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hnf1bb HNF1 homeobox Bb [ Danio rerio (zebrafish) ]

Gene ID: 324283, updated on 2-Nov-2024

Summary

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Official Symbol
hnf1bbprovided by ZNC
Official Full Name
HNF1 homeobox Bbprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3003
See related
Ensembl:ENSDARG00000022295 AllianceGenome:ZFIN:ZDB-GENE-030131-3003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
HNF1g; hnf1bl; hnf1gamma; wu:fc23f06
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within anterior/posterior pattern specification involved in pronephros development. Predicted to be active in nucleus. Is expressed in intermediate mesoderm; pronephros; and rhombomere 5. Human ortholog(s) of this gene implicated in kidney disease; maturity-onset diabetes of the young type 5; pancreas disease; renal cell carcinoma; and type 2 diabetes mellitus. Orthologous to human HNF1B (HNF1 homeobox B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See hnf1bb in Genome Data Viewer
Location:
chromosome: 21
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (38817838..38840269)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (38770215..38792767)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene RAB24, member RAS oncogene family Neighboring gene HEAT repeat containing 6 Neighboring gene toll-like receptor 22 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 52

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The small molecule probe PT-Yellow labels the renal proximal tubules in zebrafish. Sander V, et al. Chem Commun (Camb), 2015. PMID 25407666
  2. hnf1b genes in zebrafish hindbrain development. Choe SK, et al. Zebrafish, 2008 Sep. PMID 18945197, Free PMC Article
  3. Grouper tshβ promoter-driven transgenic zebrafish marks proximal kidney tubule development. Wang Y, et al. PLoS One, 2014. PMID 24905828, Free PMC Article
  4. Transcriptional profiling of the zebrafish proximal tubule. Sander V, et al. Am J Physiol Renal Physiol, 2019 Aug 1. PMID 31188030
  5. Zebrafish nephrogenesis involves dynamic spatiotemporal expression changes in renal progenitors and essential signals from retinoic acid and irx3b. Wingert RA, et al. Dev Dyn, 2011 Aug. PMID 21761484, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within anterior/posterior pattern specification involved in pronephros development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within insulin secretion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within liver development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pancreas development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
hepatocyte nuclear factor 1-beta-B
Names
liver-enriched atypical homeobox-containing transcription factor
transcription factor 2 like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_194372.3 → NP_919353.1  hepatocyte nuclear factor 1-beta-B

    See identical proteins and their annotated locations for NP_919353.1

    Status: VALIDATED

    Source sequence(s)
    CU694492, LO018189
    UniProtKB/Swiss-Prot
    Q8UW00
    Related
    ENSDARP00000143259.1, ENSDART00000177616.2
    Conserved Domains (3) summary
    cd00086
    Location:245 → 318
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:327 → 525
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
    pfam04814
    Location:12 → 182
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    38817838..38840269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068215784.1 → XP_068071885.1  hepatocyte nuclear factor 1-beta-B isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8UW00.1 GenPept UniProtKB/Swiss-Prot:Q8UW00

Gene LinkOut

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