Fn1 fibronectin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fn1provided by MGI
Official Full Name: fibronectin 1provided by MGI
Primary source: MGI:MGI:95566
See related: Ensembl:ENSMUSG00000026193 AllianceGenome:MGI:95566
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fn; Fn-1; E330027I09
Summary: Enables peptidase activator activity and receptor ligand activity. Involved in negative regulation of monocyte activation and response to muscle activity. Acts upstream of or within several processes, including calcium-independent cell-matrix adhesion; cell-substrate junction assembly; and positive regulation of axon extension. Located in apical plasma membrane and basement membrane. Is active in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; egg cylinder; embryo mesenchyme; and genitourinary system. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis; membranoproliferative glomerulonephritis; and spondylometaphyseal dysplasia corner fracture type. Orthologous to human FN1 (fibronectin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in placenta adult (RPKM 211.5), liver E18 (RPKM 196.6) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C3; 1 36.05 cM

Exon count:: 46

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (71624632..71692439, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (71585473..71653280, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The extracellular matrix protein fibronectin promotes metanephric kidney development.
Title: The extracellular matrix protein fibronectin promotes metanephric kidney development.
A proteomics approach to isolating neuropilin-dependent alpha5 integrin trafficking pathways: neuropilin 1 and 2 co-traffic alpha5 integrin through endosomal p120RasGAP to promote polarised fibronectin fibrillogenesis in endothelial cells.
Title: A proteomics approach to isolating neuropilin-dependent α5 integrin trafficking pathways: neuropilin 1 and 2 co-traffic α5 integrin through endosomal p120RasGAP to promote polarised fibronectin fibrillogenesis in endothelial cells.
LncRNA ADAMTS9-AS2 regulates periodontal ligament cell migration under mechanical compression via ADAMTS9/fibronectin.
Title: LncRNA ADAMTS9-AS2 regulates periodontal ligament cell migration under mechanical compression via ADAMTS9/fibronectin.
Matrix stiffness controls megakaryocyte adhesion, fibronectin fibrillogenesis, and proplatelet formation through Itgbeta3.
Title: Matrix stiffness controls megakaryocyte adhesion, fibronectin fibrillogenesis, and proplatelet formation through Itgβ3.
Unravelling the role of immune cells and FN1 in the recurrence and therapeutic process of skull base chordoma.
Title: Unravelling the role of immune cells and FN1 in the recurrence and therapeutic process of skull base chordoma.
Nucleation of fibronectin fibril assembly requires binding between heparin and the 13th type III module of fibronectin.
Title: Nucleation of fibronectin fibril assembly requires binding between heparin and the 13th type III module of fibronectin.
Fibronectin-LILRB4/gp49B interaction negatively regulates osteoclastogenesis through inhibition of RANKL-induced TRAF6/TAK1/NF-kB/MAPK signaling.
Title: Fibronectin-LILRB4/gp49B interaction negatively regulates osteoclastogenesis through inhibition of RANKL-induced TRAF6/TAK1/NF-kB/MAPK signaling.
LILRB4/gp49B Co-Localizes with Integrin via Fibronectin at Focal Adhesion Sites on Mast Cells.
Title: LILRB4/gp49B Co-Localizes with Integrin via Fibronectin at Focal Adhesion Sites on Mast Cells.
PDGFRbeta-positive cell-mediated post-stroke remodeling of fibronectin and laminin alpha2 for tissue repair and functional recovery.
Title: PDGFRβ-positive cell-mediated post-stroke remodeling of fibronectin and laminin α2 for tissue repair and functional recovery.
Infiltrating CD8+ T cells and M2 macrophages are retained in tumor matrix tracks enriched in low tension fibronectin fibers.
Title: Infiltrating CD8+ T cells and M2 macrophages are retained in tumor matrix tracks enriched in low tension fibronectin fibers.

Submit: New GeneRIF Correction See all GeneRIFs (132)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Gene trapped (1) 1 citation
Targeted (14) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fn1 (e-PCR), detects polymorphism
- UniSTS:462628

FN1 (e-PCR), detects polymorphism
- UniSTS:264012

NoName (e-PCR)
- UniSTS:234147

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables mercury ion binding	ISO Inferred from Sequence Orthology more info
enables peptidase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protease binding	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables proteoglycan binding	IBA Inferred from Biological aspect of Ancestor more info
enables proteoglycan binding	ISO Inferred from Sequence Orthology more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acute-phase response	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in biological process involved in interaction with symbiont	IEA Inferred from Electronic Annotation more info
involved_in biological process involved in interaction with symbiont	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium-independent cell-matrix adhesion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-matrix adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-substrate junction assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-substrate junction assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mercury ion	ISO Inferred from Sequence Orthology more info
involved_in endodermal cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in endodermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in glial cell migration	ISO Inferred from Sequence Orthology more info
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin activation	IEA Inferred from Electronic Annotation more info
involved_in integrin activation	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of monocyte activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of monocyte activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transforming growth factor beta production	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neural crest cell migration involved in autonomic nervous system development	ISO Inferred from Sequence Orthology more info	PubMed
involved_in peptide cross-linking	IEA Inferred from Electronic Annotation more info
involved_in peptide cross-linking	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of axon extension	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of substrate-dependent cell migration, cell attachment to substrate	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of substrate-dependent cell migration, cell attachment to substrate	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in response to muscle activity	IDA Inferred from Direct Assay more info	PubMed
involved_in substrate adhesion-dependent cell spreading	IEA Inferred from Electronic Annotation more info
involved_in substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-Golgi intermediate compartment	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular matrix	ISO Inferred from Sequence Orthology more info	PubMed
located_in extracellular matrix	TAS Traceable Author Statement more info	PubMed
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of fibrinogen complex	IEA Inferred from Electronic Annotation more info
part_of fibrinogen complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fibronectin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001276408.1 → NP_001263337.1 fibronectin isoform b precursor

See identical proteins and their annotated locations for NP_001263337.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.

Source sequence(s)

AC124821, AK147249, AK147683, CJ098561, CJ099024, CN534124

Consensus CDS

CCDS78612.1

UniProtKB/TrEMBL

A0A087WR50, Q3UGY5

Related

ENSMUSP00000140471.2, ENSMUST00000188894.7

Conserved Domains (5) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:187 → 231

FN1; Fibronectin type 1 domain

cd00061
Location:2293 → 2332

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

pfam00039
Location:232 → 271

fn1; Fibronectin type I domain

pfam00041
Location:1542 → 1622

fn3; Fibronectin type III domain
NM_001276409.1 → NP_001263338.1 fibronectin isoform c precursor

See identical proteins and their annotated locations for NP_001263338.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an in-frame exon and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.

Source sequence(s)

AC124821, AK147315, CJ098561

Consensus CDS

CCDS78611.1

UniProtKB/TrEMBL

Q3UGY5, Q3UHL6

Related

ENSMUSP00000140975.2, ENSMUST00000187938.7

Conserved Domains (5) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:187 → 231

FN1; Fibronectin type 1 domain

cd00061
Location:2268 → 2307

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

pfam00039
Location:232 → 271

fn1; Fibronectin type I domain

pfam00041
Location:1542 → 1622

fn3; Fibronectin type III domain
NM_001276410.1 → NP_001263339.1 fibronectin isoform d precursor

See identical proteins and their annotated locations for NP_001263339.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks two in-frame exons in the coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.

Source sequence(s)

AC124821, AK147315, AK171339, CJ098561, CK639246, CN532664, CN536551, CN692112

Consensus CDS

CCDS78609.1

UniProtKB/TrEMBL

A0A087WSN6, Q3TCF1

Related

ENSMUSP00000141123.2, ENSMUST00000186129.7

Conserved Domains (5) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:187 → 231

FN1; Fibronectin type 1 domain

cd00061
Location:2203 → 2242

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

pfam00039
Location:232 → 271

fn1; Fibronectin type I domain

pfam00041
Location:1542 → 1622

fn3; Fibronectin type III domain
NM_001276411.1 → NP_001263340.1 fibronectin isoform e precursor

See identical proteins and their annotated locations for NP_001263340.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks two in-frame exons and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (e) is shorter than isoform a.

Source sequence(s)

AC124821, AK147663, BC138421, CJ098561

Consensus CDS

CCDS78608.1

UniProtKB/TrEMBL

B9EHT6, Q3TCF1

Related

ENSMUSP00000140816.2, ENSMUST00000190780.7

Conserved Domains (6) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:187 → 231

FN1; Fibronectin type 1 domain

cd00061
Location:2178 → 2217

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:1813 → 1893

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:1450 → 1529

fn3; Fibronectin type III domain

pfam00039
Location:232 → 271

fn1; Fibronectin type I domain
NM_001276412.1 → NP_001263341.1 fibronectin isoform f precursor

Status: VALIDATED

Description

Transcript Variant: This variant (6) lacks an in-frame exon and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (f) is shorter than isoform a.

Source sequence(s)

AC124821, AK147315, AK147639, CJ098561

Consensus CDS

CCDS78610.1

UniProtKB/TrEMBL

A0A087WS56, Q3UH17

Related

ENSMUSP00000140907.2, ENSMUST00000188674.7

Conserved Domains (6) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:187 → 231

FN1; Fibronectin type 1 domain

cd00061
Location:2173 → 2212

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:1903 → 1983

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:1450 → 1529

fn3; Fibronectin type III domain

pfam00039
Location:232 → 271

fn1; Fibronectin type I domain
NM_001276413.1 → NP_001263342.1 fibronectin isoform g precursor

See identical proteins and their annotated locations for NP_001263342.1

Status: VALIDATED

Description

Transcript Variant: This variant (7) lacks two in-frame exons and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (g) is shorter than isoform a.

Source sequence(s)

AC124821, AK147701, AK171339, CJ098561

Consensus CDS

CCDS78607.1

UniProtKB/TrEMBL

B7ZNJ1, Q3UH17

Related

ENSMUSP00000139702.2, ENSMUST00000189821.7

Conserved Domains (5) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:187 → 231

FN1; Fibronectin type 1 domain

cd00061
Location:2083 → 2122

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

pfam00039
Location:232 → 271

fn1; Fibronectin type I domain

pfam00041
Location:1542 → 1622

fn3; Fibronectin type III domain
NM_010233.2 → NP_034363.1 fibronectin isoform a precursor

See identical proteins and their annotated locations for NP_034363.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC124821, AK133868, CF166960, CF727068, CJ098561, CK637170, CK638401, CN460535, CN534124, CN538894, CN694596

Consensus CDS

CCDS15031.1

UniProtKB/Swiss-Prot

G5E8B8, P11276, Q61567, Q61568, Q61569, Q64233, Q80UI4

UniProtKB/TrEMBL

Q3UGY5

Related

ENSMUSP00000054499.7, ENSMUST00000055226.13

Conserved Domains (6) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:187 → 231

FN1; Fibronectin type 1 domain

cd00061
Location:2384 → 2423

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:1994 → 2074

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00039
Location:232 → 271

fn1; Fibronectin type I domain

pfam00041
Location:1541 → 1620

fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

71624632..71692439 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017315837.2 → XP_017171326.1 fibronectin isoform X5

UniProtKB/TrEMBL

Q3UH17

Conserved Domains (5) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:187 → 231

FN1; Fibronectin type 1 domain

cd00061
Location:2174 → 2213

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

pfam00039
Location:232 → 271

fn1; Fibronectin type I domain

pfam00041
Location:1633 → 1713

fn3; Fibronectin type III domain
XM_030248098.1 → XP_030103958.1 fibronectin isoform X3

UniProtKB/TrEMBL

Q3TCF1

Conserved Domains (5) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:187 → 231

FN1; Fibronectin type 1 domain

cd00061
Location:2269 → 2308

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

pfam00039
Location:232 → 271

fn1; Fibronectin type I domain

pfam00041
Location:1633 → 1713

fn3; Fibronectin type III domain
XM_006495699.4 → XP_006495762.1 fibronectin isoform X2

See identical proteins and their annotated locations for XP_006495762.1

UniProtKB/TrEMBL

Q3TCF1

Conserved Domains (5) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:187 → 231

FN1; Fibronectin type 1 domain

cd00061
Location:2294 → 2333

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

pfam00039
Location:232 → 271

fn1; Fibronectin type I domain

pfam00041
Location:1633 → 1713

fn3; Fibronectin type III domain
XM_006495700.4 → XP_006495763.1 fibronectin isoform X4

UniProtKB/TrEMBL

Q3UH17

Conserved Domains (5) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:187 → 231

FN1; Fibronectin type 1 domain

cd00061
Location:2264 → 2303

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

pfam00039
Location:232 → 271

fn1; Fibronectin type I domain

pfam00041
Location:1633 → 1713

fn3; Fibronectin type III domain
XM_006495697.4 → XP_006495760.1 fibronectin isoform X1

UniProtKB/TrEMBL

Q3UGY5

Conserved Domains (5) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:187 → 231

FN1; Fibronectin type 1 domain

cd00061
Location:2359 → 2398

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

pfam00039
Location:232 → 271

fn1; Fibronectin type I domain

pfam00041
Location:1633 → 1713

fn3; Fibronectin type III domain