skic8 SKI8 subunit of superkiller complex [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: skic8provided by ZNC
Official Full Name: SKI8 subunit of superkiller complexprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1851
See related: AllianceGenome:ZFIN:ZDB-GENE-040426-1851
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Ski8; wdr61; zgc:77675
Summary: Predicted to be involved in histone H3-K4 methylation and transcription elongation from RNA polymerase II promoter. Predicted to be located in cytoplasm; nucleus; and transcriptionally active chromatin. Predicted to be part of Cdc73/Paf1 complex and Ski complex. Orthologous to human WDR61 (WD repeat domain 61). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (6280851..6292560, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (6153449..6165158, complement)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fk30e10.y1 (e-PCR)
- UniSTS:200782

fc92a05.x1 (e-PCR)
- UniSTS:194802

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay	ISS Inferred from Sequence or Structural Similarity more info
involved_in rescue of stalled ribosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in transcription elongation by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Cdc73/Paf1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cdc73/Paf1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of Ski complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
part_of euchromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: superkiller complex protein 8

Names: SKI8 subunit of superkiller complex protein; WD repeat domain 61; WD repeat-containing protein 61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200853.1 → NP_957147.1 superkiller complex protein 8

See identical proteins and their annotated locations for NP_957147.1

Status: PROVISIONAL

Source sequence(s)

BC062834

UniProtKB/Swiss-Prot

Q6P5M2

Conserved Domains (3) summary

COG2319
Location:14 → 304

WD40; WD40 repeat [General function prediction only]

cd00200
Location:15 → 302

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:110 → 146

7WD40; WD40 repeat [structural motif]