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Dtnb dystrobrevin, beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 362715, updated on 2-Nov-2024

Summary

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Official Symbol
Dtnbprovided by RGD
Official Full Name
dystrobrevin, betaprovided by RGD
Primary source
RGD:1309579
See related
EnsemblRapid:ENSRNOG00000011914 AllianceGenome:RGD:1309579
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables phosphatase binding activity. Predicted to be involved in neuron differentiation and synaptic signaling. Located in postsynaptic density. Orthologous to human DTNB (dystrobrevin beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 117.5), Brain (RPKM 92.7) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dtnb in Genome Data Viewer
Location:
6q14
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (32286022..32483007)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (26566418..26763467)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (27975302..28177236)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ASXL transcriptional regulator 2 Neighboring gene small ribosomal subunit protein bS21m-like Neighboring gene RNA pseudouridine synthase D4, pseudogene 1 Neighboring gene basic transcription factor 3, pseudogene 5 Neighboring gene DNA methyltransferase 3 alpha Neighboring gene uncharacterized LOC120103494 Neighboring gene Yip1 domain family, member 4 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulatory axis of circular RNA DTNB, microRNA-485-5p, and myeloid cell leukemia 1 attenuates inflammation and apoptosis in caerulein-treated AR42J cells. Tian X, et al. Funct Integr Genomics, 2024 Aug 20. PMID 39160285
  2. beta-dystrobrevin, a kinesin-binding receptor, interacts with the extracellular matrix components pancortins. Veroni C, et al. J Neurosci Res, 2007 Sep. PMID 17265465
  3. Beta-dystrobrevin interacts directly with kinesin heavy chain in brain. Macioce P, et al. J Cell Sci, 2003 Dec 1. PMID 14600269
  4. Association of dystrobrevin and regulatory subunit of protein kinase A: a new role for dystrobrevin as a scaffold for signaling proteins. Ceccarini M, et al. J Mol Biol, 2007 Aug 31. PMID 17610895
  5. Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain. Benson MA, et al. J Biol Chem, 2001 Jun 29. PMID 11316798

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulatory axis of circular RNA DTNB, microRNA-485-5p, and myeloid cell leukemia 1 attenuates inflammation and apoptosis in caerulein-treated AR42J cells.
    Title: Regulatory axis of circular RNA DTNB, microRNA-485-5p, and myeloid cell leukemia 1 attenuates inflammation and apoptosis in caerulein-treated AR42J cells.
  2. beta-dystrobrevin interacts with the HMG20 proteins iBRAF and BRAF35
    Title: The interaction with HMG20a/b proteins suggests a potential role for beta-dystrobrevin in neuronal differentiation.
  3. dystrobrevin is a scaffold protein that may play a role in different cellular processes involving PKA signaling
    Title: Association of dystrobrevin and regulatory subunit of protein kinase A: a new role for dystrobrevin as a scaffold for signaling proteins.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in basal plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in inhibitory synapse IEA
Inferred from Electronic Annotation
more info
  
located_in inhibitory synapse ISO
Inferred from Sequence Orthology
more info
  
located_in inhibitory synapse ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dystrobrevin beta
Names
DTN-B
beta-dystrobrevin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393801.1 → NP_001380730.1  dystrobrevin beta

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6AK26
    Related
    ENSRNOP00000092832.1, ENSRNOT00000114344.2
    Conserved Domains (4) summary
    PRK00286
    Location:346 → 526
    xseA; exodeoxyribonuclease VII large subunit; Reviewed
    PRK05431
    Location:440 → 510
    PRK05431; seryl-tRNA synthetase; Provisional
    cd02334
    Location:241 → 288
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16244
    Location:54 → 214
    EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins

RNA

  1. NR_172013.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    32286022..32483007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262066.1 → XP_063118136.1  dystrobrevin beta isoform X6

    Related
    ENSRNOP00000095615.1, ENSRNOT00000101006.2

  2. XM_063262067.1 → XP_063118137.1  dystrobrevin beta isoform X7

  3. XM_063262068.1 → XP_063118138.1  dystrobrevin beta isoform X8

    Related
    ENSRNOP00000087517.1, ENSRNOT00000117452.2

  4. XM_039112487.2 → XP_038968415.1  dystrobrevin beta isoform X5

    UniProtKB/Swiss-Prot
    P84060, Q66HF4
    UniProtKB/TrEMBL
    A0A8I6AK26
    Related
    ENSRNOP00000057536.4, ENSRNOT00000060810.4
    Conserved Domains (4) summary
    COG1340
    Location:434 → 515
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    PRK00286
    Location:346 → 526
    xseA; exodeoxyribonuclease VII large subunit; Reviewed
    cd02334
    Location:241 → 288
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16244
    Location:54 → 214
    EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins

  5. XM_063262062.1 → XP_063118132.1  dystrobrevin beta isoform X1

  6. XM_063262064.1 → XP_063118134.1  dystrobrevin beta isoform X3

  7. XM_063262063.1 → XP_063118133.1  dystrobrevin beta isoform X2

  8. XM_063262065.1 → XP_063118135.1  dystrobrevin beta isoform X4

RNA

  1. XR_010052110.1 RNA Sequence

  2. XR_010052111.1 RNA Sequence

    Related
    ENSRNOT00000077830.3

  3. XR_010052112.1 RNA Sequence

  4. XR_010052106.1 RNA Sequence

  5. XR_010052109.1 RNA Sequence

  6. XR_010052107.1 RNA Sequence

  7. XR_010052108.1 RNA Sequence

  8. XR_010052113.1 RNA Sequence

  9. XR_010052114.1 RNA Sequence

  10. XR_010052115.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P84060.2 GenPept UniProtKB/Swiss-Prot:P84060

Gene LinkOut

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