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sop-2 Polycomb protein sop-2;SAM domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 174874, updated on 2-Nov-2024

Summary

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Official Symbol
sop-2
Official Full Name
Polycomb protein sop-2;SAM domain-containing protein
Primary source
WormBase:WBGene00004945
Locus tag
CELE_C50E10.4
See related
AllianceGenome:WB:WBGene00004945
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables RNA binding activity; protein homodimerization activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of cytoplasmic mRNA processing body assembly; neuron differentiation; and regulation of gene expression. Located in nuclear speck. Is expressed widely. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sop-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003280.10 (12339944..12344799)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class E (Epsilon) Neighboring gene Serpentine Receptor, class E (epsilon) Neighboring gene ncRNA Neighboring gene Transcriptional regulator Neighboring gene tRNA Neighboring gene R-RAS related

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of the Caenorhabditis elegans posterior Hox gene egl-5 by microRNA and the polycomb-like gene sop-2. Zhang H, et al. Dev Dyn, 2009 Mar. PMID 19235721, Free PMC Article
  2. SUMO modification is required for in vivo Hox gene regulation by the Caenorhabditis elegans Polycomb group protein SOP-2. Zhang H, et al. Nat Genet, 2004 May. PMID 15107848
  3. A unified mode of epigenetic gene silencing: RNA meets polycomb group proteins. Sun Y, et al. RNA Biol, 2005 Jan. PMID 17132931
  4. Finally, worm polycomb-like genes meet Hox regulation. Pires-daSilva A, et al. Dev Cell, 2003 Jun. PMID 12791262
  5. RNA-binding proteins SOP-2 and SOR-1 form a novel PcG-like complex in C. elegans. Zhang T, et al. Development, 2006 Mar. PMID 16501168

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Polycomb-like genes in Caenorhabditis elegans, sop-2 and sor-3, regulate the formation of dopaminergic and serotonergic neurons and several other neuronal properties
    Title: Polycomb-like genes are necessary for specification of dopaminergic and serotonergic neurons in Caenorhabditis elegans.
  2. microRNAs may contribute to the tight restriction of egl-5 expression to particular cell lineages
    Title: Regulation of the Caenorhabditis elegans posterior Hox gene egl-5 by microRNA and the polycomb-like gene sop-2.
  3. These studies reveal that sop-2 integrates spatial, temporal, and sexual cues during C. elegans development.
    Title: The Caenorhabditis elegans PcG-like gene sop-2 regulates the temporal and sexual specificities of cell fates.
  4. SOP-2 binds to RNA via 3 RNA binding domains.
    Title: The C. elegans Polycomb gene SOP-2 encodes an RNA binding protein.
  5. SOR-1 and SOP-2 directly interact with each other and are colocalized in nuclear bodies
    Title: RNA-binding proteins SOP-2 and SOR-1 form a novel PcG-like complex in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in anterior/posterior pattern specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in epigenetic regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in epigenetic regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cytoplasmic mRNA processing body assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuron fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of development, heterochronic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nuclear body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Polycomb protein sop-2;SAM domain-containing protein
NP_001254340.1
  • Confirmed by transcript evidence
NP_001254341.1
  • Confirmed by transcript evidence
NP_001254342.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    12339944..12344799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267412.2 → NP_001254341.1  Polycomb protein sop-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254341.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A3QMA2, Q965H3
    Conserved Domains (1) summary
    PRK11633
    Location:496 → 615
    PRK11633; cell division protein DedD; Provisional

  2. NM_001267411.2 → NP_001254340.1  Polycomb protein sop-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254340.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H8P172
    Conserved Domains (1) summary
    PHA03247
    Location:366 → 621
    PHA03247; large tegument protein UL36; Provisional

  3. NM_001267413.3 → NP_001254342.1  SAM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254342.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H8P173
    Conserved Domains (1) summary
    pfam05843
    Location:272 → 427
    Suf; Suppressor of forked protein (Suf)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q965H3.2

Gene LinkOut

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