_017017065.2 → XP_016872554.1  tetraspanin-32 isoform X3

  11. XM_017017068.2 → XP_016872557.1  tetraspanin-32 isoform X8

  12. XM_017017064.2 → XP_016872553.1  tetraspanin-32 isoform X1

    Conserved Domains (1) summary
    cd03153
    Location:171 → 248
    PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...

  13. XM_017017066.2 → XP_016872555.1  tetraspanin-32 isoform X4

  14. XM_047426210.1 → XP_047282166.1  tetraspanin-32 isoform X9

  15. XM_017017069.2 → XP_016872558.1  tetraspanin-32 isoform X10

  16. XM_047426213.1 → XP_047282169.1  tetraspanin-32 isoform X15

  17. XM_017017071.2 → XP_016872560.1  tetraspanin-32 isoform X15

  18. XM_047426211.1 → XP_047282167.1  tetraspanin-32 isoform X13

  19. XM_047426214.1 → XP_047282170.1  tetraspanin-32 isoform X15

RNA

  1. XR_001747716.1 RNA Sequence

  2. XR_001747715.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    2391457..2407521
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367406.1 → XP_054223381.1  tetraspanin-32 isoform X11

  2. XM_054367400.1 → XP_054223375.1  tetraspanin-32 isoform X6

  3. XM_054367396.1 → XP_054223371.1  tetraspanin-32 isoform X2

  4. XM_054367399.1 → XP_054223374.1  tetraspanin-32 isoform X5

  5. XM_054367407.1 → XP_054223382.1  tetraspanin-32 isoform X12

  6. XM_054367413.1 → XP_054223388.1  tetraspanin-32 isoform X16

  7. XM_054367409.1 → XP_054223384.1  tetraspanin-32 isoform X14

  8. XM_054367401.1 → XP_054223376.1  tetraspanin-32 isoform X7

  9. XM_054367402.1 → XP_054223377.1  tetraspanin-32 isoform X7

  10. XM_054367397.1 → XP_054223372.1  tetraspanin-32 isoform X3

  11. XM_054367403.1 → XP_054223378.1  tetraspanin-32 isoform X8

  12. XM_054367395.1 → XP_054223370.1  tetraspanin-32 isoform X1

  13. XM_054367398.1 → XP_054223373.1  tetraspanin-32 isoform X4

  14. XM_054367404.1 → XP_054223379.1  tetraspanin-32 isoform X9

  15. XM_054367405.1 → XP_054223380.1  tetraspanin-32 isoform X10

  16. XM_054367410.1 → XP_054223385.1  tetraspanin-32 isoform X15

  17. XM_054367411.1 → XP_054223386.1  tetraspanin-32 isoform X15

  18. XM_054367408.1 → XP_054223383.1  tetraspanin-32 isoform X13

  19. XM_054367412.1 → XP_054223387.1  tetraspanin-32 isoform X15

RNA

  1. XR_008488324.1 RNA Sequence

  2. XR_008488325.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_005705.4: Suppressed sequence

    Description
    NM_005705.4: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.

  2. NM_139024.3: Suppressed sequence

    Description
    NM_139024.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96QS1.1 GenPept UniProtKB/Swiss-Prot:Q96QS1

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