arsa arylsulfatase A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: arsaprovided by ZNC
Official Full Name: arylsulfatase Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050320-118
See related: Ensembl:ENSDARG00000042270 AllianceGenome:ZFIN:ZDB-GENE-050320-118
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:101575
Summary: Predicted to enable arylsulfatase activity. Human ortholog(s) of this gene implicated in metachromatic leukodystrophy. Orthologous to human ARSA (arylsulfatase A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (8231138..8243538)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (8273119..8285519)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables arylsulfatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cerebroside-sulfatase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: arylsulfatase A

NP_001013561.2

EC 3.1.6.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013543.2 → NP_001013561.2 arylsulfatase A precursor

Status: PROVISIONAL

Source sequence(s)

BC090818

UniProtKB/TrEMBL

A0A8M1N4V1, Q5BL32

Related

ENSDARP00000121810.1, ENSDART00000140193.2

Conserved Domains (2) summary

COG3119
Location:21 → 468

AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]

cd16158
Location:23 → 500

ARSA; Arylsulfatase A or cerebroside-sulfatase