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ssh2b slingshot protein phosphatase 2b [ Danio rerio (zebrafish) ]

Gene ID: 557912, updated on 18-Sep-2024

Summary

Official Symbol
ssh2bprovided by ZNC
Official Full Name
slingshot protein phosphatase 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-081205-4
See related
Ensembl:ENSDARG00000098955 AllianceGenome:ZFIN:ZDB-GENE-081205-4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:175142
Summary
Predicted to enable actin binding activity and phosphoprotein phosphatase activity. Predicted to be involved in actin cytoskeleton organization and negative regulation of actin filament polymerization. Predicted to act upstream of or within protein dephosphorylation. Predicted to be active in cytoplasm. Orthologous to human SSH2 (slingshot protein phosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See ssh2b in Genome Data Viewer
Location:
chromosome: 21
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (40417152..40478294)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (40393599..40454734)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100534731 Neighboring gene small nucleolar RNA SNORD65 Neighboring gene nuclear speckle splicing regulatory protein 1 Neighboring gene coronin 6 Neighboring gene protein ABHD15 Neighboring gene TAO kinase 1b

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Clone Names

  • MGC175142

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
protein phosphatase Slingshot homolog 2b
Names
slingshot homolog 2b
NP_001128575.1
XP_009293925.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135103.1NP_001128575.1  protein phosphatase Slingshot homolog 2b

    See identical proteins and their annotated locations for NP_001128575.1

    Status: PROVISIONAL

    Source sequence(s)
    BC168509
    UniProtKB/TrEMBL
    B5DE33
    Related
    ENSDARP00000131244.1, ENSDART00000171244.2
    Conserved Domains (3) summary
    cd11652
    Location:3240
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:312447
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:258306
    DEK_C; DEK C terminal domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    40417152..40478294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009295650.4XP_009293925.1  protein phosphatase Slingshot homolog 2b isoform X1

    UniProtKB/TrEMBL
    A0A2R8RXU6, A0A8M3AX49
    Related
    ENSDARP00000155575.1, ENSDART00000190675.1
    Conserved Domains (3) summary
    cd11652
    Location:38254
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:326461
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:272320
    DEK_C; DEK C terminal domain