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scn3b sodium channel, voltage-gated, type III, beta [ Danio rerio (zebrafish) ]

Gene ID: 563935, updated on 12-Sep-2024

Summary

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Official Symbol
scn3bprovided by ZNC
Official Full Name
sodium channel, voltage-gated, type III, betaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070920-2
See related
Ensembl:ENSDARG00000062359 AllianceGenome:ZFIN:ZDB-GENE-070920-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable sodium channel inhibitor activity and transmembrane transporter binding activity. Predicted to be involved in regulation of heart rate by cardiac conduction; regulation of sodium ion transmembrane transporter activity; and ventricular cardiac muscle cell action potential. Predicted to act upstream of or within regulation of ion transmembrane transport and sodium ion transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of voltage-gated sodium channel complex. Is expressed in atrium; brain; cardiac ventricle; and eye. Human ortholog(s) of this gene implicated in Brugada syndrome 7. Orthologous to human SCN3B (sodium voltage-gated channel beta subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See scn3b in Genome Data Viewer
Location:
chromosome: 15
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (22131626..22147860, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (22197711..22212136, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and kinase domain containing 1 Neighboring gene dopamine receptor D2a Neighboring gene si:ch211-286b4.4 Neighboring gene multiple epidermal growth factor-like domains protein 6 Neighboring gene uncharacterized LOC100005689

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: implications for the evolution of electrical signaling in vertebrates. Chopra SS, et al. BMC Evol Biol, 2007 Jul 10. PMID 17623065, Free PMC Article
  2. Maternal Rest/Nrsf Regulates Zebrafish Behavior through snap25a/b. Moravec CE, et al. J Neurosci, 2016 Sep 7. PMID 27605615, Free PMC Article
  3. CoRest1 regulates neurogenesis in a stage-dependent manner. Monestime CM, et al. Dev Dyn, 2019 Oct. PMID 31301200, Free PMC Article
  4. Electrophysiological Properties of Adult Zebrafish Oligodendrocyte Progenitor Cells. Tsata V, et al. Front Cell Neurosci, 2019. PMID 31031593, Free PMC Article
  5. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Baraban SC, et al. Nat Commun, 2013. PMID 24002024, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables sodium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables sodium channel inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium channel regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of heart rate by cardiac conduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of sodium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in ventricular cardiac muscle cell action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated sodium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated sodium channel complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sodium channel regulatory subunit beta-3
Names
voltage-gated sodium channel beta 3 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080802.1 → NP_001074271.1  sodium channel regulatory subunit beta-3 precursor

    See identical proteins and their annotated locations for NP_001074271.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ489730
    UniProtKB/TrEMBL
    Q06W27
    Conserved Domains (2) summary
    smart00410
    Location:30 → 128
    IG_like; Immunoglobulin like
    pfam07686
    Location:34 → 127
    V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    22131626..22147860 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009291662.3 → XP_009289937.1  sodium channel regulatory subunit beta-3 isoform X2

    UniProtKB/TrEMBL
    A0A8M3APT8
    Conserved Domains (2) summary
    smart00410
    Location:51 → 149
    IG_like; Immunoglobulin like
    pfam07686
    Location:55 → 148
    V-set; Immunoglobulin V-set domain

  2. XM_009291661.3 → XP_009289936.1  sodium channel regulatory subunit beta-3 isoform X1

    UniProtKB/TrEMBL
    A0A8M3ASQ5, F8W4B3
    Related
    ENSDARP00000123929.1, ENSDART00000149784.2
    Conserved Domains (2) summary
    smart00410
    Location:51 → 149
    IG_like; Immunoglobulin like
    pfam07686
    Location:55 → 148
    V-set; Immunoglobulin V-set domain

  3. XM_068213570.1 → XP_068069671.1  sodium channel regulatory subunit beta-3 isoform X3

Nucleotide Protein
Heading Accession and Version

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