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fli1 Fli-1 proto-oncogene, ETS transcription factor [ Danio rerio (zebrafish) ]

Gene ID: 30619, updated on 12-Oct-2024

Summary

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Official Symbol
fli1provided by ZNC
Official Full Name
Fli-1 proto-oncogene, ETS transcription factorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-980526-426
See related
Ensembl:ENSDARG00000054632 AllianceGenome:ZFIN:ZDB-GENE-980526-426
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fli; cb855; fli-1; fli1a; wu:fc45b11
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within angiogenesis and positive regulation of DNA-binding transcription factor activity. Predicted to be active in nucleus. Is expressed in several structures, including angioblastic mesenchymal cell; cardiovascular system; hematopoietic system; mesoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in blood platelet disease and thrombocytopenia. Orthologous to human FLI1 (Fli-1 proto-oncogene, ETS transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See fli1 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (48421158..48487875)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (48426169..48493178)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene somatolactin alpha Neighboring gene v-ets avian erythroblastosis virus E26 oncogene homolog 1 Neighboring gene potassium inwardly rectifying channel subfamily J member 1a, tandem duplicate 6 Neighboring gene potassium inwardly rectifying channel subfamily J member 1a, tandem duplicate 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Live imaging of angiogenesis during cutaneous wound healing in adult zebrafish. Noishiki C, et al. Angiogenesis, 2019 May. PMID 30607697
  2. Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy. Al-Olabi L, et al. J Clin Invest, 2018 Apr 2. PMID 29461977, Free PMC Article
  3. Cellular resolution multiplexed FLIM tomography with dual-color Bessel beam. Xu D, et al. Biomed Opt Express, 2017 Feb 1. PMID 28270968, Free PMC Article
  4. Sequential assessment via daphnia and zebrafish for systematic toxicity screening of heterogeneous substances. Jang GH, et al. Environ Pollut, 2016 Sep. PMID 27288628
  5. Notch signaling regulates venous arterialization during zebrafish fin regeneration. Kametani Y, et al. Genes Cells, 2015 May. PMID 25810153, Free PMC Article

See all (327) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fli1 acts in parallel with Pu.1 to control macrophage and neutrophil fate in zebrafish.
    Title: Fli1 acts in parallel with Pu.1 to control macrophage and neutrophil fate in zebrafish.
  2. mesodermal Wnt3a-mediated signaling via the transcription factor Lef1 positively regulates EC specification (defined by kdrl expression) at the expense of primitive erythrocyte specification (defined by gata1 expression) in zebrafish embryos.
    Title: Wnt signaling positively regulates endothelial cell fate specification in the Fli1a-positive progenitor population via Lef1.
  3. Fli+ etsrp+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish.
    Title: Fli+ etsrp+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish.
  4. These results showed that young thrombocytes have higher GATA1 promoter activity, while mature thrombocytes have more fli1 gene promoter transcription.
    Title: Loss of GATA1 and gain of FLI1 expression during thrombocyte maturation.
  5. Interaction between EWSR1/FLI1 and EWSR1 in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.
    Title: Ewing sarcoma fusion protein EWSR1/FLI1 interacts with EWSR1 leading to mitotic defects in zebrafish embryos and human cell lines.
  6. fli1, and etsrp, demonstrated that erg and fli1 act cooperatively and are required for angiogenesis possibly via direct regulation of an endothelial cell junction molecule, VE-cadherin
    Title: Genome-wide analysis of the zebrafish ETS family identifies three genes required for hemangioblast differentiation or angiogenesis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within blood vessel morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Friend leukemia integration 1 transcription factor
Names
Fli-1 proto-oncogene, ETS transcription factor a
friend leukemia integration 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131348.2 → NP_571423.1  Friend leukemia integration 1 transcription factor

    See identical proteins and their annotated locations for NP_571423.1

    Status: PROVISIONAL

    Source sequence(s)
    BC066571
    UniProtKB/TrEMBL
    Q1LUW6, Q9PU61
    Related
    ENSDARP00000071331.4, ENSDART00000076861.6
    Conserved Domains (2) summary
    cd08541
    Location:113 → 203
    SAM_PNT-FLI-1; Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
    smart00413
    Location:279 → 362
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    48421158..48487875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021467581.2 → XP_021323256.1  Friend leukemia integration 1 transcription factor isoform X1

    UniProtKB/TrEMBL
    A0A8M9PLW9
    Conserved Domains (2) summary
    cd08541
    Location:131 → 226
    SAM_PNT-FLI-1; Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
    smart00413
    Location:302 → 385
    ETS; erythroblast transformation specific domain

  2. XM_021467582.2 → XP_021323257.1  Friend leukemia integration 1 transcription factor isoform X2

    UniProtKB/TrEMBL
    A0A8M9P0Y3
    Conserved Domains (2) summary
    cd08541
    Location:131 → 221
    SAM_PNT-FLI-1; Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
    smart00413
    Location:297 → 380
    ETS; erythroblast transformation specific domain

  3. XM_021467583.2 → XP_021323258.1  Friend leukemia integration 1 transcription factor isoform X3

    UniProtKB/TrEMBL
    A0A8M9P9W7
    Conserved Domains (2) summary
    cd08541
    Location:122 → 217
    SAM_PNT-FLI-1; Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
    smart00413
    Location:293 → 376
    ETS; erythroblast transformation specific domain

  4. XM_005159278.5 → XP_005159335.1  Friend leukemia integration 1 transcription factor isoform X4

    UniProtKB/TrEMBL
    A0A2R8QGN6, A0A8M2B691
    Related
    ENSDARP00000151205.1, ENSDART00000184233.1
    Conserved Domains (2) summary
    cd08541
    Location:122 → 212
    SAM_PNT-FLI-1; Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
    smart00413
    Location:288 → 371
    ETS; erythroblast transformation specific domain

  5. XM_068214720.1 → XP_068070821.1  Friend leukemia integration 1 transcription factor isoform X1

  6. XM_068214722.1 → XP_068070823.1  Friend leukemia integration 1 transcription factor isoform X3

  7. XM_021467584.2 → XP_021323259.1  Friend leukemia integration 1 transcription factor isoform X5

    UniProtKB/TrEMBL
    A0A8M9PF94
    Conserved Domains (2) summary
    cd08541
    Location:113 → 208
    SAM_PNT-FLI-1; Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
    smart00413
    Location:284 → 367
    ETS; erythroblast transformation specific domain
Nucleotide Protein
Heading Accession and Version

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