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    SELPLG selectin P ligand [ Homo sapiens (human) ]

    Gene ID: 6404, updated on 2-Nov-2024

    Summary

    Official Symbol
    SELPLGprovided by HGNC
    Official Full Name
    selectin P ligandprovided by HGNC
    Primary source
    HGNC:HGNC:10722
    See related
    Ensembl:ENSG00000110876 MIM:600738; AllianceGenome:HGNC:10722
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLA; CD162; PSGL1; PSGL-1
    Summary
    This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
    Expression
    Broad expression in spleen (RPKM 29.0), lymph node (RPKM 26.4) and 22 other tissues See more
    Orthologs
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    Genomic context

    See SELPLG in Genome Data Viewer
    Location:
    12q24.11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (108621895..108633894, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (108596492..108608490, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (109015671..109027670, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4828 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6967 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6969 Neighboring gene iron-sulfur cluster assembly enzyme Neighboring gene ReSE screen-validated silencer GRCh37_chr12:108976096-108976273 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:108982554-108983282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:108987423-108988089 Neighboring gene transmembrane protein 119 Neighboring gene Sharpr-MPRA regulatory region 9141 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6971 Neighboring gene uncharacterized LOC105369968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6972 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6973 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4830 Neighboring gene microRNA 4496 Neighboring gene coronin 1C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6974 Neighboring gene RNA, U7 small nuclear 169 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    EBI GWAS Catalog
    Genome-wide association study of conduct disorder symptomatology.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CD3/CD28-activated primary CD4+ T cells downregulates plasma membrane expression of SELPLG (CD162, PSGL1) PubMed
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SELPLG PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Basic sequences in the cytoplasmic domains of PSGL-1, CD43, and CD44 are required for efficient association with HIV-1 Gag in HeLa cells PubMed
    gag The highly basic region (HBR) of HIV-1 MA promotes Gag association with specific UDMs containing PSGL-1, CD43, and CD59 PubMed
    gag HIV-1 Gag multimers associate with a specific subset of uropod-directed microdomains (UDMs) containing PSGL-1, CD43, and CD44 PubMed
    gag HIV-1 Gag co-localizes with both uropod markers PSGL-1 and CD43 on the plasma membrane PubMed
    Vpu vpu HIV-1 Vpu downregulates the cell surface expression of selectin P ligand (SELPLG, CD162) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding PubMed 
    enables signaling receptor binding PubMed 
    enables virus receptor activity  
    Component Evidence Code Pubs
    located_in membrane PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane raft PubMed 
    located_in uropod PubMed 

    General protein information

    Preferred Names
    P-selectin glycoprotein ligand 1
    Names
    cutaneous lymphocyte-associated associated antigen

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206609.2NP_001193538.1  P-selectin glycoprotein ligand 1 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC007569, AC008119, AK298742, BC029782, CA427270, DC339004
      Consensus CDS
      CCDS55881.1
      UniProtKB/TrEMBL
      A0A0C4DFY0
      Related
      ENSP00000228463.6, ENST00000228463.7
      Conserved Domains (1) summary
      PRK10811
      Location:136295
      rne; ribonuclease E; Reviewed
    2. NM_003006.4NP_002997.2  P-selectin glycoprotein ligand 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_002997.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC008119, AK098315, AK225644
      Consensus CDS
      CCDS31895.2
      UniProtKB/Swiss-Prot
      A8K2Y0, B4DQC3, B7Z5C7, J3KMX6, Q12775, Q14242, Q6GTW7, Q8N7J7
      UniProtKB/TrEMBL
      A0A0C4DFY0
      Related
      ENSP00000447752.1, ENST00000550948.2
      Conserved Domains (1) summary
      PRK10811
      Location:120279
      rne; ribonuclease E; Reviewed

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      108621895..108633894 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      108596492..108608490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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