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    PSMB10 proteasome 20S subunit beta 10 [ Homo sapiens (human) ]

    Gene ID: 5699, updated on 2-Nov-2024

    Summary

    Official Symbol
    PSMB10provided by HGNC
    Official Full Name
    proteasome 20S subunit beta 10provided by HGNC
    Primary source
    HGNC:HGNC:9538
    See related
    Ensembl:ENSG00000205220 MIM:176847; AllianceGenome:HGNC:9538
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LMP10; MECL1; IMD121; PRAAS5; beta2i
    Summary
    The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in spleen (RPKM 53.2), lymph node (RPKM 48.6) and 25 other tissues See more
    Orthologs
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    Genomic context

    See PSMB10 in Genome Data Viewer
    Location:
    16q22.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67934506..67936850, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (73730280..73732624, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67968409..67970753, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67918365-67918874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67918875-67919382 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7631 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7632 Neighboring gene neuritin 1 like Neighboring gene protein serine kinase H1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67944133-67944345 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67949619-67950142 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67953295-67953800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67960875-67961376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67962749-67963459 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67964222-67964739 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67964740-67965256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10993 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67973687-67974296 Neighboring gene chymotrypsin like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67976255-67977154 Neighboring gene solute carrier family 12 member 4 Neighboring gene lecithin-cholesterol acyltransferase Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:67992978-67994177 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67998939-67999110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:68000156-68000674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7634 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7635 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:68013726-68014226 Neighboring gene dipeptidase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Proteasome-associated autoinflammatory syndrome 5
    MedGen: C5543027 OMIM: 619175 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
    EBI GWAS Catalog
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates LMP7 and MECL1 catalytic subunits of the proteasome resulting in a more efficient generation and presentation of subdominant MHC-I-binding CTL epitopes of heterologous Ags PubMed
    tat Amino acids Lys51, Arg52, and Asp67 of HIV-1 Tat represent the proteasome binding site of Tat, and Tat amino acids 37-72 are necessary for proteasomal interaction and suppression of 11 S regulator-mediated antigen presentation PubMed
    tat HIV-1 Tat binds to the alpha2, alpha4, alpha6, alpha7, beta1, beta2, beta3, beta5, beta6, beta7, LMP7/beta5i, and MECL1/beta2i subunits of the proteasome 20 S core structure and can inhibit cellular proteasome function PubMed
    tat HIV-1 Tat slightly enhances the activity of the purified 26 S proteasome PubMed
    tat HIV-1 Tat inhibits the peptidase activity of the 20 S proteasome and interferes with the formation of the 20 S proteasome-11 S regulator complex PubMed
    Vif vif HIV-1 Vif binds to the cellular cytidine deaminase APOBEC3G and targets it for degradation through an interaction with the proteasome, thereby inhibiting APOBEC3G mediated restriction of HIV-1 replication PubMed
    capsid gag HIV-1 CA downregulates PA28beta and the beta2i subunit of the immunoproteasome complex in a dendritic cell line (JAWS II), whereas in primary dendritic cells, PA28alpha, beta2i, and beta5i are downregulated by CA PubMed
    integrase gag-pol Proteasomal degradation of HIV-1 integrase in mammalian cells occurs by the N-end rule pathway PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Potential readthrough

    Included gene: CTRL

    Clone Names

    • MGC1665, FLJ00366

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables endopeptidase activity  
    enables protein binding PubMed 
    enables threonine-type endopeptidase activity  
    Component Evidence Code Pubs
    is_active_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    is_active_in nucleus  
    part_of proteasome complex PubMed 
    part_of proteasome core complex  
    part_of proteasome core complex, beta-subunit complex  
    part_of proteasome core complex, beta-subunit complex  
    part_of spermatoproteasome complex  

    General protein information

    Preferred Names
    proteasome subunit beta type-10
    Names
    low molecular mass protein 10
    macropain subunit MECl-1
    multicatalytic endopeptidase complex subunit MECl-1
    proteasome (prosome, macropain) subunit, beta type, 10
    proteasome MECl-1
    proteasome catalytic subunit 2i
    proteasome subunit MECL1
    proteasome subunit beta 10
    proteasome subunit beta 7i
    proteasome subunit beta-2i
    proteasome subunit beta2i
    NP_002792.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002801.4NP_002792.1  proteasome subunit beta type-10

      See identical proteins and their annotated locations for NP_002792.1

      Status: REVIEWED

      Source sequence(s)
      BM981173, BP289065
      Consensus CDS
      CCDS10853.1
      UniProtKB/Swiss-Prot
      B2R5J4, P40306, Q5U098
      UniProtKB/TrEMBL
      Q6IB22
      Related
      ENSP00000351314.4, ENST00000358514.9
      Conserved Domains (2) summary
      cd03763
      Location:40227
      proteasome_beta_type_7; proteasome beta type-7 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
      pfam12465
      Location:232267
      Pr_beta_C; Proteasome beta subunits C terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      67934506..67936850 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      73730280..73732624 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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