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fln-1 Calponin-homology (CH) domain-containing protein;FiLamiN (actin binding protein) homolog [ Caenorhabditis elegans ]

Gene ID: 176855, updated on 2-Nov-2024

Summary

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Official Symbol
fln-1
Official Full Name
Calponin-homology (CH) domain-containing protein;FiLamiN (actin binding protein) homolog
Primary source
WormBase:WBGene00022048
Locus tag
CELE_Y66H1B.2
See related
AllianceGenome:WB:WBGene00022048
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable actin filament binding activity. Involved in several processes, including axon development; semaphorin-plexin signaling pathway; and uterus morphogenesis. Located in actin filament. Is expressed in several structures, including body wall musculature; gonad; intestine; nervous system; and vulval muscle. Human ortholog(s) of this gene implicated in several diseases, including Larsen syndrome; X-linked chronic idiopathic intestinal pseudo-obstruction; bone development disease (multiple); heart valve disease (multiple); and myopathy (multiple). Orthologous to several human genes including FLNB (filamin B) and FLNC (filamin C). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See fln-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
25
Sequence:
Chromosome: IV; NC_003282.8 (359223..376015, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Peroxisomal membrane protein 4 Neighboring gene Cadherin domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Sphingosine-1-phosphate lyase Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. FLN-1/filamin is required to anchor the actomyosin cytoskeleton and for global organization of sub-cellular organelles in a contractile tissue. Kelley CA, et al. Cytoskeleton (Hoboken), 2020 Oct. PMID 32969593, Free PMC Article
  2. FLN-1/filamin is required for maintenance of actin and exit of fertilized oocytes from the spermatheca in C. elegans. Kovacevic I, et al. Dev Biol, 2010 Nov 15. PMID 20707996, Free PMC Article
  3. Structural and functional evaluation of C. elegans filamins FLN-1 and FLN-2. DeMaso CR, et al. PLoS One, 2011. PMID 21799850, Free PMC Article
  4. Filamin and phospholipase C-ε are required for calcium signaling in the Caenorhabditis elegans spermatheca. Kovacevic I, et al. PLoS Genet, 2013 May. PMID 23671426, Free PMC Article
  5. Tension-dependent RHGF-1 recruitment to stress fibers drives robust spermathecal tissue contraction. Avivi Kela S, et al. J Cell Biol, 2023 Feb 6. PMID 36574264, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. gene and protein structures of the C. elegans filamin orthologs fln-1 and fln-2
    Title: Structural and functional evaluation of C. elegans filamins FLN-1 and FLN-2.
  2. UNC-33, CRMP1 C. elegans homologue, interacts with FLN-1
    Title: Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling.
  3. this study answers long-standing questions concerning calcium signaling dynamics in the C. elegans spermatheca and suggests FLN-1 is needed in response to oocyte entry to trigger calcium release and coordinated contraction of the spermathecal tissue.
    Title: Filamin and phospholipase C-ε are required for calcium signaling in the Caenorhabditis elegans spermatheca.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axonal fasciculation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in semaphorin-plexin signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in uterus morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in actin filament IDA
Inferred from Direct Assay
more info
 PubMed 
located_in organelle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Calponin-homology (CH) domain-containing protein;FiLamiN (actin binding protein) homolog
NP_001023550.2
  • Confirmed by transcript evidence
NP_001023551.2
  • Confirmed by transcript evidence
NP_001255220.1
  • Confirmed by transcript evidence
NP_001255221.1
  • Confirmed by transcript evidence
NP_001294360.1
  • Confirmed by transcript evidence
NP_001294361.1
  • Confirmed by transcript evidence
NP_001294362.1
  • Confirmed by transcript evidence
NP_001294363.1
  • Confirmed by transcript evidence
NP_001294364.1
  • Confirmed by transcript evidence
NP_001294365.1
  • Confirmed by transcript evidence
NP_001294366.1
  • Confirmed by transcript evidence
NP_001294367.1
  • Confirmed by transcript evidence
NP_001294368.1
  • Confirmed by transcript evidence
NP_001294369.1
  • Confirmed by transcript evidence
NP_001294370.1
  • Confirmed by transcript evidence
NP_001294371.1
  • Confirmed by transcript evidence
NP_001294372.1
  • Confirmed by transcript evidence
NP_001367770.1
  • Product from WormBase gene class fln;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    359223..376015 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268291.4 → NP_001255220.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255220.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0IMZ7
    Conserved Domains (5) summary
    TIGR00036
    Location:1091 → 1207
    dapB; 4-hydroxy-tetrahydrodipicolinate reductase
    smart00557
    Location:1429 → 1512
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5069
    Location:23 → 275
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    pfam00630
    Location:1735 → 1786
    Filamin; Filamin/ABP280 repeat
    cl27659
    Location:641 → 735
    Filamin; Filamin/ABP280 repeat

  2. NM_001307431.4 → NP_001294360.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294360.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PM01
    Conserved Domains (5) summary
    TIGR00036
    Location:1091 → 1207
    dapB; 4-hydroxy-tetrahydrodipicolinate reductase
    smart00557
    Location:1482 → 1565
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5069
    Location:23 → 275
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    pfam00630
    Location:1788 → 1839
    Filamin; Filamin/ABP280 repeat
    cl27659
    Location:641 → 735
    Filamin; Filamin/ABP280 repeat

  3. NM_001307435.3 → NP_001294364.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294364.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PBJ9
    Conserved Domains (5) summary
    TIGR00036
    Location:1093 → 1209
    dapB; 4-hydroxy-tetrahydrodipicolinate reductase
    smart00557
    Location:1484 → 1567
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5069
    Location:23 → 277
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    pfam00630
    Location:1790 → 1841
    Filamin; Filamin/ABP280 repeat
    cl27659
    Location:643 → 737
    Filamin; Filamin/ABP280 repeat

  4. NM_001307432.3 → NP_001294361.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294361.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PR92
    Conserved Domains (5) summary
    TIGR00036
    Location:1093 → 1209
    dapB; 4-hydroxy-tetrahydrodipicolinate reductase
    smart00557
    Location:1482 → 1565
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5069
    Location:23 → 277
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    pfam00630
    Location:1788 → 1839
    Filamin; Filamin/ABP280 repeat
    cl27659
    Location:643 → 737
    Filamin; Filamin/ABP280 repeat

  5. NM_001028379.5 → NP_001023550.2  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023550.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0IMZ5
    Conserved Domains (4) summary
    smart00557
    Location:1480 → 1563
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00014
    Location:27 → 131
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00307
    Location:152 → 248
    CH; Calponin homology (CH) domain
    pfam00630
    Location:1480 → 1560
    Filamin; Filamin/ABP280 repeat

  6. NM_001268292.3 → NP_001255221.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255221.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0IMZ8
    Conserved Domains (5) summary
    TIGR00036
    Location:1091 → 1207
    dapB; 4-hydroxy-tetrahydrodipicolinate reductase
    smart00557
    Location:1431 → 1514
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5069
    Location:23 → 275
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    pfam00630
    Location:1737 → 1788
    Filamin; Filamin/ABP280 repeat
    cl27659
    Location:641 → 735
    Filamin; Filamin/ABP280 repeat

  7. NM_001307433.3 → NP_001294362.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294362.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PEE3
    Conserved Domains (5) summary
    TIGR00036
    Location:1093 → 1209
    dapB; 4-hydroxy-tetrahydrodipicolinate reductase
    smart00557
    Location:1431 → 1514
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5069
    Location:23 → 277
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    pfam00630
    Location:1737 → 1788
    Filamin; Filamin/ABP280 repeat
    cl27659
    Location:643 → 737
    Filamin; Filamin/ABP280 repeat

  8. NM_001307434.3 → NP_001294363.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294363.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PB53
    Conserved Domains (5) summary
    TIGR00036
    Location:1093 → 1209
    dapB; 4-hydroxy-tetrahydrodipicolinate reductase
    smart00557
    Location:1433 → 1516
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5069
    Location:23 → 277
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    pfam00630
    Location:1739 → 1790
    Filamin; Filamin/ABP280 repeat
    cl27659
    Location:643 → 737
    Filamin; Filamin/ABP280 repeat

  9. NM_001307437.3 → NP_001294366.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294366.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PR97
    Conserved Domains (5) summary
    TIGR00036
    Location:957 → 1073
    dapB; 4-hydroxy-tetrahydrodipicolinate reductase
    smart00557
    Location:1295 → 1378
    IG_FLMN; Filamin-type immunoglobulin domains
    pfam00307
    Location:17 → 114
    CH; Calponin homology (CH) domain
    pfam00630
    Location:1601 → 1652
    Filamin; Filamin/ABP280 repeat
    cl27659
    Location:1217 → 1287
    Filamin; Filamin/ABP280 repeat

  10. NM_001307438.3 → NP_001294367.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294367.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PEE8
    Conserved Domains (5) summary
    TIGR00036
    Location:957 → 1073
    dapB; 4-hydroxy-tetrahydrodipicolinate reductase
    smart00557
    Location:1297 → 1380
    IG_FLMN; Filamin-type immunoglobulin domains
    pfam00307
    Location:17 → 114
    CH; Calponin homology (CH) domain
    pfam00630
    Location:1603 → 1654
    Filamin; Filamin/ABP280 repeat
    cl27659
    Location:507 → 601
    Filamin; Filamin/ABP280 repeat

  11. NM_001307436.3 → NP_001294365.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294365.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PM04
    Conserved Domains (5) summary
    TIGR00036
    Location:957 → 1073
    dapB; 4-hydroxy-tetrahydrodipicolinate reductase
    smart00557
    Location:1346 → 1429
    IG_FLMN; Filamin-type immunoglobulin domains
    pfam00307
    Location:17 → 114
    CH; Calponin homology (CH) domain
    pfam00630
    Location:1652 → 1703
    Filamin; Filamin/ABP280 repeat
    cl27659
    Location:507 → 601
    Filamin; Filamin/ABP280 repeat

  12. NM_001307439.3 → NP_001294368.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294368.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PB58
    Conserved Domains (5) summary
    TIGR00036
    Location:957 → 1073
    dapB; 4-hydroxy-tetrahydrodipicolinate reductase
    smart00557
    Location:1348 → 1431
    IG_FLMN; Filamin-type immunoglobulin domains
    pfam00307
    Location:17 → 114
    CH; Calponin homology (CH) domain
    pfam00630
    Location:1654 → 1705
    Filamin; Filamin/ABP280 repeat
    cl27659
    Location:507 → 601
    Filamin; Filamin/ABP280 repeat

  13. NM_001307441.3 → NP_001294370.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294370.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PM09
    Conserved Domains (5) summary
    TIGR00036
    Location:959 → 1075
    dapB; 4-hydroxy-tetrahydrodipicolinate reductase
    smart00557
    Location:1297 → 1380
    IG_FLMN; Filamin-type immunoglobulin domains
    pfam00307
    Location:17 → 116
    CH; Calponin homology (CH) domain
    pfam00630
    Location:1603 → 1654
    Filamin; Filamin/ABP280 repeat
    cl27659
    Location:1219 → 1289
    Filamin; Filamin/ABP280 repeat

  14. NM_001307442.3 → NP_001294371.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294371.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PRA0
    Conserved Domains (5) summary
    TIGR00036
    Location:959 → 1075
    dapB; 4-hydroxy-tetrahydrodipicolinate reductase
    smart00557
    Location:1299 → 1382
    IG_FLMN; Filamin-type immunoglobulin domains
    pfam00307
    Location:17 → 116
    CH; Calponin homology (CH) domain
    pfam00630
    Location:1605 → 1656
    Filamin; Filamin/ABP280 repeat
    cl27659
    Location:509 → 603
    Filamin; Filamin/ABP280 repeat

  15. NM_001307440.3 → NP_001294369.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294369.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PBK4
    Conserved Domains (5) summary
    TIGR00036
    Location:959 → 1075
    dapB; 4-hydroxy-tetrahydrodipicolinate reductase
    smart00557
    Location:1348 → 1431
    IG_FLMN; Filamin-type immunoglobulin domains
    pfam00307
    Location:17 → 116
    CH; Calponin homology (CH) domain
    pfam00630
    Location:1654 → 1705
    Filamin; Filamin/ABP280 repeat
    cl27659
    Location:509 → 603
    Filamin; Filamin/ABP280 repeat

  16. NM_001307443.3 → NP_001294372.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294372.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PEF1
    Conserved Domains (5) summary
    TIGR00036
    Location:959 → 1075
    dapB; 4-hydroxy-tetrahydrodipicolinate reductase
    smart00557
    Location:1350 → 1433
    IG_FLMN; Filamin-type immunoglobulin domains
    pfam00307
    Location:17 → 116
    CH; Calponin homology (CH) domain
    pfam00630
    Location:1656 → 1707
    Filamin; Filamin/ABP280 repeat
    cl27659
    Location:509 → 603
    Filamin; Filamin/ABP280 repeat

  17. NM_001380004.1 → NP_001367770.1  FiLamiN (actin binding protein) homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0IMZ6
    Conserved Domains (3) summary
    smart00557
    Location:61 → 144
    IG_FLMN; Filamin-type immunoglobulin domains
    pfam00630
    Location:366 → 419
    Filamin; Filamin/ABP280 repeat
    cl27659
    Location:3 → 53
    Filamin; Filamin/ABP280 repeat

  18. NM_001028380.5 → NP_001023551.2  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023551.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9TYW4
    Conserved Domains (4) summary
    smart00557
    Location:959 → 1049
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00014
    Location:27 → 131
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00307
    Location:152 → 248
    CH; Calponin homology (CH) domain
    pfam00630
    Location:956 → 1042
    Filamin; Filamin/ABP280 repeat
Nucleotide Protein
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