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arhgef7a Rho guanine nucleotide exchange factor (GEF) 7a [ Danio rerio (zebrafish) ]

Gene ID: 553493, updated on 17-Aug-2024

Summary

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Official Symbol
arhgef7aprovided by ZNC
Official Full Name
Rho guanine nucleotide exchange factor (GEF) 7aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060322-11
See related
Ensembl:ENSDARG00000006299 AllianceGenome:ZFIN:ZDB-GENE-060322-11
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc28d09; wu:fc28d09
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within intracellular signal transduction. Predicted to be located in lamellipodium. Orthologous to human ARHGEF7 (Rho guanine nucleotide exchange factor 7). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See arhgef7a in Genome Data Viewer
Location:
chromosome: 9
Exon count:
23
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (21535370..21567083)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (21724392..21756214)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene M-phase phosphoprotein 8 Neighboring gene AF4/FMR2 family, member 3 Neighboring gene uncharacterized LOC110438834 Neighboring gene uncharacterized LOC108191313 Neighboring gene SRY-box transcription factor 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Immunotoxicity of β-Diketone Antibiotic Mixtures to Zebrafish (Danio rerio) by Transcriptome Analysis. Li F, et al. PLoS One, 2016. PMID 27046191, Free PMC Article
  2. Genome wide association and genomic prediction for growth traits in juvenile farmed Atlantic salmon using a high density SNP array. Tsai HY, et al. BMC Genomics, 2015 Nov 18. PMID 26582102, Free PMC Article
  3. A vertebrate-specific Chp-PAK-PIX pathway maintains E-cadherin at adherens junctions during zebrafish epiboly. Tay HG, et al. PLoS One, 2010 Apr 12. PMID 20405038, Free PMC Article
  4. Comparative genomic and expression analysis of group B1 sox genes in zebrafish indicates their diversification during vertebrate evolution. Okuda Y, et al. Dev Dyn, 2006 Mar. PMID 16408288
  5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 7; rho guanine nucleotide exchange factor 7a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001123235.1 → NP_001116707.1  rho guanine nucleotide exchange factor 7a

    Status: PROVISIONAL

    Source sequence(s)
    BX649266
    UniProtKB/TrEMBL
    A0A8N1Z0S2, B0S771
    Related
    ENSDARP00000121774.1, ENSDART00000141408.3
    Conserved Domains (8) summary
    cd12060
    Location:164 → 220
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    cd00014
    Location:3 → 105
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00160
    Location:250 → 427
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:458 → 556
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:476 → 556
    PH; PH domain
    pfam16523
    Location:769 → 855
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:604 → 709
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:115 → 162
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    21535370..21567083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167563.4 → XP_005167620.1  rho guanine nucleotide exchange factor 7 isoform X4

    UniProtKB/TrEMBL
    A0A8M2BF23
    Conserved Domains (8) summary
    cd12060
    Location:170 → 226
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    smart00033
    Location:21 → 106
    CH; Calponin homology domain
    cd00160
    Location:256 → 433
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:464 → 562
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:482 → 562
    PH; PH domain
    pfam16523
    Location:718 → 804
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:610 → 715
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:116 → 168
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

  2. XM_021478663.1 → XP_021334338.1  rho guanine nucleotide exchange factor 7 isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q4K4
    Conserved Domains (7) summary
    cd12060
    Location:170 → 226
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    smart00033
    Location:21 → 106
    CH; Calponin homology domain
    cd00160
    Location:256 → 433
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:464 → 562
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:775 → 861
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:621 → 715
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:116 → 168
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

  3. XM_017357678.2 → XP_017213167.1  rho guanine nucleotide exchange factor 7 isoform X6

    UniProtKB/TrEMBL
    A0A8M6Z2J5

  4. XM_005167564.4 → XP_005167621.1  rho guanine nucleotide exchange factor 7 isoform X5

    UniProtKB/TrEMBL
    A0A8M2BEZ3
    Conserved Domains (8) summary
    cd12060
    Location:165 → 221
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    smart00033
    Location:21 → 106
    CH; Calponin homology domain
    cd00160
    Location:251 → 428
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:459 → 557
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:477 → 557
    PH; PH domain
    pfam16523
    Location:713 → 799
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:605 → 710
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:116 → 163
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

  5. XM_021478664.1 → XP_021334339.1  rho guanine nucleotide exchange factor 7 isoform X2

    UniProtKB/TrEMBL
    A0A2R8Q515, A0A8M9QAP8
    Related
    ENSDARP00000147946.1, ENSDART00000182266.1
    Conserved Domains (7) summary
    cd12060
    Location:165 → 221
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    smart00033
    Location:21 → 106
    CH; Calponin homology domain
    cd00160
    Location:251 → 428
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:459 → 557
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:770 → 856
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:616 → 710
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:116 → 163
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

  6. XM_005167566.4 → XP_005167623.1  rho guanine nucleotide exchange factor 7 isoform X7

    UniProtKB/TrEMBL
    A0A8M2BF17
    Conserved Domains (7) summary
    cd12060
    Location:165 → 221
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    smart00033
    Location:21 → 106
    CH; Calponin homology domain
    cd00160
    Location:251 → 428
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:459 → 557
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:477 → 557
    PH; PH domain
    pfam16614
    Location:605 → 710
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:116 → 163
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

  7. XM_021478665.1 → XP_021334340.1  rho guanine nucleotide exchange factor 7 isoform X3

    UniProtKB/TrEMBL
    A0A8M9QJM4
    Conserved Domains (5) summary
    cd12060
    Location:8 → 64
    SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
    cd00160
    Location:94 → 271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302 → 400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:613 → 699
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:459 → 553
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394750.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    95830..125943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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