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plaa phospholipase A2-activating protein [ Danio rerio (zebrafish) ]

Gene ID: 324855, updated on 12-Sep-2024

Summary

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Official Symbol
plaaprovided by ZNC
Official Full Name
phospholipase A2-activating proteinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030826-13
See related
Ensembl:ENSDARG00000042728 AllianceGenome:ZFIN:ZDB-GENE-030826-13
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb623; zgc:56568; zgc:66193; wu:fc45d08; wu:fi33e06
Summary
Predicted to enable ubiquitin binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and ubiquitin recycling. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including eye; ovary; pectoral fin musculature; solid lens vesicle; and trigeminal placode. Orthologous to human PLAA (phospholipase A2 activating protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See plaa in Genome Data Viewer
Location:
chromosome: 7
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (61977050..62003834, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (61666888..61693672, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene SH3 domain and tetratricopeptide repeats 1 Neighboring gene gametocyte-specific factor 1 Neighboring gene tudor domain containing 7 b Neighboring gene small integral membrane protein 20 Neighboring gene uncharacterized LOC137496236

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Regulation of prostaglandin synthesis in ovaries of sexually-mature zebrafish (Danio rerio). Lister AL, et al. Mol Reprod Dev, 2009 Nov. PMID 19551897
  2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phospholipase A-2-activating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212690.1 → NP_997855.1  phospholipase A-2-activating protein

    See identical proteins and their annotated locations for NP_997855.1

    Status: PROVISIONAL

    Source sequence(s)
    BC055539
    UniProtKB/TrEMBL
    Q7SXM2
    Related
    ENSDARP00000062703.4, ENSDART00000062704.5
    Conserved Domains (5) summary
    COG2319
    Location:4 → 303
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:9 → 297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08324
    Location:536 → 791
    PUL; PUL domain
    pfam09070
    Location:346 → 457
    PFU; PFU (PLAA family ubiquitin binding)
    sd00039
    Location:69 → 110
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    61977050..62003834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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