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tprb translocated promoter region b, nuclear basket protein [ Danio rerio (zebrafish) ]

Gene ID: 558883, updated on 2-Nov-2024

Summary

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Official Symbol
tprbprovided by ZNC
Official Full Name
translocated promoter region b, nuclear basket proteinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6410
See related
Ensembl:ENSDARG00000016630 AllianceGenome:ZFIN:ZDB-GENE-030131-6410
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
tpr; wu:fi76g05; si:dkey-97o5.5
Summary
Predicted to be a structural constituent of nuclear pore. Predicted to be involved in mRNA export from nucleus and regulation of mitotic spindle assembly. Predicted to act upstream of or within protein import into nucleus. Predicted to be part of nuclear pore. Is expressed in liver. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human TPR (translocated promoter region, nuclear basket protein). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See tprb in Genome Data Viewer
Location:
chromosome: 20
Exon count:
50
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (34039281..34069938, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (34136402..34167075, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene fignl1 interacting regulator of recombination and mitosis Neighboring gene SCY1-like, kinase-like 3 Neighboring gene proteoglycan 4b Neighboring gene phosducin b Neighboring gene prostaglandin-endoperoxide synthase 2b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Comprehensive maturity of nuclear pore complexes regulates zygotic genome activation. Shen W, et al. Cell, 2022 Dec 22. PMID 36493774
  2. Tpr Deficiency Disrupts Erythroid Maturation With Impaired Chromatin Condensation in Zebrafish Embryogenesis. Wu S, et al. Front Cell Dev Biol, 2021. PMID 34722501, Free PMC Article
  3. HNF factors form a network to regulate liver-enriched genes in zebrafish. Cheng W, et al. Dev Biol, 2006 Jun 15. PMID 16631158
  4. Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. Sato Y, et al. BMC Evol Biol, 2009 Jun 5. PMID 19500364, Free PMC Article
  5. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein import into nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
translocated promoter region b, nuclear basket protein
Names
translocated promoter region (to activated MET oncogene)
translocated promoter region b (to activated MET oncogene)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030123.1 → NP_001025294.1  translocated promoter region b, nuclear basket protein

    Status: PROVISIONAL

    Source sequence(s)
    BX323056
    UniProtKB/TrEMBL
    A0A8M1N766, Q5RI09
    Related
    ENSDARP00000019846.7, ENSDART00000017941.9
    Conserved Domains (5) summary
    COG1340
    Location:72 → 355
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    TIGR02168
    Location:221 → 1049
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam04420
    Location:1516 → 1569
    CHD5; CHD5-like protein
    pfam07926
    Location:1040 → 1168
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    cl14813
    Location:230 → 348
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    34039281..34069938 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009294751.4 → XP_009293026.1  translocated promoter region b, nuclear basket protein isoform X1

    UniProtKB/TrEMBL
    A0A8M3ATA7
    Conserved Domains (5) summary
    COG1340
    Location:72 → 355
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    TIGR02168
    Location:221 → 1049
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam04420
    Location:1516 → 1569
    CHD5; CHD5-like protein
    pfam07926
    Location:1040 → 1168
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    cl14813
    Location:230 → 348
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
Nucleotide Protein Strain
Heading Accession and Version

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