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Adamtsl5 ADAMTS-like 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314626, updated on 10-Jul-2024

Summary

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Official Symbol
Adamtsl5provided by RGD
Official Full Name
ADAMTS-like 5provided by RGD
Primary source
RGD:1305607
See related
EnsemblRapid:ENSRNOG00000033787 AllianceGenome:RGD:1305607
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Thsd6
Summary
Predicted to enable heparin binding activity and microfibril binding activity. Predicted to be located in extracellular region and microfibril. Orthologous to human ADAMTSL5 (ADAMTS like 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 51.5), Muscle (RPKM 28.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Adamtsl5 in Genome Data Viewer
Location:
7q11
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10013306..10021924)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9362623..9371248)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12228706..12237382)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene mex-3 RNA binding family member D Neighboring gene polo-like kinase 5 Neighboring gene receptor accessory protein 6 Neighboring gene uncharacterized LOC108351405 Neighboring gene proprotein convertase subtilisin/kexin type 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A disintegrin-like and metalloprotease domain containing thrombospondin type 1 motif-like 5 (ADAMTSL5) is a novel fibrillin-1-, fibrillin-2-, and heparin-binding member of the ADAMTS superfamily containing a netrin-like module. Bader HL, et al. Matrix Biol, 2012 Sep-Oct. PMID 23010571, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables heparin binding ISO
Inferred from Sequence Orthology
more info
  
enables microfibril binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in microfibril ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ADAMTS-like protein 5
Names
thrombospondin, type I domain containing 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108071.2 → NP_001101541.1  ADAMTS-like protein 5 isoform 6 precursor

    See identical proteins and their annotated locations for NP_001101541.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6K8M1, F1M9K2
    Related
    ENSRNOP00000057537.3, ENSRNOT00000060811.6
    Conserved Domains (1) summary
    smart00209
    Location:49 → 98
    TSP1; Thrombospondin type 1 repeats

  2. NM_001400960.1 → NP_001387889.1  ADAMTS-like protein 5 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I6GJQ1

  3. NM_001400961.1 → NP_001387890.1  ADAMTS-like protein 5 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I6GJQ1, A6K8M0
    Related
    ENSRNOP00000108160.1, ENSRNOT00000137487.1

  4. NM_001400962.1 → NP_001387891.1  ADAMTS-like protein 5 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    Related
    ENSRNOP00000111564.1, ENSRNOT00000141752.1

  5. NM_001400963.1 → NP_001387892.1  ADAMTS-like protein 5 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I6GJQ1, A6K8M0

  6. NM_001400965.1 → NP_001387894.1  ADAMTS-like protein 5 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I6GJQ1, A6K8M0

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    10013306..10021924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078993.2 → XP_038934921.1  ADAMTS-like protein 5 isoform X6

    Conserved Domains (2) summary
    smart00209
    Location:200 → 246
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:444 → 524
    ADAM_spacer1; ADAM-TS Spacer 1

  2. XM_039078986.2 → XP_038934914.1  ADAMTS-like protein 5 isoform X1

    Conserved Domains (3) summary
    smart00209
    Location:200 → 246
    TSP1; Thrombospondin type 1 repeats
    cd03523
    Location:608 → 707
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:444 → 541
    ADAM_spacer1; ADAM-TS Spacer 1

  3. XM_039078998.2 → XP_038934926.1  ADAMTS-like protein 5 isoform X9

    Conserved Domains (2) summary
    smart00209
    Location:200 → 246
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:368 → 456
    ADAM_spacer1; ADAM-TS Spacer 1

  4. XM_039078987.2 → XP_038934915.1  ADAMTS-like protein 5 isoform X2

    Conserved Domains (3) summary
    smart00209
    Location:200 → 249
    TSP1; Thrombospondin type 1 repeats
    cd03523
    Location:598 → 697
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:434 → 531
    ADAM_spacer1; ADAM-TS Spacer 1

  5. XM_039078992.2 → XP_038934920.1  ADAMTS-like protein 5 isoform X5

    UniProtKB/TrEMBL
    A0A8I6GJQ1
    Conserved Domains (3) summary
    smart00209
    Location:200 → 246
    TSP1; Thrombospondin type 1 repeats
    cd03523
    Location:540 → 639
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:368 → 473
    ADAM_spacer1; ADAM-TS Spacer 1

  6. XM_063263416.1 → XP_063119486.1  ADAMTS-like protein 5 isoform X11

  7. XM_039078994.2 → XP_038934922.1  ADAMTS-like protein 5 isoform X7

    UniProtKB/TrEMBL
    A0A8I6GJQ1
    Conserved Domains (3) summary
    smart00209
    Location:200 → 249
    TSP1; Thrombospondin type 1 repeats
    cd03523
    Location:530 → 629
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:358 → 463
    ADAM_spacer1; ADAM-TS Spacer 1

  8. XM_039078988.2 → XP_038934916.1  ADAMTS-like protein 5 isoform X3

    UniProtKB/TrEMBL
    A0A8I6GJQ1
    Related
    ENSRNOP00000092372.2, ENSRNOT00000101922.2
    Conserved Domains (3) summary
    smart00209
    Location:145 → 191
    TSP1; Thrombospondin type 1 repeats
    cd03523
    Location:553 → 652
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:389 → 486
    ADAM_spacer1; ADAM-TS Spacer 1

  9. XM_039078991.2 → XP_038934919.1  ADAMTS-like protein 5 isoform X4

    UniProtKB/TrEMBL
    A0A8I6GJQ1
    Conserved Domains (3) summary
    smart00209
    Location:142 → 188
    TSP1; Thrombospondin type 1 repeats
    cd03523
    Location:550 → 649
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:386 → 483
    ADAM_spacer1; ADAM-TS Spacer 1

  10. XM_039078996.2 → XP_038934924.1  ADAMTS-like protein 5 isoform X8

    UniProtKB/TrEMBL
    A0A8I6GJQ1
    Conserved Domains (3) summary
    smart00209
    Location:116 → 162
    TSP1; Thrombospondin type 1 repeats
    cd03523
    Location:524 → 623
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:360 → 457
    ADAM_spacer1; ADAM-TS Spacer 1

  11. XM_039078999.2 → XP_038934927.1  ADAMTS-like protein 5 isoform X10

    UniProtKB/TrEMBL
    A0A8I6GJQ1
    Conserved Domains (3) summary
    smart00209
    Location:49 → 95
    TSP1; Thrombospondin type 1 repeats
    cd03523
    Location:457 → 556
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:293 → 390
    ADAM_spacer1; ADAM-TS Spacer 1

  12. XM_039079000.2 → XP_038934928.1  ADAMTS-like protein 5 isoform X10

    UniProtKB/TrEMBL
    A0A8I6GJQ1
    Conserved Domains (3) summary
    smart00209
    Location:49 → 95
    TSP1; Thrombospondin type 1 repeats
    cd03523
    Location:457 → 556
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:293 → 390
    ADAM_spacer1; ADAM-TS Spacer 1

  13. XM_039078990.2 → XP_038934918.1  ADAMTS-like protein 5 isoform X3

    UniProtKB/TrEMBL
    A0A8I6GJQ1
    Conserved Domains (3) summary
    smart00209
    Location:145 → 191
    TSP1; Thrombospondin type 1 repeats
    cd03523
    Location:553 → 652
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:389 → 486
    ADAM_spacer1; ADAM-TS Spacer 1

  14. XM_039078989.1 → XP_038934917.1  ADAMTS-like protein 5 isoform X3

    UniProtKB/TrEMBL
    A0A8I6GJQ1
    Conserved Domains (3) summary
    smart00209
    Location:145 → 191
    TSP1; Thrombospondin type 1 repeats
    cd03523
    Location:553 → 652
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:389 → 486
    ADAM_spacer1; ADAM-TS Spacer 1

  15. XM_039079002.2 → XP_038934930.1  ADAMTS-like protein 5 isoform X12

    Conserved Domains (3) summary
    cd03523
    Location:356 → 455
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:192 → 289
    ADAM_spacer1; ADAM-TS Spacer 1
    cl15456
    Location:16 → 84
    ADAM_CR; ADAM cysteine-rich

RNA

  1. XR_005486600.2 RNA Sequence

  2. XR_005486599.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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