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CERCAM cerebral endothelial cell adhesion molecule [ Homo sapiens (human) ]

Gene ID: 51148, updated on 4-Jan-2025

Summary

Official Symbol
CERCAMprovided by HGNC
Official Full Name
cerebral endothelial cell adhesion moleculeprovided by HGNC
Primary source
HGNC:HGNC:23723
See related
Ensembl:ENSG00000167123 MIM:616626; AllianceGenome:HGNC:23723
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CEECAM1; GLT25D3
Summary
Enables identical protein binding activity. Acts upstream of or within cell adhesion. Predicted to be located in endoplasmic reticulum lumen. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in brain (RPKM 35.8), placenta (RPKM 14.3) and 19 other tissues See more
Orthologs
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Genomic context

See CERCAM in Genome Data Viewer
Location:
9q34.11
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (128419160..128437351)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (140613098..140644454)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (131181439..131199630)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:131132825-131133688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29080 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr9:131145413-131146057 Neighboring gene ubiquitin related modifier 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:131147991-131148635 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:131155313-131156018 Neighboring gene MIR219A2 host gene Neighboring gene microRNA 219a-2 Neighboring gene microRNA 219b Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:131167036-131167836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:131173621-131174240 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20339 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29081 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:131200897-131201070 Neighboring gene protein PAT1 homolog 1-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:131217358-131218094 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:131218095-131218830 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:131218831-131219566 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr9:131219567-131220302 Neighboring gene outer dense fiber of sperm tails 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:131234689-131235190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:131235191-131235690 Neighboring gene ODF2 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Interactions

General gene information

Clone Names

  • MGC149620, MGC149621

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding PubMed 
NOT enables procollagen galactosyltransferase activity  
enables protein binding PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum lumen  
located_in plasma membrane PubMed 

General protein information

Preferred Names
inactive glycosyltransferase 25 family member 3
Names
cerebral cell adhesion molecule
cerebral endothelial cell adhesion molecule 1
glycosyltransferase 25 domain containing 3
glycosyltransferase 25 family member 3
probable inactive glycosyltransferase 25 family member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286760.1NP_001273689.1  inactive glycosyltransferase 25 family member 3 isoform b

    See identical proteins and their annotated locations for NP_001273689.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK314294, BC098432
    Consensus CDS
    CCDS69675.1
    UniProtKB/TrEMBL
    B4DNI4
    Conserved Domains (1) summary
    cd06532
    Location:243425
    Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...
  2. NM_016174.5NP_057258.3  inactive glycosyltransferase 25 family member 3 isoform a precursor

    See identical proteins and their annotated locations for NP_057258.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    BC098432, CX871555
    Consensus CDS
    CCDS6901.2
    UniProtKB/Swiss-Prot
    A7MD00, C4AMA2, Q0VDF3, Q2VPJ4, Q4KMP2, Q5T4B1, Q5T4B2, Q8N107, Q96EZ5, Q9P226, Q9UMW5
    UniProtKB/TrEMBL
    B4DNI4
    Related
    ENSP00000361929.4, ENST00000372838.9
    Conserved Domains (2) summary
    cd06532
    Location:321503
    Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...
    cl11394
    Location:3781
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    128419160..128437351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423450.1XP_047279406.1  inactive glycosyltransferase 25 family member 3 isoform X1

    UniProtKB/TrEMBL
    B4DNI4
  2. XM_011518763.4XP_011517065.1  inactive glycosyltransferase 25 family member 3 isoform X1

    See identical proteins and their annotated locations for XP_011517065.1

    UniProtKB/TrEMBL
    B4DNI4
    Related
    ENSP00000361933.1, ENST00000372842.5
    Conserved Domains (1) summary
    cd06532
    Location:243425
    Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    140613098..140644454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363062.1XP_054219037.1  inactive glycosyltransferase 25 family member 3 isoform X2

    UniProtKB/Swiss-Prot
    A7MD00, C4AMA2, Q0VDF3, Q2VPJ4, Q4KMP2, Q5T4B1, Q5T4B2, Q8N107, Q96EZ5, Q9P226, Q9UMW5
    UniProtKB/TrEMBL
    B4DNI4
  2. XM_054363061.1XP_054219036.1  inactive glycosyltransferase 25 family member 3 isoform X2

    UniProtKB/Swiss-Prot
    A7MD00, C4AMA2, Q0VDF3, Q2VPJ4, Q4KMP2, Q5T4B1, Q5T4B2, Q8N107, Q96EZ5, Q9P226, Q9UMW5
    UniProtKB/TrEMBL
    B4DNI4
  3. XM_054363063.1XP_054219038.1  inactive glycosyltransferase 25 family member 3 isoform X1

    UniProtKB/TrEMBL
    B4DNI4
  4. XM_054363064.1XP_054219039.1  inactive glycosyltransferase 25 family member 3 isoform X1

    UniProtKB/TrEMBL
    B4DNI4
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