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acvr1ba activin A receptor type 1Ba [ Danio rerio (zebrafish) ]

Gene ID: 30183, updated on 28-Oct-2024

Summary

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Official Symbol
acvr1baprovided by ZNC
Official Full Name
activin A receptor type 1Baprovided by ZNC
Primary source
ZFIN:ZDB-GENE-980526-527
See related
Ensembl:ENSDARG00000018968 AllianceGenome:ZFIN:ZDB-GENE-980526-527
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
alk4; axis; acvr1b; tarama; taram-a; wu:fb75f01
Summary
Predicted to enable activin binding activity and activin receptor activity, type I. Acts upstream of or within dorsal/ventral pattern formation; fin regeneration; and formation of primary germ layer. Predicted to be located in membrane. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including DEL; blastodisc; germ ring; margin; and presumptive shield. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; lung small cell carcinoma; malignant mesothelioma; pancreatic cancer; and stomach cancer. Orthologous to human ACVR1B (activin A receptor type 1B). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

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See acvr1ba in Genome Data Viewer
Location:
chromosome: 23
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (27800519..27822920, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (27873978..27896383, complement)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene desert hedgehog signaling molecule Neighboring gene lysine (K)-specific methyltransferase 2D Neighboring gene activin A receptor like type 1 Neighboring gene ankyrin repeat domain 33Aa

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Inhibitory interactions controlling organizer activity in fish. Peyriéras N, et al. C R Acad Sci III, 1996 Dec. PMID 9091181
  2. An Effective Feedback Loop between Cell-Cell Contact Duration and Morphogen Signaling Determines Cell Fate. Barone V, et al. Dev Cell, 2017 Oct 23. PMID 29033362
  3. Molecular cloning of activin type I and type II receptors and differential regulation of their expression by activin in grass carp pituitary cells. Song C, et al. Gen Comp Endocrinol, 2010 Mar 1. PMID 19699739
  4. Collective mesendoderm migration relies on an intrinsic directionality signal transmitted through cell contacts. Dumortier JG, et al. Proc Natl Acad Sci U S A, 2012 Oct 16. PMID 23027928, Free PMC Article
  5. Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1. Goudie DR, et al. Nat Genet, 2011 Feb 27. PMID 21358634

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables activin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables activin receptor activity, type I IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in activin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
  
acts_upstream_of_or_within endoderm formation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within endoderm formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within endodermal cell fate determination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within fin regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mesoderm formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of activin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
activin A receptor type 1Ba
Names
activin A receptor, type IB
activin A receptor, type IBa
NP_571065.1
XP_005162281.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130990.1 → NP_571065.1  activin A receptor type 1Ba precursor

    See identical proteins and their annotated locations for NP_571065.1

    Status: PROVISIONAL

    Source sequence(s)
    X94119
    UniProtKB/TrEMBL
    P79689
    Related
    ENSDARP00000004431.8, ENSDART00000023094.9
    Conserved Domains (4) summary
    smart00220
    Location:209 → 492
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14143
    Location:211 → 498
    STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors
    pfam01064
    Location:32 → 105
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:178 → 205
    TGF_beta_GS; Transforming growth factor beta type I GS-motif

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    27800519..27822920 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005162224.5 → XP_005162281.1  activin A receptor type 1Ba isoform X1

    UniProtKB/TrEMBL
    A0A8M2B949
    Conserved Domains (4) summary
    smart00220
    Location:223 → 506
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14143
    Location:225 → 512
    STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors
    pfam01064
    Location:32 → 105
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:192 → 219
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
Nucleotide Protein Strain
Heading Accession and Version

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