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KIF4A kinesin family member 4A [ Homo sapiens (human) ]

Gene ID: 24137, updated on 4-Jan-2025

Summary

Official Symbol
KIF4Aprovided by HGNC
Official Full Name
kinesin family member 4Aprovided by HGNC
Primary source
HGNC:HGNC:13339
See related
Ensembl:ENSG00000090889 MIM:300521; AllianceGenome:HGNC:13339
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIF4; TMDI; KIF4G1; MRX100; XLID100
Summary
This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, Mar 2010]
Expression
Broad expression in bone marrow (RPKM 4.3), lymph node (RPKM 2.9) and 14 other tissues See more
Orthologs
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Genomic context

See KIF4A in Genome Data Viewer
Location:
Xq13.1
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (70290104..70420886)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (68723423..68854206)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (69509954..69640736)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20889 Neighboring gene RAB41, member RAS oncogene family Neighboring gene PDZ domain containing 11 Neighboring gene TRAPPC2L pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:69622427-69622649 Neighboring gene RNY4 pseudogene 23 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:69642130-69643118 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:69643119-69644107 Neighboring gene uncharacterized LOC105373244 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29731 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20890 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29733 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:69655249-69655749 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:69664203-69664989 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 2 Neighboring gene RNA, U4 small nuclear 81, pseudogene Neighboring gene discs large MAGUK scaffold protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Intellectual disability, X-linked 100
MedGen: C3890167 OMIM: 300923 GeneReviews: Not available
Compare labs
Taurodontism, microdontia, and dens invaginatus
MedGen: C1839235 OMIM: 313490 GeneReviews: Not available
not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Deletion of residues 32-51 in the N-terminus of HIV-1 MA impairs both HIV-1 Gag interaction with KIF4 and its ability to induce microtubule (MT) acetylation, suggesting that MA-mediated targeting of KIF4 by Gag regulates MT stability in early infection PubMed
gag Disrupting the function of KIF4 leads Gag transient accumulation in discrete, perinuclear, nonendocytic clusters that co-localize with endogenous KIF4, Ubc9, and SUMO PubMed
gag Binding of HIV-1 Gag to KIF-4 may play a role in HIV-1 Gag polyprotein transport from the cytoplasm to the cell membrane PubMed
gag Binding of human KIF-4 to HIV-1 Gag is presumed based on homology to murine KIF-4 which binds to an HIV-1 Gag intermediate, consisting of Matrix and Capsid, in a yeast two-hybrid assay and in co-immunoprecipitation assays PubMed
matrix gag Deletion of residues 32-51 in the N-terminus of HIV-1 MA impairs both HIV-1 Gag interaction with KIF4 and its ability to induce microtubule (MT) acetylation, suggesting that MA-mediated targeting of KIF4 by Gag regulates MT stability in early infection PubMed
gag Binding of HIV-1 Matrix to KIF-4 may play a role in HIV-1 Gag polyprotein relocalize from the cytoplasm to the cell membrane PubMed
gag Binding of human KIF-4 to HIV-1 Matrix is presumed based on homology to murine KIF-4 which binds to an HIV-1 Gag intermediate, consisting of Matrix and Capsid, in a yeast two-hybrid assay and in co-immunoprecipitation assays PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ12530, FLJ12655, FLJ14204, FLJ20631

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding  
enables DNA binding  
enables iron-sulfur cluster binding  
enables metal ion binding  
enables microtubule binding  
enables microtubule motor activity  
enables protein binding PubMed 
Process Evidence Code Pubs
involved_in anterograde axonal transport PubMed 
involved_in mitotic cytokinesis PubMed 
involved_in mitotic spindle midzone assembly PubMed 
involved_in mitotic spindle organization  
involved_in organelle organization PubMed 
involved_in spindle elongation  
Component Evidence Code Pubs
located_in axon cytoplasm  
located_in chromosome  
located_in cytoplasm PubMed 
located_in cytosol  
located_in membrane PubMed 
part_of microtubule associated complex  
located_in midbody PubMed 
located_in nuclear matrix  
located_in nucleoplasm  
located_in spindle microtubule PubMed 

General protein information

Preferred Names
chromosome-associated kinesin KIF4A
Names
chromokinesin KIF4A
chromokinesin-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016799.2 RefSeqGene

    Range
    5002..135784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_012310.5NP_036442.3  chromosome-associated kinesin KIF4A

    See identical proteins and their annotated locations for NP_036442.3

    Status: REVIEWED

    Source sequence(s)
    AL139398, AL357752
    Consensus CDS
    CCDS14401.1
    UniProtKB/Swiss-Prot
    B2R7V5, D3DVU4, O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3
    UniProtKB/TrEMBL
    Q59HG1
    Related
    ENSP00000363524.3, ENST00000374403.4
    Conserved Domains (4) summary
    COG1196
    Location:558918
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:375714
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01372
    Location:8337
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam05033
    Location:10781120
    Pre-SET; Pre-SET motif

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    70290104..70420886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    68723423..68854206
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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