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l1cama L1 cell adhesion molecule, paralog a [ Danio rerio (zebrafish) ]

Gene ID: 30634, updated on 28-Oct-2024

Summary

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Official Symbol
l1camaprovided by ZNC
Official Full Name
L1 cell adhesion molecule, paralog aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-10
See related
Ensembl:ENSDARG00000007149 AllianceGenome:ZFIN:ZDB-GENE-990415-10
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
L1.2; nadl1.2; sb:eu320; sb:eu917; NCAM-L1.2; wu:fq26g05
Summary
Predicted to be involved in positive regulation of axon extension. Predicted to act upstream of or within cell adhesion; cell differentiation; and nervous system development. Predicted to be located in axonal growth cone. Is expressed in gut; nervous system; presumptive enteric nervous system; and solid lens vesicle. Human ortholog(s) of this gene implicated in MASA syndrome; hydrocephalus; ovarian carcinoma; pancreatic cancer; and schizophrenia. Orthologous to human L1CAM (L1 cell adhesion molecule). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

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See l1cama in Genome Data Viewer
Location:
chromosome: 23
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (28582795..28685168)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (28656243..28755830)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 Neighboring gene microRNA let7g-2 Neighboring gene microRNA let7h Neighboring gene RIB43A domain with coiled-coils 1 Neighboring gene structural maintenance of chromosomes 1A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. L1.2, the zebrafish paralog of L1.1 and ortholog of the mammalian cell adhesion molecule L1 contributes to spinal cord regeneration in adult zebrafish. Chen T, et al. Restor Neurol Neurosci, 2016. PMID 26889968
  2. Use of PCR template-derived probes prevents off-target whole mount in situ hybridization in transgenic zebrafish. Cha YR, et al. Zebrafish, 2012 Jun. PMID 22715949, Free PMC Article
  3. A Small Organic Compound Mimicking the L1 Cell Adhesion Molecule Promotes Functional Recovery after Spinal Cord Injury in Zebrafish. Sahu S, et al. Mol Neurobiol, 2018 Jan. PMID 28070857
  4. A Novel Zebrafish ret Heterozygous Model of Hirschsprung Disease Identifies a Functional Role for mapk10 as a Modifier of Enteric Nervous System Phenotype Severity. Heanue TA, et al. PLoS Genet, 2016 Nov. PMID 27902697, Free PMC Article
  5. Semaphorin3D regulates axon axon interactions by modulating levels of L1 cell adhesion molecule. Wolman MA, et al. J Neurosci, 2007 Sep 5. PMID 17804626, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study demonstrated that L1.2 contributes to spinal cord regeneration in adult zebrafish.
    Title: L1.2, the zebrafish paralog of L1.1 and ortholog of the mammalian cell adhesion molecule L1 contributes to spinal cord regeneration in adult zebrafish.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of axon extension ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in axonal growth cone ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
neural cell adhesion molecule L1.2
Names
neural adhesion molecule L1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131361.2 → NP_571436.2  neural cell adhesion molecule L1.2

    Status: VALIDATED

    Source sequence(s)
    BX664745, CR354431
    UniProtKB/TrEMBL
    A0A8M9PKJ8, F1R9X3, Q6U7I4
    Related
    ENSDARP00000005473.6, ENSDART00000020296.7
    Conserved Domains (6) summary
    smart00410
    Location:450 → 526
    IG_like; Immunoglobulin like
    cd00063
    Location:625 → 717
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:547 → 616
    Ig; Immunoglobulin domain
    cd05733
    Location:69 → 144
    Ig_L1-CAM_like; Immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
    pfam13882
    Location:1150 → 1234
    Bravo_FIGEY; Bravo-like intracellular region
    cl11960
    Location:147 → 241
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    28582795..28685168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021469729.2 → XP_021325404.1  neural cell adhesion molecule L1.2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PKJ8, F1R9X3, Q6U7I4
    Conserved Domains (6) summary
    smart00410
    Location:450 → 526
    IG_like; Immunoglobulin like
    cd00063
    Location:625 → 717
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:547 → 616
    Ig; Immunoglobulin domain
    cd05733
    Location:69 → 144
    Ig_L1-CAM_like; Immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
    pfam13882
    Location:1150 → 1234
    Bravo_FIGEY; Bravo-like intracellular region
    cl11960
    Location:147 → 241
    Ig; Immunoglobulin domain

  2. XM_005162225.5 → XP_005162282.1  neural cell adhesion molecule L1.2 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B9E7, Q6U7I4
    Conserved Domains (7) summary
    cd00096
    Location:547 → 616
    Ig; Immunoglobulin domain
    cd05733
    Location:69 → 144
    Ig6_L1-CAM_like; Sixth immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
    smart00408
    Location:454 → 517
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:263 → 343
    IG_like; Immunoglobulin like
    cd00063
    Location:625 → 717
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam13882
    Location:1150 → 1235
    Bravo_FIGEY; Bravo-like intracellular region
    cl11960
    Location:147 → 241
    Ig; Immunoglobulin domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395155.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    543076..640557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q90479.1 GenPept UniProtKB/Swiss-Prot:Q90479

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