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Dlg4 discs large MAGUK scaffold protein 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29495, updated on 2-Nov-2024

Summary

Official Symbol
Dlg4provided by RGD
Official Full Name
discs large MAGUK scaffold protein 4provided by RGD
Primary source
RGD:68424
See related
EnsemblRapid:ENSRNOG00000018526 AllianceGenome:RGD:68424
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dlgh4; PSD95; Sap90
Summary
Enables several functions, including PDZ domain binding activity; enzyme binding activity; and signaling receptor binding activity. A structural constituent of postsynaptic density. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of cellular component organization; and postsynapse organization. Located in several cellular components, including dendrite; juxtaparanode region of axon; and postsynaptic membrane. Part of voltage-gated potassium channel complex. Is active in glutamatergic synapse and postsynaptic density membrane. Biomarker of Parkinson's disease and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human DLG4 (discs large MAGUK scaffold protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 195.0), Adrenal (RPKM 29.1) and 7 other tissues See more
Orthologs
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Genomic context

See Dlg4 in Genome Data Viewer
Location:
10q24
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55239397..55267780)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54740700..54769097)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56625845..56655543)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene dishevelled segment polarity protein 2 Neighboring gene acyl-CoA dehydrogenase, very long chain Neighboring gene microRNA 324 Neighboring gene asialoglycoprotein receptor 1 Neighboring gene transfer RNA threonine (anticodon AGU) 28

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables D1 dopamine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables P2Y1 nucleotide receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables PDZ domain binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables acetylcholine receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables beta-1 adrenergic receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables beta-2 adrenergic receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables frizzled binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables glutamate receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ionotropic glutamate receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ionotropic glutamate receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables ionotropic glutamate receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables kinesin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables neuroligin family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scaffold protein binding IEA
Inferred from Electronic Annotation
more info
 
enables scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of postsynaptic density IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in AMPA glutamate receptor clustering IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in AMPA glutamate receptor clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in NMDA selective glutamate receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to potassium ion IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to potassium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cerebral cortex development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in dendritic spine morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in dendritic spine organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of protein localization IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of protein localization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in establishment or maintenance of epithelial cell apical/basal polarity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in locomotory exploration behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in locomotory exploration behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in locomotory exploration behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in maintenance of postsynaptic density structure IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neuromuscular process controlling balance IEA
Inferred from Electronic Annotation
more info
 
involved_in neuromuscular process controlling balance ISO
Inferred from Sequence Orthology
more info
 
involved_in neuromuscular process controlling balance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuronal ion channel clustering TAS
Traceable Author Statement
more info
PubMed 
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of AMPA glutamate receptor clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of excitatory postsynaptic potential IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron projection arborization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in postsynaptic neurotransmitter receptor diffusion trapping IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein localization to synapse ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to synapse ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-containing complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in receptor localization to synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of NMDA receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of grooming behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of grooming behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of grooming behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of long-term neuronal synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of long-term neuronal synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in social behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in social behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in social behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in synaptic vesicle maturation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within synaptic vesicle maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in vocalization behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in vocalization behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in vocalization behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex IEA
Inferred from Electronic Annotation
more info
 
part_of AMPA glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of AMPA glutamate receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cerebellar mossy fiber IEA
Inferred from Electronic Annotation
more info
 
located_in cerebellar mossy fiber ISO
Inferred from Sequence Orthology
more info
 
located_in cortical cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cortical cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic branch IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in excitatory synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in excitatory synapse IEA
Inferred from Electronic Annotation
more info
 
located_in excitatory synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in juxtaparanode region of axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in juxtaparanode region of axon IEA
Inferred from Electronic Annotation
more info
 
located_in juxtaparanode region of axon ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuromuscular junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection terminus IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection terminus ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection terminus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in neuron spine ISO
Inferred from Sequence Orthology
more info
 
located_in neuron spine ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in proximal dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
disks large homolog 4
Names
PSD-95
SAP-90
discs, large homolog 4
postsynaptic density protein 95
synapse-associated protein 90
synapse-associated protein SAP90

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019621.2NP_062567.1  disks large homolog 4

    See identical proteins and their annotated locations for NP_062567.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    P31016, P97631
    UniProtKB/TrEMBL
    A0A0G2K7F5
    Related
    ENSRNOP00000079351.2, ENSRNOT00000095923.2
    Conserved Domains (7) summary
    cd12030
    Location:430495
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00072
    Location:544710
    GuKc; Guanylate kinase homologues
    smart00228
    Location:310394
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:65149
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:533711
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:245312
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:1064
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    55239397..55267780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246687.5XP_006246749.1  disks large homolog 4 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K7F5
    Conserved Domains (6) summary
    cd12030
    Location:427492
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:307391
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:62146
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:530708
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:242309
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:1061
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  2. XM_039085767.2XP_038941695.1  disks large homolog 4 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K7F5
    Related
    ENSRNOP00000080177.2, ENSRNOT00000096075.2
    Conserved Domains (6) summary
    cd12030
    Location:422487
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:302386
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:57141
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:525703
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:237304
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:656
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  3. XM_008767809.4XP_008766031.2  disks large homolog 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZMM3
    Conserved Domains (5) summary
    cd12030
    Location:370435
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:250334
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:589
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:473651
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:185252
    PDZ_assoc; PDZ-associated domain of NMDA receptors
  4. XM_039085766.2XP_038941694.1  disks large homolog 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZMM3
    Conserved Domains (5) summary
    cd12030
    Location:370435
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    smart00228
    Location:250334
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00595
    Location:589
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00625
    Location:473651
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:185252
    PDZ_assoc; PDZ-associated domain of NMDA receptors
  5. XM_039085768.1XP_038941696.1  disks large homolog 4 isoform X4

    UniProtKB/TrEMBL
    A0A0G2K7F5
    Related
    ENSRNOP00000080495.2, ENSRNOT00000099685.2

RNA

  1. XR_005489771.2 RNA Sequence

    Related
    ENSRNOT00000089108.3