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abpC actin binding protein [ Dictyostelium discoideum AX4 ]

Gene ID: 8617642, updated on 18-Sep-2024

Summary

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Official Symbol
abpC
Official Full Name
actin binding protein
Primary source
dictyBase:DDB_G0269100
Locus tag
DDB_G0269100
See related
AmoebaDB:DDB_G0269100; VEuPathDB:DDB_G0269100
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Dictyostelium discoideum AX4 (strain: AX4)
Lineage
Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales; Dictyosteliaceae; Dictyostelium
Old locus tag
DDBDRAFT_0190932; DDBDRAFT_0201554; DDB_0190932; DDB_0201554
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Genomic context

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Location:
chromosome: 1
Exon count:
2
Sequence:
Chromosome: 1; NC_007087.3 (4554019..4556699, complement)

Chromosome 1 - NC_007087.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007087.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic deletion of ABP-120 alters the three-dimensional organization of actin filaments in Dictyostelium pseudopods. Cox D, et al. J Cell Biol, 1995 Mar. PMID 7876307, Free PMC Article
  2. Balanced cortical stiffness is important for efficient migration of Dictyostelium cells in confined environments. Roth H, et al. Biochem Biophys Res Commun, 2015 Nov 27. PMID 26482849
  3. Targeted disruption of the ABP-120 gene leads to cells with altered motility. Cox D, et al. J Cell Biol, 1992 Feb. PMID 1310321, Free PMC Article
  4. Use of a fusion protein between GFP and an actin-binding domain to visualize transient filamentous-actin structures. Pang KM, et al. Curr Biol, 1998 Mar 26. PMID 9545201
  5. Re-expression of ABP-120 rescues cytoskeletal, motility, and phagocytosis defects of ABP-120- Dictyostelium mutants. Cox D, et al. Mol Biol Cell, 1996 May. PMID 8744952, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by dictyBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables mitogen-activated protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase B binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within actin crosslink formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell motility IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within chemotaxis to cAMP IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hyperosmotic response IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within hyperosmotic response IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phagocytosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within phagocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phototaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pseudopodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of pseudopodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to cAMP IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within sorocarp development HMP PubMed 
acts_upstream_of_or_within sorocarp development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within thermotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with actin filament IDA
Inferred from Direct Assay
more info
 PubMed 
located_in anterior cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell leading edge IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular matrix HDA PubMed 
located_in intracellular non-membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in lateral cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in macropinocytic cup IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in phagocytic cup IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in posterior cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pseudopodium IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
actin binding protein
Names
gelation factor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007087.3 Reference assembly

    Range
    4554019..4556699 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_641577.1 → XP_646669.1  gelation factor [Dictyostelium discoideum AX4]

    See identical proteins and their annotated locations for XP_646669.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P13466, Q55C12
    Conserved Domains (3) summary
    smart00557
    Location:250 → 349
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00014
    Location:13 → 117
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00630
    Location:248 → 342
    Filamin; Filamin/ABP280 repeat
Nucleotide Protein
Heading Accession and Version

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