rbpja recombination signal binding protein for immunoglobulin kappa J region a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rbpjaprovided by ZNC
Official Full Name: recombination signal binding protein for immunoglobulin kappa J region aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031117-1
See related: Ensembl:ENSDARG00000003398 AllianceGenome:ZFIN:ZDB-GENE-031117-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: rbpj; Su(H); Su(H)1; Su(h)A; rbpsuh; tdsubc_1e8; ik:tdsubc_1e8; xx:tdsubc_1e8
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; blood vessel development; and embryonic pattern specification. Predicted to be located in nucleus. Predicted to be part of MAML1-RBP-Jkappa- ICN1 complex. Is expressed in head; midbrain; and otic vesicle. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and dilated cardiomyopathy. Orthologous to human RBPJ (recombination signal binding protein for immunoglobulin kappa J region). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (14454663..14464020)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (13768150..13777507)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intronic Flk1 genetic enhancer element directs arterial-specific expression via RBPJ-mediated venous repression.
Title: An Intronic Flk1 Enhancer Directs Arterial-Specific Expression via RBPJ-Mediated Venous Repression.
embryos treated with morpholinos against wt1a, foxc1a, or the Notch transcriptional mediator rbpj develop fewer podocytes, as determined by wt1b, hey1 and nephrin expression, while embryos deficient in any two of these factors completely lack podocytes
Title: Wt1a, Foxc1a, and the Notch mediator Rbpj physically interact and regulate the formation of podocytes in zebrafish.
her8a is positively regulated by Su(H)-dependent Notch signaling as revealed by a Notch-defective mutant and injection of variants of the Notch intracellular regulator, Su(H).
Title: Zebrafish Her8a is activated by Su(H)-dependent Notch signaling and is essential for the inhibition of neurogenesis.
one element of the Notch signalling pathway, Su(H), is required for control of retinoic acid metabolism in the tailbud
Title: Coordination of symmetric cyclic gene expression during somitogenesis by Suppressor of Hairless involves regulation of retinoic acid catabolism.
analysed the function of Su(H) in the somitogenesis process and its influence on the expression of notch pathway genes
Title: The role of Suppressor of Hairless in Notch mediated signalling during zebrafish somitogenesis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adrenal gland development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within artery development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within astrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right asymmetry in lateral mesoderm	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neurogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within podocyte cell fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pronephric duct development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pronephric glomerulus development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within segment polarity determination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somite specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somitogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sprouting angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of MAML1-RBP-Jkappa- ICN1 complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: recombination signal binding protein for immunoglobulin kappa J region a

Names: recombining binding protein suppressor of hairless

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198878.2 → NP_942579.2 recombination signal binding protein for immunoglobulin kappa J region a

See identical proteins and their annotated locations for NP_942579.2

Status: VALIDATED

Source sequence(s)

BC163922, BX530018

Related

ENSDARP00000026585.8, ENSDART00000005067.10

Conserved Domains (3) summary

cd01176
Location:345 → 433

IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...

pfam09270
Location:166 → 315

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:35 → 164

LAG1-DNAbind; LAG1, DNA binding