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actn1 actinin, alpha 1 [ Danio rerio (zebrafish) ]

Gene ID: 560400, updated on 17-Sep-2024

Summary

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Official Symbol
actn1provided by ZNC
Official Full Name
actinin, alpha 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-081113-4
See related
Ensembl:ENSDARG00000007219 AllianceGenome:ZFIN:ZDB-GENE-081113-4
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin cytoskeleton organization and muscle cell development. Predicted to be active in several cellular components, including Z disc; actin cytoskeleton; and cell junction. Is expressed in several structures, including head muscle; intestine; nervous system; ovary; and ventral intermandibularis anterior. Human ortholog(s) of this gene implicated in platelet-type bleeding disorder 15. Orthologous to human ACTN1 (actinin alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See actn1 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (36321088..36391507, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (36195259..36265698, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 8 member 3 Neighboring gene cytochrome c oxidase assembly factor COX16 Neighboring gene ddb1 and cul4 associated factor 5 Neighboring gene phosphofurin acidic cluster sorting protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. α-Actinin-2 deficiency results in sarcomeric defects in zebrafish that cannot be rescued by α-actinin-3 revealing functional differences between sarcomeric isoforms. Gupta V, et al. FASEB J, 2012 May. PMID 22253474, Free PMC Article
  2. Sequence and expression of the zebrafish alpha-actinin gene family reveals conservation and diversification among vertebrates. Holterhoff CK, et al. Dev Dyn, 2009 Nov. PMID 19842183, Free PMC Article
  3. A dynamic spatiotemporal extracellular matrix facilitates epicardial-mediated vertebrate heart regeneration. Mercer SE, et al. Dev Biol, 2013 Oct 15. PMID 23939298, Free PMC Article
  4. Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA). Sander JD, et al. Nat Methods, 2011 Jan. PMID 21151135, Free PMC Article
  5. Improved somatic mutagenesis in zebrafish using transcription activator-like effector nucleases (TALENs). Moore FE, et al. PLoS One, 2012. PMID 22655075, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in muscle cell development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cell projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ruffle IEA
Inferred from Electronic Annotation
more info
  
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
alpha-actinin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168286.2 → NP_001161758.1  alpha-actinin-1

    See identical proteins and their annotated locations for NP_001161758.1

    Status: VALIDATED

    Source sequence(s)
    CA476190, CF995888, CK141214, CR361558
    UniProtKB/TrEMBL
    B8JHU4, F6NZE7
    Related
    ENSDARP00000090990.3, ENSDART00000100217.5
    Conserved Domains (7) summary
    cd00014
    Location:155 → 259
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:760 → 827
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:405 → 632
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:42 → 140
    CH; Calponin homology (CH) domain
    pfam00435
    Location:640 → 743
    Spectrin; Spectrin repeat
    pfam08726
    Location:832 → 898
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam13499
    Location:762 → 826
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    36321088..36391507 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009307476.4 → XP_009305751.1  alpha-actinin-1 isoform X4

    UniProtKB/TrEMBL
    A0A8M3AZC5
    Conserved Domains (7) summary
    cd00014
    Location:155 → 259
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:760 → 822
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:405 → 632
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:42 → 140
    CH; Calponin homology (CH) domain
    pfam00435
    Location:640 → 743
    Spectrin; Spectrin repeat
    pfam08726
    Location:827 → 893
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam13499
    Location:762 → 821
    EF-hand_7; EF-hand domain pair

  2. XM_009307474.4 → XP_009305749.1  alpha-actinin-1 isoform X2

    UniProtKB/TrEMBL
    A0A8M3B867
    Conserved Domains (7) summary
    cd00014
    Location:155 → 259
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:760 → 827
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:405 → 632
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:42 → 140
    CH; Calponin homology (CH) domain
    pfam00435
    Location:640 → 743
    Spectrin; Spectrin repeat
    pfam08726
    Location:832 → 898
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam13499
    Location:762 → 826
    EF-hand_7; EF-hand domain pair

  3. XM_009307475.4 → XP_009305750.1  alpha-actinin-1 isoform X3

    UniProtKB/TrEMBL
    A0A8M3B5E5
    Conserved Domains (7) summary
    cd00014
    Location:155 → 259
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:760 → 822
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:405 → 632
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:42 → 140
    CH; Calponin homology (CH) domain
    pfam00435
    Location:640 → 743
    Spectrin; Spectrin repeat
    pfam08726
    Location:827 → 893
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam13499
    Location:762 → 821
    EF-hand_7; EF-hand domain pair

  4. XM_068212864.1 → XP_068068965.1  alpha-actinin-1 isoform X1

    Related
    ENSDARP00000123299.1, ENSDART00000140243.3

  5. XM_068212865.1 → XP_068068966.1  alpha-actinin-1 isoform X6

  6. XM_021480596.2 → XP_021336271.1  alpha-actinin-1 isoform X5

    UniProtKB/TrEMBL
    A0A8M9QJP5
    Conserved Domains (5) summary
    COG5069
    Location:1 → 54
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:512 → 579
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:157 → 384
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:392 → 495
    Spectrin; Spectrin repeat
    pfam08726
    Location:584 → 650
    EFhand_Ca_insen; Ca2+ insensitive EF hand
Nucleotide Protein Strain
Heading Accession and Version

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