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Syne1 spectrin repeat containing, nuclear envelope 1 [ Mus musculus (house mouse) ]

Gene ID: 64009, updated on 2-Nov-2024

Summary

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Official Symbol
Syne1provided by MGI
Official Full Name
spectrin repeat containing, nuclear envelope 1provided by MGI
Primary source
MGI:MGI:1927152
See related
Ensembl:ENSMUSG00000096054 AllianceGenome:MGI:1927152
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
8B; CPG2; KASH1; Myne1; myne-1; mKIAA1756; A330049M09Rik; C130039F11Rik
Summary
Enables actin filament binding activity and protein homodimerization activity. Involved in centrosome localization and regulation of cilium assembly. Acts upstream of or within nuclear migration. Located in nuclear envelope. Is expressed in several structures, including alimentary system; ear; genitourinary system; musculoskeletal system; and nervous system. Used to study Emery-Dreifuss muscular dystrophy. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita (multiple); bipolar disorder; cerebellar ataxia (multiple); and muscular dystrophy (multiple). Orthologous to human SYNE1 (spectrin repeat containing nuclear envelope protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 19.1), frontal lobe adult (RPKM 7.9) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Syne1 in Genome Data Viewer
Location:
10 A1; 10 2.01 cM
Exon count:
152
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (4970192..5501013, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (5020192..5550692, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25622 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:5733988-5734171 Neighboring gene STARR-seq mESC enhancer starr_25621 Neighboring gene STARR-seq mESC enhancer starr_25620 Neighboring gene glutathione S-transferase, pi 1 pseudogene Neighboring gene estrogen receptor 1 (alpha) Neighboring gene STARR-seq mESC enhancer starr_25619 Neighboring gene STARR-seq mESC enhancer starr_25618 Neighboring gene STARR-seq mESC enhancer starr_25616 Neighboring gene STARR-seq mESC enhancer starr_25614 Neighboring gene STARR-seq mESC enhancer starr_25613 Neighboring gene STARR-seq mESC enhancer starr_25612 Neighboring gene STARR-positive B cell enhancer ABC_E2314 Neighboring gene STARR-seq mESC enhancer starr_25609 Neighboring gene STARR-seq mESC enhancer starr_25607 Neighboring gene STARR-seq mESC enhancer starr_25605 Neighboring gene STARR-seq mESC enhancer starr_25604 Neighboring gene predicted gene, 51757 Neighboring gene predicted gene, 23573 Neighboring gene STARR-seq mESC enhancer starr_25603 Neighboring gene predicted gene, 40594 Neighboring gene STARR-seq mESC enhancer starr_25602 Neighboring gene STARR-seq mESC enhancer starr_25600 Neighboring gene predicted gene, 51758 Neighboring gene STARR-positive B cell enhancer mm9_chr10:4746082-4746383 Neighboring gene myc target 1 Neighboring gene vasoactive intestinal polypeptide

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Increased expression of Syne1/nesprin-1 facilitates nuclear envelope structure changes in embryonic stem cell differentiation. Smith ER, et al. Dev Dyn, 2011 Oct. PMID 21932307, Free PMC Article
  2. A variant of Nesprin1 giant devoid of KASH domain underlies the molecular etiology of autosomal recessive cerebellar ataxia type I. Razafsky D, et al. Neurobiol Dis, 2015 Jun. PMID 25843669, Free PMC Article
  3. Nuclear alignment in myotubes requires centrosome proteins recruited by nesprin-1. Espigat-Georger A, et al. J Cell Sci, 2016 Nov 15. PMID 27802164
  4. [Effect of nesprin-1 in the differentiation of mouse embryonic stem cells into cardiomyocytes]. Gao F, et al. Sichuan Da Xue Xue Bao Yi Xue Ban, 2012 Mar. PMID 22650022
  5. The KASH-containing isoform of Nesprin1 giant associates with ciliary rootlets of ependymal cells. Potter C, et al. Neurobiol Dis, 2018 Jul. PMID 29630990, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In agreement with the association of Nesprin1alpha with photoreceptor ciliary rootlets and the functional interaction between rootletin and Nesprin1 in fibroblasts, the authors demonstrate that multiple isoforms of Nesprin1 are integral components of ciliary rootlets of multiciliated ependymal and tracheal cells.
    Title: Multiple Isoforms of Nesprin1 Are Integral Components of Ciliary Rootlets.
  2. Nesprin-1alpha recruits Akap450 to the nuclear envelope (NE)independently of kinesin and that Akap450, but not other centrosomal proteins, is required for microtubule nucleation from the NE.
    Title: Nesprin-1α-Dependent Microtubule Nucleation from the Nuclear Envelope via Akap450 Is Necessary for Nuclear Positioning in Muscle Cells.
  3. Nesprin 1alpha2, which lacks actin-binding domains, was crucial for postnatal viability, nuclear positioning, and skeletal muscle function.
    Title: Nesprin 1α2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle.
  4. the positioning of nuclei requires PCM-1, a protein of the centrosome that relocalizes to the nuclear envelope at the onset of differentiation in a manner that is dependent on the presence of nesprin-1.
    Title: Nuclear alignment in myotubes requires centrosome proteins recruited by nesprin-1.
  5. Results suggest that the loss of function of KASH-LESS variant of Nesprin1 giant resulting from Nesprin1 nonsense mutations underlies the molecular etiology of autosomal recessive cerebellar ataxia Type I.
    Title: A variant of Nesprin1 giant devoid of KASH domain underlies the molecular etiology of autosomal recessive cerebellar ataxia type I.
  6. Disruption of both nesprin 1 and desmin results in decreased lifespan, body weight and muscle strength.
    Title: Disruption of both nesprin 1 and desmin results in nuclear anchorage defects and fibrosis in skeletal muscle.
  7. nesprin-dependent recruitment of kinesin-1 to the nuclear envelope through the interaction of a conserved LEWD motif with kinesin light chain might be a general mechanism for cell-type-specific nuclear positioning during development.
    Title: Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.
  8. a role for Nesprin-1 in the DNA damage response pathway
    Title: Nesprin-1 role in DNA damage response.
  9. Loss of Nesprin 1 or 2, or both, led to impairment of gene expression changes in response to biomechanical stimuli. These data suggest a model whereby biomechanical signals are communicated from proteins of the outer nuclear membrane
    Title: Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.
  10. Nesprin-1 played important roles in mouse embryonic stem cell differentiation into cardiomyocytes.
    Title: [Effect of nesprin-1 in the differentiation of mouse embryonic stem cells into cardiomyocytes].
Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1756, MGC62825

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables actin filament binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lamin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in centrosome localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear matrix anchoring at nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nuclear migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in P-body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of meiotic nuclear membrane microtubule tethering complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope TAS
Traceable Author Statement
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in sarcomere ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
nesprin-1
Names
KASH domain-containing protein 1
enaptin
enaptin165
myocyte nuclear envelope protein 1
nesprin 1
nuclear envelope spectrin repeat protein 1
synaptic nuclear envelope 1
synaptic nuclear envelope protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079686.2 → NP_001073154.1  nesprin-1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and lacks a large portion of the 5' coding region found in variant 4. These differences result in the use of an alternate start codon, compared to variant 4. The encoded isoform (3) is shorter and has distinct N-terminus compared to isoform 4.
    Source sequence(s)
    AC156393, AC161829, AC162381
    UniProtKB/Swiss-Prot
    Q6ZWR6
    UniProtKB/TrEMBL
    Q6PI72
    Conserved Domains (4) summary
    COG4942
    Location:292 → 549
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:2216 → 2426
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam10541
    Location:2953 → 3009
    KASH; Nuclear envelope localization domain
    cl02488
    Location:1377 → 1565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  2. NM_001347711.2 → NP_001334640.1  nesprin-1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4).
    Source sequence(s)
    AC156392, AC156393, AC159748, AC161829, AC162381, AC162385
    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

  3. NM_001347732.2 → NP_001334661.1  nesprin-1 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and has multiple difference in the coding region compared variant 4. These differences result in the use of an alternate start codon, compared to variant 4. The encoded isoform (5) has a unique N-terminus and is shorter than isoform 4.
    Source sequence(s)
    AC156392, AC156393, AC157020, AC159748, AC161829, AC162381, AC162385
    Consensus CDS
    CCDS87951.1
    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
    UniProtKB/TrEMBL
    A0A1L1STC6
    Related
    ENSMUSP00000150262.2, ENSMUST00000215295.2

  4. NM_022027.3 → NP_071310.2  nesprin-1 isoform 2

    See identical proteins and their annotated locations for NP_071310.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks a large portion of the 5' coding region compared to variant 4. These differences result in the use of an alternate start codon, compared to variant 4. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 4.
    Source sequence(s)
    AC156393, AC161829
    Consensus CDS
    CCDS56679.1
    UniProtKB/TrEMBL
    Q0VGB8, Q7TQH5
    Related
    ENSMUSP00000093587.4, ENSMUST00000095899.5
    Conserved Domains (2) summary
    cd00176
    Location:155 → 365
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam10541
    Location:892 → 948
    KASH; Nuclear envelope localization domain

  5. NM_153399.3 → NP_700448.2  nesprin-1 isoform 1

    See identical proteins and their annotated locations for NP_700448.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in both UTRs and has multiple differences in the coding region compared to variant 4. These differences result in the use of an alternate start codon, compared to variant 4. The encoded isoform (1) is shorter and has distinct N- and C-termini compared to isoform 4.
    Source sequence(s)
    AC157020, AC159748, AC162385
    Consensus CDS
    CCDS56680.1
    UniProtKB/TrEMBL
    Q6ZWR1, Q6ZWR5, Q80T95
    Related
    ENSMUSP00000039440.6, ENSMUST00000041639.7
    Conserved Domains (3) summary
    cd00014
    Location:28 → 141
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00307
    Location:187 → 285
    CH; Calponin homology (CH) domain
    cl02488
    Location:842 → 1006
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    4970192..5501013 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155919.1 → XP_036011812.1  nesprin-1 isoform X9

    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
    Conserved Domains (9) summary
    COG0419
    Location:3792 → 4354
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:2856 → 3639
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:6055 → 6313
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:7980 → 8190
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4944 → 5779
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:8740 → 8796
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 136
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:175 → 283
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:4326 → 4542
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  2. XM_036155938.1 → XP_036011831.1  nesprin-1 isoform X29

    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
    Conserved Domains (9) summary
    COG0419
    Location:3808 → 4370
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:2872 → 3655
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:6067 → 6324
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:7991 → 8201
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4960 → 5795
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:8728 → 8784
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 136
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:175 → 283
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:4342 → 4558
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  3. XM_036155916.1 → XP_036011809.1  nesprin-1 isoform X5

    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
    Conserved Domains (9) summary
    COG0419
    Location:3808 → 4370
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:2872 → 3655
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:6071 → 6329
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:7996 → 8206
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4960 → 5795
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:8756 → 8812
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 136
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:175 → 283
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:4342 → 4558
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  4. XM_036155917.1 → XP_036011810.1  nesprin-1 isoform X6

    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
    Conserved Domains (9) summary
    COG0419
    Location:3799 → 4361
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:2863 → 3646
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:6062 → 6320
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:7987 → 8197
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4951 → 5786
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:8747 → 8803
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:4333 → 4549
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  5. XM_036155924.1 → XP_036011817.1  nesprin-1 isoform X16

    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
    Conserved Domains (8) summary
    COG0419
    Location:3763 → 4325
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG4942
    Location:6026 → 6284
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:7951 → 8161
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4915 → 5750
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:8711 → 8767
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:4297 → 4513
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  6. XM_036155923.1 → XP_036011816.1  nesprin-1 isoform X15

    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
    Conserved Domains (9) summary
    COG0419
    Location:3815 → 4377
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:2879 → 3662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:6027 → 6285
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:7952 → 8162
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4967 → 5802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:8712 → 8768
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:4349 → 4565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  7. XM_036155921.1 → XP_036011814.1  nesprin-1 isoform X13

    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
    Conserved Domains (9) summary
    TIGR00618
    Location:5631 → 6278
    sbcc; exonuclease SbcC
    COG0419
    Location:3815 → 4377
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:2879 → 3662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:7956 → 8166
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4967 → 5802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:8716 → 8772
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:4349 → 4565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  8. XM_036155920.1 → XP_036011813.1  nesprin-1 isoform X11

    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
    Conserved Domains (9) summary
    COG0419
    Location:3815 → 4377
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:2879 → 3662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:6074 → 6331
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:7998 → 8208
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4967 → 5802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:8735 → 8791
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:4349 → 4565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  9. XM_036155915.1 → XP_036011808.1  nesprin-1 isoform X4

    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
    Conserved Domains (9) summary
    COG0419
    Location:3815 → 4377
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:2879 → 3662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:6074 → 6331
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:7998 → 8208
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4967 → 5802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:8758 → 8814
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:4349 → 4565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  10. XM_036155914.1 → XP_036011807.1  nesprin-1 isoform X3

    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
    Conserved Domains (9) summary
    COG0419
    Location:3815 → 4377
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:2879 → 3662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:6074 → 6332
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:7999 → 8209
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4967 → 5802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:8759 → 8815
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:4349 → 4565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  11. XM_036155932.1 → XP_036011825.1  nesprin-1 isoform X23

    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
    Conserved Domains (8) summary
    COG1196
    Location:2879 → 3662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:6078 → 6335
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:8002 → 8212
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4967 → 5802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:4143 → 4439
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:4349 → 4565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  12. XM_036155913.1 → XP_036011806.1  nesprin-1 isoform X2

    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
    Conserved Domains (9) summary
    COG0419
    Location:3815 → 4377
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:2879 → 3662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:6078 → 6335
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:8002 → 8212
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4967 → 5802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:8762 → 8818
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:4349 → 4565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  13. XM_036155931.1 → XP_036011824.1  nesprin-1 isoform X22

    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
    Conserved Domains (8) summary
    COG1196
    Location:2879 → 3662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:6078 → 6336
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:8003 → 8213
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4967 → 5802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:4143 → 4439
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:4349 → 4565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  14. XM_036155925.1 → XP_036011818.1  nesprin-1 isoform X17

    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
    Conserved Domains (9) summary
    COG0419
    Location:3815 → 4377
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:2879 → 3662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:6078 → 6336
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:8003 → 8213
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4967 → 5802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:8692 → 8748
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:4349 → 4565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  15. XM_036155922.1 → XP_036011815.1  nesprin-1 isoform X14

    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
    Conserved Domains (9) summary
    COG0419
    Location:3815 → 4377
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:2879 → 3662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:6078 → 6336
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:8003 → 8213
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4967 → 5802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:8715 → 8771
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:4349 → 4565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  16. XM_036155927.1 → XP_036011820.1  nesprin-1 isoform X19

    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
    Conserved Domains (8) summary
    COG1196
    Location:2879 → 3662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:6078 → 6336
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:8003 → 8213
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4967 → 5802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:4143 → 4439
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:4349 → 4565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  17. XM_036155918.1 → XP_036011811.1  nesprin-1 isoform X8

    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
    Conserved Domains (9) summary
    COG0419
    Location:3815 → 4377
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:2879 → 3662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:6078 → 6336
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:8003 → 8213
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4967 → 5802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:8740 → 8796
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:4349 → 4565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  18. XM_036155926.1 → XP_036011819.1  nesprin-1 isoform X18

    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
    Conserved Domains (8) summary
    COG1196
    Location:2879 → 3662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:6078 → 6336
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:8003 → 8213
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4967 → 5802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:4143 → 4439
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:4349 → 4565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  19. XM_036155912.1 → XP_036011805.1  nesprin-1 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
    Conserved Domains (9) summary
    COG0419
    Location:3815 → 4377
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:2879 → 3662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:6078 → 6336
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:8003 → 8213
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4967 → 5802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10541
    Location:8763 → 8819
    KASH; Nuclear envelope localization domain
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:4349 → 4565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  20. XM_036155928.1 → XP_036011821.1  nesprin-1 isoform X20

    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
    Conserved Domains (8) summary
    COG1196
    Location:2747 → 3530
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:5946 → 6204
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:7871 → 8081
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4835 → 5670
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:4011 → 4307
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam10541
    Location:8631 → 8687
    KASH; Nuclear envelope localization domain
    cd21243
    Location:50 → 158
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:4217 → 4433
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  21. XM_036155929.1 → XP_036011822.1  nesprin-1 isoform X21

    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
    Conserved Domains (8) summary
    COG1196
    Location:2731 → 3514
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:5930 → 6188
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:7855 → 8065
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4819 → 5654
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:3995 → 4291
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam10541
    Location:8615 → 8671
    KASH; Nuclear envelope localization domain
    cd21243
    Location:50 → 158
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:4201 → 4417
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  22. XM_011243086.3 → XP_011241388.1  nesprin-1 isoform X7

    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
    Conserved Domains (10) summary
    TIGR03785
    Location:1172 → 1244
    marine_sort_HK; proteobacterial dedicated sortase system histidine kinase
    COG0419
    Location:3799 → 4361
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:2863 → 3646
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:6062 → 6320
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:15 → 267
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:7987 → 8197
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4951 → 5786
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:5922 → 6099
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cl02488
    Location:4333 → 4549
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam10541
    Location:8747 → 8803
    KASH; Nuclear envelope localization domain

  23. XM_030245204.2 → XP_030101064.1  nesprin-1 isoform X12

    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
    Conserved Domains (10) summary
    TIGR03785
    Location:1156 → 1228
    marine_sort_HK; proteobacterial dedicated sortase system histidine kinase
    COG0419
    Location:3783 → 4345
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:2847 → 3630
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:6046 → 6304
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:15 → 267
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:7971 → 8181
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4935 → 5770
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:5906 → 6083
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cl02488
    Location:4317 → 4533
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam10541
    Location:8731 → 8787
    KASH; Nuclear envelope localization domain

  24. XM_036155930.1 → XP_036011823.1  nesprin-1 isoform X21

    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
    Conserved Domains (8) summary
    COG1196
    Location:2731 → 3514
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:5930 → 6188
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:7855 → 8065
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4819 → 5654
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:3995 → 4291
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam10541
    Location:8615 → 8671
    KASH; Nuclear envelope localization domain
    cd21243
    Location:50 → 158
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:4201 → 4417
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  25. XM_017314044.3 → XP_017169533.1  nesprin-1 isoform X10

    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
    Conserved Domains (10) summary
    TIGR03785
    Location:1163 → 1235
    marine_sort_HK; proteobacterial dedicated sortase system histidine kinase
    COG0419
    Location:3790 → 4352
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:2854 → 3637
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:6053 → 6311
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:15 → 274
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:7978 → 8188
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4942 → 5777
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:5913 → 6090
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    cl02488
    Location:4324 → 4540
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam10541
    Location:8738 → 8794
    KASH; Nuclear envelope localization domain

  26. XM_036155933.1 → XP_036011826.1  nesprin-1 isoform X24

    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
    Conserved Domains (7) summary
    COG1196
    Location:2397 → 3180
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:5596 → 5854
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:7521 → 7731
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4485 → 5320
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:3661 → 3957
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam10541
    Location:8281 → 8337
    KASH; Nuclear envelope localization domain
    cl02488
    Location:3867 → 4083
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  27. XM_036155934.1 → XP_036011827.1  nesprin-1 isoform X25

    UniProtKB/Swiss-Prot
    Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
    Conserved Domains (7) summary
    COG1196
    Location:2373 → 3156
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:5572 → 5830
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:7497 → 7707
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4461 → 5296
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:3637 → 3933
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam10541
    Location:8257 → 8313
    KASH; Nuclear envelope localization domain
    cl02488
    Location:3843 → 4059
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  28. XM_036155937.1 → XP_036011830.1  nesprin-1 isoform X28

    UniProtKB/TrEMBL
    Q7TQH5
    Conserved Domains (2) summary
    cd00176
    Location:155 → 365
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam10541
    Location:915 → 971
    KASH; Nuclear envelope localization domain

  29. XM_036155935.1 → XP_036011828.1  nesprin-1 isoform X26

    Conserved Domains (7) summary
    COG1196
    Location:2879 → 3662
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4942
    Location:6078 → 6266
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:3821 → 4011
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:4967 → 5802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:4349 → 4565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  30. XM_036155936.1 → XP_036011829.1  nesprin-1 isoform X27

    Conserved Domains (7) summary
    COG0419
    Location:3815 → 4377
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:2879 → 3651
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:3821 → 4036
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:1167 → 2008
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd21241
    Location:24 → 143
    CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
    cd21243
    Location:182 → 290
    CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
    cl02488
    Location:4349 → 4565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZWR6.2 GenPept UniProtKB/Swiss-Prot:Q6ZWR6

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