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hdx highly divergent homeobox [ Danio rerio (zebrafish) ]

Gene ID: 797948, updated on 12-Sep-2024

Summary

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Official Symbol
hdxprovided by ZNC
Official Full Name
highly divergent homeoboxprovided by ZNC
Primary source
ZFIN:ZDB-GENE-140106-165
See related
Ensembl:ENSDARG00000079382 AllianceGenome:ZFIN:ZDB-GENE-140106-165
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable DNA binding activity. Predicted to be located in nucleus. Orthologous to human HDX (highly divergent homeobox). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See hdx in Genome Data Viewer
Location:
chromosome: 14
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (6209808..6229020, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (5902976..5922186, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene BSCL2 lipid droplet biogenesis associated, seipin, like Neighboring gene si:ch73-22a13.3 Neighboring gene SMU1 DNA replication regulator and spliceosomal factor a Neighboring gene elongator acetyltransferase complex subunit 1 Neighboring gene TBC1 domain family, member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Pou3f transcription factor expression during embryonic development highlights distinct pou3f3 and pou3f4 localization in the Xenopus laevis kidney. Cosse-Etchepare C, et al. Int J Dev Biol, 2018. PMID 29877572
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
highly divergent homeobox
Names
zmp:0000001205

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001202494.1 → NP_001189423.1  highly divergent homeobox

    See identical proteins and their annotated locations for NP_001189423.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC124177, EB968358, EH606083, FP103005
    UniProtKB/TrEMBL
    A0A8M1P2K8, E7F5L7
    Related
    ENSDARP00000130885.1, ENSDART00000172665.2
    Conserved Domains (1) summary
    cl00084
    Location:16 → 70
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  2. NM_001202495.1 → NP_001189424.1  highly divergent homeobox

    See identical proteins and their annotated locations for NP_001189424.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    EB968358, EH606083, FP103005, FP103010
    UniProtKB/TrEMBL
    A0A8M1P2K8, E7F5L7
    Related
    ENSDARP00000102393.3, ENSDART00000111681.4
    Conserved Domains (1) summary
    cl00084
    Location:16 → 70
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    6209808..6229020 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021481070.2 → XP_021336745.1  highly divergent homeobox isoform X2

    UniProtKB/TrEMBL
    A0A8M9QP85
    Conserved Domains (1) summary
    cl00084
    Location:16 → 70
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  2. XM_068213257.1 → XP_068069358.1  highly divergent homeobox isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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