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FBXW10 F-box and WD repeat domain containing 10 [ Homo sapiens (human) ]

Gene ID: 10517, updated on 3-Nov-2024

Summary

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Official Symbol
FBXW10provided by HGNC
Official Full Name
F-box and WD repeat domain containing 10provided by HGNC
Primary source
HGNC:HGNC:1211
See related
Ensembl:ENSG00000171931 MIM:611679; AllianceGenome:HGNC:1211
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HREP; Fbw10; SM25H2; SM2SH2
Summary
Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in testis (RPKM 6.8) and esophagus (RPKM 0.4) See more
Orthologs
mouse all
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Genomic context

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See FBXW10 in Genome Data Viewer
Location:
17p11.2
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (18744054..18779349)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (18690047..18725498)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (18647367..18682662)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 286B (pseudogene) Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:18585117-18585622 Neighboring gene forkhead box O3B Neighboring gene ubiquitin conjugating enzyme E2 S pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8279 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18601479-18602036 Neighboring gene tripartite motif containing 16 like (pseudogene) Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:18621593-18622463 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:18622464-18623334 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18624898-18625462 Neighboring gene Sharpr-MPRA regulatory region 2370 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:18673855-18674355 Neighboring gene trans-golgi network vesicle protein 23 homolog B Neighboring gene NANOG hESC enhancer GRCh37_chr17:18706781-18707432 Neighboring gene coiled-coil domain-containing protein 144A-like Neighboring gene RNA, 7SL, cytoplasmic 627, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. FBXW10: a male-biased E3 ligase in liver cancer. Sahay O, et al. Trends Cancer, 2023 Nov. PMID 37775405
  2. FBXW10 is negatively regulated in transcription and expression level by protein O-GlcNAcylation. Feng Z, et al. Biochem Biophys Res Commun, 2013 Aug 23. PMID 23899520
  3. FBXW10 promotes hepatocarcinogenesis in male patients and mice. Luo YD, et al. Carcinogenesis, 2020 Jul 10. PMID 31400758
  4. Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10. Chaturvedi P, et al. PLoS One, 2010 May 13. PMID 20498703, Free PMC Article
  5. FBXW10-S6K1 promotes ANXA2 polyubiquitination and KRAS activation to drive hepatocellular carcinoma development in males. Liu ZY, et al. Cancer Lett, 2023 Jul 10. PMID 37277019

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FBXW10: a male-biased E3 ligase in liver cancer.
    Title: FBXW10: a male-biased E3 ligase in liver cancer.
  2. The E3 ubiquitin ligase SCF (FBXW10)-mediated LATS2 degradation regulates angiogenesis and liver metastasis in colorectal cancer.
    Title: The E3 ubiquitin ligase SCF (FBXW10)-mediated LATS2 degradation regulates angiogenesis and liver metastasis in colorectal cancer.
  3. FBXW10 promotes hepatocarcinogenesis in male patients and mice.
    Title: FBXW10 promotes hepatocarcinogenesis in male patients and mice.
  4. O-GlcNAcylation is involved in the regulation of ubiquitination-related genes including FBXW10
    Title: FBXW10 is negatively regulated in transcription and expression level by protein O-GlcNAcylation.
  5. Mislocalized lamins can induce ubiquitin-mediated proteasomal degradation of certain HP1 isoforms by activation of FBXW10, a member of the F-box family of proteins that is involved in E3 ubiquitin ligase activity.
    Title: Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
F-box/WD repeat-containing protein 10
Names
F-box and WD-40 domain protein 10
testicular tissue protein Li 69
ubiquitin ligase specificity factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267585.2 → NP_001254514.1  F-box/WD repeat-containing protein 10 isoform 1

    See identical proteins and their annotated locations for NP_001254514.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC107982, AL136822, AY729024, DB055860
    Consensus CDS
    CCDS11199.3
    UniProtKB/Swiss-Prot
    C9JRY8, C9JZD7, Q5XX13, Q8TC00, Q9H0F0
    Related
    ENSP00000379025.4, ENST00000395665.9
    Conserved Domains (3) summary
    COG2319
    Location:416 → 679
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:418 → 653
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:457 → 493
    7WD40; WD40 repeat [structural motif]

  2. NM_001267586.2 → NP_001254515.1  F-box/WD repeat-containing protein 10 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC107982, AL136822, DB055860
    Consensus CDS
    CCDS58524.1
    UniProtKB/Swiss-Prot
    Q5XX13
    Related
    ENSP00000306937.4, ENST00000301938.4
    Conserved Domains (3) summary
    COG2319
    Location:416 → 621
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:418 → 601
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:457 → 493
    7WD40; WD40 repeat [structural motif]

  3. NM_001411059.1 → NP_001397988.1  F-box/WD repeat-containing protein 10 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC107982
    Consensus CDS
    CCDS92270.1
    Related
    ENSP00000310382.4, ENST00000308799.8

RNA

  1. NR_051988.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses alternate 5' and 3' terminal exons, compared to variant 1. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC107982, AK310383, AL136822, DB055860
    Related
    ENST00000574478.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    18744054..18779349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024020.3 → XP_016879509.1  F-box/WD repeat-containing protein 10 isoform X12

    Conserved Domains (2) summary
    cd00200
    Location:469 → 704
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:508 → 544
    7WD40; WD40 repeat [structural motif]

  2. XM_047435121.1 → XP_047291077.1  F-box/WD repeat-containing protein 10 isoform X1

  3. XM_047435122.1 → XP_047291078.1  F-box/WD repeat-containing protein 10 isoform X2

  4. XM_047435123.1 → XP_047291079.1  F-box/WD repeat-containing protein 10 isoform X3

  5. XM_047435124.1 → XP_047291080.1  F-box/WD repeat-containing protein 10 isoform X4

  6. XM_047435125.1 → XP_047291081.1  F-box/WD repeat-containing protein 10 isoform X5

  7. XM_047435132.1 → XP_047291088.1  F-box/WD repeat-containing protein 10 isoform X11

  8. XM_047435130.1 → XP_047291086.1  F-box/WD repeat-containing protein 10 isoform X9

  9. XM_047435127.1 → XP_047291083.1  F-box/WD repeat-containing protein 10 isoform X7

  10. XM_047435126.1 → XP_047291082.1  F-box/WD repeat-containing protein 10 isoform X6

  11. XM_047435129.1 → XP_047291085.1  F-box/WD repeat-containing protein 10 isoform X8

    UniProtKB/TrEMBL
    A0A140VJJ5

  12. XM_047435131.1 → XP_047291087.1  F-box/WD repeat-containing protein 10 isoform X10

  13. XM_011523625.3 → XP_011521927.1  F-box/WD repeat-containing protein 10 isoform X12

    Conserved Domains (2) summary
    cd00200
    Location:469 → 704
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:508 → 544
    7WD40; WD40 repeat [structural motif]

  14. XM_017024021.3 → XP_016879510.1  F-box/WD repeat-containing protein 10 isoform X13

  15. XM_047435133.1 → XP_047291089.1  F-box/WD repeat-containing protein 10 isoform X14

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    18690047..18725498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314709.1 → XP_054170684.1  F-box/WD repeat-containing protein 10 isoform X3

  2. XM_054314710.1 → XP_054170685.1  F-box/WD repeat-containing protein 10 isoform X4

  3. XM_054314711.1 → XP_054170686.1  F-box/WD repeat-containing protein 10 isoform X5

  4. XM_054314717.1 → XP_054170692.1  F-box/WD repeat-containing protein 10 isoform X11

  5. XM_054314719.1 → XP_054170694.1  F-box/WD repeat-containing protein 10 isoform X12

  6. XM_054314707.1 → XP_054170682.1  F-box/WD repeat-containing protein 10 isoform X1

  7. XM_054314708.1 → XP_054170683.1  F-box/WD repeat-containing protein 10 isoform X2

  8. XM_054314715.1 → XP_054170690.1  F-box/WD repeat-containing protein 10 isoform X9

  9. XM_054314718.1 → XP_054170693.1  F-box/WD repeat-containing protein 10 isoform X12

  10. XM_054314713.1 → XP_054170688.1  F-box/WD repeat-containing protein 10 isoform X7

  11. XM_054314720.1 → XP_054170695.1  F-box/WD repeat-containing protein 10 isoform X13

  12. XM_054314712.1 → XP_054170687.1  F-box/WD repeat-containing protein 10 isoform X6

  13. XM_054314714.1 → XP_054170689.1  F-box/WD repeat-containing protein 10 isoform X8

    UniProtKB/TrEMBL
    A0A140VJJ5

  14. XM_054314716.1 → XP_054170691.1  F-box/WD repeat-containing protein 10 isoform X10

  15. XM_054314721.1 → XP_054170696.1  F-box/WD repeat-containing protein 10 isoform X14

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_031456.3: Suppressed sequence

    Description
    NM_031456.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XX13.2 GenPept UniProtKB/Swiss-Prot:Q5XX13

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