SPTBN1 spectrin beta, non-erythrocytic 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SPTBN1provided by HGNC
Official Full Name: spectrin beta, non-erythrocytic 1provided by HGNC
Primary source: HGNC:HGNC:11275
See related: Ensembl:ENSG00000115306 MIM:182790; AllianceGenome:HGNC:11275
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ELF; SPTB2; DDISBA; HEL102; betaSpII
Summary: Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in fat (RPKM 102.5), lung (RPKM 72.2) and 24 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 2p16.2

Exon count:: 44

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (54456327..54671446)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (54450519..54665452)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (54683464..54898583)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cardiomyocyte betaII spectrin plays a critical role in maintaining cardiac function by regulating mitochondrial respiratory function.
Title: Cardiomyocyte βII spectrin plays a critical role in maintaining cardiac function by regulating mitochondrial respiratory function.
Postsynaptic beta1 spectrin maintains Na[+] channels at the neuromuscular junction.
Title: Postsynaptic β1 spectrin maintains Na(+) channels at the neuromuscular junction.
Identification of bone mineral density associated genes with shared genetic architectures across multiple tissues: Functional insights for EPDR1, PKDCC, and SPTBN1.
Title: Identification of bone mineral density associated genes with shared genetic architectures across multiple tissues: Functional insights for EPDR1, PKDCC, and SPTBN1.
Tumor cell SPTBN1 inhibits M2 polarization of macrophages by suppressing CXCL1 expression.
Title: Tumor cell SPTBN1 inhibits M2 polarization of macrophages by suppressing CXCL1 expression.
SPTBN1 Mediates the Cytoplasmic Constraint of PTTG1, Impairing Its Oncogenic Activity in Human Seminoma.
Title: SPTBN1 Mediates the Cytoplasmic Constraint of PTTG1, Impairing Its Oncogenic Activity in Human Seminoma.
Clinical significance of nonerythrocytic spectrin Beta 1 (SPTBN1) in human kidney renal clear cell carcinoma and uveal melanoma: a study based on Pan-Cancer Analysis.
Title: Clinical significance of nonerythrocytic spectrin Beta 1 (SPTBN1) in human kidney renal clear cell carcinoma and uveal melanoma: a study based on Pan-Cancer Analysis.
SPTBN1 abrogates renal clear cell carcinoma progression via glycolysis reprogramming in a GPT2-dependent manner.
Title: SPTBN1 abrogates renal clear cell carcinoma progression via glycolysis reprogramming in a GPT2-dependent manner.
SPTBN1 attenuates rheumatoid arthritis synovial cell proliferation, invasion, migration and inflammatory response by binding to PIK3R2.
Title: SPTBN1 attenuates rheumatoid arthritis synovial cell proliferation, invasion, migration and inflammatory response by binding to PIK3R2.
SPTBN1 inhibits growth and epithelial-mesenchymal transition in breast cancer by downregulating miR-21.
Title: SPTBN1 inhibits growth and epithelial-mesenchymal transition in breast cancer by downregulating miR-21.
Heterozygous variants in SPTBN1 cause intellectual disability and autism.
Title: Heterozygous variants in SPTBN1 cause intellectual disability and autism.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Developmental delay, impaired speech, and behavioral abnormalities MedGen: C5561957 OMIM: 619475 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic variants on chromosome 1q41 influence ocular axial length and high myopia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. EBI GWAS Catalog EBI GWAS CatalogPubMed
Multiple genetic loci for bone mineral density and fractures. EBI GWAS Catalog EBI GWAS CatalogPubMed
New sequence variants associated with bone mineral density. EBI GWAS Catalog EBI GWAS CatalogPubMed
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Replication interactions

Interaction	Pubs
Knockdown of SPTBN1 by siRNA inhibits HIV-1 replication in primary macrophages	PubMed
Knockdown of spectrin, beta, non-erythrocytic 1 (SPTBN1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	HIV-1 Gag co-localizes with SPTBN1 both at the plasma membrane and in cytoplasm	PubMed
Rev	rev	HIV-1 Rev interacting protein, spectrin, beta, non-erythrocytic 1 (SPTBN1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells	PubMed
Tat	tat	Spectrin, beta, non-erythrocytic 1 (SPTBN1) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS	PubMed
Vpr	vpr	Co-localization of Vpr-GFP-labeled virion and SPTBN1 is observed on plasma membrane (PM) and the intracellular side of PM	PubMed
capsid	gag	HIV-1 CA associates with SPTBN1 in cells	PubMed
matrix	gag	HIV-1 MA associates with SPTBN1 in cells	PubMed
retropepsin	gag-pol	A number of focal adhesion plaque proteins are specifically cleaved by HIV-1 protease, including fimbrin, focal adhesion plaque kinase (FAK), talin, and, to a lesser extent, filamin, spectrin and fibronectin	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

D7S2262 (e-PCR)
- UniSTS:153615

G31089 (e-PCR)
- UniSTS:23074

RH80117 (e-PCR)
- UniSTS:84006

RH11563 (e-PCR)
- UniSTS:30251

D2S2825 (e-PCR)
- UniSTS:33079

RH48838 (e-PCR)
- UniSTS:8770

Cda10d06 (e-PCR)
- UniSTS:51303

SHGC-35870 (e-PCR)
- UniSTS:63849

WI-16857 (e-PCR)
- UniSTS:62838

WI-12526 (e-PCR)
- UniSTS:53891

D2S1576E (e-PCR)
- UniSTS:150660

D2S1586E (e-PCR)
- UniSTS:150670

RH120699 (e-PCR)
- UniSTS:132780

D2S2153 (e-PCR), detects polymorphism
- UniSTS:32950

SPTBN1__1999 (e-PCR)
- UniSTS:281028

RH69548 (e-PCR)
- UniSTS:42972

G59509 (e-PCR)
- UniSTS:136673

SHGC-31423 (e-PCR)
- UniSTS:32492

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA binding	HDA more info	PubMed
enables actin binding	TAS Traceable Author Statement more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables ankyrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables ankyrin binding	NAS Non-traceable Author Statement more info	PubMed
enables cadherin binding	HDA more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament capping	IEA Inferred from Electronic Annotation more info
involved_in central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-2 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization to plasma membrane	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in M band	IEA Inferred from Electronic Annotation more info
located_in axolemma	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cell junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cuticular plate	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
part_of spectrin	IEA Inferred from Electronic Annotation more info
located_in spectrin-associated cytoskeleton	NAS Non-traceable Author Statement more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: spectrin beta chain, non-erythrocytic 1

Names: beta-G spectrin; beta-II spectrin; beta-fodrin; beta-spectrin 2; beta-spectrin II; beta-spectrin non-erythrocytic 1; embryonic liver beta-fodrin; epididymis luminal protein 102; fodrin beta chain; spectrin beta chain, brain 1; spectrin, non-erythroid beta chain 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029817.1 RefSeqGene

Range

5011..220130

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_003128.3 → NP_003119.2 spectrin beta chain, non-erythrocytic 1 isoform 1

See identical proteins and their annotated locations for NP_003119.2

Status: REVIEWED

Description

Transcript Variant: This variant (1), also known as long or sigma-1, represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AB209748, AC093110, BM679686, BP218428, BP312037

Consensus CDS

CCDS33198.1

UniProtKB/Swiss-Prot

B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99

UniProtKB/TrEMBL

B2ZZ89, D6W5B9, K9MS24

Related

ENSP00000349259.4, ENST00000356805.9

Conserved Domains (6) summary

COG5069
Location:48 → 530

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00176
Location:530 → 743

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd10571
Location:2200 → 2305

PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

pfam00435
Location:2017 → 2075

Spectrin; Spectrin repeat

cd21248
Location:173 → 277

CH_SPTB_like_rpt2; second calponin homology (CH) domain found in the beta-I spectrin-like subfamily

cd21316
Location:3 → 156

CH_SPTBN1_rpt1; first calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 1 (SPTBN1) and similar proteins
NM_178313.3 → NP_842565.2 spectrin beta chain, non-erythrocytic 1 isoform 2

See identical proteins and their annotated locations for NP_842565.2

Status: REVIEWED

Description

Transcript Variant: This variant (2), also known as short or sigma-2, differs in the 5' UTR, 3' UTR, and coding region (compared to variant 1). The resulting protein (isoform 2) maintains the reading frame but has shorter and distinct sequences at both the N- and C-termini, compared to isoform 1.

Source sequence(s)

AC092839, AC093110, AF327441, AK025071, CR980403

Consensus CDS

CCDS33199.1

UniProtKB/TrEMBL

K9MS24

Related

ENSP00000334156.5, ENST00000333896.5

Conserved Domains (3) summary

COG5069
Location:34 → 517

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00176
Location:517 → 730

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:2004 → 2062

Spectrin; Spectrin repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

54456327..54671446

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017004781.2 → XP_016860270.1 spectrin beta chain, non-erythrocytic 1 isoform X1

UniProtKB/Swiss-Prot

B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99

UniProtKB/TrEMBL

B2ZZ89, D6W5B9, K9MS24

Conserved Domains (6) summary

COG5069
Location:48 → 530

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00176
Location:530 → 743

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd10571
Location:2200 → 2305

PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

pfam00435
Location:2017 → 2075

Spectrin; Spectrin repeat

cd21248
Location:173 → 277

CH_SPTB_like_rpt2; second calponin homology (CH) domain found in the beta-I spectrin-like subfamily

cd21316
Location:3 → 156

CH_SPTBN1_rpt1; first calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 1 (SPTBN1) and similar proteins
XM_017004779.2 → XP_016860268.1 spectrin beta chain, non-erythrocytic 1 isoform X1

UniProtKB/Swiss-Prot

B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99

UniProtKB/TrEMBL

B2ZZ89, D6W5B9, K9MS24

Conserved Domains (6) summary

COG5069
Location:48 → 530

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00176
Location:530 → 743

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd10571
Location:2200 → 2305

PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

pfam00435
Location:2017 → 2075

Spectrin; Spectrin repeat

cd21248
Location:173 → 277

CH_SPTB_like_rpt2; second calponin homology (CH) domain found in the beta-I spectrin-like subfamily

cd21316
Location:3 → 156

CH_SPTBN1_rpt1; first calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 1 (SPTBN1) and similar proteins
XM_005264517.3 → XP_005264574.1 spectrin beta chain, non-erythrocytic 1 isoform X1

See identical proteins and their annotated locations for XP_005264574.1

UniProtKB/Swiss-Prot

B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99

UniProtKB/TrEMBL

B2ZZ89, D6W5B9, K9MS24

Conserved Domains (6) summary

COG5069
Location:48 → 530

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00176
Location:530 → 743

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd10571
Location:2200 → 2305

PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

pfam00435
Location:2017 → 2075

Spectrin; Spectrin repeat

cd21248
Location:173 → 277

CH_SPTB_like_rpt2; second calponin homology (CH) domain found in the beta-I spectrin-like subfamily

cd21316
Location:3 → 156

CH_SPTBN1_rpt1; first calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 1 (SPTBN1) and similar proteins
XM_006712087.4 → XP_006712150.1 spectrin beta chain, non-erythrocytic 1 isoform X1

See identical proteins and their annotated locations for XP_006712150.1

UniProtKB/Swiss-Prot

B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99

UniProtKB/TrEMBL

B2ZZ89, D6W5B9, K9MS24

Conserved Domains (6) summary

COG5069
Location:48 → 530

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00176
Location:530 → 743

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd10571
Location:2200 → 2305

PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

pfam00435
Location:2017 → 2075

Spectrin; Spectrin repeat

cd21248
Location:173 → 277

CH_SPTB_like_rpt2; second calponin homology (CH) domain found in the beta-I spectrin-like subfamily

cd21316
Location:3 → 156

CH_SPTBN1_rpt1; first calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 1 (SPTBN1) and similar proteins
XM_047445595.1 → XP_047301551.1 spectrin beta chain, non-erythrocytic 1 isoform X1

UniProtKB/Swiss-Prot

B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99

UniProtKB/TrEMBL

B2ZZ89, D6W5B9
XM_047445593.1 → XP_047301549.1 spectrin beta chain, non-erythrocytic 1 isoform X1

UniProtKB/Swiss-Prot

B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99

UniProtKB/TrEMBL

B2ZZ89, D6W5B9
XM_047445591.1 → XP_047301547.1 spectrin beta chain, non-erythrocytic 1 isoform X1

UniProtKB/Swiss-Prot

B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99

UniProtKB/TrEMBL

B2ZZ89, D6W5B9
XM_017004780.2 → XP_016860269.1 spectrin beta chain, non-erythrocytic 1 isoform X1

UniProtKB/Swiss-Prot

B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99

UniProtKB/TrEMBL

B2ZZ89, D6W5B9, K9MS24

Conserved Domains (6) summary

COG5069
Location:48 → 530

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00176
Location:530 → 743

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd10571
Location:2200 → 2305

PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

pfam00435
Location:2017 → 2075

Spectrin; Spectrin repeat

cd21248
Location:173 → 277

CH_SPTB_like_rpt2; second calponin homology (CH) domain found in the beta-I spectrin-like subfamily

cd21316
Location:3 → 156

CH_SPTBN1_rpt1; first calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 1 (SPTBN1) and similar proteins
XM_047445594.1 → XP_047301550.1 spectrin beta chain, non-erythrocytic 1 isoform X1

UniProtKB/Swiss-Prot

B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99

UniProtKB/TrEMBL

B2ZZ89, D6W5B9
XM_047445592.1 → XP_047301548.1 spectrin beta chain, non-erythrocytic 1 isoform X1

UniProtKB/Swiss-Prot

B2RP63, O60837, Q01082, Q16057, Q53R99, Q59ER3, Q8IX99

UniProtKB/TrEMBL

B2ZZ89, D6W5B9
XM_005264518.3 → XP_005264575.1 spectrin beta chain, non-erythrocytic 1 isoform X2

See identical proteins and their annotated locations for XP_005264575.1

UniProtKB/TrEMBL

K9MS24

Conserved Domains (5) summary

cd00014
Location:161 → 264

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:517 → 730

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd10571
Location:2187 → 2292

PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

pfam00169
Location:2187 → 2294

PH; PH domain

pfam00435
Location:409 → 512

Spectrin; Spectrin repeat