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Erc1 ELKS/RAB6-interacting/CAST family member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 266806, updated on 14-Nov-2024

Summary

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Official Symbol
Erc1provided by RGD
Official Full Name
ELKS/RAB6-interacting/CAST family member 1provided by RGD
Primary source
RGD:628733
See related
EnsemblRapid:ENSRNOG00000009264 AllianceGenome:RGD:628733
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ERC; CAST; Elks; Cast2; ERC1b; Rab6ip2
Summary
Enables PDZ domain binding activity. Predicted to be involved in several processes, including I-kappaB phosphorylation; maintenance of presynaptic active zone structure; and positive regulation of NF-kappaB transcription factor activity. Located in membrane; postsynaptic density; and synaptic vesicle. Is active in presynaptic active zone cytoplasmic component. Orthologous to human ERC1 (ELKS/RAB6-interacting/CAST family member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 86.7), Heart (RPKM 84.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Erc1 in Genome Data Viewer
Location:
4q42
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (154435936..154727987, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (152763664..153055724, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (152087393..152380023, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene Wnt family member 5B Neighboring gene uncharacterized LOC134486631 Neighboring gene uncharacterized LOC134486632 Neighboring gene translocase of inner mitochondrial membrane 23, pseudogene 6 Neighboring gene caspase 6, pseudogene 2 Neighboring gene uncharacterized LOC120102377 Neighboring gene COMM domain containing 6-like Neighboring gene RAD52 homolog, DNA repair protein Neighboring gene WNK lysine deficient protein kinase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ELKS, a protein structurally related to the active zone protein CAST, is involved in Ca2+-dependent exocytosis from PC12 cells. Inoue E, et al. Genes Cells, 2006 Jun. PMID 16716196
  2. Involvement of ELKS, an active zone protein, in exocytotic release from RBL-2H3 cells. Nomura H, et al. Cell Immunol, 2009. PMID 19515363
  3. Solution structure of the RIM1alpha PDZ domain in complex with an ELKS1b C-terminal peptide. Lu J, et al. J Mol Biol, 2005 Sep 16. PMID 16095618
  4. ELKS controls the pool of readily releasable vesicles at excitatory synapses through its N-terminal coiled-coil domains. Held RG, et al. Elife, 2016 Jun 2. PMID 27253063, Free PMC Article
  5. The active zone protein family ELKS supports Ca2+ influx at nerve terminals of inhibitory hippocampal neurons. Liu C, et al. J Neurosci, 2014 Sep 10. PMID 25209271, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that Bassoon colocalizes with Aczonin at conventional synapses, but in ribbon synapses, CAST, Munc13, and RIM are segregated from Aczonin, and Aczonin is positioned and may control the access of neurotransmitter vesicles to the fusion site.
    Title: Molecular in situ topology of Aczonin/Piccolo and associated proteins at the mammalian neurotransmitter release site.
  2. ELKS positively regulates exocytotic release in RBL-2H3 by acting on the plasma membrane upon stimulation.
    Title: Involvement of ELKS, an active zone protein, in exocytotic release from RBL-2H3 cells.
  3. new component of the cytomatrix at the active zone (CAZ) and, together with CAST1, may be involved in the formation of the CAZ structure [CAST2]
    Title: CAST2: identification and characterization of a protein structurally related to the presynaptic cytomatrix protein CAST.
  4. ELKS is involved in Ca(2+)-dependent exocytosis from PC12 cells
    Title: ELKS, a protein structurally related to the active zone protein CAST, is involved in Ca2+-dependent exocytosis from PC12 cells.
  5. characterized a family of active zone proteins whose binding to RIMs, presynaptic active zone proteins that regulate neurotransmitter release, is regulated by tissue-specific alternative splicing
    Title: A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables PDZ domain binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables structural constituent of presynaptic active zone IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of presynaptic active zone ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in I-kappaB phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in maintenance of presynaptic active zone structure IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of calcium-dependent activation of synaptic vesicle fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of presynaptic cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in synaptic vesicle priming ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
part_of IkappaB kinase complex IEA
Inferred from Electronic Annotation
more info
  
part_of IkappaB kinase complex ISO
Inferred from Sequence Orthology
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in podosome ISO
Inferred from Sequence Orthology
more info
  
located_in podosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynaptic active zone cytoplasmic component IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynaptic active zone cytoplasmic component IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  
located_in synapse ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ELKS/Rab6-interacting/CAST family member 1
Names
CAZ-associated structural protein 2
ERC protein 1
ERC-1
RIM-Binding Protein
Rab6-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394882.1 → NP_001381811.1  ELKS/Rab6-interacting/CAST family member 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I6GKZ4, F1LPE9
    Related
    ENSRNOP00000094050.1, ENSRNOT00000109038.2
    Conserved Domains (2) summary
    pfam09457
    Location:1072 → 1112
    RBD-FIP; FIP domain
    pfam10174
    Location:155 → 986
    Cast; RIM-binding protein of the cytomatrix active zone

  2. NM_001394883.1 → NP_001381812.1  ELKS/Rab6-interacting/CAST family member 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A0G2JYT1, F1LPE9
    Conserved Domains (2) summary
    pfam09457
    Location:1068 → 1108
    RBD-FIP; FIP domain
    pfam10174
    Location:155 → 982
    Cast; RIM-binding protein of the cytomatrix active zone

  3. NM_001394884.1 → NP_001381813.1  ELKS/Rab6-interacting/CAST family member 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I6A0L5, A6IL87, F1LPE9
    Related
    ENSRNOP00000084657.2, ENSRNOT00000115061.2
    Conserved Domains (2) summary
    pfam09457
    Location:1040 → 1080
    RBD-FIP; FIP domain
    pfam10174
    Location:155 → 954
    Cast; RIM-binding protein of the cytomatrix active zone

RNA

  1. NR_172210.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    154435936..154727987 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237230.4 → XP_006237292.1  ELKS/Rab6-interacting/CAST family member 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AIL7
    Conserved Domains (4) summary
    pfam09457
    Location:996 → 1036
    RBD-FIP; FIP domain
    pfam10174
    Location:155 → 910
    Cast; RIM-binding protein of the cytomatrix active zone
    pfam16046
    Location:732 → 880
    FAM76; FAM76 protein
    cl21478
    Location:846 → 917
    ATP-synt_B; ATP synthase B/B' CF(0)

  2. XM_063285644.1 → XP_063141714.1  ELKS/Rab6-interacting/CAST family member 1 isoform X2

    Related
    ENSRNOP00000092904.2, ENSRNOT00000102886.2

  3. XM_039107148.2 → XP_038963076.1  ELKS/Rab6-interacting/CAST family member 1 isoform X1

    UniProtKB/TrEMBL
    F1LPE9
    Related
    ENSRNOP00000070778.3, ENSRNOT00000091473.3
    Conserved Domains (2) summary
    pfam09457
    Location:1071 → 1111
    RBD-FIP; FIP domain
    pfam10174
    Location:155 → 985
    Cast; RIM-binding protein of the cytomatrix active zone

  4. XM_063285649.1 → XP_063141719.1  ELKS/Rab6-interacting/CAST family member 1 isoform X8

    UniProtKB/TrEMBL
    A6IL88

  5. XM_063285647.1 → XP_063141717.1  ELKS/Rab6-interacting/CAST family member 1 isoform X6

  6. XM_063285648.1 → XP_063141718.1  ELKS/Rab6-interacting/CAST family member 1 isoform X7

    UniProtKB/TrEMBL
    A6IL89

  7. XM_063285646.1 → XP_063141716.1  ELKS/Rab6-interacting/CAST family member 1 isoform X5

  8. XM_063285645.1 → XP_063141715.1  ELKS/Rab6-interacting/CAST family member 1 isoform X4

    Related
    ENSRNOP00000012397.5, ENSRNOT00000012397.6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q811U3.1 GenPept UniProtKB/Swiss-Prot:Q811U3

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