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cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit [ Danio rerio (zebrafish) ]

Gene ID: 170581, updated on 2-Nov-2024

Summary

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Official Symbol
cacna1cprovided by ZNC
Official Full Name
calcium channel, voltage-dependent, L type, alpha 1C subunitprovided by ZNC
Primary source
ZFIN:ZDB-GENE-020129-1
See related
Ensembl:ENSDARG00000008398 AllianceGenome:ZFIN:ZDB-GENE-020129-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
isl; C-LTCC
Summary
Enables voltage-gated calcium channel activity. Acts upstream of or within several processes, including calcium ion import; embryonic organ morphogenesis; and physiological cardiac muscle hypertrophy. Predicted to be located in several cellular components, including T-tubule; perikaryon; and postsynaptic density membrane. Predicted to be part of voltage-gated calcium channel complex. Is expressed in central nervous system; digestive system; lateral plate mesoderm; pericardial region; and splanchnocranium. Human ortholog(s) of this gene implicated in Brugada syndrome 3; Timothy syndrome; long QT syndrome 8; and neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures. Orthologous to human CACNA1C (calcium voltage-gated channel subunit alpha1 C). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See cacna1c in Genome Data Viewer
Location:
chromosome: 4
Exon count:
51
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (20308987..20480303)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (20596310..20759327)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 38 like Neighboring gene calcium channel, voltage-dependent, alpha 2/delta subunit 4a Neighboring gene leucine-rich repeats and transmembrane domains 2a Neighboring gene decapping mRNA 1B Neighboring gene N-acyl phosphatidylethanolamine phospholipase D Neighboring gene integrator complex subunit 13 Neighboring gene Ras association domain family member 8b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Calcium signaling regulates ventricular hypertrophy during development independent of contraction or blood flow. Andersen ND, et al. J Mol Cell Cardiol, 2015 Mar. PMID 25536179, Free PMC Article
  2. Improved selection of zebrafish CRISPR editing by early next-generation sequencing based genotyping. Sieliwonczyk E, et al. Sci Rep, 2023 Jan 27. PMID 36707549, Free PMC Article
  3. Calcium handling in zebrafish ventricular myocytes. Zhang PC, et al. Am J Physiol Regul Integr Comp Physiol, 2011 Jan. PMID 20926764
  4. Primary cilium regulates CaV1.2 expression through Wnt signaling. Muntean BS, et al. J Cell Physiol, 2014 Dec. PMID 24700505, Free PMC Article
  5. Behavioral analysis through the lifespan of disc1 mutant zebrafish identifies defects in sensorimotor transformation. Pluimer BR, et al. iScience, 2023 Jul 21. PMID 37416451, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LITAF acts as an adaptor protein promoting NEDD4-mediated ubiquitination and subsequent degradation of L-type calcium channel.
    Title: LITAF (Lipopolysaccharide-Induced Tumor Necrosis Factor) Regulates Cardiac L-Type Calcium Channels by Modulating NEDD (Neural Precursor Cell Expressed Developmentally Downregulated Protein) 4-1 Ubiquitin Ligase.
  2. CaV1.2 expression is tightly regulated through Wnt signaling and plays an essential sensory role in primary cilia necessary for cellular homeostasis
    Title: Primary cilium regulates CaV1.2 expression through Wnt signaling.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables high voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated calcium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion import IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within calcium ion transport IMP
Inferred from Mutant Phenotype
more info
  
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
  
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within physiological cardiac muscle hypertrophy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in T-tubule IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated calcium channel complex IC
Inferred by Curator
more info
  
part_of voltage-gated calcium channel complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
voltage-dependent L-type calcium channel subunit alpha-1C
Names
ZfCav1.2
island beat

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131900.1 → NP_571975.1  voltage-dependent L-type calcium channel subunit alpha-1C

    See identical proteins and their annotated locations for NP_571975.1

    Status: PROVISIONAL

    Source sequence(s)
    AF305689
    UniProtKB/TrEMBL
    Q90ZA7
    Related
    ENSDARP00000031067.4, ENSDART00000028856.5
    Conserved Domains (4) summary
    pfam00520
    Location:1248 → 1504
    Ion_trans; Ion transport protein
    pfam08763
    Location:1577 → 1648
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1671 → 2095
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1512 → 1575
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    20308987..20480303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068219495.1 → XP_068075596.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X2

  2. XM_068219497.1 → XP_068075598.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X4

  3. XM_068219506.1 → XP_068075607.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X14

  4. XM_068219494.1 → XP_068075595.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1

  5. XM_068219501.1 → XP_068075602.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X8

  6. XM_068219504.1 → XP_068075605.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X12

  7. XM_068219496.1 → XP_068075597.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X3

  8. XM_068219505.1 → XP_068075606.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X13

  9. XM_068219500.1 → XP_068075601.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X7

  10. XM_068219502.1 → XP_068075603.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X9

  11. XM_021474920.2 → XP_021330595.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X20

    UniProtKB/TrEMBL
    A0A8M9QAY5
    Conserved Domains (4) summary
    pfam00520
    Location:156 → 452
    Ion_trans; Ion transport protein
    pfam08763
    Location:1583 → 1654
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1677 → 2110
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1511 → 1581
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  12. XM_068219499.1 → XP_068075600.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X6

  13. XM_068219498.1 → XP_068075599.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X5

  14. XM_021474904.2 → XP_021330579.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X11

    UniProtKB/TrEMBL
    A0A8M9Q050
    Conserved Domains (4) summary
    pfam00520
    Location:1253 → 1527
    Ion_trans; Ion transport protein
    pfam08763
    Location:1600 → 1671
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1694 → 2129
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1528 → 1598
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  15. XM_021474912.2 → XP_021330587.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X15

    UniProtKB/TrEMBL
    A0A8M9PGZ5
    Conserved Domains (4) summary
    pfam00520
    Location:1253 → 1511
    Ion_trans; Ion transport protein
    pfam08763
    Location:1584 → 1655
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1678 → 2113
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1512 → 1582
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  16. XM_021474913.2 → XP_021330588.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X16

    UniProtKB/TrEMBL
    A0A8M9PU49
    Conserved Domains (4) summary
    pfam00520
    Location:1253 → 1511
    Ion_trans; Ion transport protein
    pfam08763
    Location:1584 → 1655
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1678 → 2113
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1512 → 1582
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  17. XM_068219507.1 → XP_068075608.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X21

  18. XM_021474919.2 → XP_021330594.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X19

    UniProtKB/TrEMBL
    A0A8M9Q067
    Conserved Domains (4) summary
    pfam00520
    Location:1252 → 1510
    Ion_trans; Ion transport protein
    pfam08763
    Location:1583 → 1654
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1677 → 2110
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1511 → 1581
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  19. XM_021474916.2 → XP_021330591.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X17

    UniProtKB/TrEMBL
    A0A8M9Q5R3
    Conserved Domains (4) summary
    pfam00520
    Location:1253 → 1511
    Ion_trans; Ion transport protein
    pfam08763
    Location:1584 → 1655
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1678 → 2111
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1512 → 1582
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  20. XM_021474917.2 → XP_021330592.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X18

    UniProtKB/TrEMBL
    A0A8M9PH00
    Conserved Domains (4) summary
    pfam00520
    Location:1253 → 1511
    Ion_trans; Ion transport protein
    pfam08763
    Location:1584 → 1655
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1678 → 2111
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1512 → 1582
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  21. XM_068219503.1 → XP_068075604.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X10

Nucleotide Protein
Heading Accession and Version

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