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brca2 BRCA2 DNA repair associated [ Danio rerio (zebrafish) ]

Gene ID: 566758, updated on 17-Aug-2024

Summary

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Official Symbol
brca2provided by ZNC
Official Full Name
BRCA2 DNA repair associatedprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060510-3
See related
Ensembl:ENSDARG00000079015 AllianceGenome:ZFIN:ZDB-GENE-060510-3
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fancd1
Summary
Predicted to enable DNA binding activity. Acts upstream of or within several processes, including female gonad development; kidney development; and spermatogenesis. Predicted to be active in nucleus. Is expressed in gonad; heart; intermediate cell mass of mesoderm; intermediate mesoderm; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia (multiple); brain cancer (multiple); hereditary breast ovarian cancer syndrome; melanoma (multiple); and reproductive organ cancer (multiple). Orthologous to human BRCA2 (BRCA2 DNA repair associated). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 15
Exon count:
27
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (31911844..31928519)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (32053981..32070682)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene relaxin family peptide receptor 2b Neighboring gene furry homolog a (Drosophila) Neighboring gene dachsous cadherin-related 1a Neighboring gene ADP-ribosylation factor interacting protein 2a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Circulating tumor cells exit circulation while maintaining multicellularity, augmenting metastatic potential. Allen TA, et al. J Cell Sci, 2019 Sep 9. PMID 31409692, Free PMC Article
  2. Genotypic and Phenotypic Variables Affect Meiotic Cell Cycle Progression, Tumor Ploidy, and Cancer-Associated Mortality in a brca2-Mutant Zebrafish Model. Mensah L, et al. J Oncol, 2019. PMID 30930946, Free PMC Article
  3. Accurate quantification of homologous recombination in zebrafish: brca2 deficiency as a paradigm. Vierstraete J, et al. Sci Rep, 2017 Nov 28. PMID 29184099, Free PMC Article
  4. BRCA2 and TP53 collaborate in tumorigenesis in zebrafish. Shive HR, et al. PLoS One, 2014. PMID 24489863, Free PMC Article
  5. brca2 in zebrafish ovarian development, spermatogenesis, and tumorigenesis. Shive HR, et al. Proc Natl Acad Sci U S A, 2010 Nov 9. PMID 20974951, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. brca2-mutant zebrafish exhibit context- and tissue-dependent alterations in cell phenotypes and response to injury.
    Title: brca2-mutant zebrafish exhibit context- and tissue-dependent alterations in cell phenotypes and response to injury.
  2. the data suggest for the first time that brca2/fancd1 is essential for vertebrate kidney ontogeny.
    Title: The zebrafish kidney mutant zeppelin reveals that brca2/fancd1 is essential for pronephros development.
  3. Carcinogenesis in zebrafish with combined mutations in tp53 and brca2 typically requires biallelic mutation or loss of at least one of these genes.
    Title: BRCA2 and TP53 collaborate in tumorigenesis in zebrafish.
  4. The novel role of Brca2 in organizing the vertebrate egg nucleus may provide new insights into the origin of ovarian cancer
    Title: Roles of brca2 (fancd1) in oocyte nuclear architecture, gametogenesis, gonad tumors, and genome stability in zebrafish.
  5. critical roles for brca2 in ovarian development and tumorigenesis in reproductive tissues
    Title: brca2 in zebrafish ovarian development, spermatogenesis, and tumorigenesis.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within embryo development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within female gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within podocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pronephros development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of oogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within sex determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
breast cancer type 2 susceptibility protein
Names
breast and ovarian cancer susceptibility protein 2
breast cancer 2, early onset

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110394.2 → NP_001103864.2  breast cancer type 2 susceptibility protein

    See identical proteins and their annotated locations for NP_001103864.2

    Status: VALIDATED

    Source sequence(s)
    CR536612, CR628361
    UniProtKB/TrEMBL
    A0A8M2B481, F1R8E8
    Related
    ENSDARP00000099674.2, ENSDART00000111472.3
    Conserved Domains (5) summary
    cd04494
    Location:2350 → 2597
    BRCA2DBD_OB2; BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous ...
    pfam00634
    Location:1239 → 1267
    BRCA2; BRCA2 repeat
    pfam09103
    Location:2215 → 2338
    BRCA-2_OB1; BRCA2, oligonucleotide/oligosaccharide-binding, domain 1
    pfam09104
    Location:2600 → 2733
    BRCA-2_OB3; BRCA2, oligonucleotide/oligosaccharide-binding, domain 3
    pfam09169
    Location:2026 → 2212
    BRCA-2_helical; BRCA2, helical

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    31911844..31928519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005157363.3 → XP_005157420.1  breast cancer type 2 susceptibility protein isoform X1

    See identical proteins and their annotated locations for XP_005157420.1

    UniProtKB/TrEMBL
    A0A8M2B481, F1R8E8
    Conserved Domains (5) summary
    cd04494
    Location:2350 → 2597
    BRCA2DBD_OB2; BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous ...
    pfam00634
    Location:1239 → 1267
    BRCA2; BRCA2 repeat
    pfam09103
    Location:2215 → 2338
    BRCA-2_OB1; BRCA2, oligonucleotide/oligosaccharide-binding, domain 1
    pfam09104
    Location:2600 → 2733
    BRCA-2_OB3; BRCA2, oligonucleotide/oligosaccharide-binding, domain 3
    pfam09169
    Location:2026 → 2212
    BRCA-2_helical; BRCA2, helical
Nucleotide Protein
Heading Accession and Version

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