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CD36 CD36 molecule (CD36 blood group) [ Homo sapiens (human) ]

Gene ID: 948, updated on 4-Jan-2025

Summary

Official Symbol
CD36provided by HGNC
Official Full Name
CD36 molecule (CD36 blood group)provided by HGNC
Primary source
HGNC:HGNC:1663
See related
Ensembl:ENSG00000135218 MIM:173510; AllianceGenome:HGNC:1663
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAT; GP4; GP3B; GPIV; CHDS7; PASIV; SCARB3; BDPLT10
Summary
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]
Expression
Biased expression in fat (RPKM 547.7), heart (RPKM 79.1) and 4 other tissues See more
Orthologs
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Genomic context

See CD36 in Genome Data Viewer
Location:
7q21.11
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (80602207..80679274)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (81853488..81930588)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (80231523..80308590)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986812 Neighboring gene uncharacterized LOC124901685 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:80157849-80158348 Neighboring gene G protein subunit alpha transducin 3 Neighboring gene NANOG hESC enhancer GRCh37_chr7:80162485-80162986 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:80163190-80164389 Neighboring gene Sharpr-MPRA regulatory region 7331 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_100118 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:80393335-80394071 Neighboring gene uncharacterized LOC124901686 Neighboring gene semaphorin 3C Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:80512613-80513812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26210 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18334 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:80627598-80627796 Neighboring gene NANOG hESC enhancer GRCh37_chr7:80642207-80642710 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:80703763-80704962 Neighboring gene HNF1 motif-containing MPRA enhancer 195 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:80809759-80810307 Neighboring gene voltage dependent anion channel 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Coronary heart disease, susceptibility to, 7
MedGen: C1970441 OMIM: 610938 GeneReviews: Not available
Compare labs
Malaria, susceptibility to
MedGen: C1970028 OMIM: 611162 GeneReviews: Not available
Compare labs
Platelet-type bleeding disorder 10
MedGen: C1842090 OMIM: 608404 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans.
EBI GWAS Catalog
Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: the HyperGEN Study.
EBI GWAS Catalog
Genome-wide association study indicates variants associated with insulin signaling and inflammation mediate lipoprotein responses to fenofibrate.
EBI GWAS Catalog
Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env CD36 co-localizes with HIV-1 Env in the cellular virus-containing compartments of macrophages PubMed
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of CD36 molecule (CD36; thrombospondin receptor) in peptide-treated PBMCs PubMed
Nef nef HIV-1 myristoylated Nef-induced TNF-alpha release leads to downregulation of CD36 expression by myristoylated Nef in monocyte-derived macrophages PubMed
nef HIV-1 myristoylated Nef downregulates CD36 expression in monocytes from PBMCs and monocyte-derived macrophages differentiated by cytokines. Nef-dependent downregulation of CD36 involves mRNA transcriptional inhibition PubMed
Pr55(Gag) gag CD36 co-localizes with HIV-1 Gag in the cellular virus-containing compartments and is required for efficient HIV-1 release by primary macrophages PubMed
capsid gag CD36 induces release of p24 in primary macrophages. Knockdown of CD36 by siRNA restricts the activity of CD36 PubMed
matrix gag Treatment of human PBMCs with HIV-1 MA upregulates the expression of MCP-1, ICAM-1, CD40, CD86 and CD36 and downregulates the expression of nuclear receptors FXR and PPARgamma PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Items 1 - 25 of 27
Function Evidence Code Pubs
enables Toll-like receptor binding PubMed 
enables amyloid-beta binding PubMed 
enables amyloid-beta binding PubMed 
enables amyloid-beta binding PubMed 
enables cargo receptor activity PubMed 
enables high-density lipoprotein particle binding  
enables lipid binding PubMed 
enables lipoprotein particle binding PubMed 
enables lipoteichoic acid immune receptor activity  
enables long-chain fatty acid transmembrane transporter activity PubMed 
enables long-chain fatty acid transmembrane transporter activity  
enables low-density lipoprotein particle binding  
enables low-density lipoprotein particle binding PubMed 
enables low-density lipoprotein particle receptor activity  
enables low-density lipoprotein particle receptor activity PubMed 
enables low-density lipoprotein particle receptor activity PubMed 
enables oleate transmembrane transporter activity PubMed 
enables oxidised low-density lipoprotein particle receptor activity PubMed 
enables protein binding PubMed 
enables protein-containing complex binding PubMed 
enables scavenger receptor activity  
enables scavenger receptor activity PubMed 
enables scavenger receptor activity PubMed 
enables short-chain fatty acid transmembrane transporter activity PubMed 
enables thrombospondin receptor activity PubMed 
enables thrombospondin receptor activity  
enables transforming growth factor beta binding  
Items 1 - 25 of 27
Items 1 - 25 of 84
Process Evidence Code Pubs
involved_in MAPK cascade  
involved_in amyloid fibril formation  
involved_in amyloid-beta clearance by cellular catabolic process  
involved_in amyloid-beta clearance by cellular catabolic process PubMed 
involved_in apoptotic cell clearance  
involved_in blood coagulation PubMed 
involved_in cGMP-mediated signaling PubMed 
involved_in cell adhesion  
involved_in cell surface receptor signaling pathway  
involved_in cellular response to amyloid-beta PubMed 
involved_in cellular response to diacyl bacterial lipopeptide PubMed 
involved_in cellular response to diacyl bacterial lipopeptide  
involved_in cellular response to hydroperoxide  
involved_in cellular response to lipopolysaccharide  
involved_in cellular response to lipoteichoic acid  
involved_in cellular response to low-density lipoprotein particle stimulus  
involved_in cellular response to oxidised low-density lipoprotein particle stimulus PubMed 
involved_in cholesterol import  
involved_in cholesterol transport PubMed 
involved_in defense response to Gram-positive bacterium  
involved_in energy homeostasis  
involved_in fatty acid metabolic process PubMed 
involved_in fatty acid transport PubMed 
involved_in intestinal absorption  
involved_in intestinal cholesterol absorption  
involved_in lipid metabolic process PubMed 
involved_in lipid storage  
involved_in lipid storage PubMed 
involved_in lipid transport across blood-brain barrier PubMed 
involved_in lipoprotein transport  
involved_in lipoprotein transport PubMed 
involved_in lipoprotein transport PubMed 
involved_in long-chain fatty acid import across plasma membrane PubMed 
involved_in long-chain fatty acid import into cell  
involved_in long-chain fatty acid import into cell PubMed 
involved_in long-chain fatty acid transport PubMed 
involved_in low-density lipoprotein particle clearance  
involved_in low-density lipoprotein particle clearance PubMed 
involved_in low-density lipoprotein particle mediated signaling  
involved_in negative regulation of angiogenesis PubMed 
involved_in negative regulation of gene expression  
involved_in negative regulation of protein import into nucleus  
involved_in negative regulation of transcription by RNA polymerase II  
involved_in nitric oxide-cGMP-mediated signaling PubMed 
involved_in oxidised low-density lipoprotein particle clearance PubMed 
involved_in phagocytosis, engulfment PubMed 
involved_in phagocytosis, recognition  
involved_in plasma lipoprotein particle clearance PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of NLRP3 inflammasome complex assembly  
involved_in positive regulation of blood coagulation  
involved_in positive regulation of blood microparticle formation  
involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
involved_in positive regulation of cell-matrix adhesion PubMed 
involved_in positive regulation of cholesterol storage  
involved_in positive regulation of cold-induced thermogenesis PubMed 
involved_in positive regulation of cytosolic calcium ion concentration  
involved_in positive regulation of gene expression  
involved_in positive regulation of interleukin-1 beta production  
involved_in positive regulation of interleukin-12 production  
involved_in positive regulation of interleukin-6 production  
involved_in positive regulation of macrophage cytokine production  
involved_in positive regulation of macrophage derived foam cell differentiation PubMed 
involved_in positive regulation of nitric oxide biosynthetic process  
involved_in positive regulation of peptidyl-tyrosine phosphorylation  
involved_in positive regulation of phagocytosis, engulfment  
involved_in positive regulation of reactive oxygen species biosynthetic process  
involved_in positive regulation of tumor necrosis factor production  
involved_in production of molecular mediator involved in inflammatory response PubMed 
involved_in receptor internalization  
involved_in receptor-mediated endocytosis  
involved_in receptor-mediated endocytosis PubMed 
involved_in regulation of action potential  
involved_in regulation of lipopolysaccharide-mediated signaling pathway PubMed 
involved_in regulation of protein-containing complex assembly PubMed 
involved_in regulation of removal of superoxide radicals  
involved_in regulation of toll-like receptor signaling pathway PubMed 
involved_in response to fatty acid  
involved_in response to linoleic acid  
involved_in response to lipid  
involved_in response to stilbenoid  
involved_in sensory perception of taste  
involved_in short-chain fatty acid transport PubMed 
involved_in triglyceride transport  
Items 1 - 25 of 84
Component Evidence Code Pubs
located_in Golgi apparatus PubMed 
located_in apical plasma membrane  
located_in brush border membrane  
is_active_in caveola  
located_in cell periphery PubMed 
is_active_in cell surface  
located_in cell surface PubMed 
located_in cell surface  
located_in cell surface PubMed 
located_in endocytic vesicle membrane  
located_in external side of plasma membrane  
located_in extracellular space PubMed 
located_in membrane PubMed 
located_in membrane raft PubMed 
located_in phagocytic vesicle  
located_in plasma membrane PubMed 
located_in plasma membrane PubMed 
located_in platelet alpha granule membrane  
part_of receptor complex PubMed 
located_in specific granule membrane  

General protein information

Preferred Names
platelet glycoprotein 4
Names
CD36 antigen (collagen type I receptor, thrombospondin receptor)
CD36 molecule (thrombospondin receptor)
GPIIIB
PAS IV
PAS-4 protein
cluster determinant 36
fatty acid translocase
glycoprotein IIIb
leukocyte differentiation antigen CD36
platelet glycoprotein IV
scavenger receptor class B, member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008192.1 RefSeqGene

    Range
    41455..82087
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000072.3NP_000063.2  platelet glycoprotein 4 isoform 1

    See identical proteins and their annotated locations for NP_000063.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (1). Variants 1-5 and 10-13 all encode the same isoform (1).
    Source sequence(s)
    AC124834, DA857400, DC338512, L06850, M98398
    Consensus CDS
    CCDS34673.1
    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
    Related
    ENSP00000378268.3, ENST00000394788.7
    Conserved Domains (1) summary
    pfam01130
    Location:14463
    CD36; CD36 family
  2. NM_001001547.3NP_001001547.1  platelet glycoprotein 4 isoform 1

    See identical proteins and their annotated locations for NP_001001547.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon, compared to variant 3. Variants 1-5 and 10-13 all encode the same isoform (1).
    Source sequence(s)
    BP258762, BP259746, L06850, M98398
    Consensus CDS
    CCDS34673.1
    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
    Related
    ENSP00000308165.7, ENST00000309881.11
    Conserved Domains (1) summary
    pfam01130
    Location:14463
    CD36; CD36 family
  3. NM_001001548.3NP_001001548.1  platelet glycoprotein 4 isoform 1

    See identical proteins and their annotated locations for NP_001001548.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has an alternate 3' UTR, compared to variant 3. Variants 1-5 and 10-13 all encode the same isoform (1).
    Source sequence(s)
    AC073850, AC124834
    Consensus CDS
    CCDS34673.1
    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
    Related
    ENSP00000415743.2, ENST00000447544.7
    Conserved Domains (1) summary
    pfam01130
    Location:14463
    CD36; CD36 family
  4. NM_001127443.2NP_001120915.1  platelet glycoprotein 4 isoform 1

    See identical proteins and their annotated locations for NP_001120915.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 3. Variants 1-5 and 10-13 all encode the same isoform (1).
    Source sequence(s)
    AC073850, DA566475, L06850, M98398
    Consensus CDS
    CCDS34673.1
    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
    Related
    ENSP00000411411.1, ENST00000432207.5
    Conserved Domains (1) summary
    pfam01130
    Location:14463
    CD36; CD36 family
  5. NM_001127444.2NP_001120916.1  platelet glycoprotein 4 isoform 1

    See identical proteins and their annotated locations for NP_001120916.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 3. Variants 1-5 and 10-13 all encode the same isoform (1).
    Source sequence(s)
    AL596924, L06850, M98398
    Consensus CDS
    CCDS34673.1
    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
    Related
    ENSP00000392298.2, ENST00000419819.2
    Conserved Domains (1) summary
    pfam01130
    Location:14463
    CD36; CD36 family
  6. NM_001289908.1NP_001276837.1  platelet glycoprotein 4 isoform 2

    See identical proteins and their annotated locations for NP_001276837.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks two consecutive exons in the 3' coding region, compared to variant 3. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK300101, HM217026, L06850
    Consensus CDS
    CCDS78249.1
    UniProtKB/TrEMBL
    B3KUB8, D9IX63, D9IX64, D9IX65
    Related
    ENSP00000401863.2, ENST00000433696.6
    Conserved Domains (1) summary
    pfam01130
    Location:16422
    CD36; CD36 family
  7. NM_001289909.1NP_001276838.1  platelet glycoprotein 4 isoform 3

    See identical proteins and their annotated locations for NP_001276838.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an in-frame coding exon, compared to variant 3. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK300101, BC008406, HM217023, L06850
    Consensus CDS
    CCDS78250.1
    UniProtKB/TrEMBL
    B3KUB8, D9IX65
    Related
    ENSP00000439543.1, ENST00000538969.5
    Conserved Domains (1) summary
    pfam01130
    Location:16401
    CD36; CD36 family
  8. NM_001289911.2NP_001276840.1  platelet glycoprotein 4 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) contains an alternate 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate downstream AUG, compared to variant 3. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK300101, AK312920, L06850
    Consensus CDS
    CCDS78251.1
    UniProtKB/TrEMBL
    B7Z6C3, E9PLT1
    Related
    ENSP00000431296.1, ENST00000534394.5
    Conserved Domains (1) summary
    pfam01130
    Location:1385
    CD36; CD36 family
  9. NM_001371074.1NP_001358003.1  platelet glycoprotein 4 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 1-5 and 11-13, encodes isoform 1.
    Source sequence(s)
    AC073182, AC073850
    Consensus CDS
    CCDS34673.1
    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
    Conserved Domains (1) summary
    pfam01130
    Location:14463
    CD36; CD36 family
  10. NM_001371075.1NP_001358004.1  platelet glycoprotein 4 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 1-5, 10, 12, and 13, encodes isoform 1.
    Source sequence(s)
    AC073182, AC073850
    Consensus CDS
    CCDS34673.1
    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
    Conserved Domains (1) summary
    pfam01130
    Location:14463
    CD36; CD36 family
  11. NM_001371077.1NP_001358006.1  platelet glycoprotein 4 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 1-5, 10, 11, and 13, encodes isoform 1.
    Source sequence(s)
    AC073850, AC124834
    Consensus CDS
    CCDS34673.1
    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
    Conserved Domains (1) summary
    pfam01130
    Location:14463
    CD36; CD36 family
  12. NM_001371078.1NP_001358007.1  platelet glycoprotein 4 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 1-5 and 10-12, encodes isoform 1.
    Source sequence(s)
    AC073850, AC124834
    Consensus CDS
    CCDS34673.1
    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
    Related
    ENSP00000399421.1, ENST00000435819.5
    Conserved Domains (1) summary
    pfam01130
    Location:14463
    CD36; CD36 family
  13. NM_001371079.1NP_001358008.1  platelet glycoprotein 4 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC073850, AC124834
    UniProtKB/TrEMBL
    D9IX64
    Conserved Domains (1) summary
    pfam01130
    Location:16429
    CD36; CD36 family
  14. NM_001371080.1NP_001358009.1  platelet glycoprotein 4 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variant 16, encodes isoform 6.
    Source sequence(s)
    AC073182, AC073850
    UniProtKB/TrEMBL
    B7Z6C3
    Conserved Domains (1) summary
    pfam01130
    Location:1308
    CD36; CD36 family
  15. NM_001371081.1NP_001358010.1  platelet glycoprotein 4 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variant 15, encodes isoform 6.
    Source sequence(s)
    AC073182, AC073850
    UniProtKB/TrEMBL
    B7Z6C3
    Conserved Domains (1) summary
    pfam01130
    Location:1308
    CD36; CD36 family

RNA

  1. NR_110501.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks an internal exon in the 3' region, compared to variant 3. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK300101, BC008406, HM217025, L06850
    Related
    ENST00000544133.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    80602207..80679274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447003.2XP_024302771.1  platelet glycoprotein 4 isoform X1

    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
    Conserved Domains (1) summary
    pfam01130
    Location:14463
    CD36; CD36 family
  2. XM_047421046.1XP_047277002.1  platelet glycoprotein 4 isoform X1

    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
  3. XM_047421041.1XP_047276997.1  platelet glycoprotein 4 isoform X1

    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
  4. XM_047421043.1XP_047276999.1  platelet glycoprotein 4 isoform X1

    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
  5. XM_047421042.1XP_047276998.1  platelet glycoprotein 4 isoform X1

    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
  6. XM_047421044.1XP_047277000.1  platelet glycoprotein 4 isoform X1

    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
  7. XM_047421045.1XP_047277001.1  platelet glycoprotein 4 isoform X1

    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
  8. XM_047421049.1XP_047277005.1  platelet glycoprotein 4 isoform X1

    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
  9. XM_047421047.1XP_047277003.1  platelet glycoprotein 4 isoform X1

    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
  10. XM_047421048.1XP_047277004.1  platelet glycoprotein 4 isoform X1

    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
  11. XM_005250715.6XP_005250772.1  platelet glycoprotein 4 isoform X1

    See identical proteins and their annotated locations for XP_005250772.1

    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
    Conserved Domains (1) summary
    pfam01130
    Location:14463
    CD36; CD36 family
  12. XM_024447002.2XP_024302770.1  platelet glycoprotein 4 isoform X1

    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
    Conserved Domains (1) summary
    pfam01130
    Location:14463
    CD36; CD36 family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    81853488..81930588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359367.1XP_054215342.1  platelet glycoprotein 4 isoform X1

    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
  2. XM_054359365.1XP_054215340.1  platelet glycoprotein 4 isoform X1

    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
  3. XM_054359368.1XP_054215343.1  platelet glycoprotein 4 isoform X1

    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
  4. XM_054359360.1XP_054215335.1  platelet glycoprotein 4 isoform X1

    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
  5. XM_054359362.1XP_054215337.1  platelet glycoprotein 4 isoform X1

    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
  6. XM_054359361.1XP_054215336.1  platelet glycoprotein 4 isoform X1

    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
  7. XM_054359364.1XP_054215339.1  platelet glycoprotein 4 isoform X1

    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
  8. XM_054359366.1XP_054215341.1  platelet glycoprotein 4 isoform X1

    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
  9. XM_054359359.1XP_054215334.1  platelet glycoprotein 4 isoform X1

    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
  10. XM_054359363.1XP_054215338.1  platelet glycoprotein 4 isoform X1

    UniProtKB/Swiss-Prot
    D9IX66, D9IX67, D9IX68, D9IX69, P16671, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
    UniProtKB/TrEMBL
    A4D1B1, B3KUB8, D9IX63, D9IX64, D9IX65
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