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citk-2 non-specific serine/threonine protein kinase [ Caenorhabditis elegans ]

Gene ID: 173864, updated on 2-Nov-2024

Summary

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Official Symbol
citk-2
Official Full Name
non-specific serine/threonine protein kinase
Primary source
WormBase:WBGene00019087
Locus tag
CELE_F59A6.5
See related
AllianceGenome:WB:WBGene00019087
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP binding activity; metal ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in actomyosin structure organization. Predicted to be active in cytoplasm and cytoskeleton. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 17 and primary microcephaly. Orthologous to human CIT (citron rho-interacting serine/threonine kinase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See citk-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
6
Sequence:
Chromosome: II; NC_003280.10 (4999520..5003806)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Charged multivesicular body protein 3 Neighboring gene Ribonuclease H1;Ribonuclease H1 N-terminal domain-containing protein Neighboring gene Conserved secreted protein Neighboring gene TIL domain-containing protein Neighboring gene Protein kinase domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comprehensive identification of PIP3-regulated PH domains from C. elegans to H. sapiens by model prediction and live imaging. Park WS, et al. Mol Cell, 2008 May 9. PMID 18471983, Free PMC Article
  2. Cytokinesis is not controlled by calmodulin or myosin light chain kinase in the Caenorhabditis elegans early embryo. Batchelder EL, et al. FEBS Lett, 2007 Sep 4. PMID 17716666, Free PMC Article
  3. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
non-specific serine/threonine protein kinase
NP_494921.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    4999520..5003806
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062520.6 → NP_494921.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494921.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21025
    Conserved Domains (6) summary
    smart00036
    Location:965 → 1248
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:835 → 940
    PH; Pleckstrin homology domain
    COG1340
    Location:341 → 645
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00029
    Location:758 → 808
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00169
    Location:835 → 940
    PH; PH domain
    pfam14662
    Location:235 → 436
    KASH_CCD; Coiled-coil region of CCDC155 or KASH
Nucleotide Protein
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