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thoc1 THO complex 1 [ Danio rerio (zebrafish) ]

Gene ID: 373077, updated on 2-Nov-2024

Summary

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Official Symbol
thoc1provided by ZNC
Official Full Name
THO complex 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030826-9
See related
Ensembl:ENSDARG00000088246 AllianceGenome:ZFIN:ZDB-GENE-030826-9
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
p84; Tho1
Summary
Predicted to enable DNA binding activity and RNA binding activity. Acts upstream of or within regulation of apoptotic process. Predicted to be located in cytosol; nuclear matrix; and nucleoplasm. Predicted to be part of THO complex part of transcription export complex. Is expressed in nervous system; otic vesicle; pectoral fin; and post-vent region. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness. Orthologous to human THOC1 (THO complex subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See thoc1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (2772540..2790563)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (2930641..2948664)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene myosin, light chain 13 Neighboring gene aquaporin 1a (Colton blood group), tandem duplicate 1 Neighboring gene aquaporin 1a (Colton blood group), tandem duplicate 2 Neighboring gene ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) Neighboring gene Rho-associated, coiled-coil containing protein kinase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Sublethal effects of waterborne uranium exposures on the zebrafish brain: transcriptional responses and alterations of the olfactory bulb ultrastructure. Lerebours A, et al. Environ Sci Technol, 2010 Feb 15. PMID 20088580
  2. THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis. Zhang L, et al. PLoS Genet, 2020 Aug. PMID 32776944, Free PMC Article
  3. Newly identified Gon4l/Udu-interacting proteins implicate novel functions. Tsai SM, et al. Sci Rep, 2020 Aug 26. PMID 32848183, Free PMC Article
  4. Genes with homology to mammalian apoptosis regulators identified in zebrafish. Inohara N, et al. Cell Death Differ, 2000 May. PMID 10917738
  5. A new mib allele with a chromosomal deletion covering foxc1a exhibits anterior somite specification defect. Hsu CH, et al. Sci Rep, 2015 Jun 3. PMID 26039894, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis.
    Title: THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of THO complex part of transcription export complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
THO complex subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201324.1 → NP_958481.1  THO complex subunit 1

    See identical proteins and their annotated locations for NP_958481.1

    Status: PROVISIONAL

    Source sequence(s)
    BC054938
    UniProtKB/Swiss-Prot
    Q7SYB2
    Related
    ENSDARP00000105643.1, ENSDART00000124882.4
    Conserved Domains (2) summary
    cd08318
    Location:568 → 653
    Death_NMPP84; Death domain of Nuclear Matrix Protein P84
    pfam11957
    Location:74 → 544
    efThoc1; THO complex subunit 1 transcription elongation factor

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    2772540..2790563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7SYB2.1 GenPept UniProtKB/Swiss-Prot:Q7SYB2

Gene LinkOut

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